EA031087B1 - 6,7-ДИГИДРОПИРАЗОЛО[1,5-a]ПИРАЗИН-4(5H)-ОНОВЫЕ СОЕДИНЕНИЯ И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ОТРИЦАТЕЛЬНЫХ АЛЛОСТЕРИЧЕСКИХ МОДУЛЯТОРОВ РЕЦЕПТОРОВ mGluR2 - Google Patents

6,7-ДИГИДРОПИРАЗОЛО[1,5-a]ПИРАЗИН-4(5H)-ОНОВЫЕ СОЕДИНЕНИЯ И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ОТРИЦАТЕЛЬНЫХ АЛЛОСТЕРИЧЕСКИХ МОДУЛЯТОРОВ РЕЦЕПТОРОВ mGluR2 Download PDF

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Publication number
EA031087B1
EA031087B1 EA201692540A EA201692540A EA031087B1 EA 031087 B1 EA031087 B1 EA 031087B1 EA 201692540 A EA201692540 A EA 201692540A EA 201692540 A EA201692540 A EA 201692540A EA 031087 B1 EA031087 B1 EA 031087B1
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Eurasian Patent Office
Prior art keywords
alkyl
group
methyl
phenyl
dihydropyrazolo
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EA201692540A
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English (en)
Russian (ru)
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EA201692540A1 (ru
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Серхио-Алвар Алонсо-Де Диего
Михиль Люк Мария Ван Гол
Оскар Дельгадо-Гонсалес
Хосе Игнасио Андрес-Хиль
Андрес Авелино Трабанко-Суарес
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Янссен Фармацевтика Н.В.
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Publication of EA201692540A1 publication Critical patent/EA201692540A1/ru
Publication of EA031087B1 publication Critical patent/EA031087B1/ru

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • A61K31/41621,2-Diazoles condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EA201692540A 2014-08-01 2015-07-30 6,7-ДИГИДРОПИРАЗОЛО[1,5-a]ПИРАЗИН-4(5H)-ОНОВЫЕ СОЕДИНЕНИЯ И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ОТРИЦАТЕЛЬНЫХ АЛЛОСТЕРИЧЕСКИХ МОДУЛЯТОРОВ РЕЦЕПТОРОВ mGluR2 EA031087B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14179598 2014-08-01
PCT/EP2015/067530 WO2016016380A1 (en) 2014-08-01 2015-07-30 6,7-DIHYDROPYRAZOLO[1,5-α]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS

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EA201692540A1 EA201692540A1 (ru) 2017-05-31
EA031087B1 true EA031087B1 (ru) 2018-11-30

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TR (1) TR201901074T4 (enExample)
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WO2016016380A1 (en) 2016-02-04
KR20170031247A (ko) 2017-03-20
SMT201900038T1 (it) 2019-02-28
LT3177623T (lt) 2019-02-11
MX376289B (es) 2025-03-07
TR201901074T4 (tr) 2019-02-21
EP3177623A1 (en) 2017-06-14
ME03320B (me) 2019-10-20
IL250298A0 (en) 2017-03-30
AU2015295298A1 (en) 2017-01-12
RS58279B1 (sr) 2019-03-29
MA39582B1 (fr) 2019-10-31
TW201617346A (zh) 2016-05-16
HUE042871T2 (hu) 2019-07-29
SG11201700638YA (en) 2017-02-27
MX2017001452A (es) 2017-05-09
PH12017500161A1 (en) 2017-06-28
JOP20150179B1 (ar) 2021-08-17
MA39582A1 (fr) 2018-06-29
AU2015295298B2 (en) 2019-07-11
WO2016016380A8 (en) 2017-01-19
US20170217972A1 (en) 2017-08-03
PL3177623T3 (pl) 2019-04-30
SI3177623T1 (sl) 2019-01-31
NZ728122A (en) 2022-07-29
EP3177623B1 (en) 2018-11-07
US20200121677A1 (en) 2020-04-23
CA2954093C (en) 2022-11-29
ZA201700759B (en) 2018-12-19
CA2954093A1 (en) 2016-02-04
US10512646B2 (en) 2019-12-24
JP2017522340A (ja) 2017-08-10
EA201692540A1 (ru) 2017-05-31
PT3177623T (pt) 2019-02-01
KR102531689B1 (ko) 2023-05-10
TWI696624B (zh) 2020-06-21
CN106573936B (zh) 2020-01-07
CY1121649T1 (el) 2020-07-31
CN106573936A (zh) 2017-04-19
PH12017500161B1 (en) 2022-05-18
JP6662846B2 (ja) 2020-03-11
HRP20181997T1 (hr) 2019-01-25
BR112017001726A2 (pt) 2017-11-21
AR101392A1 (es) 2016-12-14
ES2708215T3 (es) 2019-04-09
CL2017000192A1 (es) 2017-07-28
US10005786B2 (en) 2018-06-26
US20180256569A1 (en) 2018-09-13
DK3177623T3 (en) 2019-02-25

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