DE60122944D1 - Mikronisierter zolpidem Hemitartrat - Google Patents

Mikronisierter zolpidem Hemitartrat

Info

Publication number
DE60122944D1
DE60122944D1 DE60122944T DE60122944T DE60122944D1 DE 60122944 D1 DE60122944 D1 DE 60122944D1 DE 60122944 T DE60122944 T DE 60122944T DE 60122944 T DE60122944 T DE 60122944T DE 60122944 D1 DE60122944 D1 DE 60122944D1
Authority
DE
Germany
Prior art keywords
zolpidem hemitartrate
micronized
micronized zolpidem
hemitartrate
polymorphs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60122944T
Other languages
English (en)
Other versions
DE60122944T2 (de
Inventor
Judith Aronhime
David Leonov
Erzebet Meszaros-Sos
Szaboles Salyi
Shlomo Zavurov
Csaba Szabo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Industries Ltd
Original Assignee
Teva Pharmaceutical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27394001&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60122944(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Teva Pharmaceutical Industries Ltd filed Critical Teva Pharmaceutical Industries Ltd
Application granted granted Critical
Publication of DE60122944D1 publication Critical patent/DE60122944D1/de
Publication of DE60122944T2 publication Critical patent/DE60122944T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Amplifiers (AREA)
  • Supply Devices, Intensifiers, Converters, And Telemotors (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Suspension Of Electric Lines Or Cables (AREA)
  • Other Liquid Machine Or Engine Such As Wave Power Use (AREA)
DE60122944T 2000-04-24 2001-04-24 Mikronisiertes Zolpidem-Hemitartrat Expired - Fee Related DE60122944T2 (de)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US19929800P 2000-04-24 2000-04-24
US199298P 2000-04-24
US20602500P 2000-05-22 2000-05-22
US206025P 2000-05-22
US22536400P 2000-08-14 2000-08-14
US225364P 2000-08-14

Publications (2)

Publication Number Publication Date
DE60122944D1 true DE60122944D1 (de) 2006-10-19
DE60122944T2 DE60122944T2 (de) 2007-04-12

Family

ID=27394001

Family Applications (7)

Application Number Title Priority Date Filing Date
DE04010435T Pending DE04010435T1 (de) 2000-04-24 2001-04-24 Zolpidem Hemitartrat Solvat
DE60125429T Expired - Fee Related DE60125429T2 (de) 2000-04-24 2001-04-24 Zolpidem hemitartrat solvat
DE60122944T Expired - Fee Related DE60122944T2 (de) 2000-04-24 2001-04-24 Mikronisiertes Zolpidem-Hemitartrat
DE20122435U Expired - Lifetime DE20122435U1 (de) 2000-04-24 2001-04-24 Mikronisiertes Zolpidem-Hemitartrat
DE60114617T Expired - Fee Related DE60114617T2 (de) 2000-04-24 2001-04-24 Zolpidem hemitartrat
DE04010651T Pending DE04010651T1 (de) 2000-04-24 2001-04-24 Mikronisiertes Zolpidem-Hemitartrat
DE60122216T Expired - Fee Related DE60122216T2 (de) 2000-04-24 2001-04-24 Zolpidem Hemitartrat Solvat

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DE04010435T Pending DE04010435T1 (de) 2000-04-24 2001-04-24 Zolpidem Hemitartrat Solvat
DE60125429T Expired - Fee Related DE60125429T2 (de) 2000-04-24 2001-04-24 Zolpidem hemitartrat solvat

Family Applications After (4)

Application Number Title Priority Date Filing Date
DE20122435U Expired - Lifetime DE20122435U1 (de) 2000-04-24 2001-04-24 Mikronisiertes Zolpidem-Hemitartrat
DE60114617T Expired - Fee Related DE60114617T2 (de) 2000-04-24 2001-04-24 Zolpidem hemitartrat
DE04010651T Pending DE04010651T1 (de) 2000-04-24 2001-04-24 Mikronisiertes Zolpidem-Hemitartrat
DE60122216T Expired - Fee Related DE60122216T2 (de) 2000-04-24 2001-04-24 Zolpidem Hemitartrat Solvat

Country Status (21)

