ATE462427T1 - Verwendung von treprostinil zur behandlung von neuropathischen diabetischen fussgeschwüren - Google Patents
Verwendung von treprostinil zur behandlung von neuropathischen diabetischen fussgeschwürenInfo
- Publication number
- ATE462427T1 ATE462427T1 AT05735648T AT05735648T ATE462427T1 AT E462427 T1 ATE462427 T1 AT E462427T1 AT 05735648 T AT05735648 T AT 05735648T AT 05735648 T AT05735648 T AT 05735648T AT E462427 T1 ATE462427 T1 AT E462427T1
- Authority
- AT
- Austria
- Prior art keywords
- treprostinil
- foot ulcers
- diabetic foot
- treat neuropathic
- neuropathic diabetic
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US56115704P | 2004-04-12 | 2004-04-12 | |
PCT/US2005/012471 WO2005099680A2 (en) | 2004-04-12 | 2005-04-12 | Use of treprostinil to treat neuropathic diabetic foot ulcers |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE462427T1 true ATE462427T1 (de) | 2010-04-15 |
Family
ID=34965914
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT05735648T ATE462427T1 (de) | 2004-04-12 | 2005-04-12 | Verwendung von treprostinil zur behandlung von neuropathischen diabetischen fussgeschwüren |
Country Status (10)
Country | Link |
---|---|
US (2) | US7879909B2 (de) |
EP (1) | EP1744739B1 (de) |
JP (1) | JP2007532663A (de) |
KR (1) | KR101186029B1 (de) |
CN (1) | CN101287457B (de) |
AT (1) | ATE462427T1 (de) |
CA (1) | CA2562614C (de) |
DE (1) | DE602005020269D1 (de) |
ES (1) | ES2340939T3 (de) |
WO (1) | WO2005099680A2 (de) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101161889B1 (ko) * | 2003-12-16 | 2012-07-02 | 유나이티드 쎄러퓨틱스 코포레이션 | 허혈성 병변의 치료 및 예방을 위한 트레프로스티닐의 용도 |
DE602005020269D1 (de) * | 2004-04-12 | 2010-05-12 | United Therapeutics Corp | Verwendung von treprostinil zur behandlung von neuropathischen diabetischen fussgeschwüren |
US8747897B2 (en) | 2006-04-27 | 2014-06-10 | Supernus Pharmaceuticals, Inc. | Osmotic drug delivery system |
ES2728785T3 (es) | 2007-09-07 | 2019-10-28 | United Therapeutics Corp | Soluciones tampón con actividad bactericida selectiva contra las bacterias gramnegativas y métodos para usarlas |
KR20160048222A (ko) | 2007-12-17 | 2016-05-03 | 유나이티드 세러퓨틱스 코오포레이션 | 레모둘린?의 활성 성분인 트레프로스티닐의 개선된 제조 방법 |
KR20110010753A (ko) * | 2008-05-08 | 2011-02-07 | 유나이티드 세러퓨틱스 코오포레이션 | 트레프로스티닐 일수화물 |
US8349892B2 (en) * | 2009-05-07 | 2013-01-08 | United Therapeutics Corporation | Solid formulations of prostacyclin analogs |
JP5681276B2 (ja) | 2010-03-15 | 2015-03-04 | ユナイテッド セラピューティクス コーポレイション | 肺高血圧症のための治療 |
WO2011153363A1 (en) | 2010-06-03 | 2011-12-08 | United Therapeutics Corporation | Treprostinil production |
CA2828958C (en) | 2011-03-02 | 2015-11-03 | United Therapeutics Corporation | Synthesis of intermediate for treprostinil production |
CN103193627B (zh) | 2012-01-10 | 2016-04-20 | 上海天伟生物制药有限公司 | 一种前列腺素类似物的晶型及其制备方法和用途 |
CN103193626B (zh) | 2012-01-10 | 2016-05-11 | 上海天伟生物制药有限公司 | 一种前列腺素类似物的晶型及其制备方法和用途 |
AU2013346624B2 (en) | 2012-11-13 | 2018-08-09 | Adocia | Quick-acting insulin formulation including a substituted anionic compound |
WO2014110491A1 (en) | 2013-01-11 | 2014-07-17 | Theratrophix Llc | Prodrugs of treprostinil |
