ES2243998T3 - Comprimido de disgregacion rapida por via intrabucal. - Google Patents
Comprimido de disgregacion rapida por via intrabucal.Info
- Publication number
- ES2243998T3 ES2243998T3 ES97927372T ES97927372T ES2243998T3 ES 2243998 T3 ES2243998 T3 ES 2243998T3 ES 97927372 T ES97927372 T ES 97927372T ES 97927372 T ES97927372 T ES 97927372T ES 2243998 T3 ES2243998 T3 ES 2243998T3
- Authority
- ES
- Spain
- Prior art keywords
- tablet
- saccharide
- weight
- constitutes
- sugar
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/10—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Nutrition Science (AREA)
- Zoology (AREA)
- Physiology (AREA)
- Epidemiology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15355396 | 1996-06-14 | ||
| JP15355396 | 1996-06-14 | ||
| JP7110797 | 1997-03-25 | ||
| JP7110797 | 1997-03-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2243998T3 true ES2243998T3 (es) | 2005-12-01 |
Family
ID=26412238
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES97927372T Expired - Lifetime ES2243998T3 (es) | 1996-06-14 | 1997-06-12 | Comprimido de disgregacion rapida por via intrabucal. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20010014340A1 (enExample) |
| EP (2) | EP0914818B1 (enExample) |
| JP (4) | JP3797387B2 (enExample) |
| CN (1) | CN1154479C (enExample) |
| AT (2) | ATE477793T1 (enExample) |
| AU (1) | AU733032C (enExample) |
| CA (1) | CA2258159C (enExample) |
| DE (2) | DE69739967D1 (enExample) |
| DK (1) | DK0914818T3 (enExample) |
| EA (1) | EA001898B1 (enExample) |
| ES (1) | ES2243998T3 (enExample) |
| PT (1) | PT914818E (enExample) |
| WO (1) | WO1997047287A1 (enExample) |
Families Citing this family (82)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997047287A1 (en) * | 1996-06-14 | 1997-12-18 | Kyowa Hakko Kogyo Co., Ltd. | Intraorally rapidly disintegrable tablet |
| US8071128B2 (en) | 1996-06-14 | 2011-12-06 | Kyowa Hakko Kirin Co., Ltd. | Intrabuccally rapidly disintegrating tablet and a production method of the tablets |
| US6024981A (en) * | 1997-04-16 | 2000-02-15 | Cima Labs Inc. | Rapidly dissolving robust dosage form |
| JP4568426B2 (ja) * | 1998-04-08 | 2010-10-27 | 協和発酵キリン株式会社 | 錠剤の製造方法及び錠剤 |
| EP1070497A4 (en) * | 1998-04-10 | 2009-01-21 | Kyowa Hakko Kogyo Kk | Tablet manufacturing methods and tablet |
| KR100554924B1 (ko) | 1998-05-18 | 2006-03-03 | 다케다 야쿠힌 고교 가부시키가이샤 | 구강내 붕괴 정제 |
| ATE308343T1 (de) | 1998-07-15 | 2005-11-15 | Asahi Kasei Chemicals Corp | Trägerhilfstoff |
| CA2581111A1 (en) | 1998-07-28 | 2000-02-10 | Takeda Pharmaceutical Company Limited | Rapidly disintegrable solid preparation |
| US6368625B1 (en) * | 1998-08-12 | 2002-04-09 | Cima Labs Inc. | Orally disintegrable tablet forming a viscous slurry |
| JP2000178204A (ja) * | 1998-10-05 | 2000-06-27 | Eisai Co Ltd | ホスフォジエステラ―ゼ阻害剤を含有する口腔内速崩壊性錠剤 |
| FR2790387B1 (fr) | 1999-03-01 | 2001-05-18 | Prographarm Laboratoires | Comprime orodispersible presentant une faible friabilite et son procede de preparation |
| KR20010006835A (ko) * | 1999-03-25 | 2001-01-26 | 김선진 | 경구용 속붕해정 |
| CA2374760A1 (en) | 1999-06-18 | 2000-12-28 | Takeda Chemical Industries, Ltd. | Quickly disintegrating solid preparations |
