DE69739967D1 - Eine im Mund schnell zerfallende Tablette - Google Patents
Eine im Mund schnell zerfallende TabletteInfo
- Publication number
- DE69739967D1 DE69739967D1 DE69739967T DE69739967T DE69739967D1 DE 69739967 D1 DE69739967 D1 DE 69739967D1 DE 69739967 T DE69739967 T DE 69739967T DE 69739967 T DE69739967 T DE 69739967T DE 69739967 D1 DE69739967 D1 DE 69739967D1
- Authority
- DE
- Germany
- Prior art keywords
- mouth
- disintegrating tablet
- rapidly disintegrating
- tablet
- saccaride
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000007884 disintegrant Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 150000005846 sugar alcohols Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/10—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15355396 | 1996-06-14 | ||
JP7110797 | 1997-03-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69739967D1 true DE69739967D1 (de) | 2010-09-30 |
Family
ID=26412238
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69733476T Expired - Lifetime DE69733476T2 (de) | 1996-06-14 | 1997-06-12 | Im munde schnellzerfallende tablette |
DE69739967T Expired - Lifetime DE69739967D1 (de) | 1996-06-14 | 1997-06-12 | Eine im Mund schnell zerfallende Tablette |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69733476T Expired - Lifetime DE69733476T2 (de) | 1996-06-14 | 1997-06-12 | Im munde schnellzerfallende tablette |
Country Status (13)
Country | Link |
---|---|
US (1) | US20010014340A1 (de) |
EP (2) | EP1598061B1 (de) |
JP (4) | JP3797387B2 (de) |
CN (1) | CN1154479C (de) |
AT (2) | ATE297191T1 (de) |
AU (1) | AU733032C (de) |
CA (1) | CA2258159C (de) |
DE (2) | DE69733476T2 (de) |
DK (1) | DK0914818T3 (de) |
EA (1) | EA001898B1 (de) |
ES (1) | ES2243998T3 (de) |
PT (1) | PT914818E (de) |
WO (1) | WO1997047287A1 (de) |
Families Citing this family (80)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20010014340A1 (en) * | 1996-06-14 | 2001-08-16 | Motohiro Ohta | Intrabuccally rapidly disintegrating tablet |
US8071128B2 (en) | 1996-06-14 | 2011-12-06 | Kyowa Hakko Kirin Co., Ltd. | Intrabuccally rapidly disintegrating tablet and a production method of the tablets |
US6024981A (en) * | 1997-04-16 | 2000-02-15 | Cima Labs Inc. | Rapidly dissolving robust dosage form |
EP1070496A4 (de) * | 1998-04-08 | 2004-07-21 | Kyowa Hakko Kogyo Kk | Verfahren zum herstellen von tabletten sowie tablette |
EP1070497A4 (de) * | 1998-04-10 | 2009-01-21 | Kyowa Hakko Kogyo Kk | Verfahren zum herstellen von tabletten sowie tablette |
DK2263660T3 (en) | 1998-05-18 | 2018-01-02 | Takeda Pharmaceuticals Co | Orally disintegrating tablets. |
EP1097722B1 (de) | 1998-07-15 | 2005-11-02 | Asahi Kasei Chemicals Corporation | Trägerhilfstoff |
CA2581111A1 (en) | 1998-07-28 | 2000-02-10 | Takeda Pharmaceutical Company Limited | Rapidly disintegrable solid preparation |
US6368625B1 (en) * | 1998-08-12 | 2002-04-09 | Cima Labs Inc. | Orally disintegrable tablet forming a viscous slurry |
JP2000178204A (ja) * | 1998-10-05 | 2000-06-27 | Eisai Co Ltd | ホスフォジエステラ―ゼ阻害剤を含有する口腔内速崩壊性錠剤 |
