ES2426008T5 - Tratamiento de síntomas de la enfermedad de Parkinson con ligandos del receptor de histamina H3 de alquilaminas no imidazólicas - Google Patents
Tratamiento de síntomas de la enfermedad de Parkinson con ligandos del receptor de histamina H3 de alquilaminas no imidazólicas Download PDFInfo
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- ES2426008T5 ES2426008T5 ES06744466T ES06744466T ES2426008T5 ES 2426008 T5 ES2426008 T5 ES 2426008T5 ES 06744466 T ES06744466 T ES 06744466T ES 06744466 T ES06744466 T ES 06744466T ES 2426008 T5 ES2426008 T5 ES 2426008T5
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- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05290727 | 2005-04-01 | ||
| EP05290727A EP1707203A1 (en) | 2005-04-01 | 2005-04-01 | Treatment of parkinson's disease obstructive sleep apnea, dementia with lewy bodies, vascular dementia with non-imidazole alkylamines histamine H3- receptor ligands |
| US66861805P | 2005-04-06 | 2005-04-06 | |
| US668618P | 2005-04-06 | ||
| PCT/IB2006/000739 WO2006103546A2 (en) | 2005-04-01 | 2006-03-30 | Treatment of parkinson's disease, obstructive sleep apnea, dementia with lewy bodies, vascular dementia with non-imidazole alkylamines histamine h3-receptor ligands |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2426008T3 ES2426008T3 (es) | 2013-10-18 |
| ES2426008T5 true ES2426008T5 (es) | 2020-03-20 |
Family
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Family Applications (1)
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|---|---|---|---|
| ES06744466T Active ES2426008T5 (es) | 2005-04-01 | 2006-03-30 | Tratamiento de síntomas de la enfermedad de Parkinson con ligandos del receptor de histamina H3 de alquilaminas no imidazólicas |
Country Status (27)
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| US (1) | US8486947B2 (OSRAM) |
| EP (2) | EP1707203A1 (OSRAM) |
| JP (3) | JP5546761B2 (OSRAM) |
| KR (1) | KR101308527B1 (OSRAM) |
| CN (1) | CN101171009B (OSRAM) |
| AU (1) | AU2006228413C1 (OSRAM) |
| BR (1) | BRPI0612216B1 (OSRAM) |
| CA (1) | CA2603656C (OSRAM) |
| CY (1) | CY1114636T1 (OSRAM) |
| DK (1) | DK1863487T4 (OSRAM) |
| EA (1) | EA016007B1 (OSRAM) |
| ES (1) | ES2426008T5 (OSRAM) |
| HR (1) | HRP20130748T4 (OSRAM) |
| MA (1) | MA29353B1 (OSRAM) |
| ME (1) | ME01713B (OSRAM) |
| MX (1) | MX2007012162A (OSRAM) |
| NO (1) | NO343603B1 (OSRAM) |
| NZ (1) | NZ561940A (OSRAM) |
| PL (1) | PL1863487T5 (OSRAM) |
| PT (1) | PT1863487E (OSRAM) |
| RS (1) | RS52911B2 (OSRAM) |
| SG (1) | SG147415A1 (OSRAM) |
| SI (1) | SI1863487T2 (OSRAM) |
| TN (1) | TNSN07365A1 (OSRAM) |
| UA (1) | UA94902C2 (OSRAM) |
| WO (1) | WO2006103546A2 (OSRAM) |
| ZA (1) | ZA200708086B (OSRAM) |
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| MX2008016343A (es) | 2006-06-23 | 2009-01-19 | Abbott Lab | Derivados ciclopropil amina como moduladores del receptro de histamina h3. |
| US9108948B2 (en) | 2006-06-23 | 2015-08-18 | Abbvie Inc. | Cyclopropyl amine derivatives |
| FR2903904A1 (fr) * | 2006-07-21 | 2008-01-25 | Bioprojet Soc Civ Ile | Association de modafinil et d'un antagoniste ou agoniste inverse du recepteur h3 |
