ITRM20010729A1 - Sale di acetil l-carnitina con un acido organico dicarbossilico e procedimento per la sua preparazione. - Google Patents
Sale di acetil l-carnitina con un acido organico dicarbossilico e procedimento per la sua preparazione.Info
- Publication number
- ITRM20010729A1 ITRM20010729A1 IT2001RM000729A ITRM20010729A ITRM20010729A1 IT RM20010729 A1 ITRM20010729 A1 IT RM20010729A1 IT 2001RM000729 A IT2001RM000729 A IT 2001RM000729A IT RM20010729 A ITRM20010729 A IT RM20010729A IT RM20010729 A1 ITRM20010729 A1 IT RM20010729A1
- Authority
- IT
- Italy
- Prior art keywords
- acetyl
- carnitine
- salt
- procedure
- preparation
- Prior art date
Links
- RDHQFKQIGNGIED-MRVPVSSYSA-N O-acetyl-L-carnitine Chemical compound CC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C RDHQFKQIGNGIED-MRVPVSSYSA-N 0.000 title abstract 2
- 150000007524 organic acids Chemical class 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/02—Preparation of carboxylic acid esters by interreacting ester groups, i.e. transesterification
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Vascular Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Saccharide Compounds (AREA)
Priority Applications (19)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2001RM000729A ITRM20010729A1 (it) | 2001-12-12 | 2001-12-12 | Sale di acetil l-carnitina con un acido organico dicarbossilico e procedimento per la sua preparazione. |
| US10/207,993 US6673837B2 (en) | 2001-12-12 | 2002-07-31 | Acetyl L-carnitine salt with a dicarboxylic organic acid and process for preparing same |
| CNB028248260A CN1250521C (zh) | 2001-12-12 | 2002-11-25 | 乙酰基l－肉碱酸式富马酸盐及其制备方法 |
| PL371130A PL207877B1 (pl) | 2001-12-12 | 2002-11-25 | Sól acetylo L-karnityny z organicznymi kwasami dikarboksylowymi oraz metody jej otrzymywania |
| DE60235318T DE60235318D1 (de) | 2001-12-12 | 2002-11-25 | Dikarbonsäuresalze des acetyl-l-carnitins und verfahren zu ihrer herstellung |
| PCT/IT2002/000743 WO2003053911A1 (en) | 2001-12-12 | 2002-11-25 | Acetyl l-carnitine salt with a dicarboxilic organic acid and process for preparing same |
| SI200230893T SI1453791T1 (sl) | 2001-12-12 | 2002-11-25 | Acetil l karnitin sol z dikarboksilično organskokislino in postopek za njeno pripravo |
| KR1020047008307A KR100860386B1 (ko) | 2001-12-12 | 2002-11-25 | 디카복실 유기산과의 아세틸 ｌ-카르니틴 염 및 이의 제조방법 |
| ES02793335T ES2339432T3 (es) | 2001-12-12 | 2002-11-25 | Sal de acetil l-carnitina con un acido dicarboxilico organico y procedimiento de preparacion. |
| AU2002358989A AU2002358989A1 (en) | 2001-12-12 | 2002-11-25 | Acetyl l-carnitine salt with a dicarboxilic organic acid and process for preparing same |
| HU0402545A HU230034B1 (hu) | 2001-12-12 | 2002-11-25 | Acetil-L-karnitin szerves dikarbonsavval alkotott sója és eljárás előállítására |
| CA2468234A CA2468234C (en) | 2001-12-12 | 2002-11-25 | Acetyl l-carnitine fumarate and process for preparing the same |
| AT02793335T ATE457300T1 (de) | 2001-12-12 | 2002-11-25 | Dikarbonsäuresalze des acetyl-l-carnitins und verfahren zu ihrer herstellung |
| JP2003554628A JP4902940B2 (ja) | 2001-12-12 | 2002-11-25 | ジカルボキシル有機酸とのアセチルｌ−カルニチンの塩およびその調製方法 |
| EP02793335A EP1453791B1 (en) | 2001-12-12 | 2002-11-25 | Acetyl l-carnitine salt with a dicarboxilic organic acid and process for preparing same |
| DK02793335.7T DK1453791T3 (da) | 2001-12-12 | 2002-11-25 | Dicarboxylsyresalte af acetyl-L.camitin og fremgangsmåde til fremstilling heraf |
| PT02793335T PT1453791E (pt) | 2001-12-12 | 2002-11-25 | Sal de acetil l-carnitina associado a um ácido orgânico dicarboxílico e processo para preparar o mesmo |
| HK05105831.7A HK1073295B (en) | 2001-12-12 | 2002-11-25 | Acetyl l-carnitine acid fumarate and process for preparing the same |
| CY20101100377T CY1110684T1 (el) | 2001-12-12 | 2010-04-27 | Αλας ακετυλο-l-καρνιτινης με δικαρβοξυλικο οργανικο οξυ και μεθοδος για την παρασκευη αυτου |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2001RM000729A ITRM20010729A1 (it) | 2001-12-12 | 2001-12-12 | Sale di acetil l-carnitina con un acido organico dicarbossilico e procedimento per la sua preparazione. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ITRM20010729A1 true ITRM20010729A1 (it) | 2003-06-12 |
Family
ID=11455916
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT2001RM000729A ITRM20010729A1 (it) | 2001-12-12 | 2001-12-12 | Sale di acetil l-carnitina con un acido organico dicarbossilico e procedimento per la sua preparazione. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6673837B2 (enExample) |
| EP (1) | EP1453791B1 (enExample) |
| JP (1) | JP4902940B2 (enExample) |
| KR (1) | KR100860386B1 (enExample) |
| CN (1) | CN1250521C (enExample) |
| AT (1) | ATE457300T1 (enExample) |
| AU (1) | AU2002358989A1 (enExample) |
| CA (1) | CA2468234C (enExample) |
| CY (1) | CY1110684T1 (enExample) |
| DE (1) | DE60235318D1 (enExample) |
| DK (1) | DK1453791T3 (enExample) |
| ES (1) | ES2339432T3 (enExample) |
| HU (1) | HU230034B1 (enExample) |
| IT (1) | ITRM20010729A1 (enExample) |
| PL (1) | PL207877B1 (enExample) |
| PT (1) | PT1453791E (enExample) |
| SI (1) | SI1453791T1 (enExample) |
| WO (1) | WO2003053911A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8173618B2 (en) * | 2003-07-25 | 2012-05-08 | University Of Massachusetts | Formulations for reducing neuronal degeneration |
| CN101209975B (zh) * | 2006-12-29 | 2010-12-01 | 沈阳科硕营养科技有限公司 | 左旋肉碱富马酸钙及其制备方法与用途 |
| US8597640B2 (en) * | 2007-10-31 | 2013-12-03 | University Of Massachusetts Lowell | Over-the-counter vitamin/nutriceutical formulation that provides neuroprotection and maintains or improves cognitive performance in alzheimer's disease and normal aging |
| JP2012092036A (ja) * | 2010-10-26 | 2012-05-17 | Mitsubishi Rayon Co Ltd | カルニチンの塩の製造方法 |
| JP2014525324A (ja) * | 2011-08-31 | 2014-09-29 | ザ プロクター アンド ギャンブル カンパニー | 接着された強化層を有するファスニング部材 |
