ES2602474T3 - Angiogénesis que usa células madre placentarias - Google Patents
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- ES2602474T3 ES2602474T3 ES11766619.8T ES11766619T ES2602474T3 ES 2602474 T3 ES2602474 T3 ES 2602474T3 ES 11766619 T ES11766619 T ES 11766619T ES 2602474 T3 ES2602474 T3 ES 2602474T3
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Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2305795B1 (en) | 2000-12-06 | 2019-07-03 | Celularity, Inc. | Method of collecting placental stem cells |
| ES2432493T3 (es) | 2001-02-14 | 2013-12-03 | Anthrogenesis Corporation | Placenta de mamífero post-parto, su uso y células madre de la misma |
| US7498171B2 (en) | 2002-04-12 | 2009-03-03 | Anthrogenesis Corporation | Modulation of stem and progenitor cell differentiation, assays, and uses thereof |
| US9119899B2 (en) * | 2006-01-18 | 2015-09-01 | Cormatrix Cardiovascular, Inc. | Method and system for treatment of cardiovascular disorders |
| NZ597304A (en) | 2005-10-13 | 2013-06-28 | Anthrogenesis Corp | Immunomodulation using placental stem cells |
| PL2471907T3 (pl) | 2005-12-29 | 2019-07-31 | Celularity, Inc. | Populacje komórek macierzystych łożyska |
| CA2677679A1 (en) | 2007-02-12 | 2008-08-21 | Anthrogenesis Corporation | Hepatocytes and chondrocytes from adherent placental stem cells; and cd34+, cd45- placental stem cell-enriched cell populations |
| US9200253B1 (en) | 2007-08-06 | 2015-12-01 | Anthrogenesis Corporation | Method of producing erythrocytes |
| RU2536242C2 (ru) | 2007-09-28 | 2014-12-20 | Антродженезис Корпорейшн | Угнетение опухолей с помощью плацентарного перфузата человека и выделенных из плаценты человека вспомогательных натуральных клеток-киллеров |
| KR20200011604A (ko) | 2008-08-20 | 2020-02-03 | 안트로제네시스 코포레이션 | 개선된 세포 조성물 및 그의 제조 방법 |
| CA2734446C (en) | 2008-08-22 | 2017-06-20 | Anthrogenesis Corporation | Methods and compositions for treatment of bone defects with placental cell populations |
| MX353489B (es) | 2009-07-02 | 2018-01-16 | Anthrogenesis Corp | Metodo para producir eritrocitos sin celulas alimentadoras. |
| DK3284818T3 (da) | 2010-01-26 | 2022-06-20 | Celularity Inc | Behandling af knoglerelateret kræft ved hjælp af placenta stamceller |
| DK2556145T3 (en) | 2010-04-07 | 2016-11-07 | Anthrogenesis Corp | Angiogenesis using placental stem cells |
| EP2555783A1 (en) | 2010-04-08 | 2013-02-13 | Anthrogenesis Corporation | Treatment of sarcoidosis using placental stem cells |
| MX342995B (es) | 2010-07-13 | 2016-10-21 | Anthrogenesis Corp | Métodos de generar células asesinas naturales. |
| WO2012092485A1 (en) | 2010-12-31 | 2012-07-05 | Anthrogenesis Corporation | Enhancement of placental stem cell potency using modulatory rna molecules |
| US20120264215A1 (en) * | 2011-04-18 | 2012-10-18 | Korea University Research And Business Foudation Of Korea University | Placenta-derived cell-conditioned culture media and animal-free, feeder-free method for culturing stem cells using the same |
| ES2707579T3 (es) | 2011-06-01 | 2019-04-04 | Celularity Inc | Tratamiento del dolor usando citoblastos placentarios |
| WO2013055476A1 (en) | 2011-09-09 | 2013-04-18 | Anthrogenesis Corporation | Treatment of amyotrophic lateral sclerosis using placental stem cells |
| WO2013082417A1 (en) * | 2011-11-30 | 2013-06-06 | Anthrogenesis Corporation | Treatment using placental stem cells |
| WO2013149211A2 (en) * | 2012-03-30 | 2013-10-03 | University Of Southern California | Compositions and treatment methods for mesenchymal stem cell-induced immunoregulation |
| CA2869163A1 (en) * | 2012-03-30 | 2013-10-03 | University Of Central Florida Research Foundation, Inc. | Methods and compositions using fgf-8 to enhance cardiac regeneration and attenuate adverse cardiac remodeling |
| US9943551B2 (en) | 2012-08-15 | 2018-04-17 | Mimedx Group, Inc. | Tissue grafts composed of micronized placental tissue and methods of making and using the same |
| US9180145B2 (en) | 2012-10-12 | 2015-11-10 | Mimedx Group, Inc. | Compositions and methods for recruiting and localizing stem cells |
| AU2013359076A1 (en) | 2012-12-14 | 2015-07-02 | Anthrogenesis Corporation | Anoikis resistant placental stem cells and uses thereof |
| US10111910B2 (en) | 2013-01-18 | 2018-10-30 | Mimedx Group, Inc. | Methods for treating cardiac conditions |
| US10206977B1 (en) | 2013-01-18 | 2019-02-19 | Mimedx Group, Inc. | Isolated placental stem cell recruiting factors |
| AU2014215458A1 (en) | 2013-02-05 | 2015-08-13 | Anthrogenesis Corporation | Natural killer cells from placenta |
| US20160030488A1 (en) * | 2013-03-14 | 2016-02-04 | Antrhogenesis Corporation | Use of placental stem cells in treatment of acute kidney injury |
| US10329529B2 (en) | 2013-03-14 | 2019-06-25 | Celularity, Inc. | Enhanced placental stem cells and uses thereof |
| US10029030B2 (en) | 2013-03-15 | 2018-07-24 | Mimedx Group, Inc. | Molded placental tissue compositions and methods of making and using the same |
| KR20160098244A (ko) * | 2013-11-15 | 2016-08-18 | 안트로제네시스 코포레이션 | 사람 태반 관류액 세포를 포함하는 조성물, 상기 세포의 부분모집단 및 이의 용도 |
| EP3094336A4 (en) * | 2014-01-17 | 2018-02-14 | MIMEDX Group Inc. | Method for inducing angiogenesis |
| CN103756957B (zh) * | 2014-01-27 | 2015-11-18 | 山东省齐鲁干细胞工程有限公司 | 一种从胎盘中洗脱内皮祖细胞的方法 |
| WO2015120114A1 (en) | 2014-02-05 | 2015-08-13 | Muffin Incorporated | Compartmented cryopreservation container and uses thereof |
| JP6474549B2 (ja) * | 2014-03-03 | 2019-02-27 | 国立大学法人徳島大学 | 幹細胞の培養産物の評価指標及びその利用 |
| WO2016011283A1 (en) * | 2014-07-17 | 2016-01-21 | Cedars-Sinai Medical Center | Blood-vessel therapeutic patch composed of endothelial cells derived from ipscs pre-treated with leptin |
