DE69931112D1 - Chimäre Adenoviren - Google Patents
Chimäre AdenovirenInfo
- Publication number
- DE69931112D1 DE69931112D1 DE69931112T DE69931112T DE69931112D1 DE 69931112 D1 DE69931112 D1 DE 69931112D1 DE 69931112 T DE69931112 T DE 69931112T DE 69931112 T DE69931112 T DE 69931112T DE 69931112 D1 DE69931112 D1 DE 69931112D1
- Authority
- DE
- Germany
- Prior art keywords
- adenoviruses
- gene therapy
- chimaeric
- decreased
- hybrid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10344—Chimeric viral vector comprising heterologous viral elements for production of another viral vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/20011—Rhabdoviridae
- C12N2760/20111—Lyssavirus, e.g. rabies virus
- C12N2760/20134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP98202297 | 1998-07-08 | ||
EP98202297 | 1998-07-08 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69931112D1 true DE69931112D1 (de) | 2006-06-08 |
DE69931112T2 DE69931112T2 (de) | 2006-12-07 |
Family
ID=8233905
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69931112T Expired - Lifetime DE69931112T2 (de) | 1998-07-08 | 1999-07-08 | Chimäre Adenoviren |
Country Status (10)
Country | Link |
---|---|
US (3) | US20030017138A1 (de) |
EP (1) | EP0978566B1 (de) |
JP (1) | JP4472178B2 (de) |
AT (1) | ATE325200T1 (de) |
AU (1) | AU765276B2 (de) |
CA (1) | CA2303477C (de) |
DE (1) | DE69931112T2 (de) |
ES (1) | ES2263250T3 (de) |
NZ (1) | NZ503018A (de) |
WO (1) | WO2000003029A2 (de) |
Families Citing this family (68)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69638058D1 (de) | 1995-06-15 | 2009-11-26 | Crucell Holland Bv | Verpackungssysteme für humane rekombinante Adenoviren zur Gentherapie |
US20030017138A1 (en) | 1998-07-08 | 2003-01-23 | Menzo Havenga | Chimeric adenoviruses |
US6929946B1 (en) | 1998-11-20 | 2005-08-16 | Crucell Holland B.V. | Gene delivery vectors provided with a tissue tropism for smooth muscle cells, and/or endothelial cells |
WO2000052186A1 (en) * | 1999-03-04 | 2000-09-08 | Introgene B.V. | Means and methods for fibroblast-like or macrophage-like cell transduction |
US6869936B1 (en) | 1999-03-04 | 2005-03-22 | Crucell Holland B.V. | Means and methods for fibroblast-like or macrophage-like cell transduction |
US20050232900A1 (en) * | 1999-05-18 | 2005-10-20 | Crucell Holland B.V. | Serotype of adenovirus and uses thereof |
US6492169B1 (en) | 1999-05-18 | 2002-12-10 | Crucell Holland, B.V. | Complementing cell lines |
US6913922B1 (en) | 1999-05-18 | 2005-07-05 | Crucell Holland B.V. | Serotype of adenovirus and uses thereof |
EP1067188A1 (de) * | 1999-07-08 | 2001-01-10 | Introgene B.V. | Infektion mit chimärischen Adenoviren der Zellen die für den Adenoviren Serotyp 5 Coxsacki Adenoviren Rezeptor (CAR) negativ sind |
DE19956763A1 (de) * | 1999-11-25 | 2001-06-13 | Guenter Cichon | Rekombinante Adenoviren mit reduzierter Affinität zu humanen Erythrozyten zur Anwendung in der Gentherapie |
US6867022B1 (en) | 2000-01-21 | 2005-03-15 | Regents Of The University Of Michigan | Replication deficient adenovirus vectors and methods of making and using them |
EP1191105A1 (de) * | 2000-09-25 | 2002-03-27 | Galapagos Genomics B.V. | Gentransfervektoren mit einer Gewebsspezifität für T-Lymphozyten |
EP1157999A1 (de) * | 2000-05-24 | 2001-11-28 | Introgene B.V. | Verfahren und Mitteln zur Verbesserung der Haut-Transplantation mittels Genabgabe-Vehikel mit Tropismus für primären Fibroblasten, sowie andere Verwendungsmöglichkeiten für diesen |
AU2001263689B2 (en) | 2000-05-31 | 2007-03-22 | University Of Saskatchewan | Modified bovine adenovirus having altered tropism |
US7754201B2 (en) * | 2000-06-02 | 2010-07-13 | GenPhar, Inc | Method of vaccination through serotype rotation |
CA2418977C (en) * | 2000-08-10 | 2011-01-18 | Crucell Holland B.V. | Gene delivery vectors with cell type specificity for primary human chondrocytes |
DE60138403D1 (de) | 2000-09-26 | 2009-05-28 | Crucell Holland Bv | Adenovirale vektoren für die übertragung von genen in zellen der skelettmuskulatur oder myoblasten |
EP1195440A1 (de) * | 2000-10-06 | 2002-04-10 | Introgene B.V. | Genverabreichung-Vektoren für Stammzellen |
AU2002211087A1 (en) * | 2000-10-06 | 2002-04-15 | Crucell Holland B.V. | Gene delivery vectors for stem cells |
AU2002314705A1 (en) * | 2001-01-09 | 2002-10-28 | Beverly L. Davidson | Adenovirus serotype 30 (ad30) fiber protein and uses thereof |
US6635466B2 (en) | 2001-01-09 | 2003-10-21 | University Of Iowa Research Foundation | Adenovirus serotype 30 (Ad30) |
WO2002068627A2 (en) | 2001-02-23 | 2002-09-06 | Novartis Ag | Vector constucts |
JP2002325573A (ja) * | 2001-04-27 | 2002-11-12 | Japan Science & Technology Corp | ベクター |
EP1256803A1 (de) | 2001-05-07 | 2002-11-13 | Crucell Holland B.V. | Verfahren zur Identifizierung von antiviralen Verbindungen |
ES2375557T3 (es) | 2001-06-22 | 2012-03-02 | The Trustees Of The University Of Pennsylvania | Adenovirus recombinantes que comprenden prote�?nas de adenovirus de simios y usos de los mismos. |
EP1944043A1 (de) * | 2001-11-21 | 2008-07-16 | The Trustees of the University of Pennsylvania | Nukleinsäure- und Aminosäuresequenzen von Affen-Adenoviren, hergeleitete Vektoren und Verwendungsverfahren. |
AU2002365366B2 (en) | 2001-11-21 | 2007-05-10 | The Trustees Of The University Of Pennsylvania | Simian adenovirus nucleic acid and amino acid sequences, vectors containing same, and methods of use |
AU2007201747B2 (en) * | 2001-11-21 | 2010-06-03 | The Trustees Of The University Of Pennsylvania | Simian adenovirus nucleic acid and amino acid sequences, vectors containing same, and methods of use |
EP1516055A4 (de) * | 2002-01-24 | 2007-08-08 | Scripps Research Inst | Faserschaftmodifikationen für effizientes zielen |
NZ534865A (en) | 2002-04-25 | 2008-07-31 | Crucell Holland Bv | Stable adenoviral vectors and methods for propagation thereof |
ATE447037T1 (de) | 2002-04-25 | 2009-11-15 | Crucell Holland Bv | Mittel und verfahren zur herstellung von adenovirusvektoren |
WO2004027073A1 (en) * | 2002-09-20 | 2004-04-01 | Crucell Holland B.V. | Modified adenoviral vectors for use in vaccines and gene therapy |
AU2003288273A1 (en) | 2002-10-23 | 2004-05-13 | Crucell Holland B.V. | New settings for recombinant adenoviral-based vaccines |
