ES2708215T3 - Compuestos de 6,7-dihidropirazolo[1,5-a]pirazin-4(5H)-ona y su uso como moduladores alostéricos negativos de receptores MGLU2 - Google Patents

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Publication number

ES2708215T3

ES2708215T3 ES15750666T ES15750666T ES2708215T3 ES 2708215 T3 ES2708215 T3 ES 2708215T3 ES 15750666 T ES15750666 T ES 15750666T ES 15750666 T ES15750666 T ES 15750666T ES 2708215 T3 ES2708215 T3 ES 2708215T3

Authority

ES

Spain

Prior art keywords

alkyl

methyl

group

phenyl

dihydropyrazolo

Prior art date

2014-08-01

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

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• 150000001875 compounds Chemical class 0.000 title claims abstract description 304
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• GLQXAHBYDJPCHG-UHFFFAOYSA-N 6,7-dihydro-5h-pyrazolo[1,5-a]pyrazin-4-one Chemical compound O=C1NCCN2N=CC=C12 GLQXAHBYDJPCHG-UHFFFAOYSA-N 0.000 title description 7
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• 125000000217 alkyl group Chemical group 0.000 claims abstract description 192
• -1 2-pyridinyl Chemical group 0.000 claims abstract description 85
• 150000003839 salts Chemical class 0.000 claims abstract description 57
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 56
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• 125000001424 substituent group Chemical group 0.000 claims abstract description 45
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• 125000003118 aryl group Chemical group 0.000 claims abstract description 21
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• 150000002431 hydrogen Chemical class 0.000 claims abstract description 15
• 125000003373 pyrazinyl group Chemical group 0.000 claims abstract description 9
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• 125000001412 tetrahydropyranyl group Chemical group 0.000 claims abstract description 7
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