ES2196385T3 - Sistema de liberacion de microparticulas dirigible biodegradables. - Google Patents

Sistema de liberacion de microparticulas dirigible biodegradables.

Info

Publication number
ES2196385T3
ES2196385T3 ES97951024T ES97951024T ES2196385T3 ES 2196385 T3 ES2196385 T3 ES 2196385T3 ES 97951024 T ES97951024 T ES 97951024T ES 97951024 T ES97951024 T ES 97951024T ES 2196385 T3 ES2196385 T3 ES 2196385T3
Authority
ES
Spain
Prior art keywords
acid subunits
alpha
amino acid
lactide
serine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97951024T
Other languages
English (en)
Inventor
Kenneth K Sokoll
Pele Chong
Michel H Klein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Pasteur Ltd
Sanofi Pasteur SA
Original Assignee
Aventis Pasteur Ltd
Aventis Pasteur SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25089888&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2196385(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aventis Pasteur Ltd, Aventis Pasteur SA filed Critical Aventis Pasteur Ltd
Application granted granted Critical
Publication of ES2196385T3 publication Critical patent/ES2196385T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/68—Polyesters containing atoms other than carbon, hydrogen and oxygen
    • C08G63/685—Polyesters containing atoms other than carbon, hydrogen and oxygen containing nitrogen
    • C08G63/6852—Polyesters containing atoms other than carbon, hydrogen and oxygen containing nitrogen derived from hydroxy carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
    • Y10S530/815—Carrier is a synthetic polymer
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
    • Y10S530/815—Carrier is a synthetic polymer
    • Y10S530/816—Attached to the carrier via a bridging agent
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Polyamides (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

COPOLIMEROS DESTINADOS A SER UTILIZADOS COMO VECTORES DE PARTICULAS QUE CONTIENEN SUBUNIDADES DE ACIDOS AMINADOS FUNCIONALIZABLES DESTINADOS A UNIRSE CON LIGANDOS DE OBJETIVADO. DICHOS COPOLIMEROS SON POLIESTERES COMPUESTOS DE SUBUNIDADES DE AL - HIDROXIACIDO COMO POR EJEMPLO EL D,L - LACTIDO Y DE SUBUNIDADES DE SEUDO - AL - ACIDOS AMINADOS QUE PUEDEN SER DERIV ADAS DE LA SERINA. SE DESCRIBEN NOS PREPARADOS DE VACUNAS ESTABLES UTILES COMO PREPARADOS DE LIBERACION PROLONGADA QUE CONTIENEN UNO O VARIOS ANTIGENOS Y ADYUVANTES ENCAPSULADOS EN DICHAS MICROPARTICULAS POLIMERAS O MEZCLADOS CON ELLAS. DICHOS VECTORES DE PARTICULAS SON UTILES PARA CANALIZAR AGENTES HASTA EL SISTEMA INMUNITARIO DE UN SUJETO POR LA VIA DE LAS MUCOSAS O POR VIA PARENTERAL PARA PRODUCIR UNAS RESPUESTAS DEL SISTEMA INMUNITARIO, INCLUYENDO RESPUESTAS INMUNITARIAS Y RESPUESTAS DE PROTECCION.
ES97951024T 1996-12-20 1997-12-19 Sistema de liberacion de microparticulas dirigible biodegradables. Expired - Lifetime ES2196385T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/770,850 US6042820A (en) 1996-12-20 1996-12-20 Biodegradable copolymer containing α-hydroxy acid and α-amino acid units

Publications (1)

Publication Number Publication Date
ES2196385T3 true ES2196385T3 (es) 2003-12-16

Family

ID=25089888

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97951024T Expired - Lifetime ES2196385T3 (es) 1996-12-20 1997-12-19 Sistema de liberacion de microparticulas dirigible biodegradables.

Country Status (13)

Country Link
US (7) US6042820A (es)
EP (1) EP0946624B1 (es)
JP (3) JP3242118B2 (es)
AT (1) ATE236207T1 (es)
AU (1) AU729305B2 (es)
BR (1) BR9714065A (es)
CA (1) CA2275033C (es)
DE (1) DE69720516T2 (es)
DK (1) DK0946624T3 (es)
ES (1) ES2196385T3 (es)
NZ (1) NZ336718A (es)
PT (1) PT946624E (es)
WO (1) WO1998028357A1 (es)

