BR112023026862A2 - Compostos de oligonucleotídeos anti-flt1 otimizados para tratamento de pré-eclâmpsia e outros distúrbios angiogênicos - Google Patents

Compostos de oligonucleotídeos anti-flt1 otimizados para tratamento de pré-eclâmpsia e outros distúrbios angiogênicos

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Publication number
BR112023026862A2
BR112023026862A2 BR112023026862A BR112023026862A BR112023026862A2 BR 112023026862 A2 BR112023026862 A2 BR 112023026862A2 BR 112023026862 A BR112023026862 A BR 112023026862A BR 112023026862 A BR112023026862 A BR 112023026862A BR 112023026862 A2 BR112023026862 A2 BR 112023026862A2
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Brazil
Prior art keywords
treatment
angiogenic disorders
flt1
eclampsia
oligonucleotide compounds
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BR112023026862A
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English (en)
Inventor
Ananth Karumanchi
Anastasia Khvorova
Annabelle Biscans
Sarah Davis
Narayan Hariharan Vignesh
Original Assignee
Beth Israel Deaconess Medical Ct Inc
Univ Massachusetts
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Application filed by Beth Israel Deaconess Medical Ct Inc, Univ Massachusetts filed Critical Beth Israel Deaconess Medical Ct Inc
Publication of BR112023026862A2 publication Critical patent/BR112023026862A2/pt

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Abstract

compostos de oligonucleotídeos anti-flt1 otimizados para tratamento de préeclâmpsia e outros distúrbios angiogênicos. a presente invenção refere-se a novos alvos para distúrbios angiogênicos. novos oligonucleotídeos também são fornecidos. métodos de uso dos novos oligonucleotídeos para o tratamento de distúrbios angiogênicos (por exemplo, pré-eclâmpsia) também são fornecidos.
BR112023026862A 2021-06-23 2022-06-22 Compostos de oligonucleotídeos anti-flt1 otimizados para tratamento de pré-eclâmpsia e outros distúrbios angiogênicos BR112023026862A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202163214224P 2021-06-23 2021-06-23
PCT/US2022/034461 WO2022271786A1 (en) 2021-06-23 2022-06-22 Optimized anti-flt1 oligonucleotide compounds for treatment of preeclampsia and other angiogenic disorders

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BR112023026862A2 true BR112023026862A2 (pt) 2024-03-05

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BR112023026862A BR112023026862A2 (pt) 2021-06-23 2022-06-22 Compostos de oligonucleotídeos anti-flt1 otimizados para tratamento de pré-eclâmpsia e outros distúrbios angiogênicos

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US (2) US11702659B2 (pt)
EP (1) EP4359539A1 (pt)
KR (1) KR20240040729A (pt)
CN (1) CN117677699A (pt)
AR (1) AR126207A1 (pt)
AU (1) AU2022299169A1 (pt)
BR (1) BR112023026862A2 (pt)
CA (1) CA3174095A1 (pt)
IL (1) IL309334A (pt)
TW (1) TW202315943A (pt)
WO (1) WO2022271786A1 (pt)

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WO2018031933A2 (en) * 2016-08-12 2018-02-15 University Of Massachusetts Conjugated oligonucleotides

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