ES2239558T3 - Hemitartrato de zolpidem micronizado. - Google Patents
Hemitartrato de zolpidem micronizado. Download PDFInfo
- Publication number
- ES2239558T3 ES2239558T3 ES04010651T ES04010651T ES2239558T3 ES 2239558 T3 ES2239558 T3 ES 2239558T3 ES 04010651 T ES04010651 T ES 04010651T ES 04010651 T ES04010651 T ES 04010651T ES 2239558 T3 ES2239558 T3 ES 2239558T3
- Authority
- ES
- Spain
- Prior art keywords
- zolpidem hemitartrate
- zolpidem
- hemitartrate
- approximately
- particles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- VXRDAMSNTXUHFX-CEAXSRTFSA-N zolpidem tartrate Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O.N1=C2C=CC(C)=CN2C(CC(=O)N(C)C)=C1C1=CC=C(C)C=C1.N1=C2C=CC(C)=CN2C(CC(=O)N(C)C)=C1C1=CC=C(C)C=C1 VXRDAMSNTXUHFX-CEAXSRTFSA-N 0.000 title claims description 47
- 239000002245 particle Substances 0.000 claims abstract description 23
- ZAFYATHCZYHLPB-UHFFFAOYSA-N zolpidem Chemical compound N1=C2C=CC(C)=CN2C(CC(=O)N(C)C)=C1C1=CC=C(C)C=C1 ZAFYATHCZYHLPB-UHFFFAOYSA-N 0.000 claims abstract description 14
- 229960001475 zolpidem Drugs 0.000 claims abstract description 14
- 238000002441 X-ray diffraction Methods 0.000 claims abstract description 10
- 239000008194 pharmaceutical composition Substances 0.000 claims description 8
- 238000000034 method Methods 0.000 description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 15
- 239000000203 mixture Substances 0.000 description 9
- 239000000843 powder Substances 0.000 description 7
- 239000007787 solid Substances 0.000 description 7
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 239000003814 drug Substances 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Substances [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
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- 238000002076 thermal analysis method Methods 0.000 description 3
- VXRDAMSNTXUHFX-UHFFFAOYSA-N 2,3-dihydroxybutanedioic acid;n,n-dimethyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]acetamide Chemical compound OC(=O)C(O)C(O)C(O)=O.N1=C2C=CC(C)=CN2C(CC(=O)N(C)C)=C1C1=CC=C(C)C=C1.N1=C2C=CC(C)=CN2C(CC(=O)N(C)C)=C1C1=CC=C(C)C=C1 VXRDAMSNTXUHFX-UHFFFAOYSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
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- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-UHFFFAOYSA-N 2-(hydroxymethyl)-6-[4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxane-3,4,5-triol Chemical compound OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O GUBGYTABKSRVRQ-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
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- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
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- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- 229920000881 Modified starch Polymers 0.000 description 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
- 229940121985 Non-benzodiazepine hypnotic Drugs 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
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- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 230000001773 anti-convulsant effect Effects 0.000 description 1
