ES2196385T3 - Sistema de liberacion de microparticulas dirigible biodegradables. - Google Patents

Sistema de liberacion de microparticulas dirigible biodegradables.

Info

Publication number
ES2196385T3
ES2196385T3 ES97951024T ES97951024T ES2196385T3 ES 2196385 T3 ES2196385 T3 ES 2196385T3 ES 97951024 T ES97951024 T ES 97951024T ES 97951024 T ES97951024 T ES 97951024T ES 2196385 T3 ES2196385 T3 ES 2196385T3
Authority
ES
Spain
Prior art keywords
acid subunits
alpha
amino acid
lactide
serine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97951024T
Other languages
English (en)
Inventor
Kenneth K Sokoll
Pele Chong
Michel H Klein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Pasteur Ltd
Sanofi Pasteur SA
Original Assignee
Aventis Pasteur Ltd
Aventis Pasteur SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25089888&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2196385(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aventis Pasteur Ltd, Aventis Pasteur SA filed Critical Aventis Pasteur Ltd
Application granted granted Critical
Publication of ES2196385T3 publication Critical patent/ES2196385T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/68—Polyesters containing atoms other than carbon, hydrogen and oxygen
    • C08G63/685—Polyesters containing atoms other than carbon, hydrogen and oxygen containing nitrogen
    • C08G63/6852—Polyesters containing atoms other than carbon, hydrogen and oxygen containing nitrogen derived from hydroxy carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
    • Y10S530/815—Carrier is a synthetic polymer
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
    • Y10S530/815—Carrier is a synthetic polymer
    • Y10S530/816—Attached to the carrier via a bridging agent
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polyamides (AREA)
  • Peptides Or Proteins (AREA)

Abstract

COPOLIMEROS DESTINADOS A SER UTILIZADOS COMO VECTORES DE PARTICULAS QUE CONTIENEN SUBUNIDADES DE ACIDOS AMINADOS FUNCIONALIZABLES DESTINADOS A UNIRSE CON LIGANDOS DE OBJETIVADO. DICHOS COPOLIMEROS SON POLIESTERES COMPUESTOS DE SUBUNIDADES DE AL - HIDROXIACIDO COMO POR EJEMPLO EL D,L - LACTIDO Y DE SUBUNIDADES DE SEUDO - AL - ACIDOS AMINADOS QUE PUEDEN SER DERIV ADAS DE LA SERINA. SE DESCRIBEN NOS PREPARADOS DE VACUNAS ESTABLES UTILES COMO PREPARADOS DE LIBERACION PROLONGADA QUE CONTIENEN UNO O VARIOS ANTIGENOS Y ADYUVANTES ENCAPSULADOS EN DICHAS MICROPARTICULAS POLIMERAS O MEZCLADOS CON ELLAS. DICHOS VECTORES DE PARTICULAS SON UTILES PARA CANALIZAR AGENTES HASTA EL SISTEMA INMUNITARIO DE UN SUJETO POR LA VIA DE LAS MUCOSAS O POR VIA PARENTERAL PARA PRODUCIR UNAS RESPUESTAS DEL SISTEMA INMUNITARIO, INCLUYENDO RESPUESTAS INMUNITARIAS Y RESPUESTAS DE PROTECCION.
ES97951024T 1996-12-20 1997-12-19 Sistema de liberacion de microparticulas dirigible biodegradables. Expired - Lifetime ES2196385T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/770,850 US6042820A (en) 1996-12-20 1996-12-20 Biodegradable copolymer containing α-hydroxy acid and α-amino acid units

Publications (1)

Publication Number Publication Date
ES2196385T3 true ES2196385T3 (es) 2003-12-16

Family

ID=25089888

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97951024T Expired - Lifetime ES2196385T3 (es) 1996-12-20 1997-12-19 Sistema de liberacion de microparticulas dirigible biodegradables.

Country Status (13)

Country Link
US (7) US6042820A (es)
EP (1) EP0946624B1 (es)
JP (3) JP3242118B2 (es)
AT (1) ATE236207T1 (es)
AU (1) AU729305B2 (es)
BR (1) BR9714065A (es)
CA (1) CA2275033C (es)
DE (1) DE69720516T2 (es)
DK (1) DK0946624T3 (es)
ES (1) ES2196385T3 (es)
NZ (1) NZ336718A (es)
PT (1) PT946624E (es)
WO (1) WO1998028357A1 (es)

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US6042820A (en) 2000-03-28
CA2275033A1 (en) 1998-07-02
US6623764B1 (en) 2003-09-23
US6312732B1 (en) 2001-11-06
US6471996B1 (en) 2002-10-29
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CA2275033C (en) 2005-08-02
US20050163745A1 (en) 2005-07-28
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WO1998028357A1 (en) 1998-07-02
DE69720516T2 (de) 2004-02-19
US6287604B1 (en) 2001-09-11
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US6228423B1 (en) 2001-05-08
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JP3428972B2 (ja) 2003-07-22
BR9714065A (pt) 2000-10-24

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