| US20170290861A1 (en) * | 2014-09-26 | 2017-10-12 | Anthrogenesis Corporation | Treatment of diabetic foot ulcer using placental stem cells |
| CN107106615A (zh) * | 2014-10-09 | 2017-08-29 | 人类起源公司 | 胎盘来源的贴壁细胞外泌体及其用途 |
| WO2016068616A1 (ko) * | 2014-10-29 | 2016-05-06 | 차의과학대학교 산학협력단 | C3 또는 c1r 보체를 분비하는 태반 유래 세포 및 이를 포함하는 조성물 |
| US20170369845A1 (en) * | 2014-12-31 | 2017-12-28 | Anthrogenesis Corporation | Methods for isolation of platelets |
| CN115478043A (zh) * | 2015-05-26 | 2022-12-16 | 细胞结构公司 | 使用受刺激的胎盘干细胞的血管生成 |
| KR102011634B1 (ko) * | 2015-08-28 | 2019-08-19 | 주식회사 차바이오텍 | 향상된 산후 부착형 세포 및 그의 용도 |
| IL281185B2 (en) * | 2015-09-15 | 2024-05-01 | Celularity Inc | Treatment of diabetic peripheral neuropathy using placental cells |
| CN108368479A (zh) * | 2015-09-29 | 2018-08-03 | 细胞结构公司 | 细胞效能分析 |
| US12551509B2 (en) | 2015-11-18 | 2026-02-17 | Lucina Patent Holdco, Llc | Acellular regenerative products and methods of their manufacture |
| CN106310227A (zh) * | 2016-09-30 | 2017-01-11 | 广州赛莱拉干细胞科技股份有限公司 | 一种干细胞制剂及其制备方法和应用 |
| WO2019177269A1 (ko) * | 2018-03-16 | 2019-09-19 | 주식회사 메디노 | 신경줄기세포를 이용한 혈관형성 유도 방법 |
| CN108904799A (zh) * | 2018-07-09 | 2018-11-30 | 夏荣木 | 一种抗肿瘤制剂及制备的方法 |
| KR102593791B1 (ko) * | 2021-02-26 | 2023-10-25 | 경희대학교 산학협력단 | Pdgf-bb를 이용한 혈관 형성능이 증진된 골수 유래 혈관내피전구세포의 제조방법 및 이를 이용한 혈관형성 부전-관련 질환 치료용 세포치료제의 제조방법 |
| CN116334210B (zh) * | 2023-03-06 | 2025-10-31 | 中国人民解放军总医院 | Aldh1a1和amigo2基因在制备房颤诊断和干预产品中的应用 |
Family Cites Families (272)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3862002A (en) | 1962-05-08 | 1975-01-21 | Sanfar Lab Inc | Production of physiologically active placental substances |
| US4829000A (en) | 1985-08-30 | 1989-05-09 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Reconstituted basement membrane complex with biological activity |
| US4798824A (en) | 1985-10-03 | 1989-01-17 | Wisconsin Alumni Research Foundation | Perfusate for the preservation of organs |
| US5902741A (en) | 1986-04-18 | 1999-05-11 | Advanced Tissue Sciences, Inc. | Three-dimensional cartilage cultures |
| US5863531A (en) | 1986-04-18 | 1999-01-26 | Advanced Tissue Sciences, Inc. | In vitro preparation of tubular tissue structures by stromal cell culture on a three-dimensional framework |
| US5266480A (en) | 1986-04-18 | 1993-11-30 | Advanced Tissue Sciences, Inc. | Three-dimensional skin culture system |
| NZ226750A (en) | 1987-10-29 | 1990-09-26 | Amrad Corp Ltd | Immortalisation of neural precursor cells by introducing a retrovirus vector containing a myc-oncogene |
| US5004681B1 (en) | 1987-11-12 | 2000-04-11 | Biocyte Corp | Preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood |
| US5192553A (en) | 1987-11-12 | 1993-03-09 | Biocyte Corporation | Isolation and preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood and methods of therapeutic use |
| GB8803697D0 (en) | 1988-02-17 | 1988-03-16 | Deltanine Research Ltd | Clinical developments using amniotic membrane cells |
| US5284766A (en) | 1989-02-10 | 1994-02-08 | Kao Corporation | Bed material for cell culture |
| FR2646438B1 (fr) | 1989-03-20 | 2007-11-02 | Pasteur Institut | Procede de remplacement specifique d'une copie d'un gene present dans le genome receveur par l'integration d'un gene different de celui ou se fait l'integration |
| US5763266A (en) | 1989-06-15 | 1998-06-09 | The Regents Of The University Of Michigan | Methods, compositions and devices for maintaining and growing human stem and/or hematopoietics cells |
| US5605822A (en) | 1989-06-15 | 1997-02-25 | The Regents Of The University Of Michigan | Methods, compositions and devices for growing human hematopoietic cells |
| US5635386A (en) | 1989-06-15 | 1997-06-03 | The Regents Of The University Of Michigan | Methods for regulating the specific lineages of cells produced in a human hematopoietic cell culture |
| US5437994A (en) | 1989-06-15 | 1995-08-01 | Regents Of The University Of Michigan | Method for the ex vivo replication of stem cells, for the optimization of hematopoietic progenitor cell cultures, and for increasing the metabolism, GM-CSF secretion and/or IL-6 secretion of human stromal cells |
| US5399493A (en) | 1989-06-15 | 1995-03-21 | The Regents Of The University Of Michigan | Methods and compositions for the optimization of human hematopoietic progenitor cell cultures |
| AU633958B2 (en) | 1989-07-25 | 1993-02-11 | Cell Genesys, Inc. | Homologous recombination for universal donor cells and chimeric mammalian hosts |
| US5464764A (en) | 1989-08-22 | 1995-11-07 | University Of Utah Research Foundation | Positive-negative selection methods and vectors |
| ATE174058T1 (de) | 1989-11-06 | 1998-12-15 | Cell Genesys Inc | Herstellung von proteinen mittels homologer rekombination |
| US5272071A (en) | 1989-12-22 | 1993-12-21 | Applied Research Systems Ars Holding N.V. | Method for the modification of the expression characteristics of an endogenous gene of a given cell line |
| US5061620A (en) | 1990-03-30 | 1991-10-29 | Systemix, Inc. | Human hematopoietic stem cell |
| US5635387A (en) | 1990-04-23 | 1997-06-03 | Cellpro, Inc. | Methods and device for culturing human hematopoietic cells and their precursors |
| US6326198B1 (en) | 1990-06-14 | 2001-12-04 | Regents Of The University Of Michigan | Methods and compositions for the ex vivo replication of stem cells, for the optimization of hematopoietic progenitor cell cultures, and for increasing the metabolism, GM-CSF secretion and/or IL-6 secretion of human stromal cells |
| US5733542A (en) | 1990-11-16 | 1998-03-31 | Haynesworth; Stephen E. | Enhancing bone marrow engraftment using MSCS |
| US5811094A (en) | 1990-11-16 | 1998-09-22 | Osiris Therapeutics, Inc. | Connective tissue regeneration using human mesenchymal stem cell preparations |