FR2790387B1 (fr) | 1999-03-01 | 2001-05-18 | Prographarm Laboratoires | Comprime orodispersible presentant une faible friabilite et son procede de preparation |
KR20010006835A (ko) * | 1999-03-25 | 2001-01-26 | 김선진 | 경구용 속붕해정 |
JP2001058944A (ja) * | 1999-06-18 | 2001-03-06 | Takeda Chem Ind Ltd | 速崩壊性固形製剤 |
CA2374760A1 (en) | 1999-06-18 | 2000-12-28 | Takeda Chemical Industries, Ltd. | Quickly disintegrating solid preparations |
CN100342846C (zh) * | 1999-10-13 | 2007-10-17 | 协和发酵工业株式会社 | 压缩成形品及其制备方法 |
WO2001026632A1 (fr) * | 1999-10-13 | 2001-04-19 | Kyowa Hakko Kogyo Co., Ltd. | Produit moule par compression et son procede de production |
DE60140657D1 (de) * | 2000-01-17 | 2010-01-14 | Eurand Pharmaceuticals Ltd | Brausetablette, brausetablette als badezusatz, waschmittelbrausetablette, brausetablette zur oralen |
AU4278301A (en) * | 2000-03-27 | 2001-10-08 | Kyowa Hakko Kogyo Co. Ltd. | Easy-to-take granule |
US6316029B1 (en) * | 2000-05-18 | 2001-11-13 | Flak Pharma International, Ltd. | Rapidly disintegrating solid oral dosage form |
JP4840549B2 (ja) * | 2000-11-20 | 2011-12-21 | トーアエイヨー株式会社 | 安定な血管拡張剤及びその製造方法 |
EP1226818A1 (de) * | 2001-01-26 | 2002-07-31 | Pfizer Products Inc. | Arzneiform mit verbesserten kohäsiven und kompressiven Eigenschaften |
CA2439873A1 (en) * | 2001-03-06 | 2002-09-12 | Kyowa Hakko Kogyo Co., Ltd. | Intraorally rapidly desintegrable tablet |
WO2002069934A1 (fr) * | 2001-03-06 | 2002-09-12 | Kyowa Hakko Kogyo Co., Ltd. | Préparations se délitant rapidement dans la bouche |
KR20030081489A (ko) * | 2001-03-06 | 2003-10-17 | 교와 핫꼬 고교 가부시끼가이샤 | 당알콜을 함유하는 분무건조 분말의 용도 |
US9358214B2 (en) | 2001-10-04 | 2016-06-07 | Adare Pharmaceuticals, Inc. | Timed, sustained release systems for propranolol |
CN100490798C (zh) * | 2001-11-13 | 2009-05-27 | 协和发酵麒麟株式会社 | 含有l-谷氨酰胺和薁磺酸钠的速崩片剂或口腔内崩解片剂及其制造方法 |
JP2003238393A (ja) * | 2002-02-15 | 2003-08-27 | Otsuka Pharmaceut Co Ltd | 施錠性が改善された錠剤及びその製造方法 |
KR20040098009A (ko) * | 2002-03-06 | 2004-11-18 | 교와 핫꼬 고교 가부시끼가이샤 | 구강 내 속붕괴성 정제 |
JPWO2003103713A1 (ja) * | 2002-06-10 | 2005-10-06 | 大日本製薬株式会社 | 速崩壊性錠剤及びその製造方法 |
JP4776229B2 (ja) * | 2002-07-16 | 2011-09-21 | エラン ファーマ インターナショナル,リミティド | 安定なナノ粒子活性物質の液体投与組成物 |
FR2845914B1 (fr) * | 2002-10-18 | 2005-11-04 | Schwarz Pharma Lab | Compose antiemetique a desagregation rapide |
DE10248652A1 (de) * | 2002-10-18 | 2004-04-29 | Solvay Interox Gmbh | Verfahren zur Herstellung von staubfreien Erdalkaliperoxiden |
FI20022007A0 (fi) | 2002-11-08 | 2002-11-08 | Juvantia Pharma Ltd Oy | Oromukosaalinen valmiste ja menetelmä sen valmistamiseksi |
GB0226076D0 (en) | 2002-11-08 | 2002-12-18 | Rp Scherer Technologies Inc | Improved formulations containing substituted imidazole derivatives |
US8367111B2 (en) | 2002-12-31 | 2013-02-05 | Aptalis Pharmatech, Inc. | Extended release dosage forms of propranolol hydrochloride |
JP5584509B2 (ja) * | 2003-02-28 | 2014-09-03 | 東和薬品株式会社 | 口腔内崩壊錠剤 |
JP4551627B2 (ja) * | 2003-02-28 | 2010-09-29 | 東和薬品株式会社 | 口腔内崩壊錠剤の製造方法 |
GB2404662A (en) * | 2003-08-01 | 2005-02-09 | Reckitt Benckiser | Cleaning composition |
