JP2007532663A5 - - Google Patents
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- Publication number
- JP2007532663A5 JP2007532663A5 JP2007508488A JP2007508488A JP2007532663A5 JP 2007532663 A5 JP2007532663 A5 JP 2007532663A5 JP 2007508488 A JP2007508488 A JP 2007508488A JP 2007508488 A JP2007508488 A JP 2007508488A JP 2007532663 A5 JP2007532663 A5 JP 2007532663A5
- Authority
- JP
- Japan
- Prior art keywords
- treprostinil
- amide
- drug
- drug according
- derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001408 amides Chemical class 0.000 claims description 14
- 125000000217 alkyl group Chemical group 0.000 claims description 5
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 3
- 150000002148 esters Chemical class 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims 21
- PAJMKGZZBBTTOY-ZFORQUDYSA-N treprostinil Chemical compound C1=CC=C(OCC(O)=O)C2=C1C[C@@H]1[C@@H](CC[C@@H](O)CCCCC)[C@H](O)C[C@@H]1C2 PAJMKGZZBBTTOY-ZFORQUDYSA-N 0.000 claims 21
- 229960005032 treprostinil Drugs 0.000 claims 21
- 229940079593 drug Drugs 0.000 claims 19
- 208000003790 Foot Ulcer Diseases 0.000 claims 8
- 208000032131 Diabetic Neuropathies Diseases 0.000 claims 6
- 206010012601 diabetes mellitus Diseases 0.000 claims 6
- 230000002981 neuropathic effect Effects 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 5
- 206010040943 Skin Ulcer Diseases 0.000 claims 4
- 239000012730 sustained-release form Substances 0.000 claims 4
- 125000005907 alkyl ester group Chemical group 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000007920 subcutaneous administration Methods 0.000 claims 2
- 230000037396 body weight Effects 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 230000008030 elimination Effects 0.000 claims 1
- 238000003379 elimination reaction Methods 0.000 claims 1
- 238000001802 infusion Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 201000002818 limb ischemia Diseases 0.000 claims 1
- 210000003141 lower extremity Anatomy 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 239000003826 tablet Substances 0.000 claims 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56115704P | 2004-04-12 | 2004-04-12 | |
| PCT/US2005/012471 WO2005099680A2 (en) | 2004-04-12 | 2005-04-12 | Use of treprostinil to treat neuropathic diabetic foot ulcers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007532663A JP2007532663A (ja) | 2007-11-15 |
| JP2007532663A5 true JP2007532663A5 (https=) | 2012-03-29 |
Family
ID=34965914
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007508488A Pending JP2007532663A (ja) | 2004-04-12 | 2005-04-12 | ニューロパシー性の糖尿病性足潰瘍を治療するためのトレプロスチニルの使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7879909B2 (https=) |
| EP (1) | EP1744739B1 (https=) |
| JP (1) | JP2007532663A (https=) |
| KR (1) | KR101186029B1 (https=) |
| CN (1) | CN101287457B (https=) |
| AT (1) | ATE462427T1 (https=) |
| CA (1) | CA2562614C (https=) |
| DE (1) | DE602005020269D1 (https=) |
| ES (1) | ES2340939T3 (https=) |
| WO (1) | WO2005099680A2 (https=) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE602004028155D1 (de) * | 2003-12-16 | 2010-08-26 | United Therapeutics Corp | Verwendung von treprostinil zur behandlung von ischämischen läsionen |
| WO2005099680A2 (en) * | 2004-04-12 | 2005-10-27 | United Therapeutics, Inc. | Use of treprostinil to treat neuropathic diabetic foot ulcers |
| US8747897B2 (en) | 2006-04-27 | 2014-06-10 | Supernus Pharmaceuticals, Inc. | Osmotic drug delivery system |
| CN103181893A (zh) * | 2007-09-07 | 2013-07-03 | 联合治疗公司 | 针对革兰氏阴性细菌具有选择性杀菌活性的缓冲液及其使用方法 |
| CN101903324B (zh) | 2007-12-17 | 2013-07-03 | 联合治疗公司 | 一种制备Remodulin中的活性成分曲前列素的改良方法 |
| RU2358757C1 (ru) * | 2008-03-11 | 2009-06-20 | Федеральное государственное образовательное учреждение высшего профессионального образования "Чувашский государственный университет им. И.Н. Ульянова" | Способ лечения длительно незаживающих ран у больных сахарным диабетом |
| CA2723540C (en) * | 2008-05-08 | 2016-01-05 | United Therapeutics Corporation | Treprostinil monohydrate |
| US8349892B2 (en) * | 2009-05-07 | 2013-01-08 | United Therapeutics Corporation | Solid formulations of prostacyclin analogs |
| ES2611187T3 (es) | 2010-03-15 | 2017-05-05 | United Therapeutics Corporation | Tratamiento para hipertensión pulmonar |
| JP6046034B2 (ja) | 2010-06-03 | 2016-12-14 | ユナイテッド セラピューティクス コーポレイション | トレプロスチニルの製造 |
| US20130345471A1 (en) | 2011-03-02 | 2013-12-26 | United Therapeutics Corporation | Synthesis of intermediate for treprostinil production |
| CN103193627B (zh) | 2012-01-10 | 2016-04-20 | 上海天伟生物制药有限公司 | 一种前列腺素类似物的晶型及其制备方法和用途 |
| CN103193626B (zh) | 2012-01-10 | 2016-05-11 | 上海天伟生物制药有限公司 | 一种前列腺素类似物的晶型及其制备方法和用途 |
| CN104902922B (zh) | 2012-11-13 | 2017-12-12 | 阿道恰公司 | 包含经取代阴离子化合物的速效胰岛素制剂 |
| US9505737B2 (en) | 2013-01-11 | 2016-11-29 | Corsair Pharma, Inc. | Treprostinil derivative compounds and methods of using same |
| EP3712142B1 (en) | 2013-01-11 | 2022-07-06 | Corsair Pharma, Inc. | Prodrugs of treprostinil |
| JP2016517410A (ja) | 2013-03-14 | 2016-06-16 | ユナイテッド セラピューティクス コーポレイション | トレプロスチニルの固体形態 |
| CN109608326A (zh) | 2013-03-15 | 2019-04-12 | 联合治疗公司 | 曲前列环素的盐 |
| JP6263604B2 (ja) | 2013-03-25 | 2018-01-17 | ユナイテッド セラピューティクス コーポレイション | チオールリンカーを持つ、ペグ化型のプロスタサイクリン化合物の製造方法 |
| ES2860975T3 (es) | 2013-10-25 | 2021-10-05 | Insmed Inc | Compuestos de prostaciclina |
| TWI685348B (zh) * | 2014-05-08 | 2020-02-21 | 美國禮來大藥廠 | 速效胰島素組合物 |
| ES2908142T3 (es) | 2014-06-13 | 2022-04-27 | United Therapeutics Corp | Formulaciones de treprostinil |
| US9593061B2 (en) | 2014-10-20 | 2017-03-14 | United Therapeutics Corporation | Synthesis of intermediates for producing prostacyclin derivatives |
| AU2015349969B2 (en) | 2014-11-18 | 2020-02-06 | Insmed Incorporated | Methods of manufacturing treprostinil and treprostinil derivative prodrugs |
| CA2967899C (en) | 2014-12-03 | 2023-09-19 | Steadymed Ltd | Preservative-free treprostinil formulations and methods and devices for use with same |
| US9643911B2 (en) | 2015-06-17 | 2017-05-09 | Corsair Pharma, Inc. | Treprostinil derivatives and compositions and uses thereof |
| US9394227B1 (en) | 2015-06-17 | 2016-07-19 | Corsair Pharma, Inc. | Treprostinil derivatives and compositions and uses thereof |
| WO2017015760A1 (en) | 2015-07-28 | 2017-02-02 | Societe De Commercialisation Des Produits De La Recherche Appliquee Socpra Sciences Sante Et Humaines, S.E.C. | A pharmaceutical preparation for improving absorption and postprandial hypoglycemic action of insulin |
| JO3749B1 (ar) | 2015-08-27 | 2021-01-31 | Lilly Co Eli | تركيبات إنسولين سريعة المفعول |
| IL262720B2 (en) | 2016-05-05 | 2024-06-01 | Liquidia Tech Inc | Dry powder treprostinil for the treatment of pulmonary hypertension |
| JP7220650B2 (ja) | 2016-09-26 | 2023-02-10 | ユナイテッド セラピューティクス コーポレイション | トレプロスチニルプロドラッグ |
| KR20190109399A (ko) * | 2016-12-05 | 2019-09-25 | 코세어 파마 인코포레이티드 | 트레프로스티닐 및 이의 염의 피부 및 경피 투여 |
| ES2976468T3 (es) | 2018-09-18 | 2024-08-01 | Lilly Co Eli | Sal de treprostinil erbumina |
| CA3123490A1 (en) * | 2019-01-22 | 2020-07-30 | Akribes Biomedical Gmbh | Selective glucocorticoid receptor modifiers for treating impaired skin wound healing |
| CN114072136B (zh) | 2019-04-29 | 2024-11-29 | 英斯梅德股份有限公司 | 曲前列素前药的干粉组合物及其使用方法 |
| EP4017588A1 (en) | 2019-08-23 | 2022-06-29 | United Therapeutics Corporation | Treprostinil prodrugs |
| JP2023523557A (ja) | 2020-04-17 | 2023-06-06 | ユナイテッド セラピューティクス コーポレイション | 間質性肺疾患の治療における使用のためのトレプロスチニル |
| IL298591A (en) | 2020-06-09 | 2023-01-01 | United Therapeutics Corp | Pomeryl dictopiperidine prodrugs of treprostinil |
| KR20250133451A (ko) | 2020-12-14 | 2025-09-05 | 유나이티드 쎄러퓨틱스 코포레이션 | 트레프로스티닐 프로드러그로 질환을 치료하는 방법 |
| JP2024510930A (ja) | 2021-03-03 | 2024-03-12 | ユナイテッド セラピューティクス コーポレイション | トレプロスチニル及びそのプロドラッグの乾燥粉末組成物、及び、さらに（ｅ）－３，６－ビス［４－（ｎ－カルボニル－２－プロペニル）アミドブチル］－２，５－ジケトピペラジン（ｆｄｋｐ）を含む乾燥粉末組成物 |
| WO2023154705A1 (en) | 2022-02-08 | 2023-08-17 | United Therapeutics Corporation | Treprostinil iloprost combination therapy |
| EP4516297A4 (en) | 2022-04-29 | 2026-02-25 | Zhaoke pharmaceutical guangzhou co ltd | Treprostinil Gentle Inhalation Mist |
| IL322117A (en) | 2023-01-18 | 2025-09-01 | United Therapeutics Corp | Treatment of pulmonary arterial hypertension |
| EP4652151A1 (en) | 2023-01-19 | 2025-11-26 | United Therapeutics Corporation | Treprostinil analogs |
| DE202023100902U1 (de) | 2023-02-24 | 2023-03-09 | Heinz Kurz Gmbh | Chirurgische Schneidevorrichtung für die Otologie |
| DE102023104616B4 (de) | 2023-02-24 | 2025-03-27 | Heinz Kurz Gmbh | Chirurgische Schneidevorrichtung für die Otologie und Verfahren zu deren Betrieb |
| IL326413A (en) | 2023-08-08 | 2026-04-01 | United Therapeutics Corp | Method for producing an oral pharmaceutical osmotic system and a pharmaceutical batch produced using the same method |
| US20260041656A1 (en) | 2024-08-06 | 2026-02-12 | United Therapeutics Corporation | Treating pulmonary hypertension based on novel biomarker |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4490537A (en) * | 1977-04-19 | 1984-12-25 | The Upjohn Company | Enlarged-hetero-ring prostacyclin analogs |
| US4306075A (en) * | 1980-03-28 | 1981-12-15 | The Upjohn Company | Composition and process |
| US4486598A (en) | 1982-02-22 | 1984-12-04 | The Upjohn Company | Carbacyclin analogs |
| DE3315356A1 (de) * | 1982-04-30 | 1983-11-17 | Ono Pharmaceutical Co. Ltd., Osaka | Verwendung von prostaglandinanalogen |
| CA1241324A (en) | 1984-03-08 | 1988-08-30 | Paul A. Aristoff | Interphenylene carbacyclin derivatives |
| JPH0680027B2 (ja) * | 1985-09-18 | 1994-10-12 | 財団法人相模中央化学研究所 | プロスタサイクリン類及びこれらを含有する薬剤 |
| US4837342A (en) * | 1986-02-28 | 1989-06-06 | Sagami Chemical Research Center | Prostacyclin analogue, and blood circulation improving agent and anti-ulcer composition containing it as active ingredient |
| US5663203A (en) * | 1986-09-11 | 1997-09-02 | Schering Aktiengesellschaft | Agents containing prostacyclin derivatives for topical application |
| US4730078A (en) * | 1987-05-13 | 1988-03-08 | G. D. Searle & Co. | Allenic prostacyclins |
| GB8814438D0 (en) * | 1988-06-17 | 1988-07-20 | Wellcome Found | Compounds for use in medicine |
| GB9011588D0 (en) * | 1990-05-24 | 1990-07-11 | Wellcome Found | Prostaglandin analogues for use in medicine |
| DE4135193C1 (https=) * | 1991-10-22 | 1993-03-11 | Schering Ag Berlin Und Bergkamen, 1000 Berlin, De | |
| US6171786B1 (en) * | 1992-09-17 | 2001-01-09 | Board Of Trustees Of University Of Illinois | Methods for preventing multidrug resistance in cancer cells |
| CA2133334A1 (en) * | 1993-02-03 | 1994-08-04 | Atsuo Hazato | External skin treatment agent composition containing prostacyclins as active ingredient |
| US6451815B1 (en) * | 1997-08-14 | 2002-09-17 | Aventis Pharmaceuticals Inc. | Method of enhancing bioavailability of fexofenadine and its derivatives |
