ES2704641T3 - Compuestos N-hidroxiamidinoheterocíclicos como moduladores de la indoleamina 2,3-dioxigenasa - Google Patents
Compuestos N-hidroxiamidinoheterocíclicos como moduladores de la indoleamina 2,3-dioxigenasa Download PDFInfo
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- ES2704641T3 ES2704641T3 ES07842681T ES07842681T ES2704641T3 ES 2704641 T3 ES2704641 T3 ES 2704641T3 ES 07842681 T ES07842681 T ES 07842681T ES 07842681 T ES07842681 T ES 07842681T ES 2704641 T3 ES2704641 T3 ES 2704641T3
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- alkynyl
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- alkenyl
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- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
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- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
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- C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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Landscapes
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- Virology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
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| US84571106P | 2006-09-19 | 2006-09-19 | |
| PCT/US2007/078759 WO2008036653A2 (en) | 2006-09-19 | 2007-09-18 | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase |
Publications (1)
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| ES2704641T3 true ES2704641T3 (es) | 2019-03-19 |
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| ES07842681T Active ES2704641T3 (es) | 2006-09-19 | 2007-09-18 | Compuestos N-hidroxiamidinoheterocíclicos como moduladores de la indoleamina 2,3-dioxigenasa |
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| US (2) | US20080214546A1 (cg-RX-API-DMAC7.html) |
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| CL (1) | CL2007002650A1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2704641T3 (cg-RX-API-DMAC7.html) |
| TW (1) | TW200819445A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2008036653A2 (cg-RX-API-DMAC7.html) |
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| WO2003062438A1 (en) * | 2002-01-22 | 2003-07-31 | Biomatera Inc. | Method of drying biodegradable polymers |
| CN101212967A (zh) | 2005-05-10 | 2008-07-02 | 因塞特公司 | 吲哚胺2,3-双加氧酶调节剂及其用法 |
| ES2540561T3 (es) | 2005-12-20 | 2015-07-10 | Incyte Corporation | N-hidroxiamidinoheterociclos como moduladores de indolamina 2,3-dioxigenasa |
| CA2663057C (en) | 2006-09-19 | 2015-12-08 | Incyte Corporation | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase |
| CL2007002650A1 (es) | 2006-09-19 | 2008-02-08 | Incyte Corp | Compuestos derivados de heterociclo n-hidroxiamino; composicion farmaceutica, util para tratar cancer, infecciones virales y desordenes neurodegenerativos entre otras. |
| CN104042611B (zh) | 2008-07-08 | 2019-05-14 | 因塞特控股公司 | 作为吲哚胺2，3-双加氧酶的抑制剂的1，2，5-噁二唑 |
| CN102558083B (zh) * | 2010-12-22 | 2015-07-01 | 无锡药明康德生物技术有限公司 | N,n-双取代-3-氨基异噁唑-5-甲醇化合物的合成方法 |
| CN102558084A (zh) * | 2010-12-22 | 2012-07-11 | 上海药明康德新药开发有限公司 | N,n-双取代-3-氨基异噁唑-5-羧酸化合物的合成方法 |
| GB201120860D0 (en) | 2011-12-05 | 2012-01-18 | Cambridge Entpr Ltd | Cancer immunotherapy |
| EP2922847A1 (en) | 2012-11-20 | 2015-09-30 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of indoleamine 2,3-dioxygenase |
| MY174254A (en) | 2013-11-08 | 2020-04-01 | Incyte Holdings Corp | Process for the synthesis of an indoleamine 2,3-dioxygenase inhibitor |
| EA032469B1 (ru) | 2013-12-24 | 2019-05-31 | Бристол-Маерс Сквибб Компани | Новые трициклические соединения в качестве противораковых средств |
| PT3151921T (pt) | 2014-06-06 | 2019-11-21 | Bristol Myers Squibb Co | Anticorpos contra recetor do fator de necrose tumoral induzido por glicocorticoide e utilizações dos mesmos |
| EP3151820A4 (en) | 2014-06-06 | 2017-11-22 | Flexus Biosciences, Inc. | Immunoregulatory agents |
| ES2807182T3 (es) | 2014-11-21 | 2021-02-22 | Bristol Myers Squibb Co | Anticuerpos frente a CD73 y sus usos |
| US10525035B2 (en) | 2014-12-18 | 2020-01-07 | Lankenau Institute For Medical Research | Methods and compositions for the treatment of retinopathy and other ocular diseases |
