AU2006228413C1 - Treatment of Parkinson's Disease, obstructive sleep apnea, dementia with lewy bodies, vascular dementia with non-imidazole alkylamines histamine H3-receptor ligands - Google Patents

Treatment of Parkinson's Disease, obstructive sleep apnea, dementia with lewy bodies, vascular dementia with non-imidazole alkylamines histamine H3-receptor ligands Download PDF

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Publication number
AU2006228413C1
AU2006228413C1 AU2006228413A AU2006228413A AU2006228413C1 AU 2006228413 C1 AU2006228413 C1 AU 2006228413C1 AU 2006228413 A AU2006228413 A AU 2006228413A AU 2006228413 A AU2006228413 A AU 2006228413A AU 2006228413 C1 AU2006228413 C1 AU 2006228413C1
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alkyl
propyl
phenyl
compounds
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AU2006228413A1 (en
AU2006228413B2 (en
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Jeanne-Marie Lecomte
Jean-Charles Schwartz
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Bioprojet SC
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Bioprojet SC
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2006228413A 2005-04-01 2006-03-29 Treatment of Parkinson's Disease, obstructive sleep apnea, dementia with lewy bodies, vascular dementia with non-imidazole alkylamines histamine H3-receptor ligands Active AU2006228413C1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP05290727.6 2005-04-01
EP05290727A EP1707203A1 (en) 2005-04-01 2005-04-01 Treatment of parkinson's disease obstructive sleep apnea, dementia with lewy bodies, vascular dementia with non-imidazole alkylamines histamine H3- receptor ligands
US66861805P 2005-04-06 2005-04-06
US60/668,618 2005-04-06
PCT/IB2006/000739 WO2006103546A2 (en) 2005-04-01 2006-03-30 Treatment of parkinson's disease, obstructive sleep apnea, dementia with lewy bodies, vascular dementia with non-imidazole alkylamines histamine h3-receptor ligands

Publications (3)

Publication Number Publication Date
AU2006228413A1 AU2006228413A1 (en) 2006-10-05
AU2006228413B2 AU2006228413B2 (en) 2011-09-15
AU2006228413C1 true AU2006228413C1 (en) 2012-02-02

Family

ID=35169680

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AU2006228413A Active AU2006228413C1 (en) 2005-04-01 2006-03-29 Treatment of Parkinson's Disease, obstructive sleep apnea, dementia with lewy bodies, vascular dementia with non-imidazole alkylamines histamine H3-receptor ligands

Country Status (27)