Families Citing this family (102)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9801288D0 (sv) 1998-04-14 1998-04-14 Astra Ab Vaccine delivery system and metod of production
US6576244B1 (en) 1998-06-19 2003-06-10 Acambis, Inc. LT and CT in parenteral immunization methods against helicobacter infection
US7807211B2 (en) * 1999-09-03 2010-10-05 Advanced Cardiovascular Systems, Inc. Thermal treatment of an implantable medical device
US20070032853A1 (en) 2002-03-27 2007-02-08 Hossainy Syed F 40-O-(2-hydroxy)ethyl-rapamycin coated stent
WO2001097857A1 (fr) * 2000-06-20 2001-12-27 Sumitomo Pharmaceuticals Company, Limited Preparations destinees au transfert d'oligonucleotides
CA2414846A1 (en) * 2000-07-05 2002-01-24 Merieux Oravax Immunological combinations for prophylaxis and therapy of helicobacter pylori infection
US9974847B2 (en) * 2000-08-24 2018-05-22 Immunitor USA, Inc. Treatment and prevention of tuberculosis
US20030092145A1 (en) * 2000-08-24 2003-05-15 Vic Jira Viral vaccine composition, process, and methods of use
US10398830B2 (en) * 2000-11-17 2019-09-03 Vactronix Scientific, Llc Device for in vivo delivery of bioactive agents and method of manufacture thereof
US8632845B2 (en) * 2000-12-28 2014-01-21 Abbott Cardiovascular Systems Inc. Method of drying bioabsorbable coating over stents
WO2002060486A2 (en) * 2001-01-29 2002-08-08 Fresco Bernard B Controlled release microsphere system for administration of drug to the eye
DK1407787T3 (da) * 2001-06-20 2009-06-02 Dainippon Sumitomo Pharma Co Fremgangsmåde til fremme af nukleinsyreoverförsel
WO2003029429A2 (en) * 2001-10-03 2003-04-10 Selective Genetics, Inc. Traversal of nucleic acid molecules through a fluid space and expression in repair cells
MXPA04003162A (es) * 2001-10-05 2005-01-25 Surmodics Inc Recubrimientos de particulas inmovilizadas y usos de los mismos.
WO2003059988A2 (en) 2002-01-14 2003-07-24 The General Hospital Corporation Biodegradable polyketal polymers and methods for their formation and use
AU2003205106A1 (en) * 2002-01-16 2003-09-02 Agency For Disease Diagnosis And Prevention Pace-a microspheres for delivery of antigens
US8088388B2 (en) * 2002-02-14 2012-01-03 United Biomedical, Inc. Stabilized synthetic immunogen delivery system
FR2839260B1 (fr) * 2002-05-03 2005-02-25 Inst Nat Sante Rech Med Microparticules a base d'un materiau bicompatible et biodegradable, supportant des cellules et des substances biologiquement actives
US20050129776A1 (en) 2002-05-03 2005-06-16 Inserm Microparticles supporting cells and active substances
AU2003237528A1 (en) * 2002-06-07 2003-12-22 Kentucky Bioprocessing, Llc Flexible vaccine assembly and vaccine delivery platform
US20040170606A1 (en) * 2002-06-07 2004-09-02 Palmer Kenneth E. Production of peptides in plants as viral coat protein fusions
US20040142887A1 (en) * 2002-07-10 2004-07-22 Chengji Cui Antigen-polymer compositions
WO2004050732A2 (en) * 2002-11-29 2004-06-17 Yissum Research Development Company Of The Hebrew University Of Jerusalem Process for preparation of biodegradable polymers and resins from proteins, and plastics obtained thereby
WO2004092388A1 (ja) * 2003-04-18 2004-10-28 Japan As Represented By President Of National Cardiovascular Center ベクター
US20050118344A1 (en) 2003-12-01 2005-06-02 Pacetti Stephen D. Temperature controlled crimping
JP2005154514A (ja) * 2003-11-21 2005-06-16 Univ Waseda 機能性生分解性材料およびその製造方法
EP1696034A4 (en) * 2003-12-19 2006-12-27 Dainippon Sumitomo Pharma Co NUCLEIC ACID TRANSFER METHOD
CA2565859A1 (en) * 2004-05-07 2005-11-24 President And Fellows Of Harvard College Pulmonary malarial vaccine
WO2006091459A2 (en) 2005-02-24 2006-08-31 Joslin Diabetes Center, Inc. Compositions and methods for treating vascular permeability
US20090062184A1 (en) * 2005-03-24 2009-03-05 Dainippon Sumitomo Pharma Co., Ltd. Fine particulate preparation comprising complex of nucleic acid molecule and collagen
US9603941B2 (en) * 2006-01-24 2017-03-28 Minghui Chai Method of preparing dendritic drugs
ATE440879T1 (de) * 2006-03-21 2009-09-15 Dsm Ip Assets Bv Mikropartikel, umfassend ein vernetztes polymer
US8202524B2 (en) * 2006-08-31 2012-06-19 Sk Chemicals Co., Ltd. Method for producing microspheres loaded with drugs and microspheres loaded with drugs produced thereby
CA2684946C (en) 2007-05-16 2015-03-31 The Brigham And Women's Hospital, Inc. Treatment of synucleinopathies
US8551072B2 (en) 2007-12-12 2013-10-08 Boston Scientific Scimed, Inc. Methods, devices and compositions for controlled drug delivery to injured myocardium
US20110208064A1 (en) 2008-07-31 2011-08-25 Ran Chongzhao Curcumin Derivatives for Amyloid-Beta Plaque Imaging
US9207242B2 (en) 2008-10-09 2015-12-08 The University Of Hong Kong Cadherin-17 as diagnostic marker and therapeutic target for liver cancer
CN102271712B (zh) 2008-10-31 2015-11-25 通用医疗公司 用于将物质递送至生物靶标的组合物和方法
CA2743600C (en) 2008-11-14 2016-11-08 Ewha University-Industry Collaboration Foundation Method for preparing microspheres and microspheres produced thereby
WO2010105096A2 (en) 2009-03-11 2010-09-16 University Of Massachusetts Modulation of human cytomegalovirus replication by micro-rna 132 (mir132), micro-rna 145 (mir145) and micro-rna 212 (mir212)
EP2756845B1 (en) 2009-04-03 2017-03-15 Dicerna Pharmaceuticals, Inc. Methods and compositions for the specific inhibition of KRAS by asymmetric double-stranded RNA
MX350667B (es) 2009-05-27 2017-09-12 Selecta Biosciences Inc Nanoportadores que poseen componentes con diferentes tasas de liberacion.
EP2482837A4 (en) 2009-09-29 2013-05-22 Joslin Diabetes Center Inc USE OF INHIBITORS OF PROTEIN KINASE C DELTA (PKCD) FOR THE TREATMENT OF DIABETES, OBESITY AND HEPATIC STEATOSIS
JP5988435B2 (ja) * 2010-01-24 2016-09-07 ノバルティス アーゲー 放射線照射された生分解性微粒子
WO2011115882A1 (en) 2010-03-15 2011-09-22 Boston Scientific Scimed, Inc. Drug eluting stents and methods of making the same
EP3388081A1 (en) 2010-05-26 2018-10-17 Selecta Biosciences, Inc. Multivalent synthetic nanocarrier vaccines
US9447027B2 (en) 2010-10-22 2016-09-20 The General Hospital Corporation Treating long QT syndrome
WO2012065182A2 (en) 2010-11-12 2012-05-18 University Of Massachusetts Modulation of ubiquitination of synaptic proteins for the treatment of neurodegenerative and psychiatric disorders
DE102011018499A1 (de) 2011-04-23 2012-10-25 Emc Microcollections Gmbh Topische Nanopartikel-Vakzine zur Immunstimulation der dendritischen Zellen in der Haut
KR20140050698A (ko) 2011-07-29 2014-04-29 셀렉타 바이오사이언시즈, 인크. 체액성 및 세포독성 t 림프구(ctl) 면역 반응을 발생시키는 합성 나노운반체
WO2013075132A1 (en) 2011-11-17 2013-05-23 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Therapeutic rna switches compositions and methods of use
EP2836514A4 (en) 2012-04-13 2015-12-30 Childrens Medical Center TIKI INHIBITORS
KR20220088949A (ko) 2012-05-08 2022-06-28 오닉스 세라퓨틱스, 인크. 펩티드 프로테아좀 억제제 제제화를 위한 사이클로덱스트린 복합체화 방법
US9738623B2 (en) 2012-08-06 2017-08-22 The General Hospital Corporation Curcumin analogs
WO2014065860A1 (en) 2012-10-24 2014-05-01 The General Hospital Corporation Functionalized 1,2,4,5-tetrazine compounds for use in bioorthogonal coupling reactions
EP2851086A1 (en) 2013-09-20 2015-03-25 Sanofi Serpins: methods of therapeutic ß-cell regeneration and function
EP2769732A1 (en) 2013-02-22 2014-08-27 Sanofi Serpins: methods of therapeutic beta-cell regeneration and function
