ES2415632T3 - Epoxicetonas peptídicas para la inhibición del proteosoma - Google Patents

Epoxicetonas peptídicas para la inhibición del proteosoma Download PDF

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Publication number
ES2415632T3
ES2415632T3 ES07809745T ES07809745T ES2415632T3 ES 2415632 T3 ES2415632 T3 ES 2415632T3 ES 07809745 T ES07809745 T ES 07809745T ES 07809745 T ES07809745 T ES 07809745T ES 2415632 T3 ES2415632 T3 ES 2415632T3
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compound
alkyl
mmol
disease
solution
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English (en)
Spanish (es)
Inventor
Kevin D. Shenk
Francesco Parlati
Han-Jie Zhou
Catherine Sylvain
Mark S. Smyth
Mark K. Bennett
Guy J. Laidig
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Onyx Pharmaceuticals Inc
Onyx Therapeutics Inc
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Proteolix Inc
Onyx Therapeutics Inc
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    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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