Country Link
US (1) US8486947B2 (OSRAM)
EP (2) EP1707203A1 (OSRAM)
JP (3) JP5546761B2 (OSRAM)
KR (1) KR101308527B1 (OSRAM)
CN (1) CN101171009B (OSRAM)
AU (1) AU2006228413C1 (OSRAM)
BR (1) BRPI0612216B1 (OSRAM)
CA (1) CA2603656C (OSRAM)
CY (1) CY1114636T1 (OSRAM)
DK (1) DK1863487T4 (OSRAM)
EA (1) EA016007B1 (OSRAM)
ES (1) ES2426008T5 (OSRAM)
HR (1) HRP20130748T4 (OSRAM)
MA (1) MA29353B1 (OSRAM)
ME (1) ME01713B (OSRAM)
MX (1) MX2007012162A (OSRAM)
NO (1) NO343603B1 (OSRAM)
NZ (1) NZ561940A (OSRAM)
PL (1) PL1863487T5 (OSRAM)
PT (1) PT1863487E (OSRAM)
RS (1) RS52911B2 (OSRAM)
SG (1) SG147415A1 (OSRAM)
SI (1) SI1863487T2 (OSRAM)
TN (1) TNSN07365A1 (OSRAM)
UA (1) UA94902C2 (OSRAM)
WO (1) WO2006103546A2 (OSRAM)
ZA (1) ZA200708086B (OSRAM)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2008016343A (es) 2006-06-23 2009-01-19 Abbott Lab Derivados ciclopropil amina como moduladores del receptro de histamina h3.
US9108948B2 (en) 2006-06-23 2015-08-18 Abbvie Inc. Cyclopropyl amine derivatives
FR2903904A1 (fr) * 2006-07-21 2008-01-25 Bioprojet Soc Civ Ile Association de modafinil et d'un antagoniste ou agoniste inverse du recepteur h3
JP5335675B2 (ja) 2006-07-25 2013-11-06 セファロン、インク． ピリジジノン誘導体
US8153813B2 (en) 2007-12-20 2012-04-10 Abbott Laboratories Benzothiazole and benzooxazole derivatives and methods of use
MX2010008375A (es) 2008-01-30 2011-03-04 Cephalon Inc Star Derivados de piperidina espirocíclicos substituidos como ligandos de receptores de histamina-3 (h3).
FR2932479A1 (fr) * 2008-06-13 2009-12-18 Servier Lab Nouveaux derives azabicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
US9186353B2 (en) 2009-04-27 2015-11-17 Abbvie Inc. Treatment of osteoarthritis pain
US8853390B2 (en) 2010-09-16 2014-10-07 Abbvie Inc. Processes for preparing 1,2-substituted cyclopropyl derivatives
US9181275B2 (en) 2011-08-11 2015-11-10 Abbvie Inc. Mercaptoamidine derivatives and methods of use
WO2013151982A1 (en) 2012-04-03 2013-10-10 Arena Pharmaceuticals, Inc. Methods and compounds useful in treating pruritus, and methods for identifying such compounds
CN104703592A (zh) * 2012-10-05 2015-06-10 转化技术制药有限责任公司 治疗轻度和中度阿尔茨海默病的方法
EP3391886A1 (en) 2017-04-19 2018-10-24 Novartis AG The use of a h3r inverse agonist for the treatment of shift work disorder
US20200282215A1 (en) 2019-03-06 2020-09-10 Medtronic Xomed, LLC Evaluating stimulation eficacy for treating sleep apnea and lingual muscle tone sensing system for improved osa therapy
EP4248969A1 (en) 2022-03-23 2023-09-27 Bioprojet Use of pitolisant for treating severe fatigue
WO2024201139A1 (en) 2023-03-31 2024-10-03 Bioprojet Pharma Polymorph form of pitolisant hydrochloride
WO2025082974A1 (en) 2023-10-16 2025-04-24 Bioprojet Pharma New formulations of pitolisant and methods of use

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995011894A1 (en) * 1993-10-29 1995-05-04 The University Of Toledo Histamine h3-receptor antagonists and therapeutic uses thereof
EP0982300A2 (en) * 1998-07-29 2000-03-01 Societe Civile Bioprojet Non-imidazole alkylamines as histamine H3 - receptor ligands and their therapeutic applications
WO2003044059A1 (en) * 2001-11-15 2003-05-30 Ortho-Mcneil Pharmaceutical, Inc. Agonists of recombinant human histamine h3 receptor
US20040006120A1 (en) * 2000-08-21 2004-01-08 Yates Stephen L Use of histamine h3 receptor inverse agonists for the control of appetite and treatment of obesity
US6855560B1 (en) * 1998-10-07 2005-02-15 Ortho Mcneil Pharmaceutical, Inc. Method of identifying compounds that modulate human histamine H3 receptor
WO2005014579A1 (en) * 2003-07-21 2005-02-17 Astrazeneca Ab Imidazol derivatives of piperdine as histamine antagonists

