CN104703592A - 治疗轻度和中度阿尔茨海默病的方法 - Google Patents
治疗轻度和中度阿尔茨海默病的方法 Download PDFInfo
- Publication number
- CN104703592A CN104703592A CN201380051206.0A CN201380051206A CN104703592A CN 104703592 A CN104703592 A CN 104703592A CN 201380051206 A CN201380051206 A CN 201380051206A CN 104703592 A CN104703592 A CN 104703592A
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- CN
- China
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- days
- experimenter
- phenoxy group
- achei
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Dermatology (AREA)
Abstract
Description
Claims (83)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910466681.3A CN110292638A (zh) | 2012-10-05 | 2013-10-02 | 治疗轻度和中度阿尔茨海默病的方法 |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261710229P | 2012-10-05 | 2012-10-05 | |
US61/710,229 | 2012-10-05 | ||
PCT/US2013/062964 WO2014055588A1 (en) | 2012-10-05 | 2013-10-02 | Treatment of mild and moderate alzheimer's disease |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201910466681.3A Division CN110292638A (zh) | 2012-10-05 | 2013-10-02 | 治疗轻度和中度阿尔茨海默病的方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN104703592A true CN104703592A (zh) | 2015-06-10 |
Family
ID=49354960
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201380051206.0A Pending CN104703592A (zh) | 2012-10-05 | 2013-10-02 | 治疗轻度和中度阿尔茨海默病的方法 |
CN201910466681.3A Pending CN110292638A (zh) | 2012-10-05 | 2013-10-02 | 治疗轻度和中度阿尔茨海默病的方法 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201910466681.3A Pending CN110292638A (zh) | 2012-10-05 | 2013-10-02 | 治疗轻度和中度阿尔茨海默病的方法 |
Country Status (15)
Country | Link |
---|---|
EP (1) | EP2903606A1 (zh) |
JP (2) | JP6566868B2 (zh) |
KR (1) | KR20150064743A (zh) |
CN (2) | CN104703592A (zh) |
AU (2) | AU2013327450B2 (zh) |
BR (1) | BR112015007641A8 (zh) |
CA (1) | CA2886785C (zh) |
EA (1) | EA201590687A1 (zh) |
HK (1) | HK1207004A1 (zh) |
IL (1) | IL237730B (zh) |
IN (1) | IN2015DN03734A (zh) |
MX (1) | MX2015003732A (zh) |
NZ (2) | NZ705813A (zh) |
SG (2) | SG10201702648YA (zh) |
WO (1) | WO2014055588A1 (zh) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2019190822A1 (en) | 2018-03-28 | 2019-10-03 | Vtv Therapeutics Llc | Crystalline forms of [3-(4- {2-butyl-1-[4-(4-chloro-phenoxy)-phenyl]-1h-imidazol-4-yl} -phenoxy)-propyl]-diethyl-amine |
WO2019190823A1 (en) * | 2018-03-28 | 2019-10-03 | Vtv Therapeutics Llc | Pharmaceutically acceptable salts of [3-(4- {2-butyl-1-[4-(4-chlorophenoxy)-phenyl]-1h-imidazol-4-yl} -phenoxy)-propyl]-diethyl-amine |
EP3864008A1 (en) | 2018-10-10 | 2021-08-18 | vTv Therapeutics LLC | Metabolites of [3-(4-{2-butyl-l-[4-(4-chloro-phenoxy)-phenyl]-lh-imidazol-4-yl } -phen ox y)-prop yl] -diethyl-amine |
WO2020086388A1 (en) * | 2018-10-22 | 2020-04-30 | Vtv Therapeutics Llc | Glucokinase activator compositions for the treatment of cognitive impairment |
JP7327788B2 (ja) * | 2019-08-06 | 2023-08-16 | 学校法人福岡大学 | 糖化産物生成抑制剤及び医薬組成物 |
CN114716551B (zh) * | 2021-11-12 | 2023-01-24 | 深圳市人民医院 | 靶向rage的纳米抗体及其应用 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE529110T1 (de) * | 2002-03-05 | 2011-11-15 | Transtech Pharma Inc | Mono- und bicyclische azolderivate die die interaktion von liganden mit rage hemmen |
MXPA05012350A (es) * | 2003-05-20 | 2006-05-25 | Transtech Pharma Inc | Antagonistas rage como agentes para la amiloidosis inversa y enfermedades asociadas con la misma. |
EP1707203A1 (en) * | 2005-04-01 | 2006-10-04 | Bioprojet | Treatment of parkinson's disease obstructive sleep apnea, dementia with lewy bodies, vascular dementia with non-imidazole alkylamines histamine H3- receptor ligands |
CN101663280A (zh) * | 2007-04-05 | 2010-03-03 | 转化技术制药公司 | [3-(4-{2-丁基-1-[4-(4-氯-苯氧基)-苯基]-1h-咪唑-4-基}-苯氧基)-丙基]-二乙基-胺的晶型ⅰ和ⅱ |
EP2144883A1 (en) * | 2007-04-05 | 2010-01-20 | TransTech Pharma, Inc | Crystalline forms i and ii of [3-(4-{2-butyl-1-[4-(4-chloro-phenoxy)-phenyl]-1h-imidazol-4-yl}-phenoxy)-propyl]-diethyl-amine |
