JP2007532663A - ニューロパシー性の糖尿病性足潰瘍を治療するためのトレプロスチニルの使用 - Google Patents
ニューロパシー性の糖尿病性足潰瘍を治療するためのトレプロスチニルの使用 Download PDFInfo
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- JP2007532663A JP2007532663A JP2007508488A JP2007508488A JP2007532663A JP 2007532663 A JP2007532663 A JP 2007532663A JP 2007508488 A JP2007508488 A JP 2007508488A JP 2007508488 A JP2007508488 A JP 2007508488A JP 2007532663 A JP2007532663 A JP 2007532663A
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- Prior art keywords
- treprostinil
- pharmaceutically acceptable
- acceptable salt
- effective amount
- derivative
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56115704P | 2004-04-12 | 2004-04-12 | |
| PCT/US2005/012471 WO2005099680A2 (en) | 2004-04-12 | 2005-04-12 | Use of treprostinil to treat neuropathic diabetic foot ulcers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007532663A true JP2007532663A (ja) | 2007-11-15 |
| JP2007532663A5 JP2007532663A5 (https=) | 2012-03-29 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007508488A Pending JP2007532663A (ja) | 2004-04-12 | 2005-04-12 | ニューロパシー性の糖尿病性足潰瘍を治療するためのトレプロスチニルの使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7879909B2 (https=) |
| EP (1) | EP1744739B1 (https=) |
| JP (1) | JP2007532663A (https=) |
| KR (1) | KR101186029B1 (https=) |
| CN (1) | CN101287457B (https=) |
| AT (1) | ATE462427T1 (https=) |
| CA (1) | CA2562614C (https=) |
| DE (1) | DE602005020269D1 (https=) |
| ES (1) | ES2340939T3 (https=) |
| WO (1) | WO2005099680A2 (https=) |
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| DE602004028155D1 (de) * | 2003-12-16 | 2010-08-26 | United Therapeutics Corp | Verwendung von treprostinil zur behandlung von ischämischen läsionen |
| WO2005099680A2 (en) * | 2004-04-12 | 2005-10-27 | United Therapeutics, Inc. | Use of treprostinil to treat neuropathic diabetic foot ulcers |
| US8747897B2 (en) | 2006-04-27 | 2014-06-10 | Supernus Pharmaceuticals, Inc. | Osmotic drug delivery system |
| CN103181893A (zh) * | 2007-09-07 | 2013-07-03 | 联合治疗公司 | 针对革兰氏阴性细菌具有选择性杀菌活性的缓冲液及其使用方法 |
| CN101903324B (zh) | 2007-12-17 | 2013-07-03 | 联合治疗公司 | 一种制备Remodulin中的活性成分曲前列素的改良方法 |
| RU2358757C1 (ru) * | 2008-03-11 | 2009-06-20 | Федеральное государственное образовательное учреждение высшего профессионального образования "Чувашский государственный университет им. И.Н. Ульянова" | Способ лечения длительно незаживающих ран у больных сахарным диабетом |
| CA2723540C (en) * | 2008-05-08 | 2016-01-05 | United Therapeutics Corporation | Treprostinil monohydrate |
| US8349892B2 (en) * | 2009-05-07 | 2013-01-08 | United Therapeutics Corporation | Solid formulations of prostacyclin analogs |
| ES2611187T3 (es) | 2010-03-15 | 2017-05-05 | United Therapeutics Corporation | Tratamiento para hipertensión pulmonar |
| JP6046034B2 (ja) | 2010-06-03 | 2016-12-14 | ユナイテッド セラピューティクス コーポレイション | トレプロスチニルの製造 |
| US20130345471A1 (en) | 2011-03-02 | 2013-12-26 | United Therapeutics Corporation | Synthesis of intermediate for treprostinil production |
| CN103193627B (zh) | 2012-01-10 | 2016-04-20 | 上海天伟生物制药有限公司 | 一种前列腺素类似物的晶型及其制备方法和用途 |
| CN103193626B (zh) | 2012-01-10 | 2016-05-11 | 上海天伟生物制药有限公司 | 一种前列腺素类似物的晶型及其制备方法和用途 |