| US5486359A (en) | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
| US5226914A (en) | 1990-11-16 | 1993-07-13 | Caplan Arnold I | Method for treating connective tissue disorders |
| US6010696A (en) | 1990-11-16 | 2000-01-04 | Osiris Therapeutics, Inc. | Enhancing hematopoietic progenitor cell engraftment using mesenchymal stem cells |
| US5197985A (en) | 1990-11-16 | 1993-03-30 | Caplan Arnold I | Method for enhancing the implantation and differentiation of marrow-derived mesenchymal cells |
| US5837539A (en) | 1990-11-16 | 1998-11-17 | Osiris Therapeutics, Inc. | Monoclonal antibodies for human mesenchymal stem cells |
| US5190556A (en) | 1991-03-19 | 1993-03-02 | O.B. Tech, Inc. | Cord cutter sampler |
| US5744361A (en) | 1991-04-09 | 1998-04-28 | Indiana University | Expansion of human hematopoietic progenitor cells in a liquid medium |
| EP0552380A4 (en) | 1991-08-08 | 1995-01-25 | Kao Corp | Cell culture support, production thereof, and production of cell cluster using same |
| EP0529751A1 (en) | 1991-08-09 | 1993-03-03 | W.R. Grace & Co.-Conn. | Cell culture substrate, test material for cell culture and preparations thereof |
| WO1993004169A1 (en) | 1991-08-20 | 1993-03-04 | Genpharm International, Inc. | Gene targeting in animal cells using isogenic dna constructs |
| FI943024L (fi) | 1991-12-23 | 1994-06-22 | British Bio Technology | Kantasoluja estävät proteiinit |
| CA2110283A1 (en) | 1992-03-31 | 1993-10-14 | Tatsutoshi Nakahata | Physiologically active protein and hemotopoietic stem cell growth agent |
| US5552267A (en) | 1992-04-03 | 1996-09-03 | The Trustees Of Columbia University In The City Of New York | Solution for prolonged organ preservation |
| US5460964A (en) | 1992-04-03 | 1995-10-24 | Regents Of The University Of Minnesota | Method for culturing hematopoietic cells |
| WO1994000484A1 (en) | 1992-06-22 | 1994-01-06 | Young Henry E | Scar inhibitory factor and use thereof |
| US5672346A (en) | 1992-07-27 | 1997-09-30 | Indiana University Foundation | Human stem cell compositions and methods |
| US5928947A (en) | 1992-07-27 | 1999-07-27 | California Institute Of Technology | Mammalian multipotent neural stem cells |
| US5849553A (en) | 1992-07-27 | 1998-12-15 | California Institute Of Technology | Mammalian multipotent neural stem cells |
| JPH08506007A (ja) | 1992-11-16 | 1996-07-02 | アプライド イミューン サイエンシーズ，インコーポレイテッド | 多能性の休止状態の幹細胞集団 |
| US5772992A (en) | 1992-11-24 | 1998-06-30 | G.D. Searle & Co. | Compositions for co-administration of interleukin-3 mutants and other cytokines and hematopoietic factors |
| US5654186A (en) | 1993-02-26 | 1997-08-05 | The Picower Institute For Medical Research | Blood-borne mesenchymal cells |
| AU694111B2 (en) | 1993-03-31 | 1998-07-16 | Pro-Neuron, Inc. | Inhibitor of stem cell proliferation and uses thereof |
| GB9308271D0 (en) | 1993-04-21 | 1993-06-02 | Univ Edinburgh | Method of isolating and/or enriching and/or selectively propagating pluripotential animal cells and animals for use in said method |
| US5709854A (en) | 1993-04-30 | 1998-01-20 | Massachusetts Institute Of Technology | Tissue formation by injecting a cell-polymeric solution that gels in vivo |
| US5372581A (en) | 1993-07-21 | 1994-12-13 | Minneapolis Children's Services Corporation | Method and apparatus for placental blood collection |
| US5591625A (en) | 1993-11-24 | 1997-01-07 | Case Western Reserve University | Transduced mesenchymal stem cells |
| US6288030B1 (en) | 1993-12-22 | 2001-09-11 | Amgen Inc. | Stem cell factor formulations and methods |
| US6001654A (en) | 1994-01-28 | 1999-12-14 | California Institute Of Technology | Methods for differentiating neural stem cells to neurons or smooth muscle cells using TGT-β super family growth factors |
| US5942496A (en) | 1994-02-18 | 1999-08-24 | The Regent Of The University Of Michigan | Methods and compositions for multiple gene transfer into bone cells |
| CA2192103C (en) | 1994-06-06 | 2002-02-05 | Arnold I. Caplan | Biomatrix for tissue regeneration |
| US6174333B1 (en) | 1994-06-06 | 2001-01-16 | Osiris Therapeutics, Inc. | Biomatrix for soft tissue regeneration using mesenchymal stem cells |
| DE4422667A1 (de) | 1994-06-30 | 1996-01-04 | Boehringer Ingelheim Int | Verfahren zur Herstellung und Züchtung hämatopoetischer Vorläuferzellen |
| US6103522A (en) | 1994-07-20 | 2000-08-15 | Fred Hutchinson Cancer Research Center | Human marrow stromal cell lines which sustain hematopoiesis |
| US5516532A (en) | 1994-08-05 | 1996-05-14 | Children's Medical Center Corporation | Injectable non-immunogenic cartilage and bone preparation |
| US5827742A (en) | 1994-09-01 | 1998-10-27 | Beth Israel Deaconess Medical Center, Inc. | Method of selecting pluripotent hematopioetic progenitor cells |
| US5665557A (en) | 1994-11-14 | 1997-09-09 | Systemix, Inc. | Method of purifying a population of cells enriched for hematopoietic stem cells populations of cells obtained thereby and methods of use thereof |
| US5914268A (en) | 1994-11-21 | 1999-06-22 | National Jewish Center For Immunology & Respiratory Medicine | Embryonic cell populations and methods to isolate such populations |
| US5874301A (en) | 1994-11-21 | 1999-02-23 | National Jewish Center For Immunology And Respiratory Medicine | Embryonic cell populations and methods to isolate such populations |
| US5789147A (en) | 1994-12-05 | 1998-08-04 | New York Blood Center, Inc. | Method for concentrating white cells from whole blood by adding a red cell sedimentation reagent to whole anticoagulated blood |
| US5736396A (en) | 1995-01-24 | 1998-04-07 | Case Western Reserve University | Lineage-directed induction of human mesenchymal stem cell differentiation |