- 239000002249 anxiolytic agent Substances 0.000 description 1
- 230000000949 anxiolytic effect Effects 0.000 description 1
- 229940049706 benzodiazepine Drugs 0.000 description 1
- 125000003310 benzodiazepinyl group Chemical class N1N=C(C=CC2=C1C=CC=C2)* 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 description 1
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
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- YHAIUSTWZPMYGG-UHFFFAOYSA-L disodium;2,2-dioctyl-3-sulfobutanedioate Chemical compound [Na+].[Na+].CCCCCCCCC(C([O-])=O)(C(C([O-])=O)S(O)(=O)=O)CCCCCCCC YHAIUSTWZPMYGG-UHFFFAOYSA-L 0.000 description 1
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- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Amplifiers (AREA)
- Supply Devices, Intensifiers, Converters, And Telemotors (AREA)
- Suspension Of Electric Lines Or Cables (AREA)
- Other Liquid Machine Or Engine Such As Wave Power Use (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19929800P | 2000-04-24 | 2000-04-24 | |
| US199298P | 2000-04-24 | ||
| US20602500P | 2000-05-22 | 2000-05-22 | |
| US206025P | 2000-05-22 | ||
| US22536400P | 2000-08-14 | 2000-08-14 | |
| US225364P | 2000-08-14 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2239558T1 ES2239558T1 (es) | 2005-10-01 |
| ES2239558T3 true ES2239558T3 (es) | 2007-04-01 |
Family
ID=27394001
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES04010651T Expired - Lifetime ES2239558T3 (es) | 2000-04-24 | 2001-04-24 | Hemitartrato de zolpidem micronizado. |
| ES05001922T Expired - Lifetime ES2277301T3 (es) | 2000-04-24 | 2001-04-24 | Solvato de hemitartrato de zolpidem. |
| ES04010435T Expired - Lifetime ES2238941T3 (es) | 2000-04-24 | 2001-04-24 | Solvato de hemitartrato de zolpidem. |
| ES01930705T Expired - Lifetime ES2248321T3 (es) | 2000-04-24 | 2001-04-24 | Hemitartrato de zolpidem. |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES05001922T Expired - Lifetime ES2277301T3 (es) | 2000-04-24 | 2001-04-24 | Solvato de hemitartrato de zolpidem. |
| ES04010435T Expired - Lifetime ES2238941T3 (es) | 2000-04-24 | 2001-04-24 | Solvato de hemitartrato de zolpidem. |
| ES01930705T Expired - Lifetime ES2248321T3 (es) | 2000-04-24 | 2001-04-24 | Hemitartrato de zolpidem. |
Country Status (21)
| Country | Link |
|---|---|
| US (8) | US20020077332A1 (enExample) |
| EP (1) | EP1292304B1 (enExample) |
| JP (3) | JP2003531173A (enExample) |
| KR (1) | KR20030069796A (enExample) |
| AT (4) | ATE338550T1 (enExample) |
| AU (2) | AU2001257213B2 (enExample) |
| CA (1) | CA2406982A1 (enExample) |
| CZ (1) | CZ20023775A3 (enExample) |
| DE (7) | DE60114617T2 (enExample) |
| DK (1) | DK1292304T3 (enExample) |
| ES (4) | ES2239558T3 (enExample) |
| HR (1) | HRP20020909A2 (enExample) |
| HU (1) | HUP0300701A2 (enExample) |
| IL (1) | IL152411A0 (enExample) |
| NZ (1) | NZ522015A (enExample) |
| PL (1) | PL358548A1 (enExample) |
| PT (3) | PT1473036E (enExample) |
| SE (1) | SE5292304T3 (enExample) |
| SK (1) | SK16372002A3 (enExample) |
| WO (1) | WO2001080857A1 (enExample) |