| CN104902922B (zh) | 2012-11-13 | 2017-12-12 | 阿道恰公司 | 包含经取代阴离子化合物的速效胰岛素制剂 |
| US9505737B2 (en) | 2013-01-11 | 2016-11-29 | Corsair Pharma, Inc. | Treprostinil derivative compounds and methods of using same |
| EP3712142B1 (en) | 2013-01-11 | 2022-07-06 | Corsair Pharma, Inc. | Prodrugs of treprostinil |
| JP2016517410A (ja) | 2013-03-14 | 2016-06-16 | ユナイテッド セラピューティクス コーポレイション | トレプロスチニルの固体形態 |
| CN109608326A (zh) | 2013-03-15 | 2019-04-12 | 联合治疗公司 | 曲前列环素的盐 |
| JP6263604B2 (ja) | 2013-03-25 | 2018-01-17 | ユナイテッド セラピューティクス コーポレイション | チオールリンカーを持つ、ペグ化型のプロスタサイクリン化合物の製造方法 |
| ES2860975T3 (es) | 2013-10-25 | 2021-10-05 | Insmed Inc | Compuestos de prostaciclina |
| TWI685348B (zh) * | 2014-05-08 | 2020-02-21 | 美國禮來大藥廠 | 速效胰島素組合物 |
| ES2908142T3 (es) | 2014-06-13 | 2022-04-27 | United Therapeutics Corp | Formulaciones de treprostinil |
| US9593061B2 (en) | 2014-10-20 | 2017-03-14 | United Therapeutics Corporation | Synthesis of intermediates for producing prostacyclin derivatives |
| AU2015349969B2 (en) | 2014-11-18 | 2020-02-06 | Insmed Incorporated | Methods of manufacturing treprostinil and treprostinil derivative prodrugs |
| CA2967899C (en) | 2014-12-03 | 2023-09-19 | Steadymed Ltd | Preservative-free treprostinil formulations and methods and devices for use with same |
| US9643911B2 (en) | 2015-06-17 | 2017-05-09 | Corsair Pharma, Inc. | Treprostinil derivatives and compositions and uses thereof |
| US9394227B1 (en) | 2015-06-17 | 2016-07-19 | Corsair Pharma, Inc. | Treprostinil derivatives and compositions and uses thereof |
| WO2017015760A1 (en) | 2015-07-28 | 2017-02-02 | Societe De Commercialisation Des Produits De La Recherche Appliquee Socpra Sciences Sante Et Humaines, S.E.C. | A pharmaceutical preparation for improving absorption and postprandial hypoglycemic action of insulin |
| JO3749B1 (ar) | 2015-08-27 | 2021-01-31 | Lilly Co Eli | تركيبات إنسولين سريعة المفعول |
| IL262720B2 (en) | 2016-05-05 | 2024-06-01 | Liquidia Tech Inc | Dry powder treprostinil for the treatment of pulmonary hypertension |
| JP7220650B2 (ja) | 2016-09-26 | 2023-02-10 | ユナイテッド セラピューティクス コーポレイション | トレプロスチニルプロドラッグ |
| KR20190109399A (ko) * | 2016-12-05 | 2019-09-25 | 코세어 파마 인코포레이티드 | 트레프로스티닐 및 이의 염의 피부 및 경피 투여 |
| ES2976468T3 (es) | 2018-09-18 | 2024-08-01 | Lilly Co Eli | Sal de treprostinil erbumina |
| CA3123490A1 (en) * | 2019-01-22 | 2020-07-30 | Akribes Biomedical Gmbh | Selective glucocorticoid receptor modifiers for treating impaired skin wound healing |
| CN114072136B (zh) | 2019-04-29 | 2024-11-29 | 英斯梅德股份有限公司 | 曲前列素前药的干粉组合物及其使用方法 |
| EP4017588A1 (en) | 2019-08-23 | 2022-06-29 | United Therapeutics Corporation | Treprostinil prodrugs |
| JP2023523557A (ja) | 2020-04-17 | 2023-06-06 | ユナイテッド セラピューティクス コーポレイション | 間質性肺疾患の治療における使用のためのトレプロスチニル |
| IL298591A (en) | 2020-06-09 | 2023-01-01 | United Therapeutics Corp | Pomeryl dictopiperidine prodrugs of treprostinil |
| KR20250133451A (ko) | 2020-12-14 | 2025-09-05 | 유나이티드 쎄러퓨틱스 코포레이션 | 트레프로스티닐 프로드러그로 질환을 치료하는 방법 |
| JP2024510930A (ja) | 2021-03-03 | 2024-03-12 | ユナイテッド セラピューティクス コーポレイション | トレプロスチニル及びそのプロドラッグの乾燥粉末組成物、及び、さらに（ｅ）－３，６－ビス［４－（ｎ－カルボニル－２－プロペニル）アミドブチル］－２，５－ジケトピペラジン（ｆｄｋｐ）を含む乾燥粉末組成物 |