| US5695998A (en) | 1995-02-10 | 1997-12-09 | Purdue Research Foundation | Submucosa as a growth substrate for islet cells |
| US6011000A (en) | 1995-03-03 | 2000-01-04 | Perrine; Susan P. | Compositions for the treatment of blood disorders |
| US5906934A (en) | 1995-03-14 | 1999-05-25 | Morphogen Pharmaceuticals, Inc. | Mesenchymal stem cells for cartilage repair |
| US5716616A (en) | 1995-03-28 | 1998-02-10 | Thomas Jefferson University | Isolated stromal cells for treating diseases, disorders or conditions characterized by bone defects |
| US5733541A (en) | 1995-04-21 | 1998-03-31 | The Regent Of The University Of Michigan | Hematopoietic cells: compositions and methods |
| US5677139A (en) | 1995-04-21 | 1997-10-14 | President And Fellows Of Harvard College | In vitro differentiation of CD34+ progenitor cells into T lymphocytes |
| CZ289896B6 (cs) | 1995-04-27 | 2002-04-17 | The Procter & Gamble Company | Nosič upravený pomocí inverzní emulze s vysokým obsahem vnitřní vodní fáze, připravené za uľití organopolysiloxan-polyoxyalkylenového emulgátoru |
| US5925567A (en) | 1995-05-19 | 1999-07-20 | T. Breeders, Inc. | Selective expansion of target cell populations |
| US5908782A (en) | 1995-06-05 | 1999-06-01 | Osiris Therapeutics, Inc. | Chemically defined medium for human mesenchymal stem cells |
| US5830708A (en) | 1995-06-06 | 1998-11-03 | Advanced Tissue Sciences, Inc. | Methods for production of a naturally secreted extracellular matrix |
| AU6223296A (en) | 1995-06-07 | 1996-12-30 | Novartis Ag | Methods for obtaining compositions enriched for hematopoieti c stem cells and antibodies for use therein |
| US5877299A (en) | 1995-06-16 | 1999-03-02 | Stemcell Technologies Inc. | Methods for preparing enriched human hematopoietic cell preparations |
| US6306575B1 (en) | 1995-06-16 | 2001-10-23 | Stemcell Technologies, Inc. | Methods for preparing enriched human hematopoietic cell preparations |
| US5654381A (en) | 1995-06-16 | 1997-08-05 | Massachusetts Institute Of Technology | Functionalized polyester graft copolymers |
| US5935576A (en) | 1995-09-13 | 1999-08-10 | Fordham University | Compositions and methods for the treatment and prevention of neoplastic diseases using heat shock proteins complexed with exogenous antigens |
| US5858782A (en) | 1995-11-13 | 1999-01-12 | Regents Of The University Of Michigan | Functional human hematopoietic cells |
| WO1997018298A1 (en) | 1995-11-14 | 1997-05-22 | Regents Of The University Of Minnesota | Ex vivo culture of stem cells |
| JP3781433B2 (ja) | 1995-11-16 | 2006-05-31 | ケース ウエスターン リザーブ ユニバーシティ | ヒト間葉幹細胞の試験管内軟骨形成誘導 |
| DE69635899T2 (de) | 1995-11-17 | 2006-11-23 | Asahi Kasei Kabushiki Kaisha | Polypeptid, das die differenzierung unterdrueckt |
| US5716794A (en) | 1996-03-29 | 1998-02-10 | Xybernaut Corporation | Celiac antigen |
| ES2329953T3 (es) | 1996-04-19 | 2009-12-02 | Osiris Therapeutics, Inc. | Regeneracion e incremento de hueso utilizando celulas madre mesenquimales. |
| AU2808397A (en) | 1996-04-26 | 1997-11-19 | Case Western Reserve University | Skin regeneration using mesenchymal stem cells |
| US5919176A (en) | 1996-05-14 | 1999-07-06 | Children's Hospital Medical Center Of Northern California | Apparatus and method for collecting blood from an umbilical cord |
| US5827740A (en) | 1996-07-30 | 1998-10-27 | Osiris Therapeutics, Inc. | Adipogenic differentiation of human mesenchymal stem cells |
| US5851984A (en) | 1996-08-16 | 1998-12-22 | Genentech, Inc. | Method of enhancing proliferation or differentiation of hematopoietic stem cells using Wnt polypeptides |
| US5916202A (en) | 1996-08-30 | 1999-06-29 | Haswell; John N. | Umbilical cord blood collection |
| US6227202B1 (en) | 1996-09-03 | 2001-05-08 | Maulana Azad Medical College | Method of organogenesis and tissue regeneration/repair using surgical techniques |
| US5945337A (en) | 1996-10-18 | 1999-08-31 | Quality Biological, Inc. | Method for culturing CD34+ cells in a serum-free medium |
| US5919702A (en) | 1996-10-23 | 1999-07-06 | Advanced Tissue Science, Inc. | Production of cartilage tissue using cells isolated from Wharton's jelly |
| US5969105A (en) | 1996-10-25 | 1999-10-19 | Feng; Yiqing | Stem cell factor receptor agonists |
| US6335195B1 (en) | 1997-01-28 | 2002-01-01 | Maret Corporation | Method for promoting hematopoietic and mesenchymal cell proliferation and differentiation |
| US6152142A (en) | 1997-02-28 | 2000-11-28 | Tseng; Scheffer C. G. | Grafts made from amniotic membrane; methods of separating, preserving, and using such grafts in surgeries |
| US6231880B1 (en) | 1997-05-30 | 2001-05-15 | Susan P. Perrine | Compositions and administration of compositions for the treatment of blood disorders |
| CA2294944A1 (en) | 1997-07-03 | 1999-01-14 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells from peripheral blood |
| CA2296704C (en) | 1997-07-14 | 2010-10-19 | Osiris Therapeutics, Inc. | Cardiac muscle regeneration using mesenchymal stem cells |
| US7514074B2 (en) | 1997-07-14 | 2009-04-07 | Osiris Therapeutics, Inc. | Cardiac muscle regeneration using mesenchymal stem cells |
| US6077708A (en) | 1997-07-18 | 2000-06-20 | Collins; Paul C. | Method of determining progenitor cell content of a hematopoietic cell culture |
| US5879318A (en) | 1997-08-18 | 1999-03-09 | Npbi International B.V. | Method of and closed system for collecting and processing umbilical cord blood |
| AU9127098A (en) | 1997-09-04 | 1999-03-22 | Osiris Therapeutics, Inc. | Ligands that modulate differentiation of mesenchymal stem cells |
| US5968829A (en) | 1997-09-05 | 1999-10-19 | Cytotherapeutics, Inc. | Human CNS neural stem cells |
| US6093531A (en) | 1997-09-29 | 2000-07-25 | Neurospheres Holdings Ltd. | Generation of hematopoietic cells from multipotent neural stem cells |