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5815945A (ja) * 1981-07-21 1983-01-29 Teikoku Hormone Mfg Co Ltd 新規なフエノキシアルキルアミン誘導体
FR2579596B1 (fr) 1985-03-26 1987-11-20 Inst Nat Sante Rech Med (imidazolyl-4) piperidines, leur preparation et leur application en therapeutique
FR2671083B1 (fr) 1990-12-31 1994-12-23 Inst Nat Sante Rech Med Nouvelles 4-(4-imidazolyl) piperidines substituees en 1, leur preparation ainsi que leurs applications therapeutiques.
ATE159248T1 (de) 1991-02-27 1997-11-15 Seed Capital Investments Imidazol-derivate mit antagonistischer aktivität auf den histamin-h3-receptor
ZA929788B (en) 1991-12-18 1993-06-22 Schering Corp Imidazolyl or imidazoylalkyl substituted with a four or five membered nitrogen containing heterocyclic ring.
WO1993012107A1 (en) 1991-12-18 1993-06-24 Schering Corporation Imidazoylalkyl substituted with a six membered nitrogen containing heterocyclic ring
FR2686084B1 (fr) 1992-01-10 1995-12-22 Bioprojet Soc Civ Nouveaux derives de l'imidazole, leur preparation et leurs applications therapeutiques.
US5639775A (en) 1992-04-01 1997-06-17 The University Of Toledo 4-[4'-piperodinyl or 3'-pirrolidinyl] substituted imidazoles as H3 -receptor antagonists and therapeutic uses thereof
US5380858A (en) 1992-04-01 1995-01-10 The University Of Toledo Process for the preparation of intermediates useful for the synthesis of histamine receptor antagonists
WO1994017058A1 (fr) 1993-01-25 1994-08-04 The Green Cross Corporation Compose d'imidazole
JP3522790B2 (ja) 1993-06-08 2004-04-26 花王株式会社 Ｈ３−レセプター刺激薬
AU7823894A (en) 1993-08-27 1995-03-21 Vrije Universiteit New imidazole derivatives having agonistic or antagonistic activity on the histamine h3 receptor
GB9319534D0 (en) * 1993-09-22 1993-11-10 Boots Co Plc Therapeutic agents
HUT74386A (en) 1993-11-15 1996-12-30 Schering Corp Phenyl-alkyl imidazoles as h3-receptor antagonists and pharmaceutical compositions containing them
GB9411045D0 (en) * 1994-06-02 1994-07-20 Smithkline Beecham Plc Compounds and use
FR2732017B1 (fr) 1995-03-21 2000-09-22 Inst Nat Sante Rech Med Nouveaux derives de l'imidazole antagonistes et/ou agonistes du recepteur h3 de l'histamine, leur preparation et leurs applications therapeutiques
US5652258A (en) 1995-05-30 1997-07-29 Gliatech, Inc. 2-(4-imidazoyl) cyclopropyl derivatives
JPH11506106A (ja) 1995-05-30 1999-06-02 グリアテツク・インコーポレイテツド １ｈ−４（５）−置換イミダゾール誘導体
AU713166B2 (en) 1995-06-07 1999-11-25 Gliatech Inc. 1H-4(5)-substituted imidazole derivatives
NZ331272A (en) 1996-02-09 2000-01-28 Black James Foundation Histamine H3 receptor ligands
JP3925579B2 (ja) * 1998-02-03 2007-06-06 日本精工株式会社 潤滑剤供給体、並びに前記潤滑剤供給体を備える転がり軸受、リニアガイド装置及びボールねじ装置
ATE438614T1 (de) 1999-06-11 2009-08-15 Toyama Chemical Co Ltd N-alkoxyalkyl-n,n-dialkylamin-derivate oder ihre salze und heilmittel zur behandlung degenerativer erkrankungen der nerven die diese enthalten
GB9924941D0 (en) 1999-10-22 1999-12-22 Univ Manchester Treatment of dyskinesia
US6620839B2 (en) * 2000-07-13 2003-09-16 Abbott Laboratories 1,3-disubstituted and 1,3,3-trisubstituted pyrrolidines as histamine-3 receptor ligands and their therapeutic applications
US7186732B2 (en) * 2000-08-08 2007-03-06 Ortho-Mcneil Pharmaceutical, Inc. Non-imidazole aryloxyalkylamines
US20020042400A1 (en) 2000-08-17 2002-04-11 Yajing Rong Novel alicyclic imidazoles as H3 agents
ES2299596T3 (es) 2001-03-29 2008-06-01 Ortho Mcneil Pharmaceutical, Inc. Derivados de imidazol utiles como ligandos del receptor h3 de la histamina.
AU2002357775A1 (en) * 2001-12-10 2003-06-23 Ortho-Mcneil Pharmaceutical, Inc. Phenylalkynes
CA2504272A1 (en) 2002-10-23 2004-05-06 Janssen Pharmaceutica, N.V. Phenylpiperidines and phenylpyrrolidines as histamine h3 receptor modulators
FR2856596B1 (fr) 2003-06-27 2007-04-27 Bioprojet Soc Civ Nouvelle association medicamenteuse psychiatrique et utilisation d'une antagoniste ou agoniste inverse du recepteur h3 de l'histamine pour preparer un medicament prevenant des effets indesirables de psychotropes.
CN1812981A (zh) * 2003-06-27 2006-08-02 万有制药株式会社 杂芳氧基含氮饱和杂环衍生物
JP4765627B2 (ja) 2003-09-22 2011-09-07 Ｍｓｄ株式会社 新規ピペリジン誘導体