| WO2023154705A1 (en) | 2022-02-08 | 2023-08-17 | United Therapeutics Corporation | Treprostinil iloprost combination therapy |
| EP4516297A4 (en) | 2022-04-29 | 2026-02-25 | Zhaoke pharmaceutical guangzhou co ltd | Treprostinil Gentle Inhalation Mist |
| IL322117A (en) | 2023-01-18 | 2025-09-01 | United Therapeutics Corp | Treatment of pulmonary arterial hypertension |
| EP4652151A1 (en) | 2023-01-19 | 2025-11-26 | United Therapeutics Corporation | Treprostinil analogs |
| DE202023100902U1 (de) | 2023-02-24 | 2023-03-09 | Heinz Kurz Gmbh | Chirurgische Schneidevorrichtung für die Otologie |
| DE102023104616B4 (de) | 2023-02-24 | 2025-03-27 | Heinz Kurz Gmbh | Chirurgische Schneidevorrichtung für die Otologie und Verfahren zu deren Betrieb |
| IL326413A (en) | 2023-08-08 | 2026-04-01 | United Therapeutics Corp | Method for producing an oral pharmaceutical osmotic system and a pharmaceutical batch produced using the same method |
| US20260041656A1 (en) | 2024-08-06 | 2026-02-12 | United Therapeutics Corporation | Treating pulmonary hypertension based on novel biomarker |
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| WO2004019952A1 (en) * | 2002-08-28 | 2004-03-11 | Università 'campus Bio-Medico' Di Roma | Use of prostacyclin and analogs thereof for improving venous flow |
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2005
- 2005-04-12 WO PCT/US2005/012471 patent/WO2005099680A2/en not_active Ceased
- 2005-04-12 CN CN2005800189046A patent/CN101287457B/zh not_active Expired - Fee Related
- 2005-04-12 JP JP2007508488A patent/JP2007532663A/ja active Pending
- 2005-04-12 KR KR1020067022940A patent/KR101186029B1/ko not_active Expired - Fee Related
- 2005-04-12 AT AT05735648T patent/ATE462427T1/de not_active IP Right Cessation
- 2005-04-12 EP EP05735648A patent/EP1744739B1/en not_active Expired - Lifetime
- 2005-04-12 US US11/103,649 patent/US7879909B2/en active Active
- 2005-04-12 DE DE602005020269T patent/DE602005020269D1/de not_active Expired - Lifetime
- 2005-04-12 ES ES05735648T patent/ES2340939T3/es not_active Expired - Lifetime
- 2005-04-12 CA CA2562614A patent/CA2562614C/en not_active Expired - Fee Related
-
2010
- 2010-12-20 US US12/926,945 patent/US8563614B2/en not_active Expired - Fee Related
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| JPN5007005935; ＳＡＲＡＴ Ｃ ＣＨＡＴＴＡＲＡＪ ｅｔ ａｌ．: 'Ｔｒｅｐｒｏｓｔｉｎｉｌ ｓｏｄｉｕｍ Ｐｈａｒｍａｃｉａ' Ｃｕｒｒｅｎｔ Ｏｐｉｎｉｏｎ Ｉｎ Ｉｎｖｅｓｔｉｇａｔｉｏｎａｌ Ｄｒｕｇｓ Ｖｏｌ． ３， Ｎｏ． ４, 200204, ｐ． ５８２-５８６ * |
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Also Published As
| Publication number | Publication date |
|---|---|
| ATE462427T1 (de) | 2010-04-15 |
| EP1744739A2 (en) | 2007-01-24 |
| KR101186029B1 (ko) | 2012-09-27 |
| WO2005099680A3 (en) | 2005-12-01 |
| US7879909B2 (en) | 2011-02-01 |
| KR20070007887A (ko) | 2007-01-16 |
| EP1744739B1 (en) | 2010-03-31 |
| ES2340939T3 (es) | 2010-06-11 |
| WO2005099680A2 (en) | 2005-10-27 |
| CA2562614A1 (en) | 2005-10-27 |
| DE602005020269D1 (de) | 2010-05-12 |
| US20110092599A1 (en) | 2011-04-21 |
| US20050282903A1 (en) | 2005-12-22 |
| US8563614B2 (en) | 2013-10-22 |
| CN101287457B (zh) | 2011-11-16 |
| CA2562614C (en) | 2013-09-17 |
| CN101287457A (zh) | 2008-10-15 |
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