CN101171009B - 非咪唑烷基胺组胺h3-受体的配体在制备治疗帕金森症、阻塞性睡眠呼吸暂停的药物中的应用 - Google Patents

非咪唑烷基胺组胺h3-受体的配体在制备治疗帕金森症、阻塞性睡眠呼吸暂停的药物中的应用 Download PDF

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CN101171009B
CN101171009B CN2006800157656A CN200680015765A CN101171009B CN 101171009 B CN101171009 B CN 101171009B CN 2006800157656 A CN2006800157656 A CN 2006800157656A CN 200680015765 A CN200680015765 A CN 200680015765A CN 101171009 B CN101171009 B CN 101171009B
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propyl
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phenyl
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CN101171009A (zh
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让-夏尔·施瓦茨
让娜-玛丽·勒孔特
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN2006800157656A 2005-04-01 2006-03-30 非咪唑烷基胺组胺h3-受体的配体在制备治疗帕金森症、阻塞性睡眠呼吸暂停的药物中的应用 Active CN101171009B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP05290727.6 2005-04-01
EP05290727A EP1707203A1 (en) 2005-04-01 2005-04-01 Treatment of parkinson's disease obstructive sleep apnea, dementia with lewy bodies, vascular dementia with non-imidazole alkylamines histamine H3- receptor ligands
US66861805P 2005-04-06 2005-04-06
US60/668,618 2005-04-06
PCT/IB2006/000739 WO2006103546A2 (en) 2005-04-01 2006-03-30 Treatment of parkinson's disease, obstructive sleep apnea, dementia with lewy bodies, vascular dementia with non-imidazole alkylamines histamine h3-receptor ligands

Publications (2)

Publication Number Publication Date
CN101171009A CN101171009A (zh) 2008-04-30
CN101171009B true CN101171009B (zh) 2012-11-07

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CN2006800157656A Active CN101171009B (zh) 2005-04-01 2006-03-30 非咪唑烷基胺组胺h3-受体的配体在制备治疗帕金森症、阻塞性睡眠呼吸暂停的药物中的应用

Country Status (27)

Country Link
US (1) US8486947B2 (OSRAM)
EP (2) EP1707203A1 (OSRAM)
JP (3) JP5546761B2 (OSRAM)
KR (1) KR101308527B1 (OSRAM)
CN (1) CN101171009B (OSRAM)
AU (1) AU2006228413C1 (OSRAM)
BR (1) BRPI0612216B1 (OSRAM)
CA (1) CA2603656C (OSRAM)
CY (1) CY1114636T1 (OSRAM)
DK (1) DK1863487T4 (OSRAM)
EA (1) EA016007B1 (OSRAM)
ES (1) ES2426008T5 (OSRAM)
HR (1) HRP20130748T4 (OSRAM)
MA (1) MA29353B1 (OSRAM)
ME (1) ME01713B (OSRAM)
MX (1) MX2007012162A (OSRAM)
NO (1) NO343603B1 (OSRAM)
NZ (1) NZ561940A (OSRAM)
PL (1) PL1863487T5 (OSRAM)
PT (1) PT1863487E (OSRAM)
RS (1) RS52911B2 (OSRAM)
SG (1) SG147415A1 (OSRAM)
SI (1) SI1863487T2 (OSRAM)
TN (1) TNSN07365A1 (OSRAM)
UA (1) UA94902C2 (OSRAM)
WO (1) WO2006103546A2 (OSRAM)
ZA (1) ZA200708086B (OSRAM)

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US9108948B2 (en) 2006-06-23 2015-08-18 Abbvie Inc. Cyclopropyl amine derivatives
FR2903904A1 (fr) * 2006-07-21 2008-01-25 Bioprojet Soc Civ Ile Association de modafinil et d'un antagoniste ou agoniste inverse du recepteur h3
JP5335675B2 (ja) 2006-07-25 2013-11-06 セファロン、インク． ピリジジノン誘導体
US8153813B2 (en) 2007-12-20 2012-04-10 Abbott Laboratories Benzothiazole and benzooxazole derivatives and methods of use
MX2010008375A (es) 2008-01-30 2011-03-04 Cephalon Inc Star Derivados de piperidina espirocíclicos substituidos como ligandos de receptores de histamina-3 (h3).
FR2932479A1 (fr) * 2008-06-13 2009-12-18 Servier Lab Nouveaux derives azabicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
US9186353B2 (en) 2009-04-27 2015-11-17 Abbvie Inc. Treatment of osteoarthritis pain
US8853390B2 (en) 2010-09-16 2014-10-07 Abbvie Inc. Processes for preparing 1,2-substituted cyclopropyl derivatives
US9181275B2 (en) 2011-08-11 2015-11-10 Abbvie Inc. Mercaptoamidine derivatives and methods of use
WO2013151982A1 (en) 2012-04-03 2013-10-10 Arena Pharmaceuticals, Inc. Methods and compounds useful in treating pruritus, and methods for identifying such compounds
CN104703592A (zh) * 2012-10-05 2015-06-10 转化技术制药有限责任公司 治疗轻度和中度阿尔茨海默病的方法
EP3391886A1 (en) 2017-04-19 2018-10-24 Novartis AG The use of a h3r inverse agonist for the treatment of shift work disorder
US20200282215A1 (en) 2019-03-06 2020-09-10 Medtronic Xomed, LLC Evaluating stimulation eficacy for treating sleep apnea and lingual muscle tone sensing system for improved osa therapy
EP4248969A1 (en) 2022-03-23 2023-09-27 Bioprojet Use of pitolisant for treating severe fatigue
WO2024201139A1 (en) 2023-03-31 2024-10-03 Bioprojet Pharma Polymorph form of pitolisant hydrochloride
WO2025082974A1 (en) 2023-10-16 2025-04-24 Bioprojet Pharma New formulations of pitolisant and methods of use

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Also Published As

Publication number Publication date
EP1863487A2 (en) 2007-12-12
KR20080002904A (ko) 2008-01-04
BRPI0612216B1 (pt) 2022-04-19
CN101171009A (zh) 2008-04-30
HRP20130748T4 (hr) 2019-11-15
EP1863487B2 (en) 2019-07-17
MA29353B1 (fr) 2008-03-03
CA2603656A1 (en) 2006-10-05
UA94902C2 (ru) 2011-06-25
US8486947B2 (en) 2013-07-16
JP2014062126A (ja) 2014-04-10
HRP20130748T1 (en) 2013-10-11
JP5955872B2 (ja) 2016-07-20
RS52911B2 (sr) 2019-11-29
TNSN07365A1 (fr) 2008-12-31
SG147415A1 (en) 2008-11-28
EA016007B1 (ru) 2012-01-30
CY1114636T1 (el) 2016-10-05
AU2006228413A1 (en) 2006-10-05
PL1863487T3 (pl) 2014-10-31
AU2006228413C1 (en) 2012-02-02
PT1863487E (pt) 2013-08-29
RS52911B (sr) 2014-02-28
DK1863487T4 (da) 2019-10-14
DK1863487T3 (da) 2013-08-12
SI1863487T2 (sl) 2019-11-29
AU2006228413B2 (en) 2011-09-15
NO343603B1 (no) 2019-04-08
ZA200708086B (en) 2008-10-29
WO2006103546A3 (en) 2007-03-01
BRPI0612216A2 (pt) 2010-10-26
EA200702135A1 (ru) 2008-04-28
ME01713B (me) 2014-09-20
JP2008534572A (ja) 2008-08-28
ES2426008T5 (es) 2020-03-20
CA2603656C (en) 2015-06-16
MX2007012162A (es) 2007-11-22
JP5546761B2 (ja) 2014-07-09
KR101308527B1 (ko) 2013-09-17
PL1863487T5 (pl) 2021-08-09
SI1863487T1 (sl) 2013-09-30
US20090318433A1 (en) 2009-12-24
JP2016106142A (ja) 2016-06-16
ES2426008T3 (es) 2013-10-18
EP1707203A1 (en) 2006-10-04
WO2006103546A2 (en) 2006-10-05
NO20075086L (no) 2007-12-27
NZ561940A (en) 2010-06-25
EP1863487B1 (en) 2013-05-29

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Application publication date: 20080430

Assignee: Shanghai Langyu Health Technology (Group) Co.,Ltd.

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Denomination of invention: Application of non imidazolidine histamine h3- receptor ligands in the preparation of drugs for the treatment of Parkinson's disease and obstructive sleep apnea

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