ES2339432T3 - Sal de acetil l-carnitina con un acido dicarboxilico organico y procedimiento de preparacion. - Google Patents

Sal de acetil l-carnitina con un acido dicarboxilico organico y procedimiento de preparacion. Download PDF

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Publication number
ES2339432T3
ES2339432T3 ES02793335T ES02793335T ES2339432T3 ES 2339432 T3 ES2339432 T3 ES 2339432T3 ES 02793335 T ES02793335 T ES 02793335T ES 02793335 T ES02793335 T ES 02793335T ES 2339432 T3 ES2339432 T3 ES 2339432T3
Authority
ES
Spain
Prior art keywords
carnitine
acetyl
fumarate
solution
hygroscopic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES02793335T
Other languages
English (en)
Spanish (es)
Inventor
Aldo Fassi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Application granted granted Critical
Publication of ES2339432T3 publication Critical patent/ES2339432T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/02—Preparation of carboxylic acid esters by interreacting ester groups, i.e. transesterification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Saccharide Compounds (AREA)
ES02793335T 2001-12-12 2002-11-25 Sal de acetil l-carnitina con un acido dicarboxilico organico y procedimiento de preparacion. Expired - Lifetime ES2339432T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2001RM000729A ITRM20010729A1 (it) 2001-12-12 2001-12-12 Sale di acetil l-carnitina con un acido organico dicarbossilico e procedimento per la sua preparazione.
ITRM01A0729 2001-12-12

Publications (1)

Publication Number Publication Date
ES2339432T3 true ES2339432T3 (es) 2010-05-20

Family

ID=11455916

Family Applications (1)

Application Number Title Priority Date Filing Date
ES02793335T Expired - Lifetime ES2339432T3 (es) 2001-12-12 2002-11-25 Sal de acetil l-carnitina con un acido dicarboxilico organico y procedimiento de preparacion.

Country Status (18)

Country Link
US (1) US6673837B2 (enExample)
EP (1) EP1453791B1 (enExample)
JP (1) JP4902940B2 (enExample)
KR (1) KR100860386B1 (enExample)
CN (1) CN1250521C (enExample)
AT (1) ATE457300T1 (enExample)
AU (1) AU2002358989A1 (enExample)
CA (1) CA2468234C (enExample)
CY (1) CY1110684T1 (enExample)
DE (1) DE60235318D1 (enExample)
DK (1) DK1453791T3 (enExample)
ES (1) ES2339432T3 (enExample)
HU (1) HU230034B1 (enExample)
IT (1) ITRM20010729A1 (enExample)
PL (1) PL207877B1 (enExample)
PT (1) PT1453791E (enExample)
SI (1) SI1453791T1 (enExample)
WO (1) WO2003053911A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8173618B2 (en) * 2003-07-25 2012-05-08 University Of Massachusetts Formulations for reducing neuronal degeneration
CN101209975B (zh) * 2006-12-29 2010-12-01 沈阳科硕营养科技有限公司 左旋肉碱富马酸钙及其制备方法与用途
US8597640B2 (en) * 2007-10-31 2013-12-03 University Of Massachusetts Lowell Over-the-counter vitamin/nutriceutical formulation that provides neuroprotection and maintains or improves cognitive performance in alzheimer's disease and normal aging
JP2012092036A (ja) * 2010-10-26 2012-05-17 Mitsubishi Rayon Co Ltd カルニチンの塩の製造方法
JP2014525324A (ja) * 2011-08-31 2014-09-29 ザ プロクター アンド ギャンブル カンパニー 接着された強化層を有するファスニング部材
JP5933383B2 (ja) * 2012-07-26 2016-06-08 ロート製薬株式会社 内服用固形製剤の吸湿性・流動性の改善方法、吸湿性・流動性が改善されてなる内服用固形製剤、及び該内服用固形製剤の製造法
JP6100939B2 (ja) * 2016-02-26 2017-03-22 ロート製薬株式会社 内服用固形製剤の吸湿性・流動性の改善方法、吸湿性・流動性が改善されてなる内服用固形製剤、及び該内服用固形製剤の製造法
JP6964876B2 (ja) * 2017-11-27 2021-11-10 株式会社古川リサーチオフィス オロット酸−カルニチン混合体粉体又はフマル酸−カルニチン混合体粉体の製造方法
CN119351483B (zh) * 2024-12-03 2025-05-30 北京佰依源生物科技有限公司 一种长碳链二元酸生产强度提高的方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0150688B1 (en) * 1983-12-28 1987-04-22 Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. Salts of l-carnitine and alkanoyl l-carnitines and process for preparing same

Also Published As

Publication number Publication date
CN1602294A (zh) 2005-03-30
KR20040064721A (ko) 2004-07-19
HU230034B1 (hu) 2015-05-28
WO2003053911A1 (en) 2003-07-03
JP2005513122A (ja) 2005-05-12
HK1073295A1 (en) 2005-09-30
HUP0402545A3 (en) 2012-09-28
ITRM20010729A1 (it) 2003-06-12
JP4902940B2 (ja) 2012-03-21
DK1453791T3 (da) 2010-05-25
PL371130A1 (en) 2005-06-13
HUP0402545A2 (hu) 2005-04-28
ATE457300T1 (de) 2010-02-15
EP1453791B1 (en) 2010-02-10
PT1453791E (pt) 2010-04-14
CY1110684T1 (el) 2015-06-10
CN1250521C (zh) 2006-04-12
SI1453791T1 (sl) 2010-11-30
US20030119904A1 (en) 2003-06-26
DE60235318D1 (de) 2010-03-25
CA2468234A1 (en) 2003-07-03
CA2468234C (en) 2010-02-23
US6673837B2 (en) 2004-01-06
AU2002358989A1 (en) 2003-07-09
KR100860386B1 (ko) 2008-09-26
PL207877B1 (pl) 2011-02-28
EP1453791A1 (en) 2004-09-08

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