US20100254983A1 (en) * | 2007-06-07 | 2010-10-07 | Ann Marie Schmidt | Uses of rage antagonists for treating obesity and related diseases |
US20090221554A1 (en) * | 2008-02-28 | 2009-09-03 | Zenyaku Kogyo Kabushiki Kaisha | Method of treating cognitive impairment |
EP2638052B1 (en) * | 2010-11-08 | 2017-03-22 | Alectos Therapeutics, Inc. | Selective glycosidase inhibitors and uses thereof |
-
2013
- 2013-10-02 IN IN3734DEN2015 patent/IN2015DN03734A/en unknown
- 2013-10-02 SG SG10201702648YA patent/SG10201702648YA/en unknown
- 2013-10-02 NZ NZ705813A patent/NZ705813A/en unknown
- 2013-10-02 AU AU2013327450A patent/AU2013327450B2/en active Active
- 2013-10-02 CN CN201380051206.0A patent/CN104703592A/zh active Pending
- 2013-10-02 KR KR1020157011366A patent/KR20150064743A/ko not_active Application Discontinuation
- 2013-10-02 NZ NZ739521A patent/NZ739521A/en unknown
- 2013-10-02 JP JP2015535750A patent/JP6566868B2/ja active Active
- 2013-10-02 SG SG11201502210VA patent/SG11201502210VA/en unknown
- 2013-10-02 CN CN201910466681.3A patent/CN110292638A/zh active Pending
- 2013-10-02 WO PCT/US2013/062964 patent/WO2014055588A1/en active Application Filing
- 2013-10-02 EP EP13776676.2A patent/EP2903606A1/en not_active Withdrawn
- 2013-10-02 MX MX2015003732A patent/MX2015003732A/es active IP Right Grant
- 2013-10-02 EA EA201590687A patent/EA201590687A1/ru unknown
- 2013-10-02 CA CA2886785A patent/CA2886785C/en active Active
- 2013-10-02 BR BR112015007641A patent/BR112015007641A8/pt active Search and Examination
-
2015
- 2015-03-12 IL IL237730A patent/IL237730B/en active IP Right Grant
- 2015-08-11 HK HK15107776.8A patent/HK1207004A1/zh unknown
-
2018
- 2018-05-16 AU AU2018203434A patent/AU2018203434A1/en not_active Abandoned
-
2019
- 2019-05-23 JP JP2019096786A patent/JP6894940B2/ja active Active
Also Published As
Publication number | Publication date |
---|---|
IN2015DN03734A (zh) | 2015-09-18 |
WO2014055588A1 (en) | 2014-04-10 |
AU2013327450B2 (en) | 2018-07-12 |
BR112015007641A2 (pt) | 2017-07-04 |
SG10201702648YA (en) | 2017-04-27 |
BR112015007641A8 (pt) | 2018-04-03 |
CN110292638A (zh) | 2019-10-01 |
CA2886785C (en) | 2022-06-07 |
AU2018203434A1 (en) | 2018-06-07 |
JP2019163301A (ja) | 2019-09-26 |
EA201590687A1 (ru) | 2015-09-30 |
JP6894940B2 (ja) | 2021-06-30 |
AU2013327450A1 (en) | 2015-05-14 |
JP6566868B2 (ja) | 2019-08-28 |
SG11201502210VA (en) | 2015-04-29 |
NZ739521A (en) | 2019-06-28 |
IL237730B (en) | 2018-10-31 |
CA2886785A1 (en) | 2014-04-10 |
EP2903606A1 (en) | 2015-08-12 |
KR20150064743A (ko) | 2015-06-11 |
JP2015535850A (ja) | 2015-12-17 |
NZ705813A (en) | 2018-02-23 |
HK1207004A1 (zh) | 2016-01-22 |
MX2015003732A (es) | 2015-09-23 |
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Legal Events
Date | Code | Title | Description |
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C06 | Publication | ||
PB01 | Publication | ||
C53 | Correction of patent of invention or patent application | ||
CB02 | Change of applicant information |
Address after: North Carolina Applicant after: vTv Therapeutics LLC Address before: North Carolina Applicant before: TRANSTECH PHARMA, Inc. |
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COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: Free format text: CORRECT: APPLICANT; FROM: TRANSFORMATION TECHNOLOGY PHARMA, LLC TO: VTV THERAPEUTICS LLC |
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C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C41 | Transfer of patent application or patent right or utility model | ||
CB02 | Change of applicant information |
Address after: North Carolina Applicant after: VTVX Holdings I LLC Address before: North Carolina Applicant before: VTV THERAPEUTICS LLC |
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TA01 | Transfer of patent application right |
Effective date of registration: 20151130 Address after: North Carolina Applicant after: VTV THERAPEUTICS LLC Address before: North Carolina Applicant before: VTVX Holdings I LLC |
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