BR9714065A - Sistema de fornecimento de micropartìculas de alvo biodegradáveis - Google Patents

Sistema de fornecimento de micropartìculas de alvo biodegradáveis

Info

Publication number
BR9714065A
BR9714065A BR9714065-1A BR9714065A BR9714065A BR 9714065 A BR9714065 A BR 9714065A BR 9714065 A BR9714065 A BR 9714065A BR 9714065 A BR9714065 A BR 9714065A
Authority
BR
Brazil
Prior art keywords
acid subunits
alpha
amino acid
lactide
serine
Prior art date
Application number
BR9714065-1A
Other languages
English (en)
Inventor
Kenneth K Sokoll
Pele Chong
Michel H Klein
Original Assignee
Connaught Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25089888&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR9714065(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Connaught Lab filed Critical Connaught Lab
Publication of BR9714065A publication Critical patent/BR9714065A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/68—Polyesters containing atoms other than carbon, hydrogen and oxygen
    • C08G63/685—Polyesters containing atoms other than carbon, hydrogen and oxygen containing nitrogen
    • C08G63/6852—Polyesters containing atoms other than carbon, hydrogen and oxygen containing nitrogen derived from hydroxy carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
    • Y10S530/815—Carrier is a synthetic polymer
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
    • Y10S530/815—Carrier is a synthetic polymer
    • Y10S530/816—Attached to the carrier via a bridging agent
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polyamides (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)

Abstract

<B>SISTEMA DE FORNECIMENTO DE MICROPARTìCULAS DE ALVO E BIODEGRADáVEIS<D> São descritos copolímeros projetados para uso como veículos em partículas contendo subunidades de aminoácido funcionalizáveis para acoplamento a ligantes de alvo. Os copolímeros são poliésteres compostos de subunidades de ácido <244>-hidroxi como subunidades de D, L-lactida e ácido pseudo- <244>-amino que podem ser derivadas de serina ou terpolímeros de subunidades de D, L-lactida e glicolida e de ácido pseudo - <244>-amino que podem ser derivadas de serina. São descritas preparações estáveis de vacina úteis como formulações de liberação retardada contendo antígeno ou antígenos e adjuvantes encapsulados em ou fisicamente misturados com micropartículas políméricas. Os veículos em partículas são úteis para fornecer agentes ao sistema imune de uma pessoa por vias de mucosa ou parenteral para produzir respostas imunes, incluindo respostas de anticorpo e de proteção.
BR9714065-1A 1996-12-20 1997-12-19 Sistema de fornecimento de micropartìculas de alvo biodegradáveis BR9714065A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/770,850 US6042820A (en) 1996-12-20 1996-12-20 Biodegradable copolymer containing α-hydroxy acid and α-amino acid units
PCT/CA1997/000980 WO1998028357A1 (en) 1996-12-20 1997-12-19 Biodegradable targetable microparticle delivery system

Publications (1)

Publication Number Publication Date
BR9714065A true BR9714065A (pt) 2000-10-24

Family

ID=25089888

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9714065-1A BR9714065A (pt) 1996-12-20 1997-12-19 Sistema de fornecimento de micropartìculas de alvo biodegradáveis

Country Status (13)

Country Link
US (7) US6042820A (pt)
EP (1) EP0946624B1 (pt)
JP (3) JP3242118B2 (pt)
AT (1) ATE236207T1 (pt)
AU (1) AU729305B2 (pt)
BR (1) BR9714065A (pt)
CA (1) CA2275033C (pt)
DE (1) DE69720516T2 (pt)
DK (1) DK0946624T3 (pt)
ES (1) ES2196385T3 (pt)
NZ (1) NZ336718A (pt)
PT (1) PT946624E (pt)
WO (1) WO1998028357A1 (pt)