EP2958585A1 (en) 2013-02-22 2015-12-30 Sanofi Serpins: methods of therapeutic beta-cell regeneration and function
US9757468B2 (en) 2013-03-13 2017-09-12 The Regents Of The University Of California Intranasal administration of guanidinylated aminoglycosides
TWI662047B (zh) 2013-03-14 2019-06-11 歐尼克斯治療公司 三肽環氧酮蛋白酶體抑制劑
AR095426A1 (es) 2013-03-14 2015-10-14 Onyx Therapeutics Inc Inhibidores tripeptídicos de la epoxicetona proteasa
US9737525B2 (en) 2013-06-07 2017-08-22 The General Hospital Corporation Small molecule activators of NRF2 pathway
US9757477B2 (en) 2013-09-06 2017-09-12 The General Hospital Corporation Imaging brown adipose tissue with curcumin derivatives
EP2994175A1 (en) 2014-02-04 2016-03-16 Abbott Cardiovascular Systems, Inc. Drug delivery scaffold or stent with a novolimus and lactide based coating such that novolimus has a minimum amount of bonding to the coating
WO2016025480A1 (en) 2014-08-11 2016-02-18 The General Hospital Corporation Cyclooctenes for bioorthogonol reactions
JO3474B1 (ar) 2014-08-29 2020-07-05 Amgen Inc مشتقات تيتراهيدرونافثالين التي تثبط بروتين mcl-1
US10723708B2 (en) 2014-11-10 2020-07-28 Evrys Bio, Llc Anti-HCMV compositions and methods
ES2820585T3 (es) 2014-11-10 2021-04-21 Evrys Bio Llc Composiciones y métodos anti-HCMV
WO2016077382A2 (en) 2014-11-11 2016-05-19 Massachusetts Eye & Ear Infirmary Conjunctivitis vaccines
ES2858403T3 (es) 2014-12-15 2021-09-30 Dicerna Pharmaceuticals Inc Acidos nucleicos de doble hebra modificados por ligando
HUE050441T2 (hu) 2015-04-03 2020-12-28 Univ Massachusetts Huntingtin-mRNS célzására szolgáló oligonukleotid-vegyületek
CA2980339A1 (en) 2015-04-03 2016-10-06 University Of Massachusetts Oligonucleotide compounds for treatment of preeclampsia and other angiogenic disorders
WO2016179497A1 (en) 2015-05-07 2016-11-10 Shire Human Genetic Therapies, Inc. Glucocerebrosidase gene therapy for parkinson's disease
US10633653B2 (en) 2015-08-14 2020-04-28 University Of Massachusetts Bioactive conjugates for oligonucleotide delivery
US10358497B2 (en) 2015-09-29 2019-07-23 Amgen Inc. Methods of treating cardiovascular disease with an ASGR inhibitor
AU2016355178B9 (en) 2015-11-19 2019-05-30 Massachusetts Institute Of Technology Lymphocyte antigen CD5-like (CD5L)-interleukin 12B (p40) heterodimers in immunity
JP2019500899A (ja) 2015-11-23 2019-01-17 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア ＣＲＩＳＰＲ／Ｃａｓ９の核送達を通じた細胞ＲＮＡの追跡と操作
CA3011894A1 (en) 2016-01-31 2017-08-03 University Of Massachusetts Branched oligonucleotides
WO2017147410A1 (en) 2016-02-25 2017-08-31 Amgen Inc. Compounds that inhibit mcl-1 protein
US11753638B2 (en) 2016-08-12 2023-09-12 University Of Massachusetts Conjugated oligonucleotides
US10449230B2 (en) 2016-10-06 2019-10-22 The Regents Of The University Of California Polymyxin derived cell penetrating scaffolds
US10443055B2 (en) 2016-12-22 2019-10-15 Beth Israel Deaconess Medical Center Compounds that target MYC microRNA responsive elements for the treatment of MYC-associated cancer
JP6453507B2 (ja) 2017-03-30 2019-01-16 アムジエン・インコーポレーテツド Ｍｃｌ−１タンパク質を阻害する化合物
WO2018208998A1 (en) 2017-05-10 2018-11-15 The Regents Of The University Of California Directed editing of cellular rna via nuclear delivery of crispr/cas9
US20210128702A1 (en) 2017-08-11 2021-05-06 Dana-Farber Cancer Institute, Inc. Use of a botulinum toxin agent for treating plasma cell disorders
US11821003B2 (en) 2017-08-14 2023-11-21 Sanford Burnham Prebys Medical Discovery Institute Cardiogenic mesoderm formation regulators
EP3668878A1 (en) 2017-08-18 2020-06-24 Amgen Inc. Compounds that inhibit mcl-1 protein
MA50033A (fr) 2017-08-29 2020-07-08 Amgen Inc Composés macrocycliques permettant d'inhiber la protéine mcl-1
WO2019046668A1 (en) 2017-08-31 2019-03-07 Kezar Life Sciences AMIDE-SUBSTITUTED THIAZOLES AS INHIBITORS OF SECRETIC PROTEIN
CA3079396A1 (en) 2017-10-18 2019-04-25 Evrys Bio, Llc Broad spectrum antiviral compositions and methods
EP3703669A4 (en) 2017-11-01 2021-11-10 Dana-Farber Cancer Institute, Inc. CANCER TREATMENT METHODS
WO2019173181A1 (en) 2018-03-05 2019-09-12 Amgen Inc. Alpha-hydroxy phenylacetic acid pharmacophore or bioisostere mcl-1 protein antagonists
KR20210008369A (ko) 2018-05-11 2021-01-21 알파 아노메리끄 에스아에스 7'-5'-알파-아노머-이중고리상 당 뉴클레오시드를 포함하는 올리고뉴클레오티드 컨쥬게이트
BR112021002440A2 (pt) 2018-08-10 2021-05-04 University Of Massachusetts oligonucleotídeos modificados visando snps
US20210292766A1 (en) 2018-08-29 2021-09-23 University Of Massachusetts Inhibition of Protein Kinases to Treat Friedreich Ataxia
JP7386382B2 (ja) 2018-12-12 2023-11-27 カイト ファーマ インコーポレイテッド キメラ抗原受容体及びｔ細胞受容体並びに使用方法
US20220153732A1 (en) 2019-02-28 2022-05-19 Kezar Life Sciences Protein secretion inhibitors
WO2020227395A2 (en) 2019-05-06 2020-11-12 University Of Massachusetts Anti-c9orf72 oligonucleotides and related methods
CN110423338B (zh) * 2019-08-12 2021-05-25 深圳市氩氪新材料技术研究服务有限公司 一种改性聚乳酸材料的制备方法
IL300736A (en) 2020-08-31 2023-04-01 Kezar Life Sciences Protein secretion inhibitors
TW202315943A (zh) 2021-06-23 2023-04-16 麻薩諸塞大學 用於治療子癇前症及其它血管新生病症的最佳化抗flt1寡核苷酸化合物
WO2023164250A1 (en) 2022-02-28 2023-08-31 Kezar Life Sciences Sec61 inhibitors and use thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US30170A (en) * 1860-09-25 Improvement in plows
US2676945A (en) 1950-10-18 1954-04-27 Du Pont Condensation polymers of hydroxyacetic acid
US3839297A (en) 1971-11-22 1974-10-01 Ethicon Inc Use of stannous octoate catalyst in the manufacture of l(-)lactide-glycolide copolymer sutures
USRE30170E (en) 1975-04-04 1979-12-18 Sutures, Inc. Hydrolyzable polymers of amino acid and hydroxy acids
DE3521994A1 (de) 1985-06-20 1987-01-02 Bayer Ag N-(2-aminoacylamido-2-desoxy-hexosyl)-amide-, -carbamate und -harnstoffe, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
US5271945A (en) * 1988-07-05 1993-12-21 Takeda Chemical Industries, Ltd. Sustained release microcapsule for water soluble drug
US5248761A (en) 1992-08-12 1993-09-28 United States Surgical Corporation Amino acid terminated polyesters having predetermined monomeric sequence
US5399665A (en) 1992-11-05 1995-03-21 Massachusetts Institute Of Technology Biodegradable polymers for cell transplantation
US5593778A (en) * 1993-09-09 1997-01-14 Kanebo, Ltd. Biodegradable copolyester, molded article produced therefrom and process for producing the molded article
WO1995018781A1 (en) * 1994-01-06 1995-07-13 Metabolix, Inc. Methods for synthesizing oligomers containing hydroxy acid units

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CA2275033C (en) 2005-08-02
US6228423B1 (en) 2001-05-08
ATE236207T1 (de) 2003-04-15
JP3990303B2 (ja) 2007-10-10
JP2003261661A (ja) 2003-09-19
US6471996B1 (en) 2002-10-29
AU5472198A (en) 1998-07-17
BR9714065A (pt) 2000-10-24
PT946624E (pt) 2003-08-29
DK0946624T3 (da) 2003-07-14
JP3242118B2 (ja) 2001-12-25
US6623764B1 (en) 2003-09-23
NZ336718A (en) 2001-01-26
JP3428972B2 (ja) 2003-07-22
WO1998028357A1 (en) 1998-07-02
CA2275033A1 (en) 1998-07-02
DE69720516T2 (de) 2004-02-19
EP0946624A1 (en) 1999-10-06
US6042820A (en) 2000-03-28
EP0946624B1 (en) 2003-04-02
US6312732B1 (en) 2001-11-06
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US6287604B1 (en) 2001-09-11
US20050163745A1 (en) 2005-07-28

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