ES2446015T3 - Inhibidores de la proteasa NS3 del VHC - Google Patents

Inhibidores de la proteasa NS3 del VHC Download PDF

Info

Publication number
ES2446015T3
ES2446015T3 ES06787698.7T ES06787698T ES2446015T3 ES 2446015 T3 ES2446015 T3 ES 2446015T3 ES 06787698 T ES06787698 T ES 06787698T ES 2446015 T3 ES2446015 T3 ES 2446015T3
Authority
ES
Spain
Prior art keywords
alkyl
aryl
cycloalkyl
heteroaryl
heterocyclyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES06787698.7T
Other languages
English (en)
Spanish (es)
Other versions
ES2446015T9 (es
Inventor
M. Katharine Holloway
Nigel J. Liverton
Steven W. Ludmerer
John A. Mccauley
David B. Olsen
Michael T. Rudd
Joseph P. Vacca
Charles J. Mcintyre
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon Pharma UK Ltd
Merck Sharp and Dohme LLC
Original Assignee
Merck Sharp and Dohme Ltd
Merck Sharp and Dohme LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp and Dohme Ltd, Merck Sharp and Dohme LLC filed Critical Merck Sharp and Dohme Ltd
Application granted granted Critical
Publication of ES2446015T3 publication Critical patent/ES2446015T3/es
Publication of ES2446015T9 publication Critical patent/ES2446015T9/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
ES06787698.7T 2005-07-20 2006-07-14 Inhibidores de la proteasa NS3 del VHC Active ES2446015T3 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US70076405P 2005-07-20 2005-07-20
US700764P 2005-07-20
US72456605P 2005-10-07 2005-10-07
US724566P 2005-10-07
PCT/US2006/027831 WO2007015855A1 (en) 2005-07-20 2006-07-14 Hcv ns3 protease inhibitors

Publications (2)

Publication Number Publication Date
ES2446015T3 true ES2446015T3 (es) 2014-03-06
ES2446015T9 ES2446015T9 (es) 2014-07-16

Family

ID=37467463

Family Applications (2)

Application Number Title Priority Date Filing Date
ES06787698.7T Active ES2446015T3 (es) 2005-07-20 2006-07-14 Inhibidores de la proteasa NS3 del VHC
ES06787475T Active ES2332821T3 (es) 2005-07-20 2006-07-14 Inhibidores de proteasa ns3 de hcv.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES06787475T Active ES2332821T3 (es) 2005-07-20 2006-07-14 Inhibidores de proteasa ns3 de hcv.

Country Status (37)

Country Link
US (2) US7470664B2 (enExample)
EP (2) EP1924593B9 (enExample)
JP (2) JP4621282B2 (enExample)
KR (1) KR101296095B1 (enExample)
AR (1) AR057456A1 (enExample)
AT (1) ATE443075T1 (enExample)
AU (1) AU2006276189B9 (enExample)
BR (1) BRPI0613633A2 (enExample)
CA (1) CA2615022C (enExample)
CR (1) CR9621A (enExample)
CY (1) CY1109671T1 (enExample)
DE (1) DE602006009280D1 (enExample)
DK (1) DK1924593T3 (enExample)
DO (2) DOP2006000171A (enExample)
EA (1) EA013331B1 (enExample)
EC (1) ECSP088107A (enExample)
ES (2) ES2446015T3 (enExample)
GE (1) GEP20115248B (enExample)
GT (1) GT200600317A (enExample)
HN (1) HN2008000087A (enExample)
HR (1) HRP20090627T1 (enExample)
IL (1) IL188618A0 (enExample)
JO (1) JO2593B1 (enExample)
MA (1) MA30198B1 (enExample)
MX (1) MX2008000866A (enExample)
MY (1) MY142240A (enExample)
NO (1) NO20080879L (enExample)
NZ (1) NZ565223A (enExample)
PE (1) PE20070364A1 (enExample)
PL (1) PL1924593T3 (enExample)
PT (1) PT1924593E (enExample)
RS (1) RS51101B (enExample)
SG (1) SG164376A1 (enExample)
SI (1) SI1924593T1 (enExample)
TN (1) TNSN08033A1 (enExample)
TW (1) TWI387603B (enExample)
WO (2) WO2007015787A1 (enExample)

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* Cited by examiner, † Cited by third party
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