Families Citing this family (105)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9801288D0 (sv) * 1998-04-14 1998-04-14 Astra Ab Vaccine delivery system and metod of production
CA2335487A1 (en) 1998-06-19 1999-12-23 Merieux Oravax Lt and ct in parenteral immunization methods against helicobacter infection
US20070032853A1 (en) 2002-03-27 2007-02-08 Hossainy Syed F 40-O-(2-hydroxy)ethyl-rapamycin coated stent
US7807211B2 (en) * 1999-09-03 2010-10-05 Advanced Cardiovascular Systems, Inc. Thermal treatment of an implantable medical device
DK1295611T3 (da) * 2000-06-20 2010-10-04 Dainippon Sumitomo Pharma Co Oligonukleotid-transformerende forbindelser
US20040033240A1 (en) * 2000-07-05 2004-02-19 Bruno Guy Immunological combinations for prophylaxis and therapy of helicobacter pylori infection
US20030092145A1 (en) * 2000-08-24 2003-05-15 Vic Jira Viral vaccine composition, process, and methods of use
US9974847B2 (en) * 2000-08-24 2018-05-22 Immunitor USA, Inc. Treatment and prevention of tuberculosis
US10398830B2 (en) * 2000-11-17 2019-09-03 Vactronix Scientific, Llc Device for in vivo delivery of bioactive agents and method of manufacture thereof
US8632845B2 (en) * 2000-12-28 2014-01-21 Abbott Cardiovascular Systems Inc. Method of drying bioabsorbable coating over stents
WO2002060486A2 (en) * 2001-01-29 2002-08-08 Fresco Bernard B Controlled release microsphere system for administration of drug to the eye
ES2324525T3 (es) * 2001-06-20 2009-08-10 Dainippon Sumitomo Pharma Co., Ltd. Metodo para promover transferencia de acidos nucleicos.
EP1438413A4 (en) * 2001-10-03 2006-06-07 Selective Genetics Inc CROSSING OF NUCLEIC ACID MOLECULES IN A FLUID SPACE AND EXPRESSION IN REPAIR CELLS
CA2457564C (en) * 2001-10-05 2009-04-07 Surmodics, Inc. Particle immobilized coatings and uses thereof
ATE410459T1 (de) * 2002-01-14 2008-10-15 Gen Hospital Corp Bioabbaubare polyketale, verfahren zu ihrer herstellung sowie ihre verwendung
US20040071780A1 (en) * 2002-01-16 2004-04-15 Lillard James W. PACE-A microspheres for delivery of antigens
US8088388B2 (en) * 2002-02-14 2012-01-03 United Biomedical, Inc. Stabilized synthetic immunogen delivery system
US20050129776A1 (en) 2002-05-03 2005-06-16 Inserm Microparticles supporting cells and active substances
FR2839260B1 (fr) * 2002-05-03 2005-02-25 Inst Nat Sante Rech Med Microparticules a base d'un materiau bicompatible et biodegradable, supportant des cellules et des substances biologiquement actives
CA2486118A1 (en) * 2002-06-07 2003-12-18 Large Scale Biology Corporation Flexible vaccine assembly and vaccine delivery platform
US20040170606A1 (en) * 2002-06-07 2004-09-02 Palmer Kenneth E. Production of peptides in plants as viral coat protein fusions
AU2003269904A1 (en) * 2002-07-10 2004-01-23 The Ohio State University Research Foundation Antigen-polymer compositions
AU2003282372A1 (en) * 2002-11-29 2004-06-23 Yissum Research Development Company Of The Hebrew University Of Jerusalem Process for preparation of biodegradable polymers and resins from proteins, and plastics obtained thereby
WO2004092388A1 (ja) * 2003-04-18 2004-10-28 Japan As Represented By President Of National Cardiovascular Center ベクター