| JP2001058944A (ja) * | 1999-06-18 | 2001-03-06 | Takeda Chem Ind Ltd | 速崩壊性固形製剤 |
| EP1222917A4 (en) * | 1999-10-13 | 2007-01-17 | Kyowa Hakko Kogyo Kk | BY COMPRESSING MOLDED PRODUCT AND METHOD FOR THE PRODUCTION THEREOF |
| CN100342846C (zh) * | 1999-10-13 | 2007-10-17 | 协和发酵工业株式会社 | 压缩成形品及其制备方法 |
| AU2001227038A1 (en) * | 2000-01-17 | 2001-07-31 | Kyowa Hakko Kogyo Co. Ltd. | Bubbling tablet, bubbling bath additive tablet, bubbling washing detergent tablet, bubbling tablet for oral administration, and processes for producing these |
| WO2001072285A1 (en) * | 2000-03-27 | 2001-10-04 | Kyowa Hakko Kogyo Co., Ltd. | Easy-to-take granule |
| US6316029B1 (en) * | 2000-05-18 | 2001-11-13 | Flak Pharma International, Ltd. | Rapidly disintegrating solid oral dosage form |
| JP4840549B2 (ja) * | 2000-11-20 | 2011-12-21 | トーアエイヨー株式会社 | 安定な血管拡張剤及びその製造方法 |
| EP1226818A1 (en) * | 2001-01-26 | 2002-07-31 | Pfizer Products Inc. | Pharmaceutical dosage forms with enhanced cohesive and compressibility properties |
| CA2440361A1 (en) * | 2001-03-06 | 2002-09-12 | Kyowa Hakko Kogyo Co. Ltd. | Intraorally rapidly disintegrable preparation |
| AU2002238848B2 (en) * | 2001-03-06 | 2007-11-15 | Kyowa Hakko Kogyo Co., Ltd. | Use of a spray-dried powder comprising a sugar alcohol |
| RU2003129506A (ru) * | 2001-03-06 | 2005-03-10 | Киова Хакко Когио Ко., Лтд. (Jp) | Быстрораспадающаяся во рту таблетка |
| US9358214B2 (en) | 2001-10-04 | 2016-06-07 | Adare Pharmaceuticals, Inc. | Timed, sustained release systems for propranolol |
| CN100490798C (zh) * | 2001-11-13 | 2009-05-27 | 协和发酵麒麟株式会社 | 含有l-谷氨酰胺和薁磺酸钠的速崩片剂或口腔内崩解片剂及其制造方法 |
| JP2003238393A (ja) * | 2002-02-15 | 2003-08-27 | Otsuka Pharmaceut Co Ltd | 施錠性が改善された錠剤及びその製造方法 |
| CN1638803A (zh) * | 2002-03-06 | 2005-07-13 | 协和发酵工业株式会社 | 口腔内速崩解性片剂 |
| US20050208127A1 (en) * | 2002-06-10 | 2005-09-22 | Kazuyoshi Ogasawara | Rapidly disintegrating tablet and process for producing the same |
| JP4776229B2 (ja) * | 2002-07-16 | 2011-09-21 | エラン ファーマ インターナショナル,リミティド | 安定なナノ粒子活性物質の液体投与組成物 |
| DE10248652A1 (de) * | 2002-10-18 | 2004-04-29 | Solvay Interox Gmbh | Verfahren zur Herstellung von staubfreien Erdalkaliperoxiden |
| FR2845914B1 (fr) * | 2002-10-18 | 2005-11-04 | Schwarz Pharma Lab | Compose antiemetique a desagregation rapide |
| GB0226076D0 (en) | 2002-11-08 | 2002-12-18 | Rp Scherer Technologies Inc | Improved formulations containing substituted imidazole derivatives |
| FI20022007A0 (fi) | 2002-11-08 | 2002-11-08 | Juvantia Pharma Ltd Oy | Oromukosaalinen valmiste ja menetelmä sen valmistamiseksi |
| US8367111B2 (en) | 2002-12-31 | 2013-02-05 | Aptalis Pharmatech, Inc. | Extended release dosage forms of propranolol hydrochloride |
| JP5584509B2 (ja) * | 2003-02-28 | 2014-09-03 | 東和薬品株式会社 | 口腔内崩壊錠剤 |
| JP4551627B2 (ja) * | 2003-02-28 | 2010-09-29 | 東和薬品株式会社 | 口腔内崩壊錠剤の製造方法 |
| GB2404662A (en) * | 2003-08-01 | 2005-02-09 | Reckitt Benckiser | Cleaning composition |
| US8545881B2 (en) | 2004-04-19 | 2013-10-01 | Eurand Pharmaceuticals, Ltd. | Orally disintegrating tablets and methods of manufacture |
| MY144631A (en) | 2004-05-24 | 2011-10-14 | Nycomed Pharma As | Particulate comprising a calcium-containing compound and a sugar alcohol |