US9505737B2 (en) | 2013-01-11 | 2016-11-29 | Corsair Pharma, Inc. | Treprostinil derivative compounds and methods of using same |
CN105164098A (zh) | 2013-03-14 | 2015-12-16 | 联合治疗公司 | 曲前列环素的固体形式 |
CN109608326A (zh) | 2013-03-15 | 2019-04-12 | 联合治疗公司 | 曲前列环素的盐 |
JP6263604B2 (ja) | 2013-03-25 | 2018-01-17 | ユナイテッド セラピューティクス コーポレイション | チオールリンカーを持つ、ペグ化型のプロスタサイクリン化合物の製造方法 |
US9469600B2 (en) | 2013-10-25 | 2016-10-18 | Insmed Incorporated | Prostacyclin compounds, compositions and methods of use thereof |
TWI685348B (zh) | 2014-05-08 | 2020-02-21 | 美國禮來大藥廠 | 速效胰島素組合物 |
CA2952223C (en) | 2014-06-13 | 2023-08-01 | United Therapeutics Corporation | Treprostinil formulations |
CN107108427A (zh) | 2014-10-20 | 2017-08-29 | 联合治疗学有限公司 | 用于制备前列环素衍生物的中间体的合成 |
WO2016081658A1 (en) | 2014-11-18 | 2016-05-26 | Insmed Incorporated | Methods of manufacturing treprostinil and treprostinil derivative prodrugs |
CA2967899C (en) | 2014-12-03 | 2023-09-19 | Steadymed Ltd | Preservative-free treprostinil formulations and methods and devices for use with same |
US9394227B1 (en) | 2015-06-17 | 2016-07-19 | Corsair Pharma, Inc. | Treprostinil derivatives and compositions and uses thereof |
US9643911B2 (en) | 2015-06-17 | 2017-05-09 | Corsair Pharma, Inc. | Treprostinil derivatives and compositions and uses thereof |
JO3749B1 (ar) | 2015-08-27 | 2021-01-31 | Lilly Co Eli | تركيبات إنسولين سريعة المفعول |
EP3452170A4 (de) | 2016-05-05 | 2020-04-01 | Liquidia Technologies, Inc. | Treprostinil in pulverform zur behandlung von pulmonaler hypertonie |
KR102541885B1 (ko) | 2016-09-26 | 2023-06-12 | 유나이티드 쎄러퓨틱스 코포레이션 | 트레프로스티닐 프로드럭 |
EP3548010A1 (de) * | 2016-12-05 | 2019-10-09 | Corsair Pharma, Inc. | Dermale und transdermale verabreichung von treprostinil und salzen davon |
WO2020060823A1 (en) | 2018-09-18 | 2020-03-26 | Eli Lilly And Company | Erbumine salt of treprostinil |
SG11202107075RA (en) * | 2019-01-22 | 2021-08-30 | Akribes Biomedical Gmbh | Selective glucocorticoid receptor modifiers for treating impaired skin wound healing |
BR112021021775A2 (pt) | 2019-04-29 | 2022-01-04 | Insmed Inc | Composições de pó seco de pró-fármacos de treprostinil e métodos de uso destas |
EP4017588A1 (de) | 2019-08-23 | 2022-06-29 | United Therapeutics Corporation | Treprostinil-prodrugs |
IL296567A (en) | 2020-04-17 | 2022-11-01 | United Therapeutics Corp | Terfostinil for use in the treatment of interstitial lung disease |
WO2021252446A1 (en) | 2020-06-09 | 2021-12-16 | United Therapeutics Corporation | Fumaryl diketopiperidine prodrugs of treprostinil |
WO2022132655A1 (en) | 2020-12-14 | 2022-06-23 | United Therapeutics Corporation | Methods of treating disease with treprostinil prodrugs |
CA3209987A1 (en) | 2021-03-03 | 2022-09-09 | Hitesh Batra | A dry powder composition of trestinil and its prodrug thereof and further comprising comprising (e)-3,6-bis[4-(n-carbonyl-2-propenyl)amidobutyl]-2,5-diketopiperazine (fdkp) |
KR20240141319A (ko) | 2022-02-08 | 2024-09-26 | 유나이티드 쎄러퓨틱스 코포레이션 | 트레프로스티닐 일로프로스트 조합 치료 요법 |
US20240238229A1 (en) | 2023-01-18 | 2024-07-18 | United Therapeutics Corporation | Treatment of pulmonary arterial hypertension |
WO2024155752A1 (en) | 2023-01-19 | 2024-07-25 | United Therapeutics Corporation | Treprostinil analogs |