US20050118344A1 (en) 2003-12-01 2005-06-02 Pacetti Stephen D. Temperature controlled crimping
JP2005154514A (ja) * 2003-11-21 2005-06-16 Univ Waseda 機能性生分解性材料およびその製造方法
EP1696034A4 (en) * 2003-12-19 2006-12-27 Dainippon Sumitomo Pharma Co NUCLEIC ACID TRANSFER METHOD
AU2005244128B2 (en) * 2004-05-07 2009-06-25 President And Fellows Of Harvard College Pulmonary malarial vaccine
EP2500031A3 (en) 2005-02-24 2012-12-26 Joslin Diabetes Center, Inc. Compositions and Methods for Treating Vascular Permeability
US20090062184A1 (en) * 2005-03-24 2009-03-05 Dainippon Sumitomo Pharma Co., Ltd. Fine particulate preparation comprising complex of nucleic acid molecule and collagen
US9603941B2 (en) * 2006-01-24 2017-03-28 Minghui Chai Method of preparing dendritic drugs
BRPI0711035A2 (pt) * 2006-03-21 2011-08-23 Dsm Ip Assests Bv micropartìculas compreendendo um polìmero reticulado
WO2008026894A1 (en) * 2006-08-31 2008-03-06 Sk Chemicals Co., Ltd. Method for producing microspheres loaded with drugs and microspheres loaded with drugs produced thereby
CA2684946C (en) 2007-05-16 2015-03-31 The Brigham And Women's Hospital, Inc. Treatment of synucleinopathies
US8551072B2 (en) * 2007-12-12 2013-10-08 Boston Scientific Scimed, Inc. Methods, devices and compositions for controlled drug delivery to injured myocardium
US20110208064A1 (en) 2008-07-31 2011-08-25 Ran Chongzhao Curcumin Derivatives for Amyloid-Beta Plaque Imaging
US9207242B2 (en) 2008-10-09 2015-12-08 The University Of Hong Kong Cadherin-17 as diagnostic marker and therapeutic target for liver cancer
EP3622968A1 (en) 2008-10-31 2020-03-18 The General Hospital Corporation Compositions and methods for delivering a substance to a biological target
JP5588993B2 (ja) * 2008-11-14 2014-09-10 イファ ユニバーシティ−インダストリー コラボレーション ファウンデーション 高分子微粒球の製造方法及びその方法により製造された高分子微粒球
WO2010105096A2 (en) 2009-03-11 2010-09-16 University Of Massachusetts Modulation of human cytomegalovirus replication by micro-rna 132 (mir132), micro-rna 145 (mir145) and micro-rna 212 (mir212)
EP2756845B1 (en) 2009-04-03 2017-03-15 Dicerna Pharmaceuticals, Inc. Methods and compositions for the specific inhibition of KRAS by asymmetric double-stranded RNA
MX2011012597A (es) 2009-05-27 2012-04-19 Selecta Biosciences Inc Nanoportadores que poseen componentes con diferentes tasas de liberacion.
US20120208750A1 (en) 2009-09-29 2012-08-16 Joslin Diabetes Center, Inc. Use of protein kinase c delta (pkcd) inhibitors to treat diabetes, obesity, and hepatic steatosis
PT2525815E (pt) * 2010-01-24 2015-03-05 Novartis Ag Micropartículas de polímero biodegradável irradiadas
US20110224770A1 (en) * 2010-03-15 2011-09-15 Boston Scientific Scimed, Inc. Drug Eluting Stents and Methods of Making the Same
CN107080839A (zh) 2010-05-26 2017-08-22 西莱克塔生物科技公司 多价的合成纳米载体疫苗
US9447027B2 (en) 2010-10-22 2016-09-20 The General Hospital Corporation Treating long QT syndrome
WO2012065182A2 (en) 2010-11-12 2012-05-18 University Of Massachusetts Modulation of ubiquitination of synaptic proteins for the treatment of neurodegenerative and psychiatric disorders
DE102011018499A1 (de) 2011-04-23 2012-10-25 Emc Microcollections Gmbh Topische Nanopartikel-Vakzine zur Immunstimulation der dendritischen Zellen in der Haut