| WO2005115345A1 (en) * | 2004-05-28 | 2005-12-08 | Imaginot Pty Ltd | Oral therapeutic compound delivery system |
| US8216610B2 (en) * | 2004-05-28 | 2012-07-10 | Imaginot Pty Ltd. | Oral paracetamol formulations |
| MY139913A (en) | 2004-06-01 | 2009-11-30 | Nycomed Pharma As | Chewable, suckable and swallowable tablet containing a calcium-containing compound as an active substance |
| US8747895B2 (en) | 2004-09-13 | 2014-06-10 | Aptalis Pharmatech, Inc. | Orally disintegrating tablets of atomoxetine |
| US9884014B2 (en) | 2004-10-12 | 2018-02-06 | Adare Pharmaceuticals, Inc. | Taste-masked pharmaceutical compositions |
| NZ709754A (en) | 2004-10-21 | 2017-02-24 | Adare Pharmaceuticals Inc | Taste-masked pharmaceutical compositions with gastrosoluble pore-formers |
| WO2006045830A1 (en) * | 2004-10-28 | 2006-05-04 | Pantec Ag | A highly porous, fast-disintegrating solid dosage form and its way of manufacturing comprising the preparation of a podwer and a freezedrying step |
| US20060105038A1 (en) * | 2004-11-12 | 2006-05-18 | Eurand Pharmaceuticals Limited | Taste-masked pharmaceutical compositions prepared by coacervation |
| EP1845949B1 (en) | 2005-02-03 | 2008-05-21 | Nycomed Pharma AS | Melt granulation of a composition containing a calcium-containing compound |
| NZ556465A (en) | 2005-02-03 | 2010-10-29 | Nycomed Pharma As | Fast wet-massing method for the preparation of calcium-containing compositions |
| US9161918B2 (en) | 2005-05-02 | 2015-10-20 | Adare Pharmaceuticals, Inc. | Timed, pulsatile release systems |
| CA2629904C (en) * | 2005-11-28 | 2018-07-10 | Imaginot Pty Ltd. | Oral therapeutic compound delivery system |
| UA95093C2 (uk) | 2005-12-07 | 2011-07-11 | Нікомед Фарма Ас | Спосіб одержання кальцієвмісної сполуки |
| JP5420907B2 (ja) | 2005-12-07 | 2014-02-19 | タケダ ニコメド エイエス | 予備圧縮されたカルシウム含有化合物 |
| US20100221333A1 (en) * | 2005-12-21 | 2010-09-02 | Burkard Schlutermann | Pellets Comprising a Core With a Water-Soluble Carrier |
| FR2898492B1 (fr) * | 2006-03-15 | 2008-06-06 | Pierre Fabre Medicament Sa | Comprimes orodispersibles de domperidone |
| BRPI0709909A2 (pt) * | 2006-03-31 | 2011-07-26 | Rubicon Res Private Ltd | tabletes de desintegraÇço oral |
| CA2661683C (en) | 2006-08-31 | 2015-11-24 | Eurand, Inc | Drug delivery systems comprising solid solutions of weakly basic drugs |
| EP2101738A2 (en) * | 2006-12-21 | 2009-09-23 | Mallinckrodt Inc. | Composition of and method for preparing orally disintegrating tablets |
| EP2133096A4 (en) * | 2007-03-13 | 2011-11-16 | Dainippon Sumitomo Pharma Co | IN THE MOUTHING TABLET |
| EP1977734A1 (en) * | 2007-04-03 | 2008-10-08 | Royal College of Surgeons in Ireland | A method of producing fast dissolving tablets |
| JP4980144B2 (ja) * | 2007-06-05 | 2012-07-18 | 日機装株式会社 | 固型化透析用剤の製造方法 |
| EP2170310A4 (en) * | 2007-06-29 | 2010-06-23 | Orchid Chemicals & Pharm Ltd | FAST-DISSOLVING COMPOSITIONS OF MEMANTINE HYDROCHLORIDE |
| EP2196221A4 (en) | 2007-09-27 | 2011-12-28 | Mitsubishi Tanabe Pharma Corp | QUICKLY CRUMPING SOLID PREPARATION |
