ES2340939T3 - Utilizacioin del treprostinil para tratar las ulceras de pie diabeticas neuropaticas. - Google Patents
Utilizacioin del treprostinil para tratar las ulceras de pie diabeticas neuropaticas. Download PDFInfo
- Publication number
- ES2340939T3 ES2340939T3 ES05735648T ES05735648T ES2340939T3 ES 2340939 T3 ES2340939 T3 ES 2340939T3 ES 05735648 T ES05735648 T ES 05735648T ES 05735648 T ES05735648 T ES 05735648T ES 2340939 T3 ES2340939 T3 ES 2340939T3
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- Prior art keywords
- treprostinil
- use according
- medicament
- derivative
- administered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56115704P | 2004-04-12 | 2004-04-12 | |
| US561157P | 2004-04-12 |
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| ES2340939T3 true ES2340939T3 (es) | 2010-06-11 |
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| ES05735648T Expired - Lifetime ES2340939T3 (es) | 2004-04-12 | 2005-04-12 | Utilizacioin del treprostinil para tratar las ulceras de pie diabeticas neuropaticas. |
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| EP (1) | EP1744739B1 (https=) |
| JP (1) | JP2007532663A (https=) |
| KR (1) | KR101186029B1 (https=) |
| CN (1) | CN101287457B (https=) |
| AT (1) | ATE462427T1 (https=) |
| CA (1) | CA2562614C (https=) |
| DE (1) | DE602005020269D1 (https=) |
| ES (1) | ES2340939T3 (https=) |
| WO (1) | WO2005099680A2 (https=) |
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| CN1917866B (zh) * | 2003-12-16 | 2010-12-15 | 联合治疗公司 | 曲前列环素或它的衍生物，或其药学上可接受的盐在制备治疗和预防缺血性损害的药物中的用途 |
| ATE462427T1 (de) * | 2004-04-12 | 2010-04-15 | United Therapeutics Corp | Verwendung von treprostinil zur behandlung von neuropathischen diabetischen fussgeschwüren |
| US8747897B2 (en) | 2006-04-27 | 2014-06-10 | Supernus Pharmaceuticals, Inc. | Osmotic drug delivery system |
| CA2698721A1 (en) | 2007-09-07 | 2009-03-12 | United Therapeutics Corporation | Buffer solutions having selective bactericidal activity against gram negative bacteria and methods of using same |
| KR20160048222A (ko) | 2007-12-17 | 2016-05-03 | 유나이티드 세러퓨틱스 코오포레이션 | 레모둘린?의 활성 성분인 트레프로스티닐의 개선된 제조 방법 |
| RU2358757C1 (ru) * | 2008-03-11 | 2009-06-20 | Федеральное государственное образовательное учреждение высшего профессионального образования "Чувашский государственный университет им. И.Н. Ульянова" | Способ лечения длительно незаживающих ран у больных сахарным диабетом |
| US8350079B2 (en) * | 2008-05-08 | 2013-01-08 | United Therapeutics Corporation | Treprostinil formulation |
| JP5649645B2 (ja) * | 2009-05-07 | 2015-01-07 | ユナイテッド セラピューティクス コーポレイション | プロスタサイクリンアナログの固形製剤 |
| EP3108888B1 (en) | 2010-03-15 | 2020-02-12 | United Therapeutics Corporation | Treatment for pulmonary hypertension |
| WO2011153363A1 (en) | 2010-06-03 | 2011-12-08 | United Therapeutics Corporation | Treprostinil production |
| EP2681204B1 (en) | 2011-03-02 | 2016-04-27 | United Therapeutics Corporation | Synthesis of intermediate for treprostinil production |
| CN103193626B (zh) | 2012-01-10 | 2016-05-11 | 上海天伟生物制药有限公司 | 一种前列腺素类似物的晶型及其制备方法和用途 |
| CN103193627B (zh) | 2012-01-10 | 2016-04-20 | 上海天伟生物制药有限公司 | 一种前列腺素类似物的晶型及其制备方法和用途 |
| EP2919804B1 (fr) | 2012-11-13 | 2018-01-31 | Adocia | Formulation à action rapide d'insuline comprenant un composé anionique substitué |
| US9505737B2 (en) | 2013-01-11 | 2016-11-29 | Corsair Pharma, Inc. | Treprostinil derivative compounds and methods of using same |
| EP3712142B1 (en) | 2013-01-11 | 2022-07-06 | Corsair Pharma, Inc. | Prodrugs of treprostinil |
| EP2970091A4 (en) | 2013-03-14 | 2017-02-08 | United Therapeutics Corporation | Solid forms of treprostinil |
| US20140275616A1 (en) | 2013-03-15 | 2014-09-18 | United Therapeutics Corporation | Salts of treprostinil |
| EP2978313B1 (en) | 2013-03-25 | 2018-02-21 | United Therapeutics Corporation | Process of making prostacyclin compounds with linker thiol and pegylated forms |
