ES2533095T3 - Agonistas de receptores de esfingosina-1-fosfato - Google Patents

Agonistas de receptores de esfingosina-1-fosfato Download PDF

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Publication number
ES2533095T3
ES2533095T3 ES10742067.1T ES10742067T ES2533095T3 ES 2533095 T3 ES2533095 T3 ES 2533095T3 ES 10742067 T ES10742067 T ES 10742067T ES 2533095 T3 ES2533095 T3 ES 2533095T3
Authority
ES
Spain
Prior art keywords
phenyl
acid
oxadiazol
trifluoromethyl
ethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES10742067.1T
Other languages
English (en)
Spanish (es)
Inventor
John L. Gilmore
James E. Sheppeck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of ES2533095T3 publication Critical patent/ES2533095T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
ES10742067.1T 2009-08-07 2010-08-06 Agonistas de receptores de esfingosina-1-fosfato Active ES2533095T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23205409P 2009-08-07 2009-08-07
US232054P 2009-08-07
PCT/US2010/044627 WO2011017578A1 (en) 2009-08-07 2010-08-06 Sphingosine-1-phosphate receptor agonists

Publications (1)

Publication Number Publication Date
ES2533095T3 true ES2533095T3 (es) 2015-04-07

Family

ID=43029859

Family Applications (1)

Application Number Title Priority Date Filing Date
ES10742067.1T Active ES2533095T3 (es) 2009-08-07 2010-08-06 Agonistas de receptores de esfingosina-1-fosfato

Country Status (19)

Country Link
US (1) US8399451B2 (cg-RX-API-DMAC10.html)
EP (1) EP2462139B1 (cg-RX-API-DMAC10.html)
JP (1) JP5602230B2 (cg-RX-API-DMAC10.html)
KR (1) KR20120108963A (cg-RX-API-DMAC10.html)
CN (1) CN102548989A (cg-RX-API-DMAC10.html)
AR (1) AR077819A1 (cg-RX-API-DMAC10.html)
AU (1) AU2010279354A1 (cg-RX-API-DMAC10.html)
BR (1) BR112012002824A2 (cg-RX-API-DMAC10.html)
CA (1) CA2770194A1 (cg-RX-API-DMAC10.html)
CL (1) CL2012000326A1 (cg-RX-API-DMAC10.html)
CO (1) CO6430439A2 (cg-RX-API-DMAC10.html)
EA (1) EA201270266A1 (cg-RX-API-DMAC10.html)
ES (1) ES2533095T3 (cg-RX-API-DMAC10.html)
MX (1) MX2012001160A (cg-RX-API-DMAC10.html)
PE (1) PE20120732A1 (cg-RX-API-DMAC10.html)
SG (1) SG177691A1 (cg-RX-API-DMAC10.html)
TW (1) TW201109323A (cg-RX-API-DMAC10.html)
WO (1) WO2011017578A1 (cg-RX-API-DMAC10.html)
ZA (1) ZA201200641B (cg-RX-API-DMAC10.html)

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Publication number Priority date Publication date Assignee Title
EP2079734A1 (en) * 2006-10-25 2009-07-22 NeuroSearch A/S Oxadiazole and thiadiazole compounds and their use as nicotinic acetylcholine receptor modulators
JP5735634B2 (ja) * 2010-04-23 2015-06-17 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ スフィンゴシン−１−リン酸受容体１アゴニストとしての４−（５−イソオキサゾリルまたは５−ピラゾリル−１，２，４−オキサジアゾール−３−イル）−マンデル酸アミド化合物
JP5788507B2 (ja) 2010-07-20 2015-09-30 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ 置換３−フェニル−１，２，４−オキサジアゾール化合物
WO2012040532A1 (en) 2010-09-24 2012-03-29 Bristol-Myers Squibb Company Substituted oxadiazole compounds and their use as s1p1 agonists
JP2013544811A (ja) * 2010-11-03 2013-12-19 ブリストル−マイヤーズ スクイブ カンパニー 自己免疫疾患および血管疾患の治療用のｓ１ｐ１アゴニストとしての複素環式化合物
TWI613182B (zh) 2013-02-21 2018-02-01 必治妥美雅史谷比公司 雙環化合物
UY36274A (es) 2014-08-20 2016-02-29 Bristol Myers Squibb Company Una Corporación Del Estado De Delaware Compuestos bicíclicos sustituidos como agonistas selectivos de la actividad del receptor s1p1 acoplado a la proteína g
PY1974248A (es) * 2018-09-13 2020-08-21 Syngenta Participations Ag Compuestos de azol-amida pesticidamente activos
CN114181276A (zh) * 2021-12-17 2022-03-15 安徽大学 硫酯肽合成方法

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Also Published As

Publication number Publication date
AU2010279354A1 (en) 2012-02-09
AR077819A1 (es) 2011-09-28
PE20120732A1 (es) 2012-06-20
JP2013501729A (ja) 2013-01-17
MX2012001160A (es) 2012-02-13
EP2462139B1 (en) 2015-01-14
CA2770194A1 (en) 2011-02-10
TW201109323A (en) 2011-03-16
KR20120108963A (ko) 2012-10-05
ZA201200641B (en) 2013-06-26
US8399451B2 (en) 2013-03-19
BR112012002824A2 (pt) 2019-09-24
CL2012000326A1 (es) 2012-10-19
EA201270266A1 (ru) 2012-07-30
SG177691A1 (en) 2012-02-28
CO6430439A2 (es) 2012-04-30
WO2011017578A1 (en) 2011-02-10
EP2462139A1 (en) 2012-06-13
US20110190255A1 (en) 2011-08-04
CN102548989A (zh) 2012-07-04
JP5602230B2 (ja) 2014-10-08

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