US8545881B2 (en) | 2004-04-19 | 2013-10-01 | Eurand Pharmaceuticals, Ltd. | Orally disintegrating tablets and methods of manufacture |
GEP20094681B (en) | 2004-05-24 | 2009-05-10 | Nycomed Pharma As | Agglomeration of calcium-containing compound obtained by roller compaction |
US20080287456A1 (en) * | 2004-05-28 | 2008-11-20 | Imaginot Pty Ltd | Oral Therapeutic Compound Delivery System |
US8216610B2 (en) * | 2004-05-28 | 2012-07-10 | Imaginot Pty Ltd. | Oral paracetamol formulations |
TWI356713B (en) | 2004-06-01 | 2012-01-21 | Nycomed Pharma As | Chewable, suckable and swallowable tablet containi |
US8747895B2 (en) | 2004-09-13 | 2014-06-10 | Aptalis Pharmatech, Inc. | Orally disintegrating tablets of atomoxetine |
US9884014B2 (en) | 2004-10-12 | 2018-02-06 | Adare Pharmaceuticals, Inc. | Taste-masked pharmaceutical compositions |
US20060105039A1 (en) * | 2004-10-21 | 2006-05-18 | Jin-Wang Lai | Taste-masked pharmaceutical compositions with gastrosoluble pore-formers |
CN102631289B (zh) * | 2004-10-28 | 2016-05-04 | 潘特克股份公司 | 高孔隙度的速崩固体剂型及其包括生产粉末和冻干步骤的制备方法 |
US20060105038A1 (en) * | 2004-11-12 | 2006-05-18 | Eurand Pharmaceuticals Limited | Taste-masked pharmaceutical compositions prepared by coacervation |
US8808735B2 (en) | 2005-02-03 | 2014-08-19 | Takeda Nycomed As | Fast wet-massing method for the preparation of calcium-containing compositions |
WO2006082499A1 (en) | 2005-02-03 | 2006-08-10 | Nycomed Pharma As | Melt granulation of a composition containing a calcium-containing compound |
US9161918B2 (en) | 2005-05-02 | 2015-10-20 | Adare Pharmaceuticals, Inc. | Timed, pulsatile release systems |
US9757455B2 (en) * | 2005-11-28 | 2017-09-12 | Johnson & Johnson Consumer Inc. | Oral therapeutic compound delivery system |
AU2006322452B2 (en) | 2005-12-07 | 2012-07-12 | Takeda Nycomed As | Pre-compacted calcium-containing compositions |
UA95093C2 (uk) | 2005-12-07 | 2011-07-11 | Нікомед Фарма Ас | Спосіб одержання кальцієвмісної сполуки |
US20100221333A1 (en) * | 2005-12-21 | 2010-09-02 | Burkard Schlutermann | Pellets Comprising a Core With a Water-Soluble Carrier |
FR2898492B1 (fr) * | 2006-03-15 | 2008-06-06 | Pierre Fabre Medicament Sa | Comprimes orodispersibles de domperidone |
WO2007113856A2 (en) * | 2006-03-31 | 2007-10-11 | Rubicon Research Private Limited | Directly compressible composite for orally disintegrating tablets |
EP2101738A2 (de) * | 2006-12-21 | 2009-09-23 | Mallinckrodt Inc. | Zusammensetzung und verfahren zur herstellung von im mund zerfallenden tabletten |
JP5537927B2 (ja) * | 2007-03-13 | 2014-07-02 | 大日本住友製薬株式会社 | 口腔内崩壊錠 |
EP1977734A1 (de) * | 2007-04-03 | 2008-10-08 | Royal College of Surgeons in Ireland | Verfahren zur Herstellung schnelllöslicher Tabletten |
JP4980144B2 (ja) * | 2007-06-05 | 2012-07-18 | 日機装株式会社 | 固型化透析用剤の製造方法 |
WO2009004440A2 (en) * | 2007-06-29 | 2009-01-08 | Orchid Chemicals & Pharmaceuticals Limited | Quick dissolve compositions of memantine hydrochloride |
JP5537943B2 (ja) * | 2007-09-27 | 2014-07-02 | 田辺三菱製薬株式会社 | 速崩壊性固形製剤 |
US9314454B2 (en) | 2007-12-28 | 2016-04-19 | Sawai Pharmaceutical Co., Ltd. | Oral cavity disintegrating tablet and method of producing the same |