| JP5933383B2 (ja) * | 2012-07-26 | 2016-06-08 | ロート製薬株式会社 | 内服用固形製剤の吸湿性・流動性の改善方法、吸湿性・流動性が改善されてなる内服用固形製剤、及び該内服用固形製剤の製造法 |
| JP6100939B2 (ja) * | 2016-02-26 | 2017-03-22 | ロート製薬株式会社 | 内服用固形製剤の吸湿性・流動性の改善方法、吸湿性・流動性が改善されてなる内服用固形製剤、及び該内服用固形製剤の製造法 |
| JP6964876B2 (ja) * | 2017-11-27 | 2021-11-10 | 株式会社古川リサーチオフィス | オロット酸−カルニチン混合体粉体又はフマル酸−カルニチン混合体粉体の製造方法 |
| CN119351483B (zh) * | 2024-12-03 | 2025-05-30 | 北京佰依源生物科技有限公司 | 一种长碳链二元酸生产强度提高的方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0150688B1 (en) * | 1983-12-28 | 1987-04-22 | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. | Salts of l-carnitine and alkanoyl l-carnitines and process for preparing same |
-
2001
- 2001-12-12 IT IT2001RM000729A patent/ITRM20010729A1/it unknown
-
2002
- 2002-07-31 US US10/207,993 patent/US6673837B2/en not_active Expired - Lifetime
- 2002-11-25 DE DE60235318T patent/DE60235318D1/de not_active Expired - Lifetime
- 2002-11-25 EP EP02793335A patent/EP1453791B1/en not_active Expired - Lifetime
- 2002-11-25 PT PT02793335T patent/PT1453791E/pt unknown
- 2002-11-25 CA CA2468234A patent/CA2468234C/en not_active Expired - Fee Related
- 2002-11-25 PL PL371130A patent/PL207877B1/pl unknown
- 2002-11-25 ES ES02793335T patent/ES2339432T3/es not_active Expired - Lifetime
- 2002-11-25 WO PCT/IT2002/000743 patent/WO2003053911A1/en not_active Ceased
- 2002-11-25 AT AT02793335T patent/ATE457300T1/de active
- 2002-11-25 JP JP2003554628A patent/JP4902940B2/ja not_active Expired - Fee Related
- 2002-11-25 AU AU2002358989A patent/AU2002358989A1/en not_active Abandoned
- 2002-11-25 SI SI200230893T patent/SI1453791T1/sl unknown
- 2002-11-25 KR KR1020047008307A patent/KR100860386B1/ko not_active Expired - Fee Related
- 2002-11-25 DK DK02793335.7T patent/DK1453791T3/da active
- 2002-11-25 HU HU0402545A patent/HU230034B1/hu not_active IP Right Cessation
- 2002-11-25 CN CNB028248260A patent/CN1250521C/zh not_active Expired - Fee Related
-
2010
- 2010-04-27 CY CY20101100377T patent/CY1110684T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1602294A (zh) | 2005-03-30 |
| KR20040064721A (ko) | 2004-07-19 |
| HU230034B1 (hu) | 2015-05-28 |
| WO2003053911A1 (en) | 2003-07-03 |
| JP2005513122A (ja) | 2005-05-12 |
| HK1073295A1 (en) | 2005-09-30 |
| HUP0402545A3 (en) | 2012-09-28 |
| JP4902940B2 (ja) | 2012-03-21 |
| DK1453791T3 (da) | 2010-05-25 |
| PL371130A1 (en) | 2005-06-13 |
| HUP0402545A2 (hu) | 2005-04-28 |
| ATE457300T1 (de) | 2010-02-15 |
| EP1453791B1 (en) | 2010-02-10 |
| PT1453791E (pt) | 2010-04-14 |
| CY1110684T1 (el) | 2015-06-10 |
| CN1250521C (zh) | 2006-04-12 |
| SI1453791T1 (sl) | 2010-11-30 |
| US20030119904A1 (en) | 2003-06-26 |
| DE60235318D1 (de) | 2010-03-25 |
| CA2468234A1 (en) | 2003-07-03 |
| CA2468234C (en) | 2010-02-23 |
| US6673837B2 (en) | 2004-01-06 |
| ES2339432T3 (es) | 2010-05-20 |
| AU2002358989A1 (en) | 2003-07-09 |
| KR100860386B1 (ko) | 2008-09-26 |
| PL207877B1 (pl) | 2011-02-28 |
| EP1453791A1 (en) | 2004-09-08 |
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