DE202023100902U1 (de) | 2023-02-24 | 2023-03-09 | Heinz Kurz Gmbh | Chirurgische Schneidevorrichtung für die Otologie |
DE102023104616A1 (de) | 2023-02-24 | 2024-08-29 | Heinz Kurz Gmbh | Chirurgische Schneidevorrichtung für die Otologie und Verfahren zu deren Betrieb |
Family Cites Families (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4490537A (en) * | 1977-04-19 | 1984-12-25 | The Upjohn Company | Enlarged-hetero-ring prostacyclin analogs |
US4306075A (en) * | 1980-03-28 | 1981-12-15 | The Upjohn Company | Composition and process |
US4486598A (en) * | 1982-02-22 | 1984-12-04 | The Upjohn Company | Carbacyclin analogs |
DE3315356A1 (de) * | 1982-04-30 | 1983-11-17 | Ono Pharmaceutical Co. Ltd., Osaka | Verwendung von prostaglandinanalogen |
CA1241324A (en) | 1984-03-08 | 1988-08-30 | Paul A. Aristoff | Interphenylene carbacyclin derivatives |
JPH0680027B2 (ja) * | 1985-09-18 | 1994-10-12 | 財団法人相模中央化学研究所 | プロスタサイクリン類及びこれらを含有する薬剤 |
US4837342A (en) * | 1986-02-28 | 1989-06-06 | Sagami Chemical Research Center | Prostacyclin analogue, and blood circulation improving agent and anti-ulcer composition containing it as active ingredient |
US5663203A (en) * | 1986-09-11 | 1997-09-02 | Schering Aktiengesellschaft | Agents containing prostacyclin derivatives for topical application |
US4730078A (en) * | 1987-05-13 | 1988-03-08 | G. D. Searle & Co. | Allenic prostacyclins |
GB8814438D0 (en) * | 1988-06-17 | 1988-07-20 | Wellcome Found | Compounds for use in medicine |
GB9011588D0 (en) * | 1990-05-24 | 1990-07-11 | Wellcome Found | Prostaglandin analogues for use in medicine |
DE4135193C1 (de) * | 1991-10-22 | 1993-03-11 | Schering Ag Berlin Und Bergkamen, 1000 Berlin, De | |
US6171786B1 (en) * | 1992-09-17 | 2001-01-09 | Board Of Trustees Of University Of Illinois | Methods for preventing multidrug resistance in cancer cells |
AU669783B2 (en) * | 1993-02-03 | 1996-06-20 | Teijin Limited | Dermatologic preparation composition containing prostacyclinas active ingredient |
US6451815B1 (en) * | 1997-08-14 | 2002-09-17 | Aventis Pharmaceuticals Inc. | Method of enhancing bioavailability of fexofenadine and its derivatives |
GB9718903D0 (en) * | 1997-09-05 | 1997-11-12 | Glaxo Group Ltd | Method,compositions and kits for increasing the oral bioavailability of pharmaceutical agents |
US6441245B1 (en) * | 1997-10-24 | 2002-08-27 | United Therapeutics Corporation | Process for stereoselective synthesis of prostacyclin derivatives |
KR100638684B1 (ko) * | 1997-11-14 | 2006-10-27 | 유나이티드 세러퓨틱스 코오포레이션 | 말초 혈관 질환의 치료를 위한 9-데옥시-2',9-알파-메타노-3-옥사-4,5,6-트리노르-3,7-(1',3'-인터페닐렌)-13,14-디하이드로-프로스타글란딘 에프1의 용도 |
US6521212B1 (en) * | 1999-03-18 | 2003-02-18 | United Therapeutics Corporation | Method for treating peripheral vascular disease by administering benzindene prostaglandins by inhalation |
JP2002540203A (ja) | 1999-03-29 | 2002-11-26 | ニューロゲン コーポレイション | Nk−3および/またはgaba(a)受容体リガンドとしての4−置換キノリン誘導体 |
US6700025B2 (en) * | 2001-01-05 | 2004-03-02 | United Therapeutics Corporation | Process for stereoselective synthesis of prostacyclin derivatives |