| YU (1) | YU79402A (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6921839B2 (en) | 2000-08-29 | 2005-07-26 | Ranbaxy Laboratories Limited | Synthesis of N,N-dimethyl-3-(4-methyl) benzoyl propionamide a key intermediate of zolpidem |
| US6869970B2 (en) | 2002-02-04 | 2005-03-22 | Novartis Ag | Crystalline salt forms of valsartan |
| EP1575952B1 (en) | 2002-12-18 | 2009-02-18 | Mallinckrodt Inc. | Synthesis of heteroaryl acetamides |
| WO2004087703A1 (en) * | 2003-03-12 | 2004-10-14 | Sun Pharmaceutical Industries Limited | Process for the preparation of n,n,6-trimethyl-2-(4-methylphenyl)-imidazo[1,2-a]pyridine-3-acetamide |
| WO2005010002A1 (en) * | 2003-07-31 | 2005-02-03 | Ranbaxy Laboratories Limited | Process for the synthesis of zolpidem |
| KR20070030178A (ko) * | 2004-02-17 | 2007-03-15 | 트랜스오랄 파마슈티칼스, 인코포레이티드 | 구강 점막을 가로지르는 수면제 전달용 조성물 및 이의사용 방법 |
| WO2006008636A2 (en) * | 2004-07-16 | 2006-01-26 | Ranbaxy Laboratories Limited | Processes for the preparation of zolpidem and its hemitartrate |
| US20070123562A1 (en) * | 2005-05-25 | 2007-05-31 | Transoral Pharmaceuticals, Inc. | Compositions and methods for treating middle-of-the-night insomnia |
| US20070287740A1 (en) * | 2005-05-25 | 2007-12-13 | Transcept Pharmaceuticals, Inc. | Compositions and methods of treating middle-of-the night insomnia |
| US20070225322A1 (en) * | 2005-05-25 | 2007-09-27 | Transoral Pharmaceuticals, Inc. | Compositions and methods for treating middle-of-the night insomnia |
| AU2006283702A1 (en) * | 2005-08-19 | 2007-03-01 | Aventis Pharmaceuticals Inc. | Comination of a hypnotic agent and R(+)-alpha-(2,3-dimethoxy-phenyl)-1-(2-(4-fluorophenl)ethyl)-4-piperidinemethanol and therapeutic application thereof |
| BRPI0614943A2 (pt) * | 2005-08-19 | 2011-04-26 | Aventis Pharma Inc | combinação de um agente hipnótico e composto de bisarila e heteroarila substituìdo e aplicação terapêutica da mesma |
| CA2624340A1 (en) * | 2005-10-03 | 2007-04-12 | Mallinckrodt Inc. | Process for preparing zolpidem hemitartrate and tartrate polymorphs |
| CA2626242A1 (en) * | 2005-10-17 | 2007-04-26 | Mallinckrodt Inc. | Polymorph transformation of zolpidem in tablet matrix |
| US20070098788A1 (en) * | 2005-10-28 | 2007-05-03 | Gore Subhash P | Non-benzodiazepine hypnotic compositions |
| MX2008012655A (es) | 2006-03-31 | 2008-12-16 | Janssen Pharmaceutica Nv | Benzoimidazol-2-il-pirimidinas y -pirazinas como moduladores de receptor de histamina h4. |
| WO2008067549A2 (en) * | 2006-11-30 | 2008-06-05 | Transcept Pharmaceuticals, Inc. | Stabilized zolpidem pharmaceutical compositions |
| US20080145425A1 (en) * | 2006-12-15 | 2008-06-19 | Pliva Research & Development Limited | Pharmaceutical composition of zolpidem |
| US9371311B2 (en) | 2008-06-30 | 2016-06-21 | Janssen Pharmaceutica Nv | Benzoimidazol-2-yl pyrimidine derivatives |
| SG192446A1 (en) * | 2008-06-30 | 2013-08-30 | Janssen Pharmaceutica Nv | Process for the preparation of benzoimidazol-2-yl pyrimidine derivatives |
| MY160542A (en) | 2009-11-27 | 2017-03-15 | Genzyme Corp | An amorphous and a crystalline form of genz 112638 hemitartrate as inhibitor of glucosylceramide synthase |
| WO2011115069A1 (ja) * | 2010-03-19 | 2011-09-22 | 第一三共株式会社 | 結晶の網羅的探索 |
| HUE047681T2 (hu) * | 2013-03-06 | 2020-05-28 | Janssen Pharmaceutica Nv | A hisztamin H4 receptor benzimidazol-2-il-pirimidin modulátorai |
| CN116283957A (zh) * | 2021-12-03 | 2023-06-23 | 山东新时代药业有限公司 | 唑吡坦水合物及其制备方法 |
| CN116283958A (zh) * | 2021-12-03 | 2023-06-23 | 山东新时代药业有限公司 | 唑吡坦共晶体及其制备方法 |
| CN117907368A (zh) * | 2024-01-27 | 2024-04-19 | 鲁南贝特制药有限公司 | 一种酒石酸唑吡坦药用晶型d中晶型a、e的定量测定方法 |
| CN118750459B (zh) * | 2024-07-22 | 2025-04-01 | 常州市武进中医医院 | 一种酒石酸唑吡坦片及其制备方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4151273A (en) * | 1974-10-31 | 1979-04-24 | The Regents Of The University Of California | Increasing the absorption rate of insoluble drugs |
| FR2408345A1 (fr) * | 1976-11-30 | 1979-06-08 | Besins Jean Louis | Nouvelle composition a action anti-conceptionnelle |
| US4302446A (en) * | 1979-10-02 | 1981-11-24 | Bristol-Myers Company | Pharmaceutical compositions |
| IT1130924B (it) * | 1980-03-06 | 1986-06-18 | Secifarma Spa | Procedimento per la preparazione di spironolattone micronizzato |
| DE3018940A1 (de) * | 1980-05-17 | 1981-11-26 | Hoechst Ag, 6000 Frankfurt | Verwendung eines vinylchlorid-pfropf-copolymerisates in der plastisolverarbeitung |
| FR2492382A1 (fr) * | 1980-10-22 | 1982-04-23 | Synthelabo | Derives d'imidazo (1,2-a) pyridine, leur preparation et leur application en therapeutique |
| FR2525601A1 (fr) * | 1982-04-21 | 1983-10-28 | Synthelabo | Derives d'imidazo(1,2-a)pyridines, leur preparation et leur application en therapeutique |
| US4675323A (en) * | 1985-08-06 | 1987-06-23 | Synthelabo | Imidazo(1,2-a)quinoline derivatives useful as anxiolytic agents |
| SE457326B (sv) * | 1986-02-14 | 1988-12-19 | Lejus Medical Ab | Foerfarande foer framstaellning av en snabbt soenderfallande kaerna innehaallande bl a mikrokristallin cellulosa |
| FR2600650B1 (fr) * | 1986-06-27 | 1988-09-09 | Synthelabo | Procede de preparation d'imidazopyridines et composes intermediaires |
| FR2606410B1 (fr) * | 1986-11-07 | 1989-02-24 | Synthelabo | Imidazopyridines, leur preparation et leur application en therapeutique |
| DE3865073D1 (de) * | 1987-03-27 | 1991-10-31 | Synthelabo | Imidazopyridinderivate, ihre herstellung und therapeutische verwendung. |
| US5271944A (en) * | 1991-04-05 | 1993-12-21 | Biofor, Ltd. | Pharmacologically enhanced formulations |
| IT1276522B1 (it) * | 1995-04-07 | 1997-10-31 | Elena Benincasa | Uso dello zolpidem per il trattamento terapeudico di sindromi neuropsichiatriche associate a disfunsione e di circuiti neurali dei |
| SI1038875T1 (en) * | 1999-03-25 | 2003-12-31 | Synthon B.V. | Imidazopyridine derivatives and process for making them |
| AU3464200A (en) * | 1999-03-25 | 2000-10-16 | Synthon B.V. | Zolpidem salts |
| WO2001042239A1 (en) * | 1999-12-13 | 2001-06-14 | Sumika Fine Chemicals Co., Ltd. | Process for the preparation of a pyridinemethanol compound |
-
2001
- 2001-04-24 AT AT04010651T patent/ATE338550T1/de not_active IP Right Cessation
- 2001-04-24 ES ES04010651T patent/ES2239558T3/es not_active Expired - Lifetime
- 2001-04-24 AU AU2001257213A patent/AU2001257213B2/en not_active Ceased