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995011894A1 (en) * 1993-10-29 1995-05-04 The University Of Toledo Histamine h3-receptor antagonists and therapeutic uses thereof
EP0982300A2 (en) * 1998-07-29 2000-03-01 Societe Civile Bioprojet Non-imidazole alkylamines as histamine H3 - receptor ligands and their therapeutic applications
US6855560B1 (en) * 1998-10-07 2005-02-15 Ortho Mcneil Pharmaceutical, Inc. Method of identifying compounds that modulate human histamine H3 receptor
US20040006120A1 (en) * 2000-08-21 2004-01-08 Yates Stephen L Use of histamine h3 receptor inverse agonists for the control of appetite and treatment of obesity
WO2003044059A1 (en) * 2001-11-15 2003-05-30 Ortho-Mcneil Pharmaceutical, Inc. Agonists of recombinant human histamine h3 receptor
WO2005014579A1 (en) * 2003-07-21 2005-02-17 Astrazeneca Ab Imidazol derivatives of piperdine as histamine antagonists

Also Published As

Publication number Publication date
EP1863487A2 (en) 2007-12-12
KR20080002904A (ko) 2008-01-04
BRPI0612216B1 (pt) 2022-04-19
CN101171009A (zh) 2008-04-30
HRP20130748T4 (hr) 2019-11-15
EP1863487B2 (en) 2019-07-17
MA29353B1 (fr) 2008-03-03
CA2603656A1 (en) 2006-10-05
UA94902C2 (ru) 2011-06-25
US8486947B2 (en) 2013-07-16
JP2014062126A (ja) 2014-04-10
HRP20130748T1 (en) 2013-10-11
CN101171009B (zh) 2012-11-07
JP5955872B2 (ja) 2016-07-20
RS52911B2 (sr) 2019-11-29
TNSN07365A1 (fr) 2008-12-31
SG147415A1 (en) 2008-11-28
EA016007B1 (ru) 2012-01-30
CY1114636T1 (el) 2016-10-05
AU2006228413A1 (en) 2006-10-05
PL1863487T3 (pl) 2014-10-31
PT1863487E (pt) 2013-08-29
RS52911B (sr) 2014-02-28
DK1863487T4 (da) 2019-10-14
DK1863487T3 (da) 2013-08-12
SI1863487T2 (sl) 2019-11-29
AU2006228413B2 (en) 2011-09-15
NO343603B1 (no) 2019-04-08
ZA200708086B (en) 2008-10-29
WO2006103546A3 (en) 2007-03-01
BRPI0612216A2 (pt) 2010-10-26
EA200702135A1 (ru) 2008-04-28
ME01713B (me) 2014-09-20
JP2008534572A (ja) 2008-08-28
ES2426008T5 (es) 2020-03-20
CA2603656C (en) 2015-06-16
MX2007012162A (es) 2007-11-22
JP5546761B2 (ja) 2014-07-09
KR101308527B1 (ko) 2013-09-17
PL1863487T5 (pl) 2021-08-09
SI1863487T1 (sl) 2013-09-30
US20090318433A1 (en) 2009-12-24
JP2016106142A (ja) 2016-06-16
ES2426008T3 (es) 2013-10-18
EP1707203A1 (en) 2006-10-04
WO2006103546A2 (en) 2006-10-05
NO20075086L (no) 2007-12-27
NZ561940A (en) 2010-06-25
EP1863487B1 (en) 2013-05-29

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