US20080153083A1 (en) | 2003-10-23 | 2008-06-26 | Crucell Holland B.V. | Settings for recombinant adenoviral-based vaccines |
WO2004055187A1 (en) | 2002-12-17 | 2004-07-01 | Crucell Holland B.V. | Recombinant viral-based malaria vaccines |
JP2007525166A (ja) * | 2003-03-28 | 2007-09-06 | ザ・スクリップス・リサーチ・インスティテュート | 樹状細胞に対する感染性が増大したアデノウイルス粒子と、肝細胞に対する感染性が低下した粒子 |
WO2004111251A2 (en) * | 2003-06-11 | 2004-12-23 | The Scripps Research Institute | Modified fiber proteins for efficient receptor binding |
US7291498B2 (en) | 2003-06-20 | 2007-11-06 | The Trustees Of The University Of Pennsylvania | Methods of generating chimeric adenoviruses and uses for such chimeric adenoviruses |
US7491508B2 (en) | 2003-06-20 | 2009-02-17 | The Trustees Of The University Of Pennsylvania | Methods of generating chimeric adenoviruses and uses for such chimeric adenoviruses |
DE602005015332D1 (de) | 2004-02-23 | 2009-08-20 | Crucell Holland Bv | Verfahren zur Reinigung von Viren |
KR101169109B1 (ko) * | 2004-05-26 | 2012-07-26 | 싸이오서스 테라퓨틱스 엘티디. | 암 치료에 사용하기 위한 키메릭 아데노바이러스 |
CA2583843C (en) * | 2004-10-13 | 2010-09-21 | Crucell Holland B.V. | Improved adenoviral vectors and uses thereof |
CN101155915B (zh) | 2005-04-11 | 2013-12-04 | 克鲁塞尔荷兰公司 | 利用超滤进行病毒纯化 |
AU2005337612A1 (en) * | 2005-10-28 | 2007-05-03 | David T. Curiel | Conditionally replicating viruses and methods for cancer virotherapy |
US20090110695A1 (en) * | 2006-03-27 | 2009-04-30 | Menzo Jans Emko Havenga | Compositions Comprising a Recombinant Adenovirus and an Adjuvant |
MX2011004292A (es) | 2008-11-03 | 2011-05-31 | Crucell Holland Bv | Metodo para la produccion de vectores adenovirales. |
CN102575233B (zh) | 2009-10-15 | 2014-07-16 | 克鲁塞尔荷兰公司 | 从高细胞密度培养物纯化腺病毒的方法 |
DK2488636T3 (da) | 2009-10-15 | 2014-06-23 | Crucell Holland Bv | Fremgangsmåde til oprensning af adenoviruspartikler fra kulturer med høj celledensitet |
WO2012024351A2 (en) * | 2010-08-16 | 2012-02-23 | Salk Institute For Biological Studies | Adenoviral assembly method |
EP2618838A1 (de) | 2010-09-20 | 2013-07-31 | Crucell Holland B.V. | Therapeutische impfung gegen aktive tuberkulose |
AU2012343981B2 (en) | 2011-11-28 | 2017-09-07 | Janssen Vaccines & Prevention B.V. | Influenza virus vaccines and uses thereof |
EP2855669B1 (de) | 2012-05-29 | 2018-10-10 | GenVec, Inc. | Modifizierte serotyp-28-adenovirusvektoren |
WO2014153204A1 (en) | 2013-03-14 | 2014-09-25 | Salk Institute For Biological Studies | Oncolytic adenovirus compositions |
AP2016009154A0 (en) | 2013-09-19 | 2016-04-30 | Crucell Holland Bv | Improved adenovirus formulations |
EP3372236A1 (de) | 2013-10-25 | 2018-09-12 | PsiOxus Therapeutics Limited | Onkolytische adenoviren, die mit heterologen genen ausgestattet sind |
AU2016256582B2 (en) | 2015-04-30 | 2020-10-29 | Akamis Bio Limited | Oncolytic adenovirus encoding a B7 protein |
US20170067028A1 (en) * | 2015-05-15 | 2017-03-09 | Douglas J. Ballon | Radiolabeling of adeno associated virus |
EA036412B1 (ru) | 2015-10-06 | 2020-11-09 | Янссен Вэксинс Энд Превеншн Б.В. | Способ обеспечения защиты аденовируса от разрушения, вызванного взаимодействием с пластиком, и применение 2-гидроксипропил--циклодекстрина для защиты аденовируса |