Country Link
US (8) US20020077332A1 (de)
EP (1) EP1292304B1 (de)
JP (3) JP2003531173A (de)
KR (1) KR20030069796A (de)
AT (4) ATE308324T1 (de)
AU (2) AU2001257213B2 (de)
CA (1) CA2406982A1 (de)
CZ (1) CZ20023775A3 (de)
DE (7) DE04010435T1 (de)
DK (1) DK1292304T3 (de)
ES (4) ES2238941T3 (de)
HR (1) HRP20020909A2 (de)
HU (1) HUP0300701A2 (de)
IL (1) IL152411A0 (de)
NZ (1) NZ522015A (de)
PL (1) PL358548A1 (de)
PT (3) PT1473036E (de)
SE (1) SE5292304T3 (de)
SK (1) SK16372002A3 (de)
WO (1) WO2001080857A1 (de)
YU (1) YU79402A (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001284322A1 (en) 2000-08-29 2002-03-13 Ranbaxy Laboratories Limited Synthesis of n,n-dimethyl-3-(4-methyl) benzoyl propionamide, a key intermediate of zolpidem
US6869970B2 (en) 2002-02-04 2005-03-22 Novartis Ag Crystalline salt forms of valsartan
WO2004058758A1 (en) 2002-12-18 2004-07-15 Mallinckrodt Inc. Synthesis of heteroaryl acetamides
WO2004087703A1 (en) * 2003-03-12 2004-10-14 Sun Pharmaceutical Industries Limited Process for the preparation of n,n,6-trimethyl-2-(4-methylphenyl)-imidazo[1,2-a]pyridine-3-acetamide
WO2005010002A1 (en) * 2003-07-31 2005-02-03 Ranbaxy Laboratories Limited Process for the synthesis of zolpidem
JP5179757B2 (ja) * 2004-02-17 2013-04-10 トランセプト ファーマシューティカルズ， インコーポレイティド 口腔粘膜を介して催眠剤をデリバリーするための組成物及びその使用方法
US20080262025A1 (en) * 2004-07-16 2008-10-23 Yatendra Kumar Processes for the Preparation of Zolpidem and its Hemitartrate
US20070225322A1 (en) * 2005-05-25 2007-09-27 Transoral Pharmaceuticals, Inc. Compositions and methods for treating middle-of-the night insomnia
KR20130042041A (ko) * 2005-05-25 2013-04-25 트랜스셉트 파마슈티칼스, 인코포레이티드 야반 불면증을 치료하기 위한 고체 조성물 및 방법
US20070287740A1 (en) * 2005-05-25 2007-12-13 Transcept Pharmaceuticals, Inc. Compositions and methods of treating middle-of-the night insomnia
ES2336142T3 (es) * 2005-08-19 2010-04-08 Aventis Pharmaceuticals Inc. Combinacion de un agente hipnotico y un compuesto sustituido, con bis arilo y heteroarilo y aplicacion terapeutica del mismo.
BRPI0615357A2 (pt) * 2005-08-19 2011-05-17 Aventis Pharma Inc combinação de um agente hipnótico e r (+)-alfa-(2,3-dimetóxi-fenil)-1-[2-(4-fluorofenil)etil]-4-pi peridinometanol e aplicação terapêutica do mesmo
AU2006297475A1 (en) * 2005-10-03 2007-04-12 Mallinckrodt Inc. Process for preparing zolpidem hemitartrate and tartrate polymorphs
WO2007047047A2 (en) * 2005-10-17 2007-04-26 Mallinckrodt Inc. Polymorph transformation of zolpidem in tablet matrix
US20070098788A1 (en) * 2005-10-28 2007-05-03 Gore Subhash P Non-benzodiazepine hypnotic compositions
KR101054325B1 (ko) 2006-03-31 2011-08-04 얀센 파마슈티카 엔.브이. 히스타민 ｈ４ 수용체 조절제로서의 벤조이미다졸―２―일 피리미딘 및 피라진
US20080132535A1 (en) * 2006-11-30 2008-06-05 Transcept Pharmaceuticals, Inc. Stabilized Zolpidem Pharmaceutical Compositions
US20080145425A1 (en) * 2006-12-15 2008-06-19 Pliva Research & Development Limited Pharmaceutical composition of zolpidem
AR072397A1 (es) * 2008-06-30 2010-08-25 Janssen Pharmaceutica Nv Proceso para la preparacion de derivados de benzoimidazol-2-ilpirimidina
US9371311B2 (en) 2008-06-30 2016-06-21 Janssen Pharmaceutica Nv Benzoimidazol-2-yl pyrimidine derivatives
PE20121337A1 (es) 2009-11-27 2012-10-12 Genzyme Corp Forma cristalina y amorfa de hemitartrato de genz 112638 como inhibidor de glucosilceramida sintasa
WO2011115069A1 (ja) * 2010-03-19 2011-09-22 第一三共株式会社 結晶の網羅的探索
SG11201507117XA (en) 2013-03-06 2015-10-29 Janssen Pharmaceutica Nv Benzoimidazol-2-yl pyrimidine modulators of the histamine h4 receptor