| GB9718903D0 (en) * | 1997-09-05 | 1997-11-12 | Glaxo Group Ltd | Method,compositions and kits for increasing the oral bioavailability of pharmaceutical agents |
| US6441245B1 (en) | 1997-10-24 | 2002-08-27 | United Therapeutics Corporation | Process for stereoselective synthesis of prostacyclin derivatives |
| KR100638684B1 (ko) * | 1997-11-14 | 2006-10-27 | 유나이티드 세러퓨틱스 코오포레이션 | 말초 혈관 질환의 치료를 위한 9-데옥시-2',9-알파-메타노-3-옥사-4,5,6-트리노르-3,7-(1',3'-인터페닐렌)-13,14-디하이드로-프로스타글란딘 에프1의 용도 |
| US6521212B1 (en) * | 1999-03-18 | 2003-02-18 | United Therapeutics Corporation | Method for treating peripheral vascular disease by administering benzindene prostaglandins by inhalation |
| AU4038000A (en) | 1999-03-29 | 2000-10-16 | Neurogen Corporation | 4-substituted quinoline derivatives as gaba receptor ligands |
| US6700025B2 (en) | 2001-01-05 | 2004-03-02 | United Therapeutics Corporation | Process for stereoselective synthesis of prostacyclin derivatives |
| US6803386B2 (en) | 2002-01-16 | 2004-10-12 | United Therapeutics Corporation | Prostacyclin derivative containing compositions and methods of using the same for the treatment of cancer |
| WO2004019952A1 (en) * | 2002-08-28 | 2004-03-11 | Università 'campus Bio-Medico' Di Roma | Use of prostacyclin and analogs thereof for improving venous flow |
| ES2622471T5 (es) * | 2003-05-22 | 2020-07-23 | United Therapeutics Corp | Compuestos y procedimientos para la administración de análogos de prostaciclina |
| US20050101608A1 (en) * | 2003-09-24 | 2005-05-12 | Santel Donald J. | Iloprost in combination therapies for the treatment of pulmonary arterial hypertension |
| ATE441418T1 (de) | 2003-12-16 | 2009-09-15 | United Therapeutics Corp | Verwendung von treprostinil zur verbesserung der nierenfunktion |
| DE602004028155D1 (de) * | 2003-12-16 | 2010-08-26 | United Therapeutics Corp | Verwendung von treprostinil zur behandlung von ischämischen läsionen |
| WO2005099680A2 (en) | 2004-04-12 | 2005-10-27 | United Therapeutics, Inc. | Use of treprostinil to treat neuropathic diabetic foot ulcers |
| EP2026816B1 (en) | 2006-05-15 | 2018-10-24 | United Therapeutics Corporation | Treprostinil administration using a metered dose inhaler |
| US20090036465A1 (en) | 2006-10-18 | 2009-02-05 | United Therapeutics Corporation | Combination therapy for pulmonary arterial hypertension |
| JP2010518122A (ja) | 2007-02-09 | 2010-05-27 | ユナイテッド セラピューティクス コーポレーション | 間質性肺疾患および喘息のためのトレプロスチニル処置 |
| CN101903324B (zh) | 2007-12-17 | 2013-07-03 | 联合治疗公司 | 一种制备Remodulin中的活性成分曲前列素的改良方法 |
| US8349892B2 (en) | 2009-05-07 | 2013-01-08 | United Therapeutics Corporation | Solid formulations of prostacyclin analogs |
-
2005
- 2005-04-12 WO PCT/US2005/012471 patent/WO2005099680A2/en not_active Ceased
- 2005-04-12 CN CN2005800189046A patent/CN101287457B/zh not_active Expired - Fee Related
- 2005-04-12 JP JP2007508488A patent/JP2007532663A/ja active Pending
- 2005-04-12 KR KR1020067022940A patent/KR101186029B1/ko not_active Expired - Fee Related
- 2005-04-12 AT AT05735648T patent/ATE462427T1/de not_active IP Right Cessation
- 2005-04-12 EP EP05735648A patent/EP1744739B1/en not_active Expired - Lifetime
- 2005-04-12 US US11/103,649 patent/US7879909B2/en active Active
- 2005-04-12 DE DE602005020269T patent/DE602005020269D1/de not_active Expired - Lifetime
- 2005-04-12 ES ES05735648T patent/ES2340939T3/es not_active Expired - Lifetime
- 2005-04-12 CA CA2562614A patent/CA2562614C/en not_active Expired - Fee Related
-
2010
- 2010-12-20 US US12/926,945 patent/US8563614B2/en not_active Expired - Fee Related
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