- 2001-04-24 DE DE60114617T patent/DE60114617T2/de not_active Expired - Fee Related
- 2001-04-24 JP JP2001577956A patent/JP2003531173A/ja not_active Withdrawn
- 2001-04-24 DE DE60122944T patent/DE60122944T2/de not_active Expired - Fee Related
- 2001-04-24 DE DE04010651T patent/DE04010651T1/de active Pending
- 2001-04-24 HU HU0300701A patent/HUP0300701A2/hu unknown
- 2001-04-24 HR HR20020909A patent/HRP20020909A2/hr not_active Application Discontinuation
- 2001-04-24 ES ES05001922T patent/ES2277301T3/es not_active Expired - Lifetime
- 2001-04-24 NZ NZ522015A patent/NZ522015A/en unknown
- 2001-04-24 SK SK1637-2002A patent/SK16372002A3/sk not_active Application Discontinuation
- 2001-04-24 EP EP01930705A patent/EP1292304B1/en not_active Revoked
- 2001-04-24 WO PCT/US2001/013175 patent/WO2001080857A1/en not_active Ceased
- 2001-04-24 PL PL01358548A patent/PL358548A1/xx not_active Application Discontinuation
- 2001-04-24 AU AU5721301A patent/AU5721301A/xx active Pending
- 2001-04-24 PT PT04010435T patent/PT1473036E/pt unknown
- 2001-04-24 AT AT01930705T patent/ATE308324T1/de not_active IP Right Cessation
- 2001-04-24 DE DE04010435T patent/DE04010435T1/de active Pending
- 2001-04-24 DK DK01930705T patent/DK1292304T3/da active
- 2001-04-24 ES ES04010435T patent/ES2238941T3/es not_active Expired - Lifetime
- 2001-04-24 DE DE60122216T patent/DE60122216T2/de not_active Expired - Fee Related
- 2001-04-24 CA CA002406982A patent/CA2406982A1/en not_active Abandoned
- 2001-04-24 AT AT04010435T patent/ATE335481T1/de not_active IP Right Cessation
- 2001-04-24 ES ES01930705T patent/ES2248321T3/es not_active Expired - Lifetime
- 2001-04-24 SE SE01930705T patent/SE5292304T3/xx unknown
- 2001-04-24 US US09/841,025 patent/US20020077332A1/en not_active Abandoned
- 2001-04-24 PT PT04010651T patent/PT1475093E/pt unknown
- 2001-04-24 KR KR1020027014220A patent/KR20030069796A/ko not_active Ceased
- 2001-04-24 DE DE20122435U patent/DE20122435U1/de not_active Expired - Lifetime
- 2001-04-24 YU YU79402A patent/YU79402A/sh unknown
- 2001-04-24 CZ CZ20023775A patent/CZ20023775A3/cs unknown
- 2001-04-24 DE DE60125429T patent/DE60125429T2/de not_active Expired - Fee Related
- 2001-04-24 AT AT05001922T patent/ATE348613T1/de not_active IP Right Cessation
- 2001-04-24 IL IL15241101A patent/IL152411A0/xx unknown
- 2001-04-24 PT PT05001922T patent/PT1541146E/pt unknown
-
2004
- 2004-05-24 US US10/853,345 patent/US20040220213A1/en not_active Abandoned
- 2004-05-24 US US10/853,338 patent/US20040220212A1/en not_active Abandoned
- 2004-05-24 US US10/853,033 patent/US20040220211A1/en not_active Abandoned
- 2004-05-24 US US10/852,912 patent/US20040214858A1/en not_active Abandoned
- 2004-05-24 US US10/853,640 patent/US20040214859A1/en not_active Abandoned
- 2004-05-24 US US10/853,031 patent/US20040220210A1/en not_active Abandoned
-
2006
- 2006-02-09 JP JP2006033099A patent/JP2006137778A/ja active Pending
- 2006-06-27 JP JP2006177160A patent/JP2006249105A/ja active Pending
- 2006-10-25 US US11/588,122 patent/US20070037843A1/en not_active Abandoned
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