HK1213579A1 - 大環酮酰胺免疫蛋白酶體抑制劑 - Google Patents

大環酮酰胺免疫蛋白酶體抑制劑

Info

Publication number
HK1213579A1
HK1213579A1 HK16101504.9A HK16101504A HK1213579A1 HK 1213579 A1 HK1213579 A1 HK 1213579A1 HK 16101504 A HK16101504 A HK 16101504A HK 1213579 A1 HK1213579 A1 HK 1213579A1
Authority
HK
Hong Kong
Prior art keywords
ketoamide
macrocyclic
immunoproteasome inhibitors
immunoproteasome
inhibitors
Prior art date
Application number
HK16101504.9A
Other languages
English (en)
Inventor
Stephen M Lynch
Arjun Narayanan
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of HK1213579A1 publication Critical patent/HK1213579A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
    • C07K5/123—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
HK16101504.9A 2012-10-12 2016-02-11 大環酮酰胺免疫蛋白酶體抑制劑 HK1213579A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261712840P 2012-10-12 2012-10-12
PCT/EP2013/070993 WO2014056954A1 (en) 2012-10-12 2013-10-09 Macrocyclic ketoamide immunoproteasome inhibitors

Publications (1)

Publication Number Publication Date
HK1213579A1 true HK1213579A1 (zh) 2016-07-08

Family

ID=49326670

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16101504.9A HK1213579A1 (zh) 2012-10-12 2016-02-11 大環酮酰胺免疫蛋白酶體抑制劑

Country Status (11)

Country Link
US (1) US20150266920A1 (zh)
EP (1) EP2906582A1 (zh)
JP (1) JP2015536913A (zh)
KR (1) KR20150068464A (zh)
CN (1) CN104854124A (zh)
BR (1) BR112015008161A2 (zh)
CA (1) CA2892370A1 (zh)
HK (1) HK1213579A1 (zh)
MX (1) MX2015004593A (zh)
RU (1) RU2015117581A (zh)
WO (1) WO2014056954A1 (zh)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS64286B1 (sr) 2016-06-29 2023-07-31 Kezar Life Sciences Kristalne soli inhibitora imunoproteazoma za peptid epoksiketon
AU2017290147B2 (en) 2016-06-29 2021-09-09 Kezar Life Sciences Process of preparing a peptide epoxyketone immunoproteasome inhibitor, and precursors thereof
WO2019060651A1 (en) 2017-09-21 2019-03-28 Kezar Life Sciences POLY THERAPY FOR IMMUNOLOGICAL DISEASES

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2604133C (en) * 2005-04-07 2015-12-01 Centre National De La Recherche Scientifique Compounds useful as modulators of the proteasome activity
BRPI0713309A2 (pt) * 2006-06-19 2012-04-17 Proteolix Inc compostos para inibição de enzimas

Also Published As

Publication number Publication date
CA2892370A1 (en) 2014-04-17
KR20150068464A (ko) 2015-06-19
JP2015536913A (ja) 2015-12-24
MX2015004593A (es) 2015-07-21
EP2906582A1 (en) 2015-08-19
RU2015117581A (ru) 2016-12-10
BR112015008161A2 (pt) 2017-07-04
WO2014056954A1 (en) 2014-04-17
CN104854124A (zh) 2015-08-19
US20150266920A1 (en) 2015-09-24

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