ES2625689T3 - Modulación de la expresión de transtiretina - Google Patents

Modulación de la expresión de transtiretina Download PDF

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Publication number
ES2625689T3
ES2625689T3 ES11778071.8T ES11778071T ES2625689T3 ES 2625689 T3 ES2625689 T3 ES 2625689T3 ES 11778071 T ES11778071 T ES 11778071T ES 2625689 T3 ES2625689 T3 ES 2625689T3
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Prior art keywords
isis
transthyretin
utr
certain embodiments
compounds
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ES11778071.8T
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Spanish (es)
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Brett P. Monia
Susan M. Freier
Andrew M. Siwkowski
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Ionis Pharmaceuticals Inc
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Ionis Pharmaceuticals Inc
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    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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ES11778071.8T 2010-04-29 2011-04-29 Modulación de la expresión de transtiretina Active ES2625689T3 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US32953810P 2010-04-29 2010-04-29
US329538P 2010-04-29
US40516310P 2010-10-20 2010-10-20
US405163P 2010-10-20
PCT/US2011/034661 WO2011139917A1 (en) 2010-04-29 2011-04-29 Modulation of transthyretin expression

Publications (1)

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ES2625689T3 true ES2625689T3 (es) 2017-07-20

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ES11778071.8T Active ES2625689T3 (es) 2010-04-29 2011-04-29 Modulación de la expresión de transtiretina

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US (9) US20110294868A1 (OSRAM)
EP (1) EP2563920B1 (OSRAM)
JP (1) JP5896175B2 (OSRAM)
KR (2) KR101835386B1 (OSRAM)
CN (1) CN103038345B (OSRAM)
BR (1) BR112012027547B1 (OSRAM)
CA (2) CA2797792C (OSRAM)
CY (2) CY1119070T1 (OSRAM)
DK (1) DK2563920T3 (OSRAM)
ES (1) ES2625689T3 (OSRAM)
HR (1) HRP20170737T1 (OSRAM)
HU (2) HUE031909T2 (OSRAM)
IL (1) IL222697A (OSRAM)
LT (2) LT2563920T (OSRAM)
LU (1) LUC00096I2 (OSRAM)
MX (1) MX343559B (OSRAM)
NL (1) NL300963I2 (OSRAM)
NO (1) NO2019001I1 (OSRAM)
NZ (1) NZ603339A (OSRAM)
PL (1) PL2563920T3 (OSRAM)
PT (1) PT2563920T (OSRAM)
RS (1) RS56011B1 (OSRAM)
RU (1) RU2592669C2 (OSRAM)
SI (1) SI2563920T1 (OSRAM)
SM (1) SMT201700209T1 (OSRAM)
WO (1) WO2011139917A1 (OSRAM)

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EP2496238A4 (en) 2009-11-03 2013-10-02 Alnylam Pharmaceuticals Inc FORMULATED LIPID COMPOSITIONS AND METHODS FOR INHIBITING TRANSTHYRETIN EXPRESSION (TTR)
MX343559B (es) * 2010-04-29 2016-11-10 Ionis Pharmaceuticals Inc Modulacion de la expresion de transtiretina.
EP3533873A1 (en) 2011-09-14 2019-09-04 Translate Bio MA, Inc. Multimeric oligonucleotide compounds
PE20142362A1 (es) 2011-11-18 2015-01-30 Alnylam Pharmaceuticals Inc Agentes de iarn, composiciones y metodos de uso de los mismos para tratar enfermedades asociadas con transtiretina (ttr)
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US9574193B2 (en) 2012-05-17 2017-02-21 Ionis Pharmaceuticals, Inc. Methods and compositions for modulating apolipoprotein (a) expression
WO2013173789A2 (en) 2012-05-17 2013-11-21 Isis Pharmaceuticals, Inc. Antisense oligonucleotide compositions
US20150247141A1 (en) 2012-09-14 2015-09-03 Rana Therapeutics, Inc. Multimeric oligonucleotide compounds
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WO2014118267A1 (en) 2013-01-30 2014-08-07 Santaris Pharma A/S Lna oligonucleotide carbohydrate conjugates
PL2992098T3 (pl) * 2013-05-01 2019-09-30 Ionis Pharmaceuticals, Inc. Kompozycje i sposoby modulowania ekspresji hbv i ttr
PH12016502062B1 (en) 2014-05-01 2023-01-27 Ionis Pharmaceuticals Inc Compositions and methods for modulating complement factor b expression
US10570169B2 (en) 2014-05-22 2020-02-25 Ionis Pharmaceuticals, Inc. Conjugated antisense compounds and their use
DK3185957T3 (da) * 2014-08-29 2022-08-29 Alnylam Pharmaceuticals Inc Patisiran til anvendelse ved behandlingen af transthyretin-medieret amyloidosis
WO2016040748A1 (en) 2014-09-12 2016-03-17 Ionis Pharmaceuticals, Inc. Compositions and methods for detection of smn protein in a subject and treatment of a subject
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US10982215B2 (en) * 2015-12-09 2021-04-20 Alnylam Pharmaceuticals, Inc. Polynucleotide agents targeting programmed cell death 1 ligand 1 (PD-L1) and methods of use thereof
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CN109661233A (zh) 2016-10-06 2019-04-19 Ionis 制药公司 缀合低聚化合物的方法
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