| US9314454B2 (en) * | 2007-12-28 | 2016-04-19 | Sawai Pharmaceutical Co., Ltd. | Oral cavity disintegrating tablet and method of producing the same |
| DK2356989T3 (en) | 2008-10-24 | 2018-05-07 | Toray Industries | Stable tablet containing 4,5-epoxymorphinane derivative |
| ES2437851T3 (es) | 2008-11-17 | 2014-01-14 | Takeda Nycomed As | Comprimidos de carbonato de calcio con estabilidad de disolución mejorada |
| CN102223880B (zh) | 2008-11-25 | 2017-04-26 | 田边三菱制药株式会社 | 口腔速崩片及其制备方法 |
| TR200903014A1 (tr) * | 2009-04-17 | 2010-11-22 | Sanovel İlaç San. Ve Ti̇c. A.Ş. | Oral yolla dağılan dimebolin bileşimleri. |
| HRP20181266T1 (hr) | 2009-10-01 | 2018-10-05 | Adare Pharmaceuticals, Inc. | Kortikosteroidni pripravci za oralnu primjenu |
| TWI643027B (zh) | 2009-11-09 | 2018-12-01 | 尼康股份有限公司 | 曝光裝置、曝光方法、曝光裝置之維修方法、曝光裝置之調整方法、以及元件製造方法 |
| JP5854476B2 (ja) | 2009-11-30 | 2016-02-09 | アデア ファーマスーティカルズ,インコーポレイテッド | 圧縮性コーティングで被覆された医薬組成物及び錠剤並びに製造方法 |
| RU2563623C2 (ru) | 2009-12-02 | 2015-09-20 | Апталис Фарма Лимитед | Микрокапсулы фексофенадина и содержащие их композиции |
| UY33173A (enExample) * | 2010-01-08 | 2011-07-29 | Eurand Inc | |
| US8426461B2 (en) | 2011-01-17 | 2013-04-23 | Takeda Pharmaceutical Company Limited | Orally dispersible tablet |
| PH12013501512A1 (en) | 2011-01-17 | 2013-09-16 | Takeda Pharmaceuticals Co | Orally dispersible tablet |
| JP6061516B2 (ja) * | 2011-07-14 | 2017-01-18 | 協和発酵キリン株式会社 | ドンペリドン口腔内崩壊錠 |
| JP6061924B2 (ja) | 2011-10-14 | 2017-01-18 | 武田薬品工業株式会社 | 口腔内分散性製剤 |
| JP6004882B2 (ja) * | 2012-10-15 | 2016-10-12 | 三菱商事フードテック株式会社 | 圧縮成形に用いるためのマンニトール賦形剤及びこれを含有する錠剤 |
| WO2015034678A2 (en) | 2013-09-06 | 2015-03-12 | Aptalis Pharmatech, Inc. | Corticosteroid containing orally disintegrating tablet compositions for eosinophilic esophagitis |
| TWI777515B (zh) | 2016-08-18 | 2022-09-11 | 美商愛戴爾製藥股份有限公司 | 治療嗜伊紅性食道炎之方法 |
| JP2022130075A (ja) * | 2021-02-25 | 2022-09-06 | フロイント産業株式会社 | 顆粒及びその製造方法、並びに錠剤 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2246013A1 (de) * | 1972-09-20 | 1974-03-28 | Boehringer Mannheim Gmbh | Verfahren zur herstellung von poroesen tabletten |
| IE45770B1 (en) | 1976-10-06 | 1982-11-17 | Wyeth John & Brother Ltd | Pharmaceutical dosage forms |
| JPS5614098A (en) * | 1979-07-13 | 1981-02-10 | Takeda Chem Ind Ltd | Externally lubricating tablet making machine |
| JPH0653658B2 (ja) * | 1984-12-17 | 1994-07-20 | 中外製薬株式会社 | 安定な錠剤の製造法 |
| JPH0774153B2 (ja) * | 1986-04-14 | 1995-08-09 | 三共株式会社 | ロキソプロフェン・ナトリウム含有製剤 |
| JPS63162619A (ja) * | 1986-12-25 | 1988-07-06 | Teisan Seiyaku Kk | 遅溶性顆粒及びそれを用いた持続性複合顆粒 |
| KR960011236B1 (ko) * | 1987-05-08 | 1996-08-21 | 스미스 클라인 앤드 프렌취 라보라토리스 리미티드 | 제약학적 조성물 및 고체 제형 |
| GB8710965D0 (en) * | 1987-05-08 | 1987-06-10 | Smith Kline French Lab | Pharmaceutical compositions |
| DE68903605T2 (de) * | 1988-05-04 | 1993-04-01 | Smith Kline French Lab | Kautablette. |
| GB8824392D0 (en) * | 1988-10-18 | 1988-11-23 | Ciba Geigy Ag | Dispersible formulation |
| HU200926B (en) | 1988-10-28 | 1990-09-28 | Egyt Gyogyszervegyeszeti Gyar | Pharmaceutical composition comprising piroxicam and lactose for use in making tablets or capsules |
| JP2781442B2 (ja) * | 1990-02-19 | 1998-07-30 | 旭化成工業株式会社 | 顆粒含有錠剤 |