| US6248587B1 (en) | 1997-11-26 | 2001-06-19 | University Of Southern Cailfornia | Method for promoting mesenchymal stem and lineage-specific cell proliferation |
| US6059968A (en) | 1998-01-20 | 2000-05-09 | Baxter International Inc. | Systems for processing and storing placenta/umbilical cord blood |
| US6291240B1 (en) | 1998-01-29 | 2001-09-18 | Advanced Tissue Sciences, Inc. | Cells or tissues with increased protein factors and methods of making and using same |
| AU749675B2 (en) | 1998-03-13 | 2002-07-04 | Mesoblast International Sarl | Uses for human non-autologous mesenchymal stem cells |
| US6368636B1 (en) | 1998-03-18 | 2002-04-09 | Osiris Therapeutics, Inc. | Mesenchymal stem cells for prevention and treatment of immune responses in transplantation |
| AU755888B2 (en) | 1998-03-18 | 2003-01-02 | Mesoblast International Sarl | Mesenchymal stem cells for prevention and treatment of immune responses in transplantation |
| AU2999199A (en) | 1998-04-03 | 1999-10-25 | Osiris Therapeutics, Inc. | Mesenchymal stem cells as immunosuppressants |
| CA2331122A1 (en) | 1998-05-04 | 1999-11-11 | Point Therapeutics, Inc. | Hematopoietic stimulation |
| US6835377B2 (en) | 1998-05-13 | 2004-12-28 | Osiris Therapeutics, Inc. | Osteoarthritis cartilage regeneration |
| AU4094099A (en) | 1998-05-22 | 1999-12-13 | Osiris Therapeutics, Inc. | Production of megakaryocytes by co-culturing human mesenchymal stem cells with cd34+ cells |
| PT1082410E (pt) | 1998-05-29 | 2007-11-09 | Osiris Therapeutics Inc | Células estaminais mesenquimatosas humanas cd45+ e/ou fibroblastos+ |
| AU4336599A (en) | 1998-06-08 | 1999-12-30 | Osiris Therapeutics, Inc. | (in vitro) maintenance of hematopoietic stem cells |
| DE69937347T2 (de) | 1998-06-08 | 2008-09-04 | Osiris Therapeutics, Inc. | Regulierung der hämatopoietischen stammzelldifferenzierung durch verwendung von menschlichen mesenchymalen stammzellen |
| US6713245B2 (en) | 1998-07-06 | 2004-03-30 | Diacrin, Inc. | Methods for storing neural cells such that they are suitable for transplantation |
| PT1100488E (pt) | 1998-07-28 | 2003-09-30 | Synthes Ag | Utilizacao de compostos de creatina para tratamento das celulas e tecidos do osso ou cartilagem |
| US5958767A (en) | 1998-08-14 | 1999-09-28 | The Children's Medical Center Corp. | Engraftable human neural stem cells |
| JP3517359B2 (ja) | 1998-09-14 | 2004-04-12 | テルモ株式会社 | 細胞分離・回収装置および細胞の分離・回収方法 |
| CA2345397A1 (en) | 1998-09-23 | 2000-03-30 | Mount Sinai Hospital | Trophoblast cell preparations |
| WO2000027995A1 (en) | 1998-11-09 | 2000-05-18 | Monash University | Embryonic stem cells |
| US6548299B1 (en) | 1999-11-12 | 2003-04-15 | Mark J. Pykett | Lymphoid tissue-specific cell production from hematopoietic progenitor cells in three-dimensional devices |
| WO2000027999A2 (en) | 1998-11-12 | 2000-05-18 | Cell Science Therapeutics, Inc. | Lymphoid tissue-specific cell production from hematopoietic progenitor cells in three-dimensional devices |
| US6184035B1 (en) | 1998-11-18 | 2001-02-06 | California Institute Of Technology | Methods for isolation and activation of, and control of differentiation from, skeletal muscle stem or progenitor cells |
| US6328765B1 (en) | 1998-12-03 | 2001-12-11 | Gore Enterprise Holdings, Inc. | Methods and articles for regenerating living tissue |
| HK1041454B (en) | 1998-12-24 | 2004-12-31 | 生物安全股份有限公司 | Blood separation system particularly for concentrating hematopoietic stem cells |
| US20030007954A1 (en) | 1999-04-12 | 2003-01-09 | Gail K. Naughton | Methods for using a three-dimensional stromal tissue to promote angiogenesis |
| JP2002542349A (ja) | 1999-04-16 | 2002-12-10 | ダブリューエム・マーシュ・ライス・ユニバーシティー | ポリ（プロピレンフマラート）−ジアクリレートマクロマーで交差結合された生体分解性のポリ（プロピレンフマラート）ネットワーク |
| IN191359B (https=) | 1999-04-20 | 2003-11-29 | Nat Inst Immunology | |
| AU4860900A (en) | 1999-06-02 | 2000-12-18 | Lifebank Services, L.L.C. | Methods of isolation, cryopreservation, and therapeutic use of human amniotic epithelial cells |
| US6333029B1 (en) | 1999-06-30 | 2001-12-25 | Ethicon, Inc. | Porous tissue scaffoldings for the repair of regeneration of tissue |
| US6355699B1 (en) | 1999-06-30 | 2002-03-12 | Ethicon, Inc. | Process for manufacturing biomedical foams |
| US8075881B2 (en) | 1999-08-05 | 2011-12-13 | Regents Of The University Of Minnesota | Use of multipotent adult stem cells in treatment of myocardial infarction and congestive heart failure |
| US7838289B2 (en) | 2001-02-14 | 2010-11-23 | Abt Holding Company | Assay utilizing multipotent adult stem cells |
| US8147824B2 (en) | 1999-08-05 | 2012-04-03 | Athersys, Inc. | Immunomodulatory properties of multipotent adult progenitor cells and uses thereof |
| US7015037B1 (en) | 1999-08-05 | 2006-03-21 | Regents Of The University Of Minnesota | Multiponent adult stem cells and methods for isolation |
| US6239157B1 (en) | 1999-09-10 | 2001-05-29 | Osiris Therapeutics, Inc. | Inhibition of osteoclastogenesis |
| US6685936B2 (en) | 1999-10-12 | 2004-02-03 | Osiris Therapeutics, Inc. | Suppressor cells induced by culture with mesenchymal stem cells for treatment of immune responses in transplantation |
| US6280718B1 (en) | 1999-11-08 | 2001-08-28 | Wisconsin Alumni Reasearch Foundation | Hematopoietic differentiation of human pluripotent embryonic stem cells |
| EP1264877B1 (en) | 2000-03-16 | 2013-10-02 | Cellseed Inc. | Cell cultivation-support material, method of cocultivation of cells and cocultivated cell sheet obtained therefrom |
| US20010038836A1 (en) | 2000-04-04 | 2001-11-08 | Matthew During | Application of myeloid-origin cells to the nervous system |
