JP2005501110A5 - - Google Patents
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- Publication number
- JP2005501110A5 JP2005501110A5 JP2003522564A JP2003522564A JP2005501110A5 JP 2005501110 A5 JP2005501110 A5 JP 2005501110A5 JP 2003522564 A JP2003522564 A JP 2003522564A JP 2003522564 A JP2003522564 A JP 2003522564A JP 2005501110 A5 JP2005501110 A5 JP 2005501110A5
- Authority
- JP
- Japan
- Prior art keywords
- hdl
- use according
- administered
- ischemia
- reperfusion injury
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108010010234 HDL Lipoproteins Proteins 0.000 claims 15
- 206010063837 Reperfusion injury Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 208000028867 ischemia Diseases 0.000 claims 3
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
- 238000001802 infusion Methods 0.000 claims 2
- 238000002347 injection Methods 0.000 claims 2
- 239000007924 injection Substances 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 102000005666 Apolipoprotein A-I Human genes 0.000 claims 1
- 108010059886 Apolipoprotein A-I Proteins 0.000 claims 1
- 108010071619 Apolipoproteins Proteins 0.000 claims 1
- 102000007592 Apolipoproteins Human genes 0.000 claims 1
- 208000032382 Ischaemic stroke Diseases 0.000 claims 1
- 108010080283 Pre-beta High-Density Lipoproteins Proteins 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 230000037396 body weight Effects 0.000 claims 1
- 230000000747 cardiac effect Effects 0.000 claims 1
- 230000002612 cardiopulmonary effect Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 235000012000 cholesterol Nutrition 0.000 claims 1
- 150000001840 cholesterol esters Chemical class 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- -1 for example Proteins 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 230000000302 ischemic effect Effects 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 208000031225 myocardial ischemia Diseases 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 150000003904 phospholipids Chemical class 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
- 230000010410 reperfusion Effects 0.000 claims 1
- 150000003408 sphingolipids Chemical class 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 208000037816 tissue injury Diseases 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
- 150000003626 triacylglycerols Chemical class 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31360501P | 2001-08-20 | 2001-08-20 | |
| EP01120026A EP1285662A1 (en) | 2001-08-20 | 2001-08-20 | Reconstituted HDL for the treatment of stroke and ischemic conditions |
| PCT/EP2002/009294 WO2003018047A2 (en) | 2001-08-20 | 2002-08-20 | Hdl for the treatment of stroke and other ischemic conditions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005501110A JP2005501110A (ja) | 2005-01-13 |
| JP2005501110A5 true JP2005501110A5 (https=) | 2005-12-22 |
| JP4284177B2 JP4284177B2 (ja) | 2009-06-24 |
Family
ID=26076691
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003522564A Expired - Fee Related JP4284177B2 (ja) | 2001-08-20 | 2002-08-20 | 脳卒中および他の虚血性症状の治療用ｈｄｌ |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20040266660A1 (https=) |
| EP (1) | EP1425031B8 (https=) |
| JP (1) | JP4284177B2 (https=) |
| AT (1) | ATE396736T1 (https=) |
| AU (1) | AU2002340825B2 (https=) |
| CA (1) | CA2457840C (https=) |
| DE (1) | DE60226881D1 (https=) |
| ES (1) | ES2304452T3 (https=) |
| WO (1) | WO2003018047A2 (https=) |
| ZA (1) | ZA200401360B (https=) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR0310100A (pt) * | 2002-05-17 | 2007-04-27 | Esperion Therapeutics Inc | métodos para tratar, prevenir ou reduzir a lesão de reperfusão isquêmica em um tecido ou órgão, e para prevenir ou tratar de uma condição associada com a privação de oxigênio, seguida por suprimento de oxigênio aumentado a um tecido ou órgão em necessidade disto |
| US8206750B2 (en) | 2005-03-24 | 2012-06-26 | Cerenis Therapeutics Holding S.A. | Charged lipoprotein complexes and their uses |
| WO2007000924A1 (ja) * | 2005-06-28 | 2007-01-04 | Osaka University | プログラニュリン活性を抑制または促進する物質を含む医薬組成物、およびプログラニュリン活性を抑制または促進する物質のスクリーニング方法 |
| US20070110751A1 (en) * | 2005-10-25 | 2007-05-17 | Maclellan Robb | Compositions and methods for reducing infarct size |
| JP5601750B2 (ja) * | 2007-03-01 | 2014-10-08 | シーエスエル、リミテッド | 糖尿病患者の内皮機能異常の治療 |
| AU2007200908B2 (en) * | 2007-03-01 | 2012-08-16 | Csl Limited | Treatment of endothelial dysfunction in diabetic patients |
| WO2010151096A1 (en) | 2009-06-25 | 2010-12-29 | Tetra, Sia | Therapeutic combinations of nicotinic acid and meldonium |
| JP2012532919A (ja) * | 2009-07-16 | 2012-12-20 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 治療因子を含むｈｄｌおよび治療における使用 |
| US12419839B2 (en) | 2009-10-09 | 2025-09-23 | Signablok, Inc. | Methods and compositions for targeted delivery of protein fragments |
| US10525152B2 (en) | 2009-10-09 | 2020-01-07 | Signablok, Inc. | Methods and compositions for targeted imaging |
| US10894098B2 (en) | 2012-04-09 | 2021-01-19 | Signablok, Inc. | Methods and compositions for targeted imaging |
| US20120189612A1 (en) * | 2011-01-25 | 2012-07-26 | The Cleveland Clinic Foundation | Compositions and methods for treating cancer while preventing or reducing cardiotoxicity and/or cardiomyopathy |
| HUE042314T2 (hu) | 2011-02-07 | 2019-06-28 | Cerenis Therapeutics Holding Sa | Lipoprotein komplexek és azok gyártása és alkalmazásai |
| AU2012236889A1 (en) * | 2011-03-25 | 2013-05-09 | The Trustees Of Columbia University In The City Of New York | Pegylated human HDL particle and process for production thereof |
| EP2853259A1 (en) | 2013-09-30 | 2015-04-01 | Université Pierre et Marie Curie (Paris 6) | Reconstituted high density lipoproteins composition and uses thereof |
| CA2947127A1 (en) | 2014-05-02 | 2015-11-19 | Cerenis Therapeutics Holding Sa | Hdl therapy markers |
| ES2984286T3 (es) | 2017-08-10 | 2024-10-29 | Abionyx Pharma Sa | Apómeros |
| EP3668600B1 (en) | 2017-08-10 | 2024-05-15 | Abionyx Pharma SA | Cargomers |
| WO2021191266A1 (en) | 2020-03-25 | 2021-09-30 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Aerosolization of hdl for the treatment of lung infections |
| MX2022012969A (es) | 2020-04-16 | 2022-11-09 | Abionyx Pharma Sa | Metodos para el tratamiento de condiciones agudas usando complejos basados en proteinas de union a lipidos. |
| IL301769A (en) | 2020-10-01 | 2023-05-01 | Abionyx Pharma Sa | Methods for treating eye diseases using lipid binding protein-based complexes |
| US12599677B2 (en) | 2020-10-05 | 2026-04-14 | Northwestern University | Targeted PH sensitive liposomes |
| MX2023012223A (es) | 2021-04-15 | 2023-10-26 | Abionyx Pharma Sa | Uso de complejos a base de proteinas de union a lipidos en soluciones de conservacion de organos. |
| AU2023250345A1 (en) | 2022-04-06 | 2024-11-14 | Abionyx Pharma Sa | Methods for treating eye diseases using lipid binding protein-based complexes |
| CN119317440A (zh) | 2022-04-06 | 2025-01-14 | 阿比奥尼克斯制药公司 | 使用基于脂质结合蛋白的复合物治疗白细胞增多、内皮功能障碍和心脏炎的方法 |
| JP2025519606A (ja) | 2022-06-10 | 2025-06-26 | アビオニクス ファーマ エスエー | 脂質結合タンパク質に基づく複合体を使用して急性状態を処置するための方法 |
| IL317448A (en) | 2022-06-10 | 2025-02-01 | Abionyx Pharma Sa | Methods for treating hyperinflammatory conditions using complexes based on lipid-binding proteins |
| IL322074A (en) | 2023-01-13 | 2025-09-01 | Abionyx Pharma Sa | Treatment using a lipid-binding protein molecule |
| WO2025093929A1 (en) | 2023-10-31 | 2025-05-08 | Abionyx Pharma Sa | Lipid binding protein molecule therapy |
| WO2026008645A1 (en) | 2024-07-02 | 2026-01-08 | Institut National de la Santé et de la Recherche Médicale | Aerosolization of apolipoprotein a1 nanoparticles enriched with alpha-1-antitrypsin for the treatment of pulmonary emphysema in patients suffering from alpha-1 antitrypsin deficiency |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19547648A1 (de) * | 1995-12-20 | 1997-06-26 | Hoechst Ag | Zubereitung, enthaltend High Density Lipoproteine und Crotonsäureamidderivate |
| JP2004500332A (ja) * | 1999-07-08 | 2004-01-08 | テュラリク インコーポレイテッド | Ｈｄｌコレステロール値を上昇させる組成物および方法 |
| GB9919713D0 (en) * | 1999-08-19 | 1999-10-20 | Queen Mary & Westfield College | New medical use of high density lipoprotein |
| AUPQ429399A0 (en) | 1999-11-26 | 1999-12-23 | Heart Research Institute, The | Oxidized apolipoproteins and methods of use |
-
2002
- 2002-08-20 DE DE60226881T patent/DE60226881D1/de not_active Expired - Lifetime
- 2002-08-20 AU AU2002340825A patent/AU2002340825B2/en not_active Ceased
- 2002-08-20 JP JP2003522564A patent/JP4284177B2/ja not_active Expired - Fee Related
- 2002-08-20 EP EP02774525A patent/EP1425031B8/en not_active Expired - Lifetime
- 2002-08-20 WO PCT/EP2002/009294 patent/WO2003018047A2/en not_active Ceased
- 2002-08-20 CA CA2457840A patent/CA2457840C/en not_active Expired - Fee Related
- 2002-08-20 AT AT02774525T patent/ATE396736T1/de active
- 2002-08-20 ES ES02774525T patent/ES2304452T3/es not_active Expired - Lifetime
- 2002-08-20 US US10/487,224 patent/US20040266660A1/en not_active Abandoned
-
2004
- 2004-02-19 ZA ZA2004/01360A patent/ZA200401360B/en unknown
-
2007
- 2007-05-04 US US11/744,780 patent/US7491693B2/en not_active Expired - Lifetime
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