| NZ246091A (en) | 1991-12-24 | 1995-08-28 | Yamanouchi Pharma Co Ltd | Intrabuccally disintegrating preparation containing an active ingredient, agar, and lactose and/or mannitol |
| EP0553777B1 (en) * | 1992-01-29 | 2002-04-24 | Takeda Chemical Industries, Ltd. | Fast dissolving tablet and its production |
| ATE210968T1 (de) | 1992-02-18 | 2002-01-15 | Nippon Shinyaku Co Ltd | Verfahren zur herstellung von schnelllöslicher tabletten und schnelllöslichen tablette beinhaltend xylitol |
| GB9224855D0 (en) * | 1992-11-27 | 1993-01-13 | Smithkline Beecham Plc | Pharmaceutical compositions |
| WO1997047287A1 (en) * | 1996-06-14 | 1997-12-18 | Kyowa Hakko Kogyo Co., Ltd. | Intraorally rapidly disintegrable tablet |
-
1997
- 1997-06-12 WO PCT/JP1997/002032 patent/WO1997047287A1/ja not_active Ceased
- 1997-06-12 US US09/147,374 patent/US20010014340A1/en not_active Abandoned
- 1997-06-12 JP JP50144898A patent/JP3797387B2/ja not_active Expired - Lifetime
- 1997-06-12 AU AU31895/97A patent/AU733032C/en not_active Expired
- 1997-06-12 AT AT05012137T patent/ATE477793T1/de not_active IP Right Cessation
- 1997-06-12 EP EP97927372A patent/EP0914818B1/en not_active Revoked
- 1997-06-12 EP EP05012137A patent/EP1598061B1/en not_active Expired - Lifetime
- 1997-06-12 EA EA199900028A patent/EA001898B1/ru not_active IP Right Cessation
- 1997-06-12 DE DE69739967T patent/DE69739967D1/de not_active Expired - Lifetime
- 1997-06-12 DK DK97927372T patent/DK0914818T3/da active
- 1997-06-12 AT AT97927372T patent/ATE297191T1/de active
- 1997-06-12 CN CNB971955204A patent/CN1154479C/zh not_active Expired - Lifetime
- 1997-06-12 PT PT97927372T patent/PT914818E/pt unknown
- 1997-06-12 ES ES97927372T patent/ES2243998T3/es not_active Expired - Lifetime
- 1997-06-12 CA CA002258159A patent/CA2258159C/en not_active Expired - Lifetime
- 1997-06-12 DE DE69733476T patent/DE69733476T2/de not_active Expired - Lifetime
-
2005
- 2005-09-16 JP JP2005269822A patent/JP2006077018A/ja active Pending
-
2009
- 2009-07-31 JP JP2009179843A patent/JP2009256372A/ja active Pending
-
2012
- 2012-04-23 JP JP2012097573A patent/JP5484514B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EA199900028A1 (ru) | 1999-06-24 |
| PT914818E (pt) | 2005-08-31 |
| ATE297191T1 (de) | 2005-06-15 |
| EP1598061A1 (en) | 2005-11-23 |
| EA001898B1 (ru) | 2001-10-22 |
| EP0914818A4 (en) | 2001-03-14 |
| AU733032C (en) | 2002-01-03 |
| AU733032B2 (en) | 2001-05-03 |
| JP3797387B2 (ja) | 2006-07-19 |
| EP0914818A1 (en) | 1999-05-12 |
| EP0914818B1 (en) | 2005-06-08 |
| CN1224349A (zh) | 1999-07-28 |
| CA2258159C (en) | 2006-03-21 |
| DK0914818T3 (da) | 2005-07-04 |
| DE69733476D1 (de) | 2005-07-14 |
| EP1598061B1 (en) | 2010-08-18 |
| JP5484514B2 (ja) | 2014-05-07 |
| DE69739967D1 (de) | 2010-09-30 |
| ATE477793T1 (de) | 2010-09-15 |
| JP2009256372A (ja) | 2009-11-05 |
| AU3189597A (en) | 1998-01-07 |
| WO1997047287A1 (en) | 1997-12-18 |
| DE69733476T2 (de) | 2006-03-23 |
| CA2258159A1 (en) | 1997-12-18 |
| JP2012167105A (ja) | 2012-09-06 |
| CN1154479C (zh) | 2004-06-23 |
| US20010014340A1 (en) | 2001-08-16 |
| JP2006077018A (ja) | 2006-03-23 |
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