| TW201630907A (zh) | 2014-12-22 | 2016-09-01 | 必治妥美雅史谷比公司 | ＴＧＦβＲ拮抗劑 |
| JP6180663B2 (ja) | 2014-12-23 | 2017-08-16 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | Ｔｉｇｉｔに対する抗体 |
| WO2016127052A1 (en) | 2015-02-05 | 2016-08-11 | Bristol-Myers Squibb Company | Cxcl11 and smica as predictive biomarkers for efficacy of anti-ctla4 immunotherapy |
| AU2016226468B2 (en) | 2015-03-02 | 2020-10-22 | Bristol-Myers Squibb Company | TGF-beta inhibitors |
| MX2017012729A (es) | 2015-04-03 | 2017-11-15 | Bristol Myers Squibb Co | Inhibidores de indolamina 2,3-dioxigenasa (ido) para el tratamiento de cancer. |
| WO2016162505A1 (en) | 2015-04-08 | 2016-10-13 | F-Star Biotechnology Limited | Her2 binding agent therapies |
| JP6971850B2 (ja) | 2015-04-13 | 2021-11-24 | ファイヴ プライム セラピューティクス インク | がんの併用療法 |
| WO2016183114A1 (en) | 2015-05-11 | 2016-11-17 | Bristol-Myers Squibb Company | Tricyclic compounds as anticancer agents |
| EP3307740B1 (en) | 2015-05-12 | 2019-12-18 | Bristol-Myers Squibb Company | 5h-pyrido[3,2-b]indole compounds as anticancer agents |
| US9725449B2 (en) | 2015-05-12 | 2017-08-08 | Bristol-Myers Squibb Company | Tricyclic compounds as anticancer agents |
| RS63897B1 (sr) | 2015-05-29 | 2023-02-28 | Bristol Myers Squibb Co | Antitela protiv ox40 i njihova primena |
| CA2990015A1 (en) | 2015-06-29 | 2017-01-05 | The Rockefeller University | Antibodies to cd40 with enhanced agonist activity |
| US10399987B2 (en) | 2015-07-28 | 2019-09-03 | Bristol-Myer Squibb Company | TGF beta receptor antagonists |
| KR20180042370A (ko) | 2015-08-25 | 2018-04-25 | 브리스톨-마이어스 스큅 컴퍼니 | Tgf 베타 수용체 길항제 |
| MX2018005517A (es) | 2015-11-02 | 2018-11-09 | Five Prime Therapeutics Inc | Polipeptidos del dominio extracelular de cd80 y su uso en el tratamiento del cancer. |
| BR112018010172A2 (pt) | 2015-11-19 | 2018-11-21 | Bristol Myers Squibb Co | anticorpos contra receptor de fator de necrose de tumor induzido por glicocorticoide (gitr) e usos dos mesmos |
| CA3004794A1 (en) | 2015-11-23 | 2017-06-01 | Five Prime Therapeutics, Inc. | Fgfr2 inhibitors alone or in combination with immune stimulating agents in cancer treatment |
| KR102738306B1 (ko) | 2015-12-15 | 2024-12-03 | 브리스톨-마이어스 스큅 컴퍼니 | Cxcr4 수용체 길항제 |
| US11752131B2 (en) | 2016-02-19 | 2023-09-12 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and pharmaceutical compositions for the treatment of obesity |
| RU2638530C2 (ru) * | 2016-02-29 | 2017-12-14 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) | ПРОИЗВОДНЫЕ 5-АМИНОИЗОКСАЗОЛА - КОНФОРМАЦИОННО-ЖЕСТКИЕ АНАЛОГИ γ-АМИНОМАСЛЯНОЙ КИСЛОТЫ И СПОСОБ ИХ ПОЛУЧЕНИЯ |
| SG10201913033UA (en) | 2016-03-04 | 2020-03-30 | Bristol Myers Squibb Co | Combination therapy with anti-cd73 antibodies |
| US10865244B2 (en) | 2016-04-18 | 2020-12-15 | Celldex Therapeutics, Inc. | Nucleic acids encoding agonistic antibodies that bind CD40 |
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2007
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- 2007-09-18 ES ES07842681T patent/ES2704641T3/es active Active
- 2007-09-18 JP JP2009529343A patent/JP5432715B2/ja not_active Expired - Fee Related
- 2007-09-18 US US11/856,982 patent/US20080214546A1/en not_active Abandoned
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- 2007-09-18 WO PCT/US2007/078759 patent/WO2008036653A2/en not_active Ceased
- 2007-09-19 TW TW096135025A patent/TW200819445A/zh unknown
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Also Published As
| Publication number | Publication date |
|---|---|
| CA2662773C (en) | 2015-11-24 |
| JP2010504347A (ja) | 2010-02-12 |
| US20110165188A1 (en) | 2011-07-07 |
| CL2007002650A1 (es) | 2008-02-08 |
| TW200819445A (en) | 2008-05-01 |
| WO2008036653A3 (en) | 2008-07-31 |
| JP5432715B2 (ja) | 2014-03-05 |
| EP2064194B1 (en) | 2018-11-07 |
| US20080214546A1 (en) | 2008-09-04 |
| CA2662773A1 (en) | 2008-03-27 |
| US8507541B2 (en) | 2013-08-13 |
| EP2064194A2 (en) | 2009-06-03 |
| WO2008036653A2 (en) | 2008-03-27 |
| AR062881A1 (es) | 2008-12-10 |
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