MX2020003901A - Composiciones y metodos para modular la expresion del receptor de la hormona del crecimiento. - Google Patents

Composiciones y metodos para modular la expresion del receptor de la hormona del crecimiento.

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Publication number
MX2020003901A
MX2020003901A MX2020003901A MX2020003901A MX2020003901A MX 2020003901 A MX2020003901 A MX 2020003901A MX 2020003901 A MX2020003901 A MX 2020003901A MX 2020003901 A MX2020003901 A MX 2020003901A MX 2020003901 A MX2020003901 A MX 2020003901A
Authority
MX
Mexico
Prior art keywords
growth hormone
compositions
hormone receptor
methods
receptor expression
Prior art date
Application number
MX2020003901A
Other languages
English (en)
Inventor
Eric E Swayze
Sanjay Bhanot
Punit P Seth
Thazha P Prakash
Huynh-Hoa Bui
Susan M Freier
Original Assignee
Ionis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ionis Pharmaceuticals Inc filed Critical Ionis Pharmaceuticals Inc
Publication of MX2020003901A publication Critical patent/MX2020003901A/es

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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • A—HUMAN NECESSITIES
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/555—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound pre-targeting systems involving an organic compound, other than a peptide, protein or antibody, for targeting specific cells
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
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    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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Abstract

Las presentes modalidades proporcionan métodos, compuestos y composiciones para tratar, prevenir o mejorar una enfermedad asociada a un exceso de la hormona del crecimiento usando compuestos u oligonucleótidos antisentido dirigidos al receptor de la hormona del crecimiento (GHR).
MX2020003901A 2014-05-01 2016-10-25 Composiciones y metodos para modular la expresion del receptor de la hormona del crecimiento. MX2020003901A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461987470P 2014-05-01 2014-05-01
US201462061071P 2014-10-07 2014-10-07
US201462082511P 2014-11-20 2014-11-20

Publications (1)

Publication Number Publication Date
MX2020003901A true MX2020003901A (es) 2020-08-20

Family

ID=54359509

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2016014013A MX2016014013A (es) 2014-05-01 2015-05-01 Composiciones y metodos para modular la expresion del receptor de la hormona del crecimiento.
MX2020003901A MX2020003901A (es) 2014-05-01 2016-10-25 Composiciones y metodos para modular la expresion del receptor de la hormona del crecimiento.

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MX2016014013A MX2016014013A (es) 2014-05-01 2015-05-01 Composiciones y metodos para modular la expresion del receptor de la hormona del crecimiento.

Country Status (14)

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US (5) US9994855B2 (es)
EP (3) EP3974534A1 (es)
JP (2) JP6667453B2 (es)
KR (2) KR20200102553A (es)
CN (2) CN106459969B (es)
AU (2) AU2015252841B2 (es)
BR (2) BR112016022742B1 (es)
CA (1) CA2942570A1 (es)
DK (1) DK3137604T3 (es)
ES (1) ES2812099T3 (es)
IL (2) IL247716B (es)
MX (2) MX2016014013A (es)
RU (1) RU2724527C2 (es)
WO (1) WO2015168618A2 (es)

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JP6626101B2 (ja) 2014-10-10 2019-12-25 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ ＧａｌＮＡｃホスホラミダイト、その核酸結合体およびそれらの使用
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KR20190065341A (ko) 2016-10-06 2019-06-11 아이오니스 파마수티컬즈, 인코포레이티드 올리고머 화합물들의 접합 방법
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AU2020371736A1 (en) * 2019-10-24 2022-06-02 Genevant Sciences Gmbh Conjugates and methods for treating acromegaly
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CA3226651A1 (en) * 2021-08-03 2023-02-09 Kallanthottathil G. Rajeev Compositions and methods for targeted rna delivery
US11692001B2 (en) 2021-08-30 2023-07-04 Hongene Biotech Corporation Functionalized n-acetylgalactosamine analogs
US11993626B2 (en) 2021-12-15 2024-05-28 Hongene Biotech Corporation Functionalized N-acetylgalactosamine analogs
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EP3757215A3 (en) 2021-03-17
US11312964B2 (en) 2022-04-26
IL247716B (en) 2020-03-31
WO2015168618A2 (en) 2015-11-05
BR112016022742B1 (pt) 2022-06-14
CN110903337A (zh) 2020-03-24
JP2020019798A (ja) 2020-02-06
EP3974534A1 (en) 2022-03-30
KR102149571B1 (ko) 2020-08-31
US20230118177A1 (en) 2023-04-20
JP6882411B2 (ja) 2021-06-02
BR122020024446B8 (pt) 2022-06-28
IL272653A (en) 2020-03-31
EP3757215A2 (en) 2020-12-30
EP3137604B1 (en) 2020-07-15
AU2015252841A1 (en) 2016-09-22
AU2015252841B2 (en) 2020-03-19
KR20170002471A (ko) 2017-01-06
DK3137604T3 (da) 2020-08-03
RU2724527C2 (ru) 2020-06-23
CN106459969B (zh) 2019-11-15
JP2017518278A (ja) 2017-07-06
US20170166899A1 (en) 2017-06-15
AU2020204024A1 (en) 2020-07-09
BR122020024446B1 (pt) 2022-04-26
BR112016022742A2 (pt) 2017-10-31
US20200123551A1 (en) 2020-04-23
JP6667453B2 (ja) 2020-03-18
IL247716A0 (en) 2016-11-30
US9994855B2 (en) 2018-06-12
CN106459969A (zh) 2017-02-22
CA2942570A1 (en) 2015-11-05
ES2812099T3 (es) 2021-03-16
WO2015168618A3 (en) 2015-12-23
RU2016146819A3 (es) 2019-02-20
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EP3137604A2 (en) 2017-03-08

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