CN103702687A (zh) 2011-07-29 2014-04-02 西莱克塔生物科技公司 产生体液和细胞毒性t淋巴细胞（ctl）免疫应答的合成纳米载体
WO2013075132A1 (en) 2011-11-17 2013-05-23 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Therapeutic rna switches compositions and methods of use
EP2836514A4 (en) 2012-04-13 2015-12-30 Childrens Medical Center TIKI INHIBITORS
EP4410374A2 (en) 2012-05-08 2024-08-07 Onyx Therapeutics, Inc. Cylodextrin complexation methods for formulating peptide proteasome inhibitors
WO2014025808A1 (en) 2012-08-06 2014-02-13 The General Hospital Corporation Curcumin analogs
WO2014065860A1 (en) 2012-10-24 2014-05-01 The General Hospital Corporation Functionalized 1,2,4,5-tetrazine compounds for use in bioorthogonal coupling reactions
WO2014128257A1 (en) 2013-02-22 2014-08-28 Sanofi Serpins: methods of therapeutic beta-cell regeneration and function
EP2769732A1 (en) 2013-02-22 2014-08-27 Sanofi Serpins: methods of therapeutic beta-cell regeneration and function
EP2851086A1 (en) 2013-09-20 2015-03-25 Sanofi Serpins: methods of therapeutic ß-cell regeneration and function
WO2014159878A2 (en) 2013-03-13 2014-10-02 Regents Of The University Of California Intranasal administration of guanidinylated aminoglycosides
AR095426A1 (es) 2013-03-14 2015-10-14 Onyx Therapeutics Inc Inhibidores tripeptídicos de la epoxicetona proteasa
WO2014152127A1 (en) 2013-03-14 2014-09-25 Onyx Therapeutics, Inc. Dipeptide and tripeptide epoxy ketone protease inhibitors
US9737525B2 (en) 2013-06-07 2017-08-22 The General Hospital Corporation Small molecule activators of NRF2 pathway
US9757477B2 (en) 2013-09-06 2017-09-12 The General Hospital Corporation Imaging brown adipose tissue with curcumin derivatives
CN105142688B (zh) 2014-02-04 2018-01-19 艾博特心血管系统公司 具有基于novolimus和丙交酯的涂层使得novolimus与涂层具有最小键合量的药物递送支架或支撑件
US10179775B2 (en) 2014-08-11 2019-01-15 The General Hospital Corporation Cyclooctenes for bioorthogonol reactions
JO3474B1 (ar) 2014-08-29 2020-07-05 Amgen Inc مشتقات تيتراهيدرونافثالين التي تثبط بروتين mcl-1
AU2015346657B9 (en) 2014-11-10 2020-01-16 Evrys Bio, Llc Anti-HCMV compositions and methods
WO2016077240A2 (en) 2014-11-10 2016-05-19 Forge Life Science, Llc Anti-hcmv compositions and methods
US10420826B2 (en) 2014-11-11 2019-09-24 Massachusetts Eye & Ear Infirmary Conjunctivitis vaccines
JP7105065B2 (ja) 2014-12-15 2022-07-22 ダイセルナ ファーマシューティカルズ， インコーポレイテッド リガンド修飾二本鎖核酸
SI3277814T1 (sl) 2015-04-03 2020-12-31 University Of Massachusetts Oligonukleotidne spojine za ciljanja MRNA huntingtina
SI3277815T1 (sl) 2015-04-03 2022-01-31 University Of Massachusetts Ologonukleotidne spojine za zdravljenje preeklampsije in drugih angiogeneznih motenj
AU2016256895B2 (en) 2015-05-07 2022-05-26 Takeda Pharmaceutical Company Limited Glucocerebrosidase gene therapy for parkinson's disease
US10633653B2 (en) 2015-08-14 2020-04-28 University Of Massachusetts Bioactive conjugates for oligonucleotide delivery
EP4435105A2 (en) 2015-09-29 2024-09-25 Amgen Inc. Asgr inhibitors for reduzing cholesterol levels
AU2016355178B9 (en) 2015-11-19 2019-05-30 Massachusetts Institute Of Technology Lymphocyte antigen CD5-like (CD5L)-interleukin 12B (p40) heterodimers in immunity
EP3380613B1 (en) 2015-11-23 2022-10-26 The Regents of the University of California Tracking and manipulating cellular rna via nuclear delivery of crispr/cas9