| LT3060041T (lt) | 2013-10-25 | 2021-03-25 | Insmed Incorporated | Prostaciklino junginiai |
| TWI685348B (zh) * | 2014-05-08 | 2020-02-21 | 美國禮來大藥廠 | 速效胰島素組合物 |
| CN106573066A (zh) | 2014-06-13 | 2017-04-19 | 联合治疗学有限公司 | 曲前列环素制剂 |
| ES2778274T3 (es) | 2014-10-20 | 2020-08-10 | United Therapeutics Corp | Síntesis de productos intermedios para producir derivados de prostaciclina |
| JP6866043B2 (ja) | 2014-11-18 | 2021-04-28 | インスメッド インコーポレイテッド | トレプロスチニルプロドラッグおよびトレプロスチニル誘導体プロドラッグの製造方法 |
| IL252577B (en) | 2014-12-03 | 2022-07-01 | Steadymed Ltd | Preservative-free treprostinil formulations and methods and devices for use with same |
| US9394227B1 (en) | 2015-06-17 | 2016-07-19 | Corsair Pharma, Inc. | Treprostinil derivatives and compositions and uses thereof |
| US9643911B2 (en) | 2015-06-17 | 2017-05-09 | Corsair Pharma, Inc. | Treprostinil derivatives and compositions and uses thereof |
| ES2972423T3 (es) | 2015-07-28 | 2024-06-12 | Lilly Co Eli | Preparado farmacéutico para mejorar la absorción y la acción hipoglucemiante postprandial de la insulina |
| JO3749B1 (ar) | 2015-08-27 | 2021-01-31 | Lilly Co Eli | تركيبات إنسولين سريعة المفعول |
| US10898494B2 (en) | 2016-05-05 | 2021-01-26 | Liquidia Technologies, Inc. | Dry powder treprostinil for the treatment of pulmonary hypertension |
| JP7220650B2 (ja) | 2016-09-26 | 2023-02-10 | ユナイテッド セラピューティクス コーポレイション | トレプロスチニルプロドラッグ |
| US20190290597A1 (en) * | 2016-12-05 | 2019-09-26 | Corsair Pharma, Inc. | Dermal and transdermal administration of treprostinil and salts thereof |
| AU2019344541B2 (en) | 2018-09-18 | 2022-01-06 | Eli Lilly And Company | Erbumine salt of treprostinil |
| ES2980934T3 (es) * | 2019-01-22 | 2024-10-03 | Akribes Biomedical Gmbh | Modificadores selectivos del receptor de glucocorticoides para tratar la cicatrización alterada de heridas en la piel |
| JP7455144B2 (ja) | 2019-04-29 | 2024-03-25 | インスメッド インコーポレイテッド | トレプロスチニルプロドラッグの乾燥粉末組成物およびその使用方法 |
| JP2022546314A (ja) | 2019-08-23 | 2022-11-04 | ユナイテッド セラピューティクス コーポレイション | トレプロスチニルプロドラッグ |
| AU2021255621A1 (en) | 2020-04-17 | 2022-10-20 | United Therapeutics Corporation | Treprostinil for use in the treatment of intersitial lung disease |
| JP7608480B2 (ja) | 2020-06-09 | 2025-01-06 | ユナイテッド セラピューティクス コーポレイション | トレプロスチニルのフマリルジケトピペリジンプロドラッグ |
| WO2022132655A1 (en) | 2020-12-14 | 2022-06-23 | United Therapeutics Corporation | Methods of treating disease with treprostinil prodrugs |
| AU2022229367A1 (en) | 2021-03-03 | 2023-09-14 | United Therapeutics Corporation | A dry powder composition of trestinil and its prodrug thereof and further comprising comprising (e)-3,6-bis[4-(n-carbonyl-2-propenyl)amidobutyl]-2,5-diketopiperazine (fdkp) |
| US20230263807A1 (en) | 2022-02-08 | 2023-08-24 | United Therapeutics Corporation | Treprostinil iloprost combination therapy |
| KR20250002687A (ko) | 2022-04-29 | 2025-01-07 | 자오커 파마슈티컬 (광저우) 컴퍼니., 리미티드 | 트레프로스티닐 소프트 미스트 흡입제 |
| JP2026503509A (ja) | 2023-01-18 | 2026-01-29 | ユナイテッド セラピューティクス コーポレイション | 肺動脈性肺高血圧症の治療 |
| AU2024208919A1 (en) | 2023-01-19 | 2025-07-17 | United Therapeutics Corporation | Treprostinil analogs |
| DE102023104616B4 (de) | 2023-02-24 | 2025-03-27 | Heinz Kurz Gmbh | Chirurgische Schneidevorrichtung für die Otologie und Verfahren zu deren Betrieb |
| DE202023100902U1 (de) | 2023-02-24 | 2023-03-09 | Heinz Kurz Gmbh | Chirurgische Schneidevorrichtung für die Otologie |
| US20250049743A1 (en) | 2023-08-08 | 2025-02-13 | United Therapeutics Corporation | Method of producing an oral osmotic pharmaceutical delivery system and a pharmaceutical batch produced using the same |
| WO2026035705A1 (en) | 2024-08-06 | 2026-02-12 | United Therapeutics Corporation | Treating pulmonary hypertension based on novel biomarker |
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| GB9011588D0 (en) * | 1990-05-24 | 1990-07-11 | Wellcome Found | Prostaglandin analogues for use in medicine |
| DE4135193C1 (https=) * | 1991-10-22 | 1993-03-11 | Schering Ag Berlin Und Bergkamen, 1000 Berlin, De | |
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| WO1994017806A1 (fr) * | 1993-02-03 | 1994-08-18 | Teijin Limited | Composition de preparation dermatologique contenant de la prostacycline comme principe actif |
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| GB9718903D0 (en) * | 1997-09-05 | 1997-11-12 | Glaxo Group Ltd | Method,compositions and kits for increasing the oral bioavailability of pharmaceutical agents |
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| US6521212B1 (en) | 1999-03-18 | 2003-02-18 | United Therapeutics Corporation | Method for treating peripheral vascular disease by administering benzindene prostaglandins by inhalation |
| JP2002540203A (ja) | 1999-03-29 | 2002-11-26 | ニューロゲン コーポレイション | Ｎｋ−３および／またはｇａｂａ（ａ）受容体リガンドとしての４−置換キノリン誘導体 |
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| AU2002339730A1 (en) * | 2002-08-28 | 2004-03-19 | Universita "Campus Bio-Medico" Di Roma | Use of prostacyclin and analogs thereof for improving venous flow |
| CN101265226B (zh) | 2003-05-22 | 2013-04-24 | 联合治疗公司 | 化合物和释放前列环素类似物的方法 |
| US20050101608A1 (en) * | 2003-09-24 | 2005-05-12 | Santel Donald J. | Iloprost in combination therapies for the treatment of pulmonary arterial hypertension |
| CN1917866B (zh) | 2003-12-16 | 2010-12-15 | 联合治疗公司 | 曲前列环素或它的衍生物，或其药学上可接受的盐在制备治疗和预防缺血性损害的药物中的用途 |
| CA2549801C (en) | 2003-12-16 | 2012-10-16 | United Therapeutics Corporation | Use of treprostinil to improve kidney functions |
| ATE462427T1 (de) | 2004-04-12 | 2010-04-15 | United Therapeutics Corp | Verwendung von treprostinil zur behandlung von neuropathischen diabetischen fussgeschwüren |
| CN101495122B (zh) | 2006-05-15 | 2011-10-05 | 联合治疗公司 | 使用定量吸入器给予曲前列尼 |
| US20090036465A1 (en) | 2006-10-18 | 2009-02-05 | United Therapeutics Corporation | Combination therapy for pulmonary arterial hypertension |
| CA2678258A1 (en) | 2007-02-09 | 2008-08-14 | United Therapeutics Corporation | Treprostinil treatment for interstitial lung disease and asthma |
| KR20160048222A (ko) | 2007-12-17 | 2016-05-03 | 유나이티드 세러퓨틱스 코오포레이션 | 레모둘린?의 활성 성분인 트레프로스티닐의 개선된 제조 방법 |
| JP5649645B2 (ja) | 2009-05-07 | 2015-01-07 | ユナイテッド セラピューティクス コーポレイション | プロスタサイクリンアナログの固形製剤 |
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- 2005-04-12 KR KR1020067022940A patent/KR101186029B1/ko not_active Expired - Fee Related
- 2005-04-12 CA CA2562614A patent/CA2562614C/en not_active Expired - Fee Related
- 2005-04-12 ES ES05735648T patent/ES2340939T3/es not_active Expired - Lifetime
- 2005-04-12 DE DE602005020269T patent/DE602005020269D1/de not_active Expired - Lifetime
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- 2005-04-12 EP EP05735648A patent/EP1744739B1/en not_active Expired - Lifetime
- 2005-04-12 CN CN2005800189046A patent/CN101287457B/zh not_active Expired - Fee Related
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- 2005-04-12 US US11/103,649 patent/US7879909B2/en active Active
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2010
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Also Published As
| Publication number | Publication date |
|---|---|
| US7879909B2 (en) | 2011-02-01 |
| WO2005099680A2 (en) | 2005-10-27 |
| KR101186029B1 (ko) | 2012-09-27 |
| US20110092599A1 (en) | 2011-04-21 |
| CN101287457A (zh) | 2008-10-15 |
| KR20070007887A (ko) | 2007-01-16 |
| CA2562614A1 (en) | 2005-10-27 |
| US8563614B2 (en) | 2013-10-22 |
| DE602005020269D1 (de) | 2010-05-12 |
| CA2562614C (en) | 2013-09-17 |
| US20050282903A1 (en) | 2005-12-22 |
| WO2005099680A3 (en) | 2005-12-01 |
| JP2007532663A (ja) | 2007-11-15 |
| EP1744739A2 (en) | 2007-01-24 |
| CN101287457B (zh) | 2011-11-16 |
| ATE462427T1 (de) | 2010-04-15 |
| EP1744739B1 (en) | 2010-03-31 |
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