| ES2267778T3 (es) | 2000-06-06 | 2007-03-16 | Glaxo Group Limited | Composicion para el tratamiento del cancer, que contiene un agente anti-neoplastico y un inhibidor de pde4. |
| AU2002253795B2 (en) | 2000-11-30 | 2007-02-01 | The Children's Medical Center Corporation | Synthesis of 4-Amino-Thalidomide enantiomers |
| US7311905B2 (en) | 2002-02-13 | 2007-12-25 | Anthrogenesis Corporation | Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells |
| US20080152629A1 (en) | 2000-12-06 | 2008-06-26 | James Edinger | Placental stem cell populations |
| EP2305795B1 (en) | 2000-12-06 | 2019-07-03 | Celularity, Inc. | Method of collecting placental stem cells |
| US7091353B2 (en) | 2000-12-27 | 2006-08-15 | Celgene Corporation | Isoindole-imide compounds, compositions, and uses thereof |
| US20030045552A1 (en) | 2000-12-27 | 2003-03-06 | Robarge Michael J. | Isoindole-imide compounds, compositions, and uses thereof |
| ES2432493T3 (es) | 2001-02-14 | 2013-12-03 | Anthrogenesis Corporation | Placenta de mamífero post-parto, su uso y células madre de la misma |
| EP2316918B1 (en) | 2001-02-14 | 2015-07-01 | Anthrogenesis Corporation | Post-partum mammalian placenta, its use and placental stem cells therefrom |
| US20020132343A1 (en) | 2001-03-19 | 2002-09-19 | Clark Lum | System and method for delivering umbilical cord-derived tissue-matched stem cells for transplantation |
| US20030022358A1 (en) | 2001-05-29 | 2003-01-30 | Hall Jane H. | Growth of filterable organisms that require non-diffusable media components |
| US20030044977A1 (en) | 2001-08-10 | 2003-03-06 | Norio Sakuragawa | Human stem cells originated from human amniotic mesenchymal cell layer |
| DE10139783C1 (de) | 2001-08-14 | 2003-04-17 | Transtissue Technologies Gmbh | Zellzusammensetzungen zur Behandlung von Osteoarthrose, sowie Verfahren zu deren Herstellung |
| EP1288293A1 (en) | 2001-08-30 | 2003-03-05 | Norio Sakuragawa | Human neural stem cells originated from human amniotic mesenchymal cell layer |
| CN1195055C (zh) | 2001-09-06 | 2005-03-30 | 周胜利 | 从胎盘组织中提取造血干细胞用于建立造血干细胞库的新方法 |
| US9969980B2 (en) | 2001-09-21 | 2018-05-15 | Garnet Biotherapeutics | Cell populations which co-express CD49c and CD90 |
| JP4330995B2 (ja) | 2001-11-15 | 2009-09-16 | チルドレンズ メディカル センター コーポレーション | 絨毛膜絨毛、羊水、および胎盤からの胎児性幹細胞を単離、増殖、および分化させる方法、ならびにその治療的使用方法 |
| JP3728750B2 (ja) | 2001-11-22 | 2005-12-21 | ニプロ株式会社 | 培養皮膚及びその製造方法 |
| US7799324B2 (en) | 2001-12-07 | 2010-09-21 | Geron Corporation | Using undifferentiated embryonic stem cells to control the immune system |
| JP3934539B2 (ja) | 2001-12-12 | 2007-06-20 | 独立行政法人科学技術振興機構 | 胎盤等由来の成体又は生後組織の前駆細胞 |
| US20040018178A1 (en) | 2002-01-22 | 2004-01-29 | Advanced Cell Technology | Stem cell-derived endothelial cells modified to disrupt tumor angiogenesis |
| NZ534643A (en) | 2002-02-13 | 2010-06-25 | Anthrogenesis Corp | Embryonic-like stem cells derived from post-partum mammalian placenta and uses and methods of treatment using said cells |
| US20030161818A1 (en) | 2002-02-25 | 2003-08-28 | Kansas State University Research Foundation | Cultures, products and methods using stem cells |
| US7736892B2 (en) | 2002-02-25 | 2010-06-15 | Kansas State University Research Foundation | Cultures, products and methods using umbilical cord matrix cells |
| IL164079A0 (en) | 2002-03-15 | 2005-12-18 | Us Dept Veterans Affairs | Methods and compositions using cellular asialodeterminants and glycoconjugates for targeting cells to tissues and organs |
| US20030187515A1 (en) | 2002-03-26 | 2003-10-02 | Hariri Robert J. | Collagen biofabric and methods of preparing and using the collagen biofabric |
| US7498171B2 (en) | 2002-04-12 | 2009-03-03 | Anthrogenesis Corporation | Modulation of stem and progenitor cell differentiation, assays, and uses thereof |
| KR20050000400A (ko) | 2002-04-12 | 2005-01-03 | 셀진 코포레이션 | 줄기 및 전구 세포 분화의 조절, 측정 및 이들의 용도 |
| ZA200408369B (en) | 2002-04-12 | 2006-11-29 | Celgene Corp | Methods for identification of modulators of angiogenesis, compounds discovered thereby, and methods of treatment using the compounds |
| US20030235563A1 (en) | 2002-04-19 | 2003-12-25 | Strom Stephen C. | Placental derived stem cells and uses thereof |
| US20040161419A1 (en) | 2002-04-19 | 2004-08-19 | Strom Stephen C. | Placental stem cells and uses thereof |
| CA2488013A1 (en) | 2002-05-30 | 2003-12-11 | Celgene Corporation | Methods of using jnk or mkk inhibitors to modulate cell differentiation and to treat myeloproliferative disorders and myelodysplastic syndromes |
| US7422736B2 (en) | 2002-07-26 | 2008-09-09 | Food Industry Research And Development Institute | Somatic pluripotent cells |
| JP4603883B2 (ja) | 2002-07-31 | 2010-12-22 | サントル・ナショナル・ドゥ・ラ・レシェルシュ・サイエンティフィーク−セ・エン・エール・エス− | 脂肪組織由来の幹細胞および前記細胞から分化した細胞 |
| EP1535994A4 (en) | 2002-08-23 | 2005-12-07 | Srl Inc | HUMAN BONE STEM CELLS |
| US20040062753A1 (en) | 2002-09-27 | 2004-04-01 | Alireza Rezania | Composite scaffolds seeded with mammalian cells |
| US7189740B2 (en) | 2002-10-15 | 2007-03-13 | Celgene Corporation | Methods of using 3-(4-amino-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myelodysplastic syndromes |
| AU2003298775B2 (en) | 2002-11-26 | 2008-07-17 | Anthrogenesis Corporation | Cytotherapeutics, cytotherapeutic units and methods for treatments using them |
| EP2277992A3 (en) | 2003-02-11 | 2011-03-02 | John E. Davies | Progenitor cells from Wharton's jelly of human umbilical cord |
| CN1770976A (zh) | 2003-02-13 | 2006-05-10 | 人类起源公司 | 利用脐带血治疗患有疾病、紊乱或状况的个体的用途 |
| WO2004087896A2 (en) | 2003-03-31 | 2004-10-14 | Pfizer Products Inc. | Hepatocyte differentiation of stem cells |
| CN1548529A (zh) | 2003-05-09 | 2004-11-24 | 中国人民解放军军事医学科学院基础医 | 一种人胎盘间充质干细胞的分离方法 |
| US7255729B2 (en) | 2003-05-30 | 2007-08-14 | Noritake Co., Limited | Porous cylindrical-body module, structure for supporting porous cylindrical bodies, and method for fastening a supporting member |
| US7875272B2 (en) * | 2003-06-27 | 2011-01-25 | Ethicon, Incorporated | Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells |
| EP2399990B1 (en) | 2003-06-27 | 2015-07-22 | DePuy Synthes Products, Inc. | Cells derived from post-partum umbilical cord for use in treatment of disease of the heart and circulatory system |
| US20050042595A1 (en) | 2003-08-14 | 2005-02-24 | Martin Haas | Banking of multipotent amniotic fetal stem cells |
| US20050089513A1 (en) | 2003-10-28 | 2005-04-28 | Norio Sakuragawa | Side population cells originated from human amnion and their uses |
| WO2005047491A2 (en) | 2003-11-10 | 2005-05-26 | Amgen Inc. | Methods of using g-csf mobilized c-kit+cells in the production of embryoid body-like cell clusters for tissue repair and in the treatment of cardiac myopathy |
| KR100560340B1 (ko) | 2003-11-11 | 2006-03-14 | 한훈 | 제대혈로부터 중간엽 줄기세포의 분리 및 배양 방법 |
| JP2005151907A (ja) | 2003-11-27 | 2005-06-16 | Shigeo Saito | 胎盤又は羊膜由来ヒト幹細胞及びその樹立方法並びに臓器への分化誘導方法 |
| KR20120039065A (ko) | 2003-12-02 | 2012-04-24 | 셀진 코포레이션 | 혈색소병증 및 빈혈의 치료 및 관리를 위한 방법및 조성물 |
| TWI338714B (en) | 2003-12-02 | 2011-03-11 | Cathay General Hospital | Method of isolation and enrichment of mesenchymal stem cells from amniotic fluid |
| US20050176139A1 (en) | 2004-01-12 | 2005-08-11 | Yao-Chang Chen | Placental stem cell and methods thereof |
| US20050266391A1 (en) | 2004-01-15 | 2005-12-01 | Bennett Brydon L | Methods for preserving tissue |
| EP2298864B1 (en) | 2004-03-22 | 2017-10-11 | Mesoblast International Sàrl | Mesenchymal stem cells and uses therefor |
| WO2005097190A2 (en) | 2004-03-26 | 2005-10-20 | Celgene Corporation | Systems and methods for providing a stem cell bank |
| WO2005105992A1 (en) | 2004-04-21 | 2005-11-10 | New York Eye & Ear Infirmary | Chondrocyte culture formulations |
| JP2006006249A (ja) | 2004-06-28 | 2006-01-12 | Hiroshima Univ | 羊膜由来細胞の培養方法及びその利用 |
| US7244759B2 (en) | 2004-07-28 | 2007-07-17 | Celgene Corporation | Isoindoline compounds and methods of making and using the same |
| US20080292597A1 (en) | 2004-07-29 | 2008-11-27 | David A Steenblock | Umbilical Cord Stem Cell Composition & Method of Treating Neurological Diseases |
| KR101322889B1 (ko) | 2004-08-16 | 2013-10-30 | 셀리서치 코포레이션 피티이 리미티드 | 제대의 양막으로부터 줄기/전구세포의 추출 |
| US7147626B2 (en) | 2004-09-23 | 2006-12-12 | Celgene Corporation | Cord blood and placenta collection kit |
| US7909806B2 (en) | 2004-09-23 | 2011-03-22 | Anthrogenesis Corporation | Cord blood and placenta collection kit |
| US8039258B2 (en) | 2004-09-28 | 2011-10-18 | Ethicon, Inc. | Tissue-engineering scaffolds containing self-assembled-peptide hydrogels |
| US20060171930A1 (en) | 2004-12-21 | 2006-08-03 | Agnieszka Seyda | Postpartum cells derived from umbilical cord tissue, and methods of making, culturing, and using the same |
| US20060166361A1 (en) | 2004-12-21 | 2006-07-27 | Agnieszka Seyda | Postpartum cells derived from placental tissue, and methods of making, culturing, and using the same |
| CA2589041C (en) | 2004-12-23 | 2019-08-20 | DePuy Synthes Products, Inc. | Postpartum cells derived from umbilical cord tissue, and methods of making and using the same |
| EP1835924B1 (en) | 2004-12-23 | 2013-08-21 | Ethicon, Incorporated | Treatment of parkinson's disease and related disorders using postpartum derived cells |
| US20070041943A1 (en) | 2004-12-29 | 2007-02-22 | Children's Hospital Research | Expression of virus entry inhibitors and recombinant AAV thereof |
| CA2593549C (en) | 2005-01-07 | 2016-04-26 | Wake Forest University Health Sciences | Regeneration of pancreatic islets by amniotic fluid stem cell therapy |
| WO2006091766A2 (en) | 2005-02-24 | 2006-08-31 | Jau-Nan Lee | Human trophoblast stem cells and use thereof |
| US20060222634A1 (en) | 2005-03-31 | 2006-10-05 | Clarke Diana L | Amnion-derived cell compositions, methods of making and uses thereof |
| CA2648506A1 (en) | 2005-04-16 | 2006-10-26 | Axordia Limited | Cytotrophoblast stem cell |
| AU2006202209B2 (en) | 2005-05-27 | 2011-04-14 | Lifescan, Inc. | Amniotic fluid derived cells |
| WO2006135843A2 (en) | 2005-06-10 | 2006-12-21 | Celgene Corporation | Human placental collagen compositions, processes for their preparation, methods of their use and kits comprising the compositions |
| WO2007005807A2 (en) | 2005-06-30 | 2007-01-11 | Anthrogenesis Corporation | Repair of tympanic membrane using placenta derived collagen biofabric |
| EP1919365A2 (en) | 2005-07-13 | 2008-05-14 | Anthrogenesis Corporation | Ocular plug formed from placenta derived collagen biofabric |
| US7928280B2 (en) | 2005-07-13 | 2011-04-19 | Anthrogenesis Corporation | Treatment of leg ulcers using placenta derived collagen biofabric |
| WO2007011693A2 (en) | 2005-07-14 | 2007-01-25 | Medistem Laboratories, Inc. | Compositions of placentally-derived stem cells for the treatment of cancer |
| EP1915440A4 (en) | 2005-08-19 | 2009-11-04 | Bio Regenerate Inc | COMPOSITIONS OF CELLS ENRICHED WITH COMBINATIONS OF VARIOUS STRAIN AND PRECURSOR CELL POPULATIONS, METHOD OF USE THEREOF, AND METHOD FOR THE PREPARATION OF PRIVATE BANKS THEREOF |
| ZA200803929B (en) | 2005-10-13 | 2009-08-26 | Anthrogenesis Corp | Production of oligodendrocytes from placenta-derived stem cells |
| NZ597304A (en) | 2005-10-13 | 2013-06-28 | Anthrogenesis Corp | Immunomodulation using placental stem cells |
| CN100344757C (zh) | 2005-10-18 | 2007-10-24 | 天津昂赛细胞基因工程有限公司 | 人胎盘、脐带间充质干细胞库及其构建方法 |
| WO2007070870A1 (en) | 2005-12-16 | 2007-06-21 | Ethicon, Inc. | Compositions and methods for inhibiting adverse immune response in histocompatibility-mismatched transplantation |
| US8741638B2 (en) | 2005-12-19 | 2014-06-03 | DePuy Synthes Products, LLC | In vitro expansion of postpartum-derived cells in roller bottles |
| CN103173401A (zh) | 2005-12-22 | 2013-06-26 | 简·恩尼斯 | 来自冷冻的脐带组织的活细胞 |
| EP1979050B1 (en) | 2005-12-28 | 2017-04-19 | DePuy Synthes Products, Inc. | Treatment of peripheral vascular disease using postpartum-derived cells |
| EP1976978A2 (en) | 2005-12-29 | 2008-10-08 | Anthrogenesis Corporation | Co-culture of placental stem cells and stem cells from a second source |
| ZA200804717B (en) | 2005-12-29 | 2010-02-24 | Anthrogenesis Corp | Improved composition for collecting and preserving a placental stem cells and methods of using the composition |
| PL2471907T3 (pl) * | 2005-12-29 | 2019-07-31 | Celularity, Inc. | Populacje komórek macierzystych łożyska |
| US20070253931A1 (en) | 2006-01-12 | 2007-11-01 | Osiris Therapeutics, Inc. | Use of mesenchymal stem cells for treating genetic diseases and disorders |
| US9944900B2 (en) | 2006-01-18 | 2018-04-17 | Hemacell Perfusion | Pulsatile perfusion extraction method for non-embryonic pluripotent stem cells |
| US11992507B2 (en) | 2006-01-23 | 2024-05-28 | Abt Holding Company | MAPC therapeutics without adjunctive immunosuppressive treatment |
| KR20090031895A (ko) | 2006-06-09 | 2009-03-30 | 안트로제네시스 코포레이션 | 태반 니치 및 줄기 세포 배양을 위한 이의 용도 |
| US20070287176A1 (en) | 2006-06-13 | 2007-12-13 | Alireza Rezania | Chorionic villus derived cells |
| US7993918B2 (en) | 2006-08-04 | 2011-08-09 | Anthrogenesis Corporation | Tumor suppression using placental stem cells |
| WO2008021391A1 (en) | 2006-08-15 | 2008-02-21 | Anthrogenesis Corporation | Umbilical cord biomaterial for medical use |
| WO2008042441A1 (en) | 2006-10-03 | 2008-04-10 | Anthrogenesis Corporation | Use of umbilical cord biomaterial for ocular surgery |
| WO2008060377A2 (en) | 2006-10-04 | 2008-05-22 | Anthrogenesis Corporation | Placental or umbilical cord tissue compositions |
| CN101622007A (zh) | 2006-10-06 | 2010-01-06 | 人类起源公司 | 天然(端肽)胎盘胶原组合物 |
| US8562972B2 (en) * | 2006-10-23 | 2013-10-22 | Anthrogenesis Corporation | Methods and compositions for treatment of bone defects with placental cell populations |
| CN101611139B (zh) | 2006-11-13 | 2012-07-04 | 伊西康公司 | 利用微载体的产后来源的细胞的体外扩增 |
| CA2677679A1 (en) | 2007-02-12 | 2008-08-21 | Anthrogenesis Corporation | Hepatocytes and chondrocytes from adherent placental stem cells; and cd34+, cd45- placental stem cell-enriched cell populations |
| NZ612888A (en) | 2007-02-12 | 2015-02-27 | Anthrogenesis Corp | Treatment of inflammatory diseases using placental stem cells |
| US20100172830A1 (en) | 2007-03-29 | 2010-07-08 | Cellx Inc. | Extraembryonic Tissue cells and method of use thereof |
| KR20140107677A (ko) | 2007-09-19 | 2014-09-04 | 플루리스템 리미티드 | 지방 또는 태반 조직 유래의 부착 세포 및 이의 치료 용도 |
| KR20220122774A (ko) * | 2007-09-26 | 2022-09-02 | 셀룰래리티 인코포레이티드 | 인간 태반 관류액으로부터의 혈관형성 세포 |
| RU2536242C2 (ru) | 2007-09-28 | 2014-12-20 | Антродженезис Корпорейшн | Угнетение опухолей с помощью плацентарного перфузата человека и выделенных из плаценты человека вспомогательных натуральных клеток-киллеров |
| EP2217329B1 (en) | 2007-11-07 | 2018-01-10 | Anthrogenesis Corporation | Use of umbilical cord blood in the treatment of premature birth complications |
| KR20200011604A (ko) * | 2008-08-20 | 2020-02-03 | 안트로제네시스 코포레이션 | 개선된 세포 조성물 및 그의 제조 방법 |
| CA2734237C (en) * | 2008-08-20 | 2019-07-02 | Anthrogenesis Corporation | Treatment of stroke using isolated placental cells |
| CA2734446C (en) | 2008-08-22 | 2017-06-20 | Anthrogenesis Corporation | Methods and compositions for treatment of bone defects with placental cell populations |
| RU2539786C2 (ru) * | 2008-09-02 | 2015-01-27 | Плуристем Лтд. | Выращенные в прикрепленной к субстрату культуре клетки из ткани плаценты и их использование при лечении |
| RU2015130665A (ru) | 2008-11-19 | 2018-12-24 | Антродженезис Корпорейшн | Амниотические адгезивные клетки |
| DK2375907T3 (da) | 2008-11-21 | 2019-06-11 | Celularity Inc | Behandling af sygdomme, lidelser eller tilstande i lungerne under anvendelse af placentaceller |
| WO2010141654A1 (en) | 2009-06-05 | 2010-12-09 | Anthrogenesis Corporation | Improved method of collecting placental cells |
| MX353489B (es) | 2009-07-02 | 2018-01-16 | Anthrogenesis Corp | Metodo para producir eritrocitos sin celulas alimentadoras. |
| DK3284818T3 (da) | 2010-01-26 | 2022-06-20 | Celularity Inc | Behandling af knoglerelateret kræft ved hjælp af placenta stamceller |
| US20110280849A1 (en) | 2010-03-26 | 2011-11-17 | Anthrogenesis Corporation | Tumor suppression using human placenta-derived intermediate natural killer cells and immunomodulatory compounds |
| DK2556145T3 (en) | 2010-04-07 | 2016-11-07 | Anthrogenesis Corp | Angiogenesis using placental stem cells |
| EP2555783A1 (en) | 2010-04-08 | 2013-02-13 | Anthrogenesis Corporation | Treatment of sarcoidosis using placental stem cells |
| MX342995B (es) | 2010-07-13 | 2016-10-21 | Anthrogenesis Corp | Métodos de generar células asesinas naturales. |
| KR20230084328A (ko) | 2010-12-30 | 2023-06-12 | 셀룰래리티 인코포레이티드 | 세포의 동결보존 및 캡슐화 방법 |
| US20120171161A1 (en) | 2010-12-30 | 2012-07-05 | Sascha Abramson | Compositions comprising placental stem cells and platelet rich plasma, and methods of use thereof |
| WO2012092485A1 (en) | 2010-12-31 | 2012-07-05 | Anthrogenesis Corporation | Enhancement of placental stem cell potency using modulatory rna molecules |
| ES2707579T3 (es) | 2011-06-01 | 2019-04-04 | Celularity Inc | Tratamiento del dolor usando citoblastos placentarios |
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