IL260027B (en) | 2015-12-17 | 2022-07-01 | Psioxus Therapeutics Ltd | A group b adenovirus that encodes an anti-tcr–complex antibody or particle |
AU2017222568B2 (en) | 2016-02-23 | 2020-09-10 | Salk Institute For Biological Studies | High throughput assay for measuring adenovirus replication kinetics |
AU2017223589B2 (en) | 2016-02-23 | 2023-08-03 | Salk Institute For Biological Studies | Exogenous gene expression in therapeutic adenovirus for minimal impact on viral kinetics |
GB201713765D0 (en) | 2017-08-28 | 2017-10-11 | Psioxus Therapeutics Ltd | Modified adenovirus |
EP3532082A4 (de) | 2016-12-12 | 2020-08-26 | Salk Institute for Biological Studies | Auf tumoren gerichtete synthetische adenoviren und verwendungen davon |
CA3060573A1 (en) | 2017-04-21 | 2018-10-25 | Baylor College Of Medicine | Oncolytic virotherapy and immunotherapy |
CA3064863A1 (en) | 2017-05-26 | 2018-11-29 | Epicentrx, Inc. | Recombinant adenoviruses carrying transgenes |
GB202013940D0 (en) | 2020-09-04 | 2020-10-21 | Synpromics Ltd | Regulatory nucleic acid sequences |
EP4225382A2 (de) | 2020-10-07 | 2023-08-16 | Asklepios Biopharmaceutical, Inc. | Therapeutische adeno-assoziierte virusverabreichung von fkutin-verwandtem protein (fkrp) zur behandlung von dystroglycanopathie. erkrankungen mit gliedmassengürtel 21 |
EP4338727A1 (de) | 2022-09-14 | 2024-03-20 | Roquette Freres | Adenovirus-formulierungen |
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-
1999
- 1999-07-07 US US09/348,354 patent/US20030017138A1/en not_active Abandoned
- 1999-07-08 ES ES99202233T patent/ES2263250T3/es not_active Expired - Lifetime
- 1999-07-08 CA CA2303477A patent/CA2303477C/en not_active Expired - Fee Related
- 1999-07-08 EP EP99202233A patent/EP0978566B1/de not_active Expired - Lifetime
- 1999-07-08 AT AT99202233T patent/ATE325200T1/de not_active IP Right Cessation
- 1999-07-08 NZ NZ503018A patent/NZ503018A/xx not_active IP Right Cessation
- 1999-07-08 WO PCT/NL1999/000436 patent/WO2000003029A2/en active IP Right Grant
- 1999-07-08 JP JP2000559250A patent/JP4472178B2/ja not_active Expired - Fee Related
- 1999-07-08 DE DE69931112T patent/DE69931112T2/de not_active Expired - Lifetime
- 1999-07-08 AU AU49356/99A patent/AU765276B2/en not_active Ceased
-
2001
- 2001-09-14 US US09/953,280 patent/US20030073072A1/en not_active Abandoned
-
2005
- 2005-08-18 US US11/207,626 patent/US7749493B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
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DE69931112T2 (de) | 2006-12-07 |
EP0978566B1 (de) | 2006-05-03 |
ATE325200T1 (de) | 2006-06-15 |
AU765276B2 (en) | 2003-09-11 |
WO2000003029A2 (en) | 2000-01-20 |
JP4472178B2 (ja) | 2010-06-02 |
CA2303477C (en) | 2010-04-06 |
EP0978566A3 (de) | 2000-04-19 |
AU4935699A (en) | 2000-02-01 |
US7749493B2 (en) | 2010-07-06 |
US20060014276A1 (en) | 2006-01-19 |
NZ503018A (en) | 2003-06-30 |
WO2000003029A3 (en) | 2000-03-16 |
CA2303477A1 (en) | 2000-01-20 |
EP0978566A2 (de) | 2000-02-09 |
ES2263250T3 (es) | 2006-12-01 |
US20030073072A1 (en) | 2003-04-17 |
JP2002520026A (ja) | 2002-07-09 |
US20030017138A1 (en) | 2003-01-23 |
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