ES2676208T3 - Proceso para la producción de composiciones hemostáticas secas y estables - Google Patents
Proceso para la producción de composiciones hemostáticas secas y estables Download PDFInfo
- Publication number
- ES2676208T3 ES2676208T3 ES11724602.5T ES11724602T ES2676208T3 ES 2676208 T3 ES2676208 T3 ES 2676208T3 ES 11724602 T ES11724602 T ES 11724602T ES 2676208 T3 ES2676208 T3 ES 2676208T3
- Authority
- ES
- Spain
- Prior art keywords
- dry
- component
- thrombin
- final container
- syringe
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229960005055 sodium ascorbate Drugs 0.000 claims description 3
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 claims description 3
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- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 5
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- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 4
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- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
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- 150000001299 aldehydes Chemical class 0.000 description 2
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Classifications
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- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
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- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4833—Thrombin (3.4.21.5)
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| CO6620018A2 (es) | 2013-02-15 |
| JP5973997B2 (ja) | 2016-08-23 |
| BR112012030455B1 (pt) | 2021-08-17 |
| KR101967085B1 (ko) | 2019-04-08 |
| AU2011260258A1 (en) | 2012-12-06 |
| US10245348B2 (en) | 2019-04-02 |
| US20190231922A1 (en) | 2019-08-01 |
| WO2011151384A1 (en) | 2011-12-08 |
| CA2801116A1 (en) | 2011-12-08 |
| US9084728B2 (en) | 2015-07-21 |
| KR20130121701A (ko) | 2013-11-06 |
| US20150367022A1 (en) | 2015-12-24 |
| US12208176B2 (en) | 2025-01-28 |
| JP2013532139A (ja) | 2013-08-15 |
| US20120121532A1 (en) | 2012-05-17 |
| BR112012030455A2 (pt) | 2016-08-09 |
| US20210220512A1 (en) | 2021-07-22 |
| MX344402B (es) | 2016-12-14 |
| EP2575775B1 (en) | 2018-04-04 |
| CA2801116C (en) | 2019-02-12 |
| CN103037847B (zh) | 2016-01-20 |
| US10994045B2 (en) | 2021-05-04 |
| EP2575775A1 (en) | 2013-04-10 |
| AU2011260258B2 (en) | 2015-07-09 |
| MX2012014002A (es) | 2013-02-12 |
| CN103037847A (zh) | 2013-04-10 |
| KR101814841B1 (ko) | 2018-01-03 |
| KR101967085B9 (ko) | 2022-07-20 |
| JP2015193651A (ja) | 2015-11-05 |
| KR20170118948A (ko) | 2017-10-25 |
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