EA031087B1 - 6,7-ДИГИДРОПИРАЗОЛО[1,5-a]ПИРАЗИН-4(5H)-ОНОВЫЕ СОЕДИНЕНИЯ И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ОТРИЦАТЕЛЬНЫХ АЛЛОСТЕРИЧЕСКИХ МОДУЛЯТОРОВ РЕЦЕПТОРОВ mGluR2 - Google Patents

6,7-ДИГИДРОПИРАЗОЛО[1,5-a]ПИРАЗИН-4(5H)-ОНОВЫЕ СОЕДИНЕНИЯ И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ОТРИЦАТЕЛЬНЫХ АЛЛОСТЕРИЧЕСКИХ МОДУЛЯТОРОВ РЕЦЕПТОРОВ mGluR2 Download PDF

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Publication number
EA031087B1
EA031087B1 EA201692540A EA201692540A EA031087B1 EA 031087 B1 EA031087 B1 EA 031087B1 EA 201692540 A EA201692540 A EA 201692540A EA 201692540 A EA201692540 A EA 201692540A EA 031087 B1 EA031087 B1 EA 031087B1
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Eurasian Patent Office
Prior art keywords
alkyl
group
methyl
phenyl
dihydropyrazolo
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EA201692540A
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Russian (ru)
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EA201692540A1 (ru
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Серхио-Алвар Алонсо-Де Диего
Михиль Люк Мария Ван Гол
Оскар Дельгадо-Гонсалес
Хосе Игнасио Андрес-Хиль
Андрес Авелино Трабанко-Суарес
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Янссен Фармацевтика Н.В.
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Publication of EA201692540A1 publication Critical patent/EA201692540A1/ru
Publication of EA031087B1 publication Critical patent/EA031087B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EA201692540A 2014-08-01 2015-07-30 6,7-ДИГИДРОПИРАЗОЛО[1,5-a]ПИРАЗИН-4(5H)-ОНОВЫЕ СОЕДИНЕНИЯ И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ОТРИЦАТЕЛЬНЫХ АЛЛОСТЕРИЧЕСКИХ МОДУЛЯТОРОВ РЕЦЕПТОРОВ mGluR2 EA031087B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14179598 2014-08-01
PCT/EP2015/067530 WO2016016380A1 (en) 2014-08-01 2015-07-30 6,7-DIHYDROPYRAZOLO[1,5-α]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS

Publications (2)

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EA201692540A1 EA201692540A1 (ru) 2017-05-31
EA031087B1 true EA031087B1 (ru) 2018-11-30

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UA (1) UA121552C2 (enExample)
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JP2017522340A (ja) 2017-08-10
MA39582A1 (fr) 2018-06-29
KR102531689B1 (ko) 2023-05-10
CA2954093A1 (en) 2016-02-04
HRP20181997T1 (hr) 2019-01-25
CN106573936B (zh) 2020-01-07
AR101392A1 (es) 2016-12-14
EP3177623B1 (en) 2018-11-07
ZA201700759B (en) 2018-12-19
HUE042871T2 (hu) 2019-07-29
MX376289B (es) 2025-03-07
RS58279B1 (sr) 2019-03-29
BR112017001726A2 (pt) 2017-11-21
MA39582B1 (fr) 2019-10-31
WO2016016380A1 (en) 2016-02-04
TR201901074T4 (tr) 2019-02-21
KR20170031247A (ko) 2017-03-20
EP3177623A1 (en) 2017-06-14
WO2016016380A8 (en) 2017-01-19
NZ728122A (en) 2022-07-29
SI3177623T1 (sl) 2019-01-31
DK3177623T3 (en) 2019-02-25
PL3177623T3 (pl) 2019-04-30
US20170217972A1 (en) 2017-08-03
JOP20150179B1 (ar) 2021-08-17
PT3177623T (pt) 2019-02-01
JP6662846B2 (ja) 2020-03-11
LT3177623T (lt) 2019-02-11
CA2954093C (en) 2022-11-29
CL2017000192A1 (es) 2017-07-28
IL250298A0 (en) 2017-03-30
TWI696624B (zh) 2020-06-21
TW201617346A (zh) 2016-05-16
CY1121649T1 (el) 2020-07-31
MX2017001452A (es) 2017-05-09
PH12017500161A1 (en) 2017-06-28
US20180256569A1 (en) 2018-09-13
AU2015295298B2 (en) 2019-07-11
EA201692540A1 (ru) 2017-05-31
US20200121677A1 (en) 2020-04-23
PH12017500161B1 (en) 2022-05-18
ME03320B (me) 2019-10-20
US10005786B2 (en) 2018-06-26
SMT201900038T1 (it) 2019-02-28
SG11201700638YA (en) 2017-02-27
AU2015295298A1 (en) 2017-01-12
US10512646B2 (en) 2019-12-24
ES2708215T3 (es) 2019-04-09
CN106573936A (zh) 2017-04-19
UA121552C2 (uk) 2020-06-25

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