| JP5335675B2 (ja) | 2006-07-25 | 2013-11-06 | セファロン、インク． | ピリジジノン誘導体 |
| US8153813B2 (en) | 2007-12-20 | 2012-04-10 | Abbott Laboratories | Benzothiazole and benzooxazole derivatives and methods of use |
| MX2010008375A (es) | 2008-01-30 | 2011-03-04 | Cephalon Inc Star | Derivados de piperidina espirocíclicos substituidos como ligandos de receptores de histamina-3 (h3). |
| FR2932479A1 (fr) * | 2008-06-13 | 2009-12-18 | Servier Lab | Nouveaux derives azabicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| US9186353B2 (en) | 2009-04-27 | 2015-11-17 | Abbvie Inc. | Treatment of osteoarthritis pain |
| US8853390B2 (en) | 2010-09-16 | 2014-10-07 | Abbvie Inc. | Processes for preparing 1,2-substituted cyclopropyl derivatives |
| US9181275B2 (en) | 2011-08-11 | 2015-11-10 | Abbvie Inc. | Mercaptoamidine derivatives and methods of use |
| WO2013151982A1 (en) | 2012-04-03 | 2013-10-10 | Arena Pharmaceuticals, Inc. | Methods and compounds useful in treating pruritus, and methods for identifying such compounds |
| CN104703592A (zh) * | 2012-10-05 | 2015-06-10 | 转化技术制药有限责任公司 | 治疗轻度和中度阿尔茨海默病的方法 |
| EP3391886A1 (en) | 2017-04-19 | 2018-10-24 | Novartis AG | The use of a h3r inverse agonist for the treatment of shift work disorder |
| US20200282215A1 (en) | 2019-03-06 | 2020-09-10 | Medtronic Xomed, LLC | Evaluating stimulation eficacy for treating sleep apnea and lingual muscle tone sensing system for improved osa therapy |
| EP4248969A1 (en) | 2022-03-23 | 2023-09-27 | Bioprojet | Use of pitolisant for treating severe fatigue |
| WO2024201139A1 (en) | 2023-03-31 | 2024-10-03 | Bioprojet Pharma | Polymorph form of pitolisant hydrochloride |
| WO2025082974A1 (en) | 2023-10-16 | 2025-04-24 | Bioprojet Pharma | New formulations of pitolisant and methods of use |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JPS5815945A (ja) * | 1981-07-21 | 1983-01-29 | Teikoku Hormone Mfg Co Ltd | 新規なフエノキシアルキルアミン誘導体 |
| FR2579596B1 (fr) | 1985-03-26 | 1987-11-20 | Inst Nat Sante Rech Med | (imidazolyl-4) piperidines, leur preparation et leur application en therapeutique |
| FR2671083B1 (fr) | 1990-12-31 | 1994-12-23 | Inst Nat Sante Rech Med | Nouvelles 4-(4-imidazolyl) piperidines substituees en 1, leur preparation ainsi que leurs applications therapeutiques. |
| ATE159248T1 (de) | 1991-02-27 | 1997-11-15 | Seed Capital Investments | Imidazol-derivate mit antagonistischer aktivität auf den histamin-h3-receptor |
| ZA929788B (en) | 1991-12-18 | 1993-06-22 | Schering Corp | Imidazolyl or imidazoylalkyl substituted with a four or five membered nitrogen containing heterocyclic ring. |
| WO1993012107A1 (en) | 1991-12-18 | 1993-06-24 | Schering Corporation | Imidazoylalkyl substituted with a six membered nitrogen containing heterocyclic ring |
| FR2686084B1 (fr) | 1992-01-10 | 1995-12-22 | Bioprojet Soc Civ | Nouveaux derives de l'imidazole, leur preparation et leurs applications therapeutiques. |
| US5639775A (en) | 1992-04-01 | 1997-06-17 | The University Of Toledo | 4-[4'-piperodinyl or 3'-pirrolidinyl] substituted imidazoles as H3 -receptor antagonists and therapeutic uses thereof |
