ES2623094T3 - Procedimientos de preparación de cristales que incluyen una sal de ácido málico de N-[2-(dietilamino)etil]-5-[(5-fluoro-1,2-dihidro-2-oxo-3H-indol-3-iliden)metil]-2,4-dimetil-1H-pirrol-3-carboxamida - Google Patents

Procedimientos de preparación de cristales que incluyen una sal de ácido málico de N-[2-(dietilamino)etil]-5-[(5-fluoro-1,2-dihidro-2-oxo-3H-indol-3-iliden)metil]-2,4-dimetil-1H-pirrol-3-carboxamida Download PDF

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Publication number
ES2623094T3
ES2623094T3 ES11156767.3T ES11156767T ES2623094T3 ES 2623094 T3 ES2623094 T3 ES 2623094T3 ES 11156767 T ES11156767 T ES 11156767T ES 2623094 T3 ES2623094 T3 ES 2623094T3
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ES
Spain
Prior art keywords
diethylamino
pyrrole
oxo
fluoro
dimethyl
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Expired - Lifetime
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ES11156767.3T
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English (en)
Spanish (es)
Inventor
Michael Hawley
Thomas J. Fleck
Stephen P. Prescott
Mark T. Maloney
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Pharmacia and Upjohn Co LLC
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Pharmacia and Upjohn Co LLC
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
ES11156767.3T 2001-08-15 2002-08-13 Procedimientos de preparación de cristales que incluyen una sal de ácido málico de N-[2-(dietilamino)etil]-5-[(5-fluoro-1,2-dihidro-2-oxo-3H-indol-3-iliden)metil]-2,4-dimetil-1H-pirrol-3-carboxamida Expired - Lifetime ES2623094T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31235301P 2001-08-15 2001-08-15
US312353P 2001-08-15

Publications (1)

Publication Number Publication Date
ES2623094T3 true ES2623094T3 (es) 2017-07-10

Family

ID=23211067

Family Applications (3)

Application Number Title Priority Date Filing Date
ES11156767.3T Expired - Lifetime ES2623094T3 (es) 2001-08-15 2002-08-13 Procedimientos de preparación de cristales que incluyen una sal de ácido málico de N-[2-(dietilamino)etil]-5-[(5-fluoro-1,2-dihidro-2-oxo-3H-indol-3-iliden)metil]-2,4-dimetil-1H-pirrol-3-carboxamida
ES02759342.5T Expired - Lifetime ES2453164T3 (es) 2001-08-15 2002-08-13 Cristales que incluyen una sal de ácido málico de N-[2-(dietilamino)etil]-5-[(5-fluoro-1,2-dihidro-2-oxo-3H-indol-3-iliden)metil]-2,4-dimetil-1H-pirrol-3-carboxamida, procedimientos para su preparación y sus composiciones
ES16196036T Expired - Lifetime ES2705063T3 (es) 2001-08-15 2002-08-13 Un cristal que comprende una sal de ácido L-málico de N-[2-(dietilamino)etil]-5-[(5-fluoro-1,2-dihidro-2-oxo-3H-indol-3-iliden)metil]-2,4-dimetil-1H-pirrol-3-carboxamida para su uso como un medicamento

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES02759342.5T Expired - Lifetime ES2453164T3 (es) 2001-08-15 2002-08-13 Cristales que incluyen una sal de ácido málico de N-[2-(dietilamino)etil]-5-[(5-fluoro-1,2-dihidro-2-oxo-3H-indol-3-iliden)metil]-2,4-dimetil-1H-pirrol-3-carboxamida, procedimientos para su preparación y sus composiciones
ES16196036T Expired - Lifetime ES2705063T3 (es) 2001-08-15 2002-08-13 Un cristal que comprende una sal de ácido L-málico de N-[2-(dietilamino)etil]-5-[(5-fluoro-1,2-dihidro-2-oxo-3H-indol-3-iliden)metil]-2,4-dimetil-1H-pirrol-3-carboxamida para su uso como un medicamento

Country Status (42)

Country Link
US (2) US20030069298A1 (https=)
EP (3) EP3168218B1 (https=)
JP (1) JP4159988B2 (https=)
KR (1) KR100639281B1 (https=)
CN (2) CN100364991C (https=)
AP (1) AP1660A (https=)
AR (1) AR036261A1 (https=)
AU (1) AU2002324684B2 (https=)
BG (1) BG108553A (https=)
BR (1) BR0211612A (https=)
CA (1) CA2455050C (https=)
CO (1) CO5550431A2 (https=)
CU (1) CU23713B7 (https=)
CY (1) CY1121552T1 (https=)
CZ (1) CZ2004196A3 (https=)
DK (2) DK1419151T3 (https=)
EA (1) EA006445B9 (https=)
EC (1) ECSP044975A (https=)
ES (3) ES2623094T3 (https=)
GE (1) GEP20063777B (https=)
HR (1) HRP20040112B1 (https=)
HU (1) HU229206B1 (https=)
IL (1) IL160097A0 (https=)
IS (1) IS7147A (https=)
MA (1) MA27058A1 (https=)
ME (1) ME00414B (https=)
MX (1) MXPA04001452A (https=)
MY (1) MY139383A (https=)
NO (1) NO326508B1 (https=)
NZ (1) NZ531232A (https=)
OA (1) OA12650A (https=)
PL (1) PL216524B1 (https=)
PT (2) PT3168218T (https=)
RS (1) RS53251B (https=)
SI (2) SI1419151T1 (https=)
SK (1) SK902004A3 (https=)
TN (1) TNSN04028A1 (https=)
TR (1) TR201900509T4 (https=)
TW (1) TWI269796B (https=)
UA (1) UA76483C2 (https=)
WO (1) WO2003016305A1 (https=)
ZA (1) ZA200400706B (https=)

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WO2009156837A2 (en) 2008-06-26 2009-12-30 Medichem, S.A. Amorphous form of a 3-pyrrole substituted 2-indolinone malate salt

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