TR201802379T4 (tr) | 2008-10-24 | 2018-03-21 | Toray Industries | 4,5-epoksimorfinan türevi içeren stabil tablet. |
BRPI0921599B8 (pt) | 2008-11-17 | 2021-05-25 | Nycomed Pharma As | método para a preparação de um comprimido, e, comprimido de carbonato de cálcio |
KR101753411B1 (ko) | 2008-11-25 | 2017-07-03 | 미쓰비시 타나베 파마 코퍼레이션 | 구강 내 속붕괴성정 및 그의 제조 방법 |
TR200903014A1 (tr) * | 2009-04-17 | 2010-11-22 | Sanovel İlaç San. Ve Ti̇c. A.Ş. | Oral yolla dağılan dimebolin bileşimleri. |
UA118087C2 (uk) | 2009-10-01 | 2018-11-26 | Адер Фармасьютікалз, Інк. | Композиція кортикостероїду, застосована перорально |
KR20120101437A (ko) | 2009-11-09 | 2012-09-13 | 가부시키가이샤 니콘 | 노광 장치, 노광 방법, 노광 장치의 메인터넌스 방법, 노광 장치의 조정 방법, 및 디바이스 제조 방법 |
AU2010324835B2 (en) | 2009-11-30 | 2015-06-18 | Adare Pharmaceuticals, Inc. | Compressible-coated pharmaceutical compositions and tablets and methods of manufacture |
CN102958515A (zh) | 2009-12-02 | 2013-03-06 | 阿普塔利斯制药有限公司 | 非索非那定微胶囊及含有非索非那定微胶囊的组合物 |
WO2011085181A1 (en) * | 2010-01-08 | 2011-07-14 | Eurand, Inc. | Taste masked topiramate composition and an orally disintegrating tablet comprising the same |
US8426461B2 (en) | 2011-01-17 | 2013-04-23 | Takeda Pharmaceutical Company Limited | Orally dispersible tablet |
CA2824430A1 (en) | 2011-01-17 | 2012-07-26 | Takeda Pharmaceutical Company Limited | Orally dispersible tablet |
JP6061516B2 (ja) * | 2011-07-14 | 2017-01-18 | 協和発酵キリン株式会社 | ドンペリドン口腔内崩壊錠 |
JP6061924B2 (ja) | 2011-10-14 | 2017-01-18 | 武田薬品工業株式会社 | 口腔内分散性製剤 |
JP6004882B2 (ja) * | 2012-10-15 | 2016-10-12 | 三菱商事フードテック株式会社 | 圧縮成形に用いるためのマンニトール賦形剤及びこれを含有する錠剤 |
WO2015034678A2 (en) | 2013-09-06 | 2015-03-12 | Aptalis Pharmatech, Inc. | Corticosteroid containing orally disintegrating tablet compositions for eosinophilic esophagitis |
TWI777515B (zh) | 2016-08-18 | 2022-09-11 | 美商愛戴爾製藥股份有限公司 | 治療嗜伊紅性食道炎之方法 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2246013A1 (de) * | 1972-09-20 | 1974-03-28 | Boehringer Mannheim Gmbh | Verfahren zur herstellung von poroesen tabletten |
IE45770B1 (en) | 1976-10-06 | 1982-11-17 | Wyeth John & Brother Ltd | Pharmaceutical dosage forms |
JPS5614098A (en) * | 1979-07-13 | 1981-02-10 | Takeda Chem Ind Ltd | Externally lubricating tablet making machine |
JPH0653658B2 (ja) | 1984-12-17 | 1994-07-20 | 中外製薬株式会社 | 安定な錠剤の製造法 |
JPH0774153B2 (ja) * | 1986-04-14 | 1995-08-09 | 三共株式会社 | ロキソプロフェン・ナトリウム含有製剤 |
JPS63162619A (ja) * | 1986-12-25 | 1988-07-06 | Teisan Seiyaku Kk | 遅溶性顆粒及びそれを用いた持続性複合顆粒 |
KR960011236B1 (ko) * | 1987-05-08 | 1996-08-21 | 스미스 클라인 앤드 프렌취 라보라토리스 리미티드 | 제약학적 조성물 및 고체 제형 |
GB8710965D0 (en) * | 1987-05-08 | 1987-06-10 | Smith Kline French Lab | Pharmaceutical compositions |
EP0349103B1 (de) * | 1988-05-04 | 1992-11-25 | Smith Kline & French Laboratories Limited | Kautablette |
GB8824392D0 (en) * | 1988-10-18 | 1988-11-23 | Ciba Geigy Ag | Dispersible formulation |
HU200926B (en) * | 1988-10-28 | 1990-09-28 | Egyt Gyogyszervegyeszeti Gyar | Pharmaceutical composition comprising piroxicam and lactose for use in making tablets or capsules |
JP2781442B2 (ja) * | 1990-02-19 | 1998-07-30 | 旭化成工業株式会社 | 顆粒含有錠剤 |
US5466464A (en) | 1991-12-24 | 1995-11-14 | Yamanouchi Pharmaceutical Co., Ltd. | Intrabuccally disintegrating preparation and production thereof |
DE69331839T2 (de) | 1992-01-29 | 2002-12-12 | Takeda Chemical Industries Ltd | Schnellösliche Tablette und ihre Herstellung |
ATE210968T1 (de) | 1992-02-18 | 2002-01-15 | Nippon Shinyaku Co Ltd | Verfahren zur herstellung von schnelllöslicher tabletten und schnelllöslichen tablette beinhaltend xylitol |
GB9224855D0 (en) * | 1992-11-27 | 1993-01-13 | Smithkline Beecham Plc | Pharmaceutical compositions |
US20010014340A1 (en) * | 1996-06-14 | 2001-08-16 | Motohiro Ohta | Intrabuccally rapidly disintegrating tablet |
-
1997
- 1997-06-12 US US09/147,374 patent/US20010014340A1/en not_active Abandoned
- 1997-06-12 AU AU31895/97A patent/AU733032C/en not_active Expired
- 1997-06-12 JP JP50144898A patent/JP3797387B2/ja not_active Expired - Lifetime
- 1997-06-12 EP EP05012137A patent/EP1598061B1/de not_active Expired - Lifetime
- 1997-06-12 AT AT97927372T patent/ATE297191T1/de active
- 1997-06-12 EA EA199900028A patent/EA001898B1/ru not_active IP Right Cessation
- 1997-06-12 AT AT05012137T patent/ATE477793T1/de not_active IP Right Cessation
- 1997-06-12 PT PT97927372T patent/PT914818E/pt unknown
- 1997-06-12 DK DK97927372T patent/DK0914818T3/da active
- 1997-06-12 EP EP97927372A patent/EP0914818B1/de not_active Revoked
- 1997-06-12 ES ES97927372T patent/ES2243998T3/es not_active Expired - Lifetime
- 1997-06-12 DE DE69733476T patent/DE69733476T2/de not_active Expired - Lifetime
- 1997-06-12 DE DE69739967T patent/DE69739967D1/de not_active Expired - Lifetime
- 1997-06-12 CA CA002258159A patent/CA2258159C/en not_active Expired - Lifetime
- 1997-06-12 WO PCT/JP1997/002032 patent/WO1997047287A1/ja active IP Right Grant
- 1997-06-12 CN CNB971955204A patent/CN1154479C/zh not_active Expired - Lifetime
-
2005
- 2005-09-16 JP JP2005269822A patent/JP2006077018A/ja active Pending
-
2009
- 2009-07-31 JP JP2009179843A patent/JP2009256372A/ja active Pending
-
2012
- 2012-04-23 JP JP2012097573A patent/JP5484514B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
WO1997047287A1 (fr) | 1997-12-18 |
JP3797387B2 (ja) | 2006-07-19 |
JP2012167105A (ja) | 2012-09-06 |
CA2258159C (en) | 2006-03-21 |
AU733032C (en) | 2002-01-03 |
US20010014340A1 (en) | 2001-08-16 |
CN1224349A (zh) | 1999-07-28 |
EP0914818A4 (de) | 2001-03-14 |
CA2258159A1 (en) | 1997-12-18 |
DE69733476T2 (de) | 2006-03-23 |
DE69733476D1 (de) | 2005-07-14 |
ATE477793T1 (de) | 2010-09-15 |
JP5484514B2 (ja) | 2014-05-07 |
EP0914818A1 (de) | 1999-05-12 |
EP1598061B1 (de) | 2010-08-18 |
EP1598061A1 (de) | 2005-11-23 |
EA199900028A1 (ru) | 1999-06-24 |
DK0914818T3 (da) | 2005-07-04 |
JP2006077018A (ja) | 2006-03-23 |
ES2243998T3 (es) | 2005-12-01 |
CN1154479C (zh) | 2004-06-23 |
EP0914818B1 (de) | 2005-06-08 |
ATE297191T1 (de) | 2005-06-15 |
AU733032B2 (en) | 2001-05-03 |
EA001898B1 (ru) | 2001-10-22 |
PT914818E (pt) | 2005-08-31 |
JP2009256372A (ja) | 2009-11-05 |
AU3189597A (en) | 1998-01-07 |
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