| US5380858A (en) | 1992-04-01 | 1995-01-10 | The University Of Toledo | Process for the preparation of intermediates useful for the synthesis of histamine receptor antagonists |
| US5486526A (en) * | 1992-04-01 | 1996-01-23 | The University Of Toledo | Histamine H3 -receptor antagonists and therapeutic uses thereof |
| WO1994017058A1 (fr) | 1993-01-25 | 1994-08-04 | The Green Cross Corporation | Compose d'imidazole |
| JP3522790B2 (ja) | 1993-06-08 | 2004-04-26 | 花王株式会社 | Ｈ３−レセプター刺激薬 |
| AU7823894A (en) | 1993-08-27 | 1995-03-21 | Vrije Universiteit | New imidazole derivatives having agonistic or antagonistic activity on the histamine h3 receptor |
| GB9319534D0 (en) * | 1993-09-22 | 1993-11-10 | Boots Co Plc | Therapeutic agents |
| HUT74386A (en) | 1993-11-15 | 1996-12-30 | Schering Corp | Phenyl-alkyl imidazoles as h3-receptor antagonists and pharmaceutical compositions containing them |
| GB9411045D0 (en) * | 1994-06-02 | 1994-07-20 | Smithkline Beecham Plc | Compounds and use |
| FR2732017B1 (fr) | 1995-03-21 | 2000-09-22 | Inst Nat Sante Rech Med | Nouveaux derives de l'imidazole antagonistes et/ou agonistes du recepteur h3 de l'histamine, leur preparation et leurs applications therapeutiques |
| US5652258A (en) | 1995-05-30 | 1997-07-29 | Gliatech, Inc. | 2-(4-imidazoyl) cyclopropyl derivatives |
| JPH11506106A (ja) | 1995-05-30 | 1999-06-02 | グリアテツク・インコーポレイテツド | １ｈ−４（５）−置換イミダゾール誘導体 |
| AU713166B2 (en) | 1995-06-07 | 1999-11-25 | Gliatech Inc. | 1H-4(5)-substituted imidazole derivatives |
| NZ331272A (en) | 1996-02-09 | 2000-01-28 | Black James Foundation | Histamine H3 receptor ligands |
| JP3925579B2 (ja) * | 1998-02-03 | 2007-06-06 | 日本精工株式会社 | 潤滑剤供給体、並びに前記潤滑剤供給体を備える転がり軸受、リニアガイド装置及びボールねじ装置 |
| EP0982300A3 (en) * | 1998-07-29 | 2000-03-08 | Societe Civile Bioprojet | Non-imidazole alkylamines as histamine H3 - receptor ligands and their therapeutic applications |
| US6136559A (en) * | 1998-10-07 | 2000-10-24 | Ortho Pharmaceutical Corporation | DNA encoding as human histamine receptor of the H3 subtype |
| ATE438614T1 (de) | 1999-06-11 | 2009-08-15 | Toyama Chemical Co Ltd | N-alkoxyalkyl-n,n-dialkylamin-derivate oder ihre salze und heilmittel zur behandlung degenerativer erkrankungen der nerven die diese enthalten |
| GB9924941D0 (en) | 1999-10-22 | 1999-12-22 | Univ Manchester | Treatment of dyskinesia |
| US6620839B2 (en) * | 2000-07-13 | 2003-09-16 | Abbott Laboratories | 1,3-disubstituted and 1,3,3-trisubstituted pyrrolidines as histamine-3 receptor ligands and their therapeutic applications |
| US7186732B2 (en) * | 2000-08-08 | 2007-03-06 | Ortho-Mcneil Pharmaceutical, Inc. | Non-imidazole aryloxyalkylamines |
| US20020042400A1 (en) | 2000-08-17 | 2002-04-11 | Yajing Rong | Novel alicyclic imidazoles as H3 agents |
| WO2002015905A1 (en) * | 2000-08-21 | 2002-02-28 | Gliatech, Inc. | The use of histamine h3 receptor inverse agonists for the control of appetite and treatment of obesity |
| ES2299596T3 (es) | 2001-03-29 | 2008-06-01 | Ortho Mcneil Pharmaceutical, Inc. | Derivados de imidazol utiles como ligandos del receptor h3 de la histamina. |