EP3408391A4 (en) 2016-01-31 2019-08-28 University of Massachusetts BRANCHED OLIGONUCLEOTIDES
WO2017147410A1 (en) 2016-02-25 2017-08-31 Amgen Inc. Compounds that inhibit mcl-1 protein
CA3033368A1 (en) 2016-08-12 2018-02-15 University Of Massachusetts Conjugated oligonucleotides
US10449230B2 (en) 2016-10-06 2019-10-22 The Regents Of The University Of California Polymyxin derived cell penetrating scaffolds
US10443055B2 (en) 2016-12-22 2019-10-15 Beth Israel Deaconess Medical Center Compounds that target MYC microRNA responsive elements for the treatment of MYC-associated cancer
JP6453507B2 (ja) 2017-03-30 2019-01-16 アムジエン・インコーポレーテツド Ｍｃｌ−１タンパク質を阻害する化合物
CN110869498A (zh) 2017-05-10 2020-03-06 加利福尼亚大学董事会 经由核递送crispr/cas9导向编辑细胞rna
JP7406793B2 (ja) 2017-06-23 2023-12-28 ユニバーシティー オブ マサチューセッツ ２テイル自己デリバリー型ｓｉＲＮＡおよび関連方法
US20210128702A1 (en) 2017-08-11 2021-05-06 Dana-Farber Cancer Institute, Inc. Use of a botulinum toxin agent for treating plasma cell disorders
US11821003B2 (en) 2017-08-14 2023-11-21 Sanford Burnham Prebys Medical Discovery Institute Cardiogenic mesoderm formation regulators
US11364248B2 (en) 2017-08-18 2022-06-21 Amgen Inc. Compounds that inhibit Mcl-1 protein
MA50033A (fr) 2017-08-29 2020-07-08 Amgen Inc Composés macrocycliques permettant d'inhiber la protéine mcl-1
WO2019046668A1 (en) 2017-08-31 2019-03-07 Kezar Life Sciences AMIDE-SUBSTITUTED THIAZOLES AS INHIBITORS OF SECRETIC PROTEIN
BR112020007879A2 (pt) 2017-10-18 2020-10-13 Evrys Bio, Llc composições antivirais de amplo espectro e métodos
WO2019089216A1 (en) 2017-11-01 2019-05-09 Dana-Farber Cancer Institute, Inc. Methods of treating cancers
MA54985A (fr) 2018-03-05 2021-12-29 Amgen Inc Pharmacophores d'acide alpha-hydroxy phénylacétique ou antagonistes de la protéine bio-isostère mcl-1
EP3790968A1 (en) 2018-05-11 2021-03-17 Alpha Anomeric SAS Oligonucleotides conjugates comprising 7'-5'-alpha-anomeric-bicyclic sugar nucleosides
SG11202101288TA (en) 2018-08-10 2021-03-30 Univ Massachusetts Modified oligonucleotides targeting snps
CA3110661A1 (en) 2018-08-29 2020-03-05 University Of Massachusetts Inhibition of protein kinases to treat friedreich ataxia
EP3893899A2 (en) 2018-12-12 2021-10-20 Kite Pharma, Inc. Chimeric antigen receptors and car-t cells and methods of use
AU2020228307A1 (en) 2019-02-28 2021-09-23 Kezar Life Sciences Thiazole derivatives as protein secretion inhibitors
EP3966328A4 (en) 2019-05-06 2023-10-18 University Of Massachusetts ANTI-C9ORF72 OLIGONUCLEOTIDES AND RELATED METHODS
JP2022547790A (ja) 2019-08-09 2022-11-16 ユニバーシティー オブ マサチューセッツ Ｓｎｐを標的とする化学修飾オリゴヌクレオチド
CN110423338B (zh) * 2019-08-12 2021-05-25 深圳市氩氪新材料技术研究服务有限公司 一种改性聚乳酸材料的制备方法
US12037585B2 (en) 2019-12-23 2024-07-16 University Of Massachusetts Oligonucleotides for tissue specific gene expression modulation
IL300736A (en) 2020-08-31 2023-04-01 Kezar Life Sciences Protein secretion inhibitors
BR112023026862A2 (pt) 2021-06-23 2024-03-05 Beth Israel Deaconess Medical Ct Inc Compostos de oligonucleotídeos anti-flt1 otimizados para tratamento de pré-eclâmpsia e outros distúrbios angiogênicos
AR128634A1 (es) 2022-02-28 2024-05-29 Kezar Life Sciences Inhibidores de sec61 y uso de los mismos