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4151273A (en) * 1974-10-31 1979-04-24 The Regents Of The University Of California Increasing the absorption rate of insoluble drugs
FR2408345A1 (fr) * 1976-11-30 1979-06-08 Besins Jean Louis Nouvelle composition a action anti-conceptionnelle
US4302446A (en) * 1979-10-02 1981-11-24 Bristol-Myers Company Pharmaceutical compositions
IT1130924B (it) * 1980-03-06 1986-06-18 Secifarma Spa Procedimento per la preparazione di spironolattone micronizzato
DE3018940A1 (de) * 1980-05-17 1981-11-26 Hoechst Ag, 6000 Frankfurt Verwendung eines vinylchlorid-pfropf-copolymerisates in der plastisolverarbeitung
FR2492382A1 (fr) * 1980-10-22 1982-04-23 Synthelabo Derives d'imidazo (1,2-a) pyridine, leur preparation et leur application en therapeutique
FR2525601A1 (fr) * 1982-04-21 1983-10-28 Synthelabo Derives d'imidazo(1,2-a)pyridines, leur preparation et leur application en therapeutique
US4675323A (en) * 1985-08-06 1987-06-23 Synthelabo Imidazo(1,2-a)quinoline derivatives useful as anxiolytic agents
SE457326B (sv) * 1986-02-14 1988-12-19 Lejus Medical Ab Foerfarande foer framstaellning av en snabbt soenderfallande kaerna innehaallande bl a mikrokristallin cellulosa
FR2600650B1 (fr) * 1986-06-27 1988-09-09 Synthelabo Procede de preparation d'imidazopyridines et composes intermediaires
FR2606410B1 (fr) * 1986-11-07 1989-02-24 Synthelabo Imidazopyridines, leur preparation et leur application en therapeutique
EP0289371B1 (de) * 1987-03-27 1991-09-25 Synthelabo Imidazopyridinderivate, ihre Herstellung und therapeutische Verwendung
US5271944A (en) * 1991-04-05 1993-12-21 Biofor, Ltd. Pharmacologically enhanced formulations
IT1276522B1 (it) * 1995-04-07 1997-10-31 Elena Benincasa Uso dello zolpidem per il trattamento terapeudico di sindromi neuropsichiatriche associate a disfunsione e di circuiti neurali dei
ES2240074T3 (es) * 1999-03-25 2005-10-16 Synthon B.V. Sales de zolpidem.
PT1038875E (pt) * 1999-03-25 2003-10-31 Synthon Bv Derivados de imidazopiridina e processo para os preparar
AU6474200A (en) * 1999-12-13 2001-06-18 Sumika Fine Chemicals Co., Ltd. Process for the preparation of a pyridinemethanol compound

Also Published As

Publication number Publication date
EP1292304B1 (de) 2005-11-02
DE60125429D1 (de) 2007-02-01
PT1473036E (pt) 2006-10-31
US20040214858A1 (en) 2004-10-28
DE60122216T2 (de) 2007-08-30
US20040220210A1 (en) 2004-11-04
DE04010651T1 (de) 2005-09-01
HRP20020909A2 (en) 2004-08-31
IL152411A0 (en) 2003-05-29
JP2006137778A (ja) 2006-06-01
AU2001257213B2 (en) 2005-09-29
JP2006249105A (ja) 2006-09-21
ATE308324T1 (de) 2005-11-15
EP1292304A4 (de) 2003-07-23
CZ20023775A3 (cs) 2003-10-15
SK16372002A3 (sk) 2003-04-01
DK1292304T3 (da) 2005-12-19
US20070037843A1 (en) 2007-02-15
ES2238941T1 (es) 2005-09-16
DE60122944T2 (de) 2007-04-12
EP1292304A1 (de) 2003-03-19
KR20030069796A (ko) 2003-08-27
US20040220211A1 (en) 2004-11-04
AU5721301A (en) 2001-11-07
ATE335481T1 (de) 2006-09-15
JP2003531173A (ja) 2003-10-21
US20040220212A1 (en) 2004-11-04
ES2239558T3 (es) 2007-04-01
DE60122216D1 (de) 2006-09-21
US20020077332A1 (en) 2002-06-20
US20040220213A1 (en) 2004-11-04
NZ522015A (en) 2004-08-27
WO2001080857A1 (en) 2001-11-01
ATE338550T1 (de) 2006-09-15
DE60114617D1 (de) 2005-12-08
ATE348613T1 (de) 2007-01-15
ES2277301T3 (es) 2007-07-01
WO2001080857A9 (en) 2002-06-27
PT1541146E (pt) 2007-01-31
YU79402A (sh) 2006-03-03
HUP0300701A2 (hu) 2003-07-28
PL358548A1 (en) 2004-08-09
US20040214859A1 (en) 2004-10-28
ES2238941T3 (es) 2007-04-01
DE60114617T2 (de) 2006-07-27
DE20122435U1 (de) 2005-10-06
DE04010435T1 (de) 2005-09-01
PT1475093E (pt) 2006-11-30
ES2248321T3 (es) 2006-03-16
CA2406982A1 (en) 2001-11-01
SE5292304T3 (de) 2005-11-02
ES2239558T1 (es) 2005-10-01
DE60125429T2 (de) 2007-09-27

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee