AU2007261345B2 - Peptide epoxyketones for proteasome inhibition - Google Patents

Peptide epoxyketones for proteasome inhibition Download PDF

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Publication number
AU2007261345B2
AU2007261345B2 AU2007261345A AU2007261345A AU2007261345B2 AU 2007261345 B2 AU2007261345 B2 AU 2007261345B2 AU 2007261345 A AU2007261345 A AU 2007261345A AU 2007261345 A AU2007261345 A AU 2007261345A AU 2007261345 B2 AU2007261345 B2 AU 2007261345B2
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alkyl
compound
mmol
hydrogen
absent
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AU2007261345A1 (en
Inventor
Mark K. Bennett
Guy J. Laidig
Francesco Parlati
Kevin D. Shenk
Mark S. Smyth
Catherine Sylvain
Han-Jie Zhou
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Onyx Therapeutics Inc
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Onyx Therapeutics Inc
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Assigned to ONYX THERAPEUTICS, INC. reassignment ONYX THERAPEUTICS, INC. Request to Amend Deed and Register Assignors: PROTEOLIX, INC.
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    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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