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US30170A (en) * 1860-09-25 Improvement in plows
US2676945A (en) 1950-10-18 1954-04-27 Du Pont Condensation polymers of hydroxyacetic acid
US3839297A (en) 1971-11-22 1974-10-01 Ethicon Inc Use of stannous octoate catalyst in the manufacture of l(-)lactide-glycolide copolymer sutures
USRE30170E (en) 1975-04-04 1979-12-18 Sutures, Inc. Hydrolyzable polymers of amino acid and hydroxy acids
DE3521994A1 (de) 1985-06-20 1987-01-02 Bayer Ag N-(2-aminoacylamido-2-desoxy-hexosyl)-amide-, -carbamate und -harnstoffe, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
US5271945A (en) * 1988-07-05 1993-12-21 Takeda Chemical Industries, Ltd. Sustained release microcapsule for water soluble drug
US5248761A (en) 1992-08-12 1993-09-28 United States Surgical Corporation Amino acid terminated polyesters having predetermined monomeric sequence
US5399665A (en) * 1992-11-05 1995-03-21 Massachusetts Institute Of Technology Biodegradable polymers for cell transplantation
US5593778A (en) * 1993-09-09 1997-01-14 Kanebo, Ltd. Biodegradable copolyester, molded article produced therefrom and process for producing the molded article
WO1995018781A1 (en) * 1994-01-06 1995-07-13 Metabolix, Inc. Methods for synthesizing oligomers containing hydroxy acid units

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DK0946624T3 (da) 2003-07-14
US6228423B1 (en) 2001-05-08
CA2275033A1 (en) 1998-07-02
US6287604B1 (en) 2001-09-11
AU729305B2 (en) 2001-02-01
EP0946624B1 (en) 2003-04-02
ES2196385T3 (es) 2003-12-16
EP0946624A1 (en) 1999-10-06
JP2003261661A (ja) 2003-09-19
US6312732B1 (en) 2001-11-06
WO1998028357A1 (en) 1998-07-02
JP3428972B2 (ja) 2003-07-22
US6042820A (en) 2000-03-28
JP2002138139A (ja) 2002-05-14
JP3242118B2 (ja) 2001-12-25
AU5472198A (en) 1998-07-17
US6471996B1 (en) 2002-10-29
NZ336718A (en) 2001-01-26
PT946624E (pt) 2003-08-29
US6623764B1 (en) 2003-09-23
JP2000509428A (ja) 2000-07-25
ATE236207T1 (de) 2003-04-15
DE69720516T2 (de) 2004-02-19
CA2275033C (en) 2005-08-02
DE69720516D1 (de) 2003-05-08
US20050163745A1 (en) 2005-07-28

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