| WO2003044059A1 (en) * | 2001-11-15 | 2003-05-30 | Ortho-Mcneil Pharmaceutical, Inc. | Agonists of recombinant human histamine h3 receptor |
| AU2002357775A1 (en) * | 2001-12-10 | 2003-06-23 | Ortho-Mcneil Pharmaceutical, Inc. | Phenylalkynes |
| CA2504272A1 (en) | 2002-10-23 | 2004-05-06 | Janssen Pharmaceutica, N.V. | Phenylpiperidines and phenylpyrrolidines as histamine h3 receptor modulators |
| FR2856596B1 (fr) | 2003-06-27 | 2007-04-27 | Bioprojet Soc Civ | Nouvelle association medicamenteuse psychiatrique et utilisation d'une antagoniste ou agoniste inverse du recepteur h3 de l'histamine pour preparer un medicament prevenant des effets indesirables de psychotropes. |
| CN1812981A (zh) * | 2003-06-27 | 2006-08-02 | 万有制药株式会社 | 杂芳氧基含氮饱和杂环衍生物 |
| SE0302116D0 (sv) * | 2003-07-21 | 2003-07-21 | Astrazeneca Ab | Novel compounds |
| JP4765627B2 (ja) | 2003-09-22 | 2011-09-07 | Ｍｓｄ株式会社 | 新規ピペリジン誘導体 |
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2005
- 2005-04-01 EP EP05290727A patent/EP1707203A1/en not_active Withdrawn
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2006
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- 2006-03-30 CN CN2006800157656A patent/CN101171009B/zh active Active
- 2006-03-30 MX MX2007012162A patent/MX2007012162A/es active IP Right Grant
- 2006-03-30 ME MEP-2013-98A patent/ME01713B/me unknown
- 2006-03-30 SI SI200631636T patent/SI1863487T2/sl unknown
- 2006-03-30 BR BRPI0612216-7A patent/BRPI0612216B1/pt active IP Right Grant
- 2006-03-30 DK DK06744466.1T patent/DK1863487T4/da active
- 2006-03-30 UA UAA200710712A patent/UA94902C2/ru unknown
- 2006-03-30 EA EA200702135A patent/EA016007B1/ru not_active IP Right Cessation
- 2006-03-30 EP EP06744466.1A patent/EP1863487B2/en active Active
- 2006-03-30 PT PT67444661T patent/PT1863487E/pt unknown
- 2006-03-30 WO PCT/IB2006/000739 patent/WO2006103546A2/en not_active Ceased
- 2006-03-30 JP JP2008503613A patent/JP5546761B2/ja active Active
- 2006-03-30 NZ NZ561940A patent/NZ561940A/en unknown
- 2006-03-30 US US11/909,778 patent/US8486947B2/en active Active
- 2006-03-30 CA CA2603656A patent/CA2603656C/en active Active
- 2006-03-30 RS RS20130359 patent/RS52911B2/sr unknown
- 2006-03-30 KR KR1020077025126A patent/KR101308527B1/ko active Active
- 2006-03-30 ES ES06744466T patent/ES2426008T5/es active Active
- 2006-03-30 SG SG200807447-8A patent/SG147415A1/en unknown
- 2006-03-30 HR HRP20130748T patent/HRP20130748T4/hr unknown
- 2006-03-30 PL PL06744466T patent/PL1863487T5/pl unknown
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2007
- 2007-09-20 ZA ZA200708086A patent/ZA200708086B/xx unknown
- 2007-09-26 TN TNP2007000365A patent/TNSN07365A1/fr unknown
- 2007-09-27 MA MA30254A patent/MA29353B1/fr unknown
- 2007-10-09 NO NO20075086A patent/NO343603B1/no unknown
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2013
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2014
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2016
- 2016-03-09 JP JP2016045424A patent/JP2016106142A/ja active Pending
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