US6803386B2 (en) * | 2002-01-16 | 2004-10-12 | United Therapeutics Corporation | Prostacyclin derivative containing compositions and methods of using the same for the treatment of cancer |
AU2002339730A1 (en) | 2002-08-28 | 2004-03-19 | Universita "Campus Bio-Medico" Di Roma | Use of prostacyclin and analogs thereof for improving venous flow |
EP2792353B1 (de) * | 2003-05-22 | 2018-02-28 | United Therapeutics Corporation | Polymorph von Treprostinil-Diethanolaminsalz |
US20050101608A1 (en) * | 2003-09-24 | 2005-05-12 | Santel Donald J. | Iloprost in combination therapies for the treatment of pulmonary arterial hypertension |
KR101161889B1 (ko) * | 2003-12-16 | 2012-07-02 | 유나이티드 쎄러퓨틱스 코포레이션 | 허혈성 병변의 치료 및 예방을 위한 트레프로스티닐의 용도 |
CA2549801C (en) * | 2003-12-16 | 2012-10-16 | United Therapeutics Corporation | Use of treprostinil to improve kidney functions |
DE602005020269D1 (de) * | 2004-04-12 | 2010-05-12 | United Therapeutics Corp | Verwendung von treprostinil zur behandlung von neuropathischen diabetischen fussgeschwüren |
KR101390579B1 (ko) * | 2006-05-15 | 2014-05-19 | 유나이티드 세러퓨틱스 코오포레이션 | 정량 흡입기를 사용한 트레프로스티닐 투여 |
WO2008049000A2 (en) * | 2006-10-18 | 2008-04-24 | United Therapeutics Corporation | Combination therapy for pulmonary arterial hypertension |
EP2120961A1 (de) * | 2007-02-09 | 2009-11-25 | United Therapeutics Corporation | Treprostinil-behandlung für interstitielle lungenerkrankungen und asthma |
KR20160048222A (ko) * | 2007-12-17 | 2016-05-03 | 유나이티드 세러퓨틱스 코오포레이션 | 레모둘린?의 활성 성분인 트레프로스티닐의 개선된 제조 방법 |
US8349892B2 (en) * | 2009-05-07 | 2013-01-08 | United Therapeutics Corporation | Solid formulations of prostacyclin analogs |
-
2005
- 2005-04-12 DE DE602005020269T patent/DE602005020269D1/de active Active
- 2005-04-12 JP JP2007508488A patent/JP2007532663A/ja active Pending
- 2005-04-12 ES ES05735648T patent/ES2340939T3/es active Active
- 2005-04-12 CN CN2005800189046A patent/CN101287457B/zh not_active Expired - Fee Related
- 2005-04-12 AT AT05735648T patent/ATE462427T1/de not_active IP Right Cessation
- 2005-04-12 KR KR1020067022940A patent/KR101186029B1/ko not_active IP Right Cessation
- 2005-04-12 WO PCT/US2005/012471 patent/WO2005099680A2/en active Application Filing
- 2005-04-12 CA CA2562614A patent/CA2562614C/en not_active Expired - Fee Related
- 2005-04-12 EP EP05735648A patent/EP1744739B1/de not_active Not-in-force
- 2005-04-12 US US11/103,649 patent/US7879909B2/en active Active
-
2010
- 2010-12-20 US US12/926,945 patent/US8563614B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
KR20070007887A (ko) | 2007-01-16 |
CN101287457A (zh) | 2008-10-15 |
EP1744739B1 (de) | 2010-03-31 |
CA2562614C (en) | 2013-09-17 |
US8563614B2 (en) | 2013-10-22 |
ES2340939T3 (es) | 2010-06-11 |
CA2562614A1 (en) | 2005-10-27 |
CN101287457B (zh) | 2011-11-16 |
WO2005099680A3 (en) | 2005-12-01 |
US20050282903A1 (en) | 2005-12-22 |
JP2007532663A (ja) | 2007-11-15 |
DE602005020269D1 (de) | 2010-05-12 |
US7879909B2 (en) | 2011-02-01 |
EP1744739A2 (de) | 2007-01-24 |
KR101186029B1 (ko) | 2012-09-27 |
WO2005099680A2 (en) | 2005-10-27 |
US20110092599A1 (en) | 2011-04-21 |
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RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |