ES2188907T3 - Dispositivo de soporte farmaceutico adecuado ppara la administracion de compuestos farmaceuticos a las superficies de las mucosas. - Google Patents

Dispositivo de soporte farmaceutico adecuado ppara la administracion de compuestos farmaceuticos a las superficies de las mucosas.

Info

Publication number
ES2188907T3
ES2188907T3 ES97910117T ES97910117T ES2188907T3 ES 2188907 T3 ES2188907 T3 ES 2188907T3 ES 97910117 T ES97910117 T ES 97910117T ES 97910117 T ES97910117 T ES 97910117T ES 2188907 T3 ES2188907 T3 ES 2188907T3
Authority
ES
Spain
Prior art keywords
pharmaceutical
mucose
administration
support device
appropriate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97910117T
Other languages
English (en)
Inventor
Gilles H Tapolsky
David W Osborne
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ViroTex Corp
Original Assignee
ViroTex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24952019&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2188907(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by ViroTex Corp filed Critical ViroTex Corp
Application granted granted Critical
Publication of ES2188907T3 publication Critical patent/ES2188907T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4515—Non condensed piperidines, e.g. piperocaine having a butyrophenone group in position 1, e.g. haloperidol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Dispositivo de soporte para difundir compuestos farmacéuticos en la superficie de las mucosas. El dispositivo se compone de una capa adhesiva y de una capa de soporte no adhesiva, y el producto farmacéutico puede estar presente en una u otra capa o en ambas. Durante la aplicación, el dispositivo se adhiere a la superficie de las mucosas y garantiza una distribución localizada del medicamento y una protección del lugar a tratar. La cinética de erosión se modifica fácilmente variando el número de capas y/o los componentes.
ES97910117T 1996-10-18 1997-10-16 Dispositivo de soporte farmaceutico adecuado ppara la administracion de compuestos farmaceuticos a las superficies de las mucosas. Expired - Lifetime ES2188907T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/734,519 US5800832A (en) 1996-10-18 1996-10-18 Bioerodable film for delivery of pharmaceutical compounds to mucosal surfaces

Publications (1)

Publication Number Publication Date
ES2188907T3 true ES2188907T3 (es) 2003-07-01

Family

ID=24952019

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97910117T Expired - Lifetime ES2188907T3 (es) 1996-10-18 1997-10-16 Dispositivo de soporte farmaceutico adecuado ppara la administracion de compuestos farmaceuticos a las superficies de las mucosas.

Country Status (11)

Country Link
US (9) US5800832A (es)
EP (1) EP0973497B1 (es)
JP (3) JP3964465B2 (es)
AT (1) ATE229322T1 (es)
AU (1) AU729516B2 (es)
CA (1) CA2268187C (es)
DE (1) DE69717862T2 (es)
DK (1) DK0973497T3 (es)
ES (1) ES2188907T3 (es)
PT (1) PT973497E (es)
WO (1) WO1998017251A1 (es)

Families Citing this family (250)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6607727B1 (en) * 1991-08-26 2003-08-19 The Scripps Research Institute Peptides for inducing cytotoxic T lymphocyte responses to hepatitus B virus
EP0987019A1 (en) * 1998-09-01 2000-03-22 Virotex Corporation Topical antibiotic composition for rapid wound healing
US5800832A (en) * 1996-10-18 1998-09-01 Virotex Corporation Bioerodable film for delivery of pharmaceutical compounds to mucosal surfaces
DE19652257A1 (de) * 1996-12-16 1998-06-18 Lohmann Therapie Syst Lts Einzeln dosierte, bei Kontakt mit Flüssigkeit schnell zerfallende, wirkstoff- und insbesondere aromastoffhaltige, folienförmige Darreichnungsform
GB9707980D0 (en) * 1997-04-21 1997-06-11 Brax Genomics Ltd Characterising DNA
US6096328A (en) * 1997-06-06 2000-08-01 The Procter & Gamble Company Delivery system for an oral care substance using a strip of material having low flexural stiffness
US20050074495A1 (en) * 1997-06-17 2005-04-07 Fziomed, Inc. Compositions of polyacids and methods for their use in reducing adhesions
US6869938B1 (en) * 1997-06-17 2005-03-22 Fziomed, Inc. Compositions of polyacids and polyethers and methods for their use in reducing adhesions
US7192984B2 (en) * 1997-06-17 2007-03-20 Fziomed, Inc. Compositions of polyacids and polyethers and methods for their use as dermal fillers
US20040096422A1 (en) * 1997-06-17 2004-05-20 Schwartz Herbert E. Compositions of polyacids and polyethers and methods for their use in reducing pain
US6624200B2 (en) 1998-08-25 2003-09-23 Columbia Laboratories, Inc. Bioadhesive progressive hydration tablets
US7153845B2 (en) * 1998-08-25 2006-12-26 Columbia Laboratories, Inc. Bioadhesive progressive hydration tablets
US6248358B1 (en) 1998-08-25 2001-06-19 Columbia Laboratories, Inc. Bioadhesive progressive hydration tablets and methods of making and using the same
US8765177B2 (en) * 1997-09-12 2014-07-01 Columbia Laboratories, Inc. Bioadhesive progressive hydration tablets
JP3460538B2 (ja) * 1997-10-08 2003-10-27 救急薬品工業株式会社 速溶性フィルム製剤
US20050048102A1 (en) * 1997-10-16 2005-03-03 Virotex Corporation Pharmaceutical carrier device suitable for delivery of pharmaceutical compounds to mucosal surfaces
EP1079813B1 (en) * 1998-04-29 2005-02-09 Virotex Corporation Pharmaceutical carrier device suitable for delivery of pharmaceutical compounds to mucosal surfaces
EP1181023B1 (en) * 1999-04-02 2008-08-13 Fziomed, Inc. Compositions of polyacids, non-ionic polymers consisting of alkylene oxide monomers and multivalent cations and their use in reducing adhesions
US6297337B1 (en) 1999-05-19 2001-10-02 Pmd Holdings Corp. Bioadhesive polymer compositions
MXPA02000262A (es) * 1999-07-02 2005-08-16 Procter & Gamble Sistema de administracion para composiciones de cuidado oral que comprenden resinas de organosiloxano utilizando una tira de refuerzo removible.
CA2386422A1 (en) * 1999-10-22 2001-04-26 Lif-Hlaup Ehf. Bio-Gels Pharmaceuticals Inc. Pharmaceutical composition for treatment of mucosal epithelial ulceration and/or erosion
EP1221972B1 (en) 1999-10-26 2011-01-12 Novartis Vaccines and Diagnostics, Inc. Plant lectins as mucosal adjuvants
US6863896B1 (en) 1999-10-26 2005-03-08 Chiron Corporation Plant lectins as mucosal adjuvants
DE19954245A1 (de) 1999-11-11 2001-07-19 Lohmann Therapie Syst Lts Mehrschichtige filmförmige Zubereitung aus hydrophilen Polymeren zur schnellen Freisetzung von Wirkstoffen
US6555125B2 (en) * 1999-11-30 2003-04-29 Phillip Campbell Lesion and ulcer medication
US6706781B2 (en) * 1999-12-08 2004-03-16 The Procter & Gamble Company Denture adhesive compositions with antimicrobial agents
US6566345B2 (en) 2000-04-28 2003-05-20 Fziomed, Inc. Polyacid/polyalkylene oxide foams and gels and methods for their delivery
US6682721B2 (en) * 2000-03-17 2004-01-27 Lg Household & Healthcare Ltd. Patches for teeth whitening
US8652446B2 (en) * 2000-03-17 2014-02-18 Lg Household & Healthcare Ltd. Apparatus and method for whitening teeth
US7067116B1 (en) * 2000-03-23 2006-06-27 Warner-Lambert Company Llc Fast dissolving orally consumable solid film containing a taste masking agent and pharmaceutically active agent at weight ratio of 1:3 to 3:1
ATE425776T1 (de) * 2000-04-28 2009-04-15 Fziomed Inc Haemostatische zusammenstellung von polysauren und polyalkylenoxyden und deren verwendungsmethoden
WO2001091553A1 (en) * 2000-05-26 2001-12-06 Demegen, Inc. Composite wafer for controlled drug delivery
USRE44145E1 (en) 2000-07-07 2013-04-09 A.V. Topchiev Institute Of Petrochemical Synthesis Preparation of hydrophilic pressure sensitive adhesives having optimized adhesive properties
US7803392B2 (en) * 2000-12-27 2010-09-28 University Of Kentucky Research Foundation pH-Sensitive mucoadhesive film-forming gels and wax-film composites suitable for topical and mucosal delivery of molecules
DE10107659B4 (de) * 2001-02-19 2008-03-13 Lts Lohmann Therapie-Systeme Ag Mucoadhäsive zerfallsfähige Arzneizubereitung zur Wirkstoffverabreichung in der Veterinär- und Humanmedizin
EP1236466B1 (en) * 2001-02-28 2011-09-21 Axiomedic Ltd. Solid self-adhesive compositions for topical treatment of oral mucosal disorders
US8980334B2 (en) * 2001-02-28 2015-03-17 Axiomedic Ltd. Double-layered absorbable solid compositions for the topical treatment of oral mucosal disorders
JP4850346B2 (ja) * 2001-03-15 2012-01-11 救急薬品工業株式会社 粘膜貼付剤
CA2445086C (en) 2001-05-01 2008-04-08 A.V. Topchiev Institute Of Petrochemical Synthesis Hydrogel compositions
US8541021B2 (en) 2001-05-01 2013-09-24 A.V. Topchiev Institute Of Petrochemical Synthesis Hydrogel compositions demonstrating phase separation on contact with aqueous media
US20030235549A1 (en) * 2001-05-01 2003-12-25 Parminder Singh Hydrogel compositions demonstrating phase separation on contact with aqueous media
US8840918B2 (en) 2001-05-01 2014-09-23 A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences Hydrogel compositions for tooth whitening
US20050215727A1 (en) 2001-05-01 2005-09-29 Corium Water-absorbent adhesive compositions and associated methods of manufacture and use
US8206738B2 (en) 2001-05-01 2012-06-26 Corium International, Inc. Hydrogel compositions with an erodible backing member
US20050113510A1 (en) 2001-05-01 2005-05-26 Feldstein Mikhail M. Method of preparing polymeric adhesive compositions utilizing the mechanism of interaction between the polymer components
WO2002087642A2 (en) 2001-05-01 2002-11-07 A.V. Topchiev Institute Of Petrochemical Synthesis Two-phase, water-absorbent bioadhesive composition
HUP0401022A3 (en) * 2001-08-14 2006-11-28 Biotie Therapies Corp Method for the preparation of pharmaceutical compositions containing opioid antagonist for treating alcoholism or alcohol abuse
US20060073174A1 (en) * 2001-08-16 2006-04-06 Access Pharmaceuticals, Inc. Adherent and erodible film to treat a moist surface of a body tissue
US6585997B2 (en) 2001-08-16 2003-07-01 Access Pharmaceuticals, Inc. Mucoadhesive erodible drug delivery device for controlled administration of pharmaceuticals and other active compounds
US8603514B2 (en) 2002-04-11 2013-12-10 Monosol Rx, Llc Uniform films for rapid dissolve dosage form incorporating taste-masking compositions
US20070281003A1 (en) 2001-10-12 2007-12-06 Fuisz Richard C Polymer-Based Films and Drug Delivery Systems Made Therefrom
US8900497B2 (en) 2001-10-12 2014-12-02 Monosol Rx, Llc Process for making a film having a substantially uniform distribution of components
US20110033542A1 (en) 2009-08-07 2011-02-10 Monosol Rx, Llc Sublingual and buccal film compositions
US7425292B2 (en) * 2001-10-12 2008-09-16 Monosol Rx, Llc Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom
US8663687B2 (en) * 2001-10-12 2014-03-04 Monosol Rx, Llc Film compositions for delivery of actives
US8900498B2 (en) 2001-10-12 2014-12-02 Monosol Rx, Llc Process for manufacturing a resulting multi-layer pharmaceutical film
US8765167B2 (en) * 2001-10-12 2014-07-01 Monosol Rx, Llc Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US7357891B2 (en) * 2001-10-12 2008-04-15 Monosol Rx, Llc Process for making an ingestible film
US7666337B2 (en) * 2002-04-11 2010-02-23 Monosol Rx, Llc Polyethylene oxide-based films and drug delivery systems made therefrom
US10285910B2 (en) 2001-10-12 2019-05-14 Aquestive Therapeutics, Inc. Sublingual and buccal film compositions
US11207805B2 (en) 2001-10-12 2021-12-28 Aquestive Therapeutics, Inc. Process for manufacturing a resulting pharmaceutical film
US20190328679A1 (en) 2001-10-12 2019-10-31 Aquestive Therapeutics, Inc. Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US7201930B2 (en) * 2001-11-05 2007-04-10 Haley Jeffrey T Licorice root extract oral patch for treating canker sores
US20030124178A1 (en) * 2001-12-28 2003-07-03 Haley Jeffrey T. Soft, adherent, soluble oral patch
DE10207394B4 (de) * 2002-02-21 2007-03-29 Lts Lohmann Therapie-Systeme Ag Geschmacksmaskierte oblatenförmige Arzneizubereitung
US8017150B2 (en) 2002-04-11 2011-09-13 Monosol Rx, Llc Polyethylene oxide-based films and drug delivery systems made therefrom
US20030194420A1 (en) * 2002-04-11 2003-10-16 Richard Holl Process for loading a drug delivery device
EP1519718A1 (de) * 2002-05-24 2005-04-06 AgfaPhoto GmbH Wirkstoff enthaltende, zumindest teilweise abbaubare folien und verfahren zu deren herstellung
AU2003256329A1 (en) * 2002-06-27 2004-01-19 University Of Washington Use of adhesion molecules as bond stress-enhanced nanoscale binding switches
CA2505796C (en) * 2002-07-22 2012-01-03 Monosolrx Llc Packaging and dispensing of rapid dissolve dosage form
US20050100515A1 (en) * 2002-09-11 2005-05-12 The Procter & Gamble Company Tooth whitening products
US8524200B2 (en) 2002-09-11 2013-09-03 The Procter & Gamble Company Tooth whitening products
US6893629B2 (en) * 2002-10-30 2005-05-17 Isp Investments Inc. Delivery system for a tooth whitener
US20050186526A1 (en) * 2002-11-01 2005-08-25 Bas Medical, Inc. Methods and systems for enabling and stabilizing tooth movement
US6984128B2 (en) 2002-11-01 2006-01-10 Bas Medical, Inc. Methods for enabling and stabilizing tooth movement
US20050013845A1 (en) * 2002-11-12 2005-01-20 Warren Stephen L. Adhesive bioerodible ocular drug delivery system
DE10252726B4 (de) 2002-11-13 2008-05-08 Lts Lohmann Therapie-Systeme Ag Mehrschichtiges transmucosales therapeutisches System
US20040156794A1 (en) * 2003-02-11 2004-08-12 Barkalow David G. Bioerodible and bioadhesive confectionery products and methods of making same
US20040185009A1 (en) * 2003-03-19 2004-09-23 Dexcel Pharma Technologies Ltd. Composition and device for treating periodontal diseases
WO2004103328A1 (en) * 2003-04-30 2004-12-02 Icure Pharmaceutical Corporation Patch for tooth whitening
US7276246B2 (en) * 2003-05-09 2007-10-02 Cephalon, Inc. Dissolvable backing layer for use with a transmucosal delivery device
US7306812B2 (en) 2003-05-09 2007-12-11 Cephalon, Inc. Dissolvable backing layer for use with a transmucosal delivery device
US20040241151A1 (en) * 2003-05-27 2004-12-02 Sca Hygiene Products Ab Polymer matrix with lactic acid producing bacteria
US20050118261A1 (en) * 2003-06-12 2005-06-02 Oien Hal J. Compositions and methods of administering doxepin to mucosal tissue
JP2007502823A (ja) * 2003-08-15 2007-02-15 キューエルティー・ユーエスエイ・インコーポレーテッド 接着性および生体侵食性の経粘膜薬物送達システム
US20080317828A1 (en) * 2003-09-24 2008-12-25 Kazuyoshi Furusawa Fentanyl compound-containing edible patch to be applied to oral mucosa
WO2005039499A2 (en) 2003-10-24 2005-05-06 Adhesives Research, Inc. Rapidly disintegrating film
US8627828B2 (en) 2003-11-07 2014-01-14 U.S. Smokeless Tobacco Company Llc Tobacco compositions
EP1691631A4 (en) 2003-11-07 2012-09-05 Us Smokeless Tobacco Co TOBACCO COMPOSITIONS
RU2380092C2 (ru) * 2004-01-30 2010-01-27 Кориум Интернэшнл, Инк. Быстро растворяющаяся пленка для доставки активного агента
GB0403808D0 (en) * 2004-02-20 2004-03-24 Bioprogress Technology Ltd Films for use as dosage forms
EP1734917A1 (en) * 2004-04-01 2006-12-27 Smithkline Beecham Corporation Dissolvable tooth whitening strip
US20050281757A1 (en) * 2004-06-17 2005-12-22 Sayed Ibrahim Oral care film
EP1773366A4 (en) * 2004-06-22 2009-11-11 E L Management Corp SOLUBLE FILM COMPOSITION
EP1791575B1 (en) 2004-08-05 2014-10-08 Corium International, Inc. Adhesive composition
US8252321B2 (en) 2004-09-13 2012-08-28 Chrono Therapeutics, Inc. Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like
EP1802258A4 (en) 2004-09-13 2015-09-23 Chrono Therapeutics Inc BIOSYNCHRONE TRANSDERMAL MEDICINES
US8899976B2 (en) 2004-09-24 2014-12-02 Align Technology, Inc. Release agent receptacle
EP1793872B1 (en) * 2004-09-30 2016-05-11 Covalon Technologies Inc. Non-adhesive elastic gelatin matrices
JP2006096728A (ja) * 2004-09-30 2006-04-13 Kobayashi Pharmaceut Co Ltd 口腔内定着型固形製剤
AR051397A1 (es) 2004-10-21 2007-01-10 Novartis Ag Composicion farmaceutica
US9198897B2 (en) * 2005-01-19 2015-12-01 Neurohealing Pharmaceuticals, Inc. Methods and compositions for decreasing saliva production
WO2006096914A1 (en) * 2005-03-15 2006-09-21 Animal Ethics Pty Ltd A topical analgesic composition
US7803817B2 (en) * 2005-05-11 2010-09-28 Vecta, Ltd. Composition and methods for inhibiting gastric acid secretion
US7981908B2 (en) * 2005-05-11 2011-07-19 Vecta, Ltd. Compositions and methods for inhibiting gastric acid secretion
WO2006135491A2 (en) * 2005-06-08 2006-12-21 Basf Aktiengesellschaft Medicament carrier composition and method of forming a film therefrom
US20070042027A1 (en) * 2005-08-22 2007-02-22 Haley Jeffrey T Water soluble anesthetic in an oral patch of hydrophilic gums
US8623334B1 (en) 2005-09-29 2014-01-07 Alan J. Wickenhauser Topical anesthetic
US8263047B2 (en) * 2005-09-29 2012-09-11 Wickenhauser Alan J Topical anesthetic for dental procedures
US20070154542A1 (en) * 2005-12-30 2007-07-05 Cogentus Pharmaceuticals, Inc. Oral pharmaceutical formulations containing non-steroidal anti-inflammatory drugs and acid inhibitors
US8252328B2 (en) * 2006-01-06 2012-08-28 Acelrx Pharmaceuticals, Inc. Bioadhesive drug formulations for oral transmucosal delivery
US9289583B2 (en) 2006-01-06 2016-03-22 Acelrx Pharmaceuticals, Inc. Methods for administering small volume oral transmucosal dosage forms using a dispensing device
US9066847B2 (en) * 2007-01-05 2015-06-30 Aceirx Pharmaceuticals, Inc. Storage and dispensing devices for administration of oral transmucosal dosage forms
US8202535B2 (en) 2006-01-06 2012-06-19 Acelrx Pharmaceuticals, Inc. Small-volume oral transmucosal dosage forms
US8535714B2 (en) 2006-01-06 2013-09-17 Acelrx Pharmaceuticals, Inc. Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain
US8753308B2 (en) 2006-01-06 2014-06-17 Acelrx Pharmaceuticals, Inc. Methods for administering small volume oral transmucosal dosage forms using a dispensing device
US8357114B2 (en) 2006-01-06 2013-01-22 Acelrx Pharmaceuticals, Inc. Drug dispensing device with flexible push rod
US8865743B2 (en) 2006-01-06 2014-10-21 Acelrx Pharmaceuticals, Inc. Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain
US8252329B2 (en) 2007-01-05 2012-08-28 Acelrx Pharmaceuticals, Inc. Bioadhesive drug formulations for oral transmucosal delivery
JP2009523808A (ja) * 2006-01-20 2009-06-25 モノソル アールエックス リミテッド ライアビリティ カンパニー 活性物質の粘膜投与のためのフィルム包帯
US20070192182A1 (en) * 2006-02-10 2007-08-16 Tovin Monaco Method of delivering coupons using customer data
US20070192438A1 (en) * 2006-02-10 2007-08-16 Esmond Goei System and method for on-demand delivery of media products
US20070192183A1 (en) * 2006-02-10 2007-08-16 Tovin Monaco System and architecture for providing retail buying options to consumer using customer data
US20070190013A1 (en) * 2006-02-13 2007-08-16 Yeli Zhang Film and film-forming compositions
US8349120B2 (en) * 2006-03-07 2013-01-08 Ora Health Corporation Multi-layer patch made on a sheet and enclosed in a blister
DE602007010254D1 (de) * 2006-03-16 2010-12-16 Novartis Ag Feste dosierungsform mit einem wirkstoff mit unterdrücktem geschmack
AU2007230730B2 (en) 2006-03-24 2013-03-28 Auxilium International Holdings, Inc. Stabilized compositions containing alkaline labile drugs
CN101489756B (zh) * 2006-03-24 2013-08-07 奥克思利尤姆国际控股公司 热熔挤出层压材料的制备方法
CN101460154B (zh) 2006-04-04 2015-07-01 Kg艾克维泽生公司 包含抗血小板剂和抑酸剂的口服剂型
US20070248655A1 (en) * 2006-04-21 2007-10-25 Haley Jeffrey T Lenticular shaped protective mouth sore discs
JP5410964B2 (ja) * 2006-05-23 2014-02-05 オラヘルス コーポレーション 付着性アカシアゴムを含む二層構造の口腔内付着錠
US20070298087A1 (en) * 2006-06-27 2007-12-27 Biegajski James E Two-phase mucoadhesive composition
ES2577390T3 (es) * 2006-07-21 2016-07-14 Biodelivery Sciences International, Inc. Dispositivos de administración transmucosa con mayor captación
PL2046334T3 (pl) * 2006-07-25 2015-02-27 Vecta Ltd Kompozycje i sposoby hamowania wydzielania kwasów żołądkowych z wykorzystaniem pochodnych małych kwasów dikarboksylowych w połączeniu z PPI
JP4739452B2 (ja) 2006-09-20 2011-08-03 モノソル アールエックス リミテッド ライアビリティ カンパニー 発泡を減じる風味付与剤を含む喫食可能な水溶性フィルム
HUE038022T4 (hu) 2006-10-02 2023-02-28 Spepharm Ag Nem mukoadhezív filmdózisformák
US10265265B2 (en) 2007-03-15 2019-04-23 Drug Delivery Solutions Limited Topical composition
US20080292683A1 (en) * 2007-05-24 2008-11-27 Monosolrx, Llc. Film shreds and delivery system incorporating same
EP2008651A1 (en) * 2007-06-26 2008-12-31 Drug Delivery Solutions Limited A bioerodible patch
US8298583B2 (en) * 2007-10-19 2012-10-30 Monosol Rx, Llc Film delivery system for tetrahydrolipstatin
AU2008346830B2 (en) 2007-12-31 2014-07-24 Acclarent, Inc. Mucosal tissue dressing and method of use
US8172569B2 (en) 2008-06-12 2012-05-08 Align Technology, Inc. Dental appliance
CA2728912C (en) 2008-06-23 2018-04-10 Biodelivery Sciences International, Inc. Multidirectional mucosal delivery devices and methods of use
KR101794899B1 (ko) * 2008-08-09 2017-11-07 메사츄세츠 인스티튜트 어브 테크놀로지 남성 비뇨생식기 및 주위 조직을 치료하는 방법 및 체내이식형 약물 전달 장치
US20100040727A1 (en) * 2008-08-18 2010-02-18 Monosol Rx, Llc Method for Improving Uniformity of Content in Edible Film Manufacturing
US8945592B2 (en) 2008-11-21 2015-02-03 Acelrx Pharmaceuticals, Inc. Sufentanil solid dosage forms comprising oxygen scavengers and methods of using the same
US8282954B2 (en) * 2008-12-15 2012-10-09 Monosol Rx, Llc Method for manufacturing edible film
US8784879B2 (en) 2009-01-14 2014-07-22 Corium International, Inc. Transdermal administration of tamsulosin
US20100209484A1 (en) * 2009-02-13 2010-08-19 Hoo-Kyun Choi Transdermal Triptan Delivery System
EP2424950A4 (en) 2009-04-28 2014-04-30 3M Innovative Properties Co WATER-SOLUBLE ADHESIVES
US20100297232A1 (en) * 2009-05-19 2010-11-25 Monosol Rx, Llc Ondansetron film compositions
EP2432450B1 (en) * 2009-05-22 2019-07-31 Wyeth LLC Single-use, disposable strip for application of topical compositions
PL2952191T3 (pl) 2009-06-12 2019-02-28 Sunovion Pharmaceuticals Inc. Apomorfina w postaci do podawania podjęzykowego
US8475832B2 (en) * 2009-08-07 2013-07-02 Rb Pharmaceuticals Limited Sublingual and buccal film compositions
US8701671B2 (en) 2011-02-04 2014-04-22 Joseph E. Kovarik Non-surgical method and system for reducing snoring
US9549842B2 (en) 2011-02-04 2017-01-24 Joseph E. Kovarik Buccal bioadhesive strip and method of treating snoring and sleep apnea
EP2504019A2 (en) 2009-11-25 2012-10-03 ArisGen SA Mucosal delivery composition comprising a peptide complexed with a crown compound and/or a counter ion
EP2519226A1 (en) * 2009-12-28 2012-11-07 MonoSol Rx, LLC Orally administrable film dosage forms containing ondansetron
EP2377526A1 (en) 2010-03-23 2011-10-19 BioAlliance Pharma Fast dissolving drug delivery systems
RU2560693C2 (ru) 2010-03-23 2015-08-20 Апр Эпплайд Фарма Рисерч, С.А. Быстро растворяющиеся системы, освобождающие лекарственные препараты
US20110237563A1 (en) * 2010-03-23 2011-09-29 Dominique Costantini Fast dissolving drug delivery systems
EP2579844B1 (en) 2010-06-10 2016-02-24 Midatech Ltd. Nanoparticle film delivery systems
US9211175B2 (en) 2010-07-08 2015-12-15 Covidien Lp Self-detachable medical devices
FR2962646B1 (fr) 2010-07-16 2012-06-22 Sofradim Production Prothese avec element radio-opaque
US9572907B2 (en) 2010-10-01 2017-02-21 Covidien Lp Implantable polymeric films
US8632839B2 (en) 2010-10-19 2014-01-21 Covidien Lp Methods of forming self-supporting films for delivery of therapeutic agents
US9861590B2 (en) 2010-10-19 2018-01-09 Covidien Lp Self-supporting films for delivery of therapeutic agents
US8920867B2 (en) 2010-10-19 2014-12-30 Covidien Lp Methods of forming self-supporting films for delivery of therapeutic agents
US9149959B2 (en) 2010-10-22 2015-10-06 Monosol Rx, Llc Manufacturing of small film strips
US8865198B2 (en) 2010-10-25 2014-10-21 Dexcel Pharma Technologies Ltd. Method for treating a periodontal disease
WO2012083269A1 (en) 2010-12-16 2012-06-21 Cynapsus Therapeutics, Inc. Sublingual films
US9144634B2 (en) 2011-01-14 2015-09-29 Covidien Lp Medical device with intrapore films
WO2012104834A1 (en) * 2011-02-03 2012-08-09 Pharmedica Ltd. New oral dissolving films for insulin administration, for treating diabetes
US11951139B2 (en) 2015-11-30 2024-04-09 Seed Health, Inc. Method and system for reducing the likelihood of osteoporosis
US11998479B2 (en) 2011-02-04 2024-06-04 Seed Health, Inc. Method and system for addressing adverse effects on the oral microbiome and restoring gingival health caused by sodium lauryl sulphate exposure
US11844720B2 (en) 2011-02-04 2023-12-19 Seed Health, Inc. Method and system to reduce the likelihood of dental caries and halitosis
US11951140B2 (en) 2011-02-04 2024-04-09 Seed Health, Inc. Modulation of an individual's gut microbiome to address osteoporosis and bone disease
HUE045467T2 (hu) 2011-03-14 2020-01-28 Drug Delivery Solutions Ltd Szemészeti készítmény
JP5727292B2 (ja) * 2011-05-11 2015-06-03 富士フイルム株式会社 複合フィルム
US8241661B1 (en) 2011-06-24 2012-08-14 Fuisz Richard C Biocompatible film with variable cross-sectional properties
US20130017259A1 (en) 2011-07-06 2013-01-17 The Parkinson's Institute Compositions and Methods for Treatment of Symptoms in Parkinson's Disease Patients
FR2977790B1 (fr) 2011-07-13 2013-07-19 Sofradim Production Prothese pour hernie ombilicale
US8579924B2 (en) 2011-07-26 2013-11-12 Covidien Lp Implantable devices including a mesh and a pivotable film
CA2845634C (en) 2011-08-18 2021-07-13 Biodelivery Sciences International, Inc. Abuse-resistant mucoadhesive devices for delivery of buprenorphine
US9782957B2 (en) 2011-08-24 2017-10-10 Covidien Lp Medical device films
US9179994B2 (en) 2011-10-25 2015-11-10 Covidien Lp Implantable film/mesh composite
US9005308B2 (en) 2011-10-25 2015-04-14 Covidien Lp Implantable film/mesh composite for passage of tissue therebetween
US8932621B2 (en) 2011-10-25 2015-01-13 Covidien Lp Implantable film/mesh composite
EP2793870A4 (en) 2011-12-21 2016-02-17 Biodelivery Sciences Int Inc DEVICES FOR TRANSMUCOSAL ACTIVE INGREDIENT RELEASE FOR USE IN THE TREATMENT OF CHRONIC PAIN
US9901539B2 (en) 2011-12-21 2018-02-27 Biodelivery Sciences International, Inc. Transmucosal drug delivery devices for use in chronic pain relief
US10806703B2 (en) * 2012-01-20 2020-10-20 Lts Lohmann Therapie-System Ag Transmucosal administration system for a pharmaceutical drug
US10206769B2 (en) 2012-03-30 2019-02-19 Covidien Lp Implantable devices including a film providing folding characteristics
FR2992662B1 (fr) 2012-06-28 2014-08-08 Sofradim Production Tricot avec picots
FR2992547B1 (fr) 2012-06-29 2015-04-24 Sofradim Production Prothese pour hernie
EP2874824A1 (en) 2012-07-23 2015-05-27 Crayola LLC Dissolvable films and methods of using the same
BR112015008666B1 (pt) 2012-10-17 2020-04-07 Procter & Gamble produto extensível para tratamento dental e método de aplicação de um ativo para tratamento bucal
US20150104493A1 (en) * 2012-10-22 2015-04-16 Robert W. McDonald, III Dissolvable Strip for Treatment of Oral Thermal Burns
US20140120150A1 (en) * 2012-10-29 2014-05-01 Robert W. McDonald, III Dissolvable Strip for Treatment of Oral Thermal Burns
WO2014070485A1 (en) * 2012-10-22 2014-05-08 2010 Mfi, Llc Dissolvable strip for treatment of oral thermal burns
US11446364B2 (en) 2012-11-14 2022-09-20 Smith & Nephew, Inc. Stable thermolysin hydrogel
JP6893086B2 (ja) 2013-03-13 2021-06-23 エーブリー デニソン コーポレイション 接着特性の向上
US20140271787A1 (en) 2013-03-15 2014-09-18 Monosol Rx, Llc Continuous single layer film structure including discrete domains
EP3659630B1 (en) 2013-03-15 2023-12-27 Smith & Nephew, Inc. Dissolvable gel-forming film for delivery of active agents
KR101751631B1 (ko) * 2013-05-31 2017-06-27 히사미쓰 세이야꾸 가부시키가이샤 구강 첩부제
US20160213575A1 (en) * 2013-09-11 2016-07-28 3M Innovative Properties Company Coating compositions, dental structures thereof and methods for generating contrast
DE102013112468A1 (de) 2013-11-13 2015-05-13 Heraeus Kulzer Gmbh Zahnprothese als nicht-invasive, transmuköse Darreichungsform zur Behandlung chronischer Erkrankungen, Verfahren zu Ihrer Herstellung sowie deren Verwendung
US11980643B2 (en) 2013-12-20 2024-05-14 Seed Health, Inc. Method and system to modify an individual's gut-brain axis to provide neurocognitive protection
US11826388B2 (en) 2013-12-20 2023-11-28 Seed Health, Inc. Topical application of Lactobacillus crispatus to ameliorate barrier damage and inflammation
US11839632B2 (en) 2013-12-20 2023-12-12 Seed Health, Inc. Topical application of CRISPR-modified bacteria to treat acne vulgaris
US12005085B2 (en) 2013-12-20 2024-06-11 Seed Health, Inc. Probiotic method and composition for maintaining a healthy vaginal microbiome
US11969445B2 (en) 2013-12-20 2024-04-30 Seed Health, Inc. Probiotic composition and method for controlling excess weight, obesity, NAFLD and NASH
US11833177B2 (en) 2013-12-20 2023-12-05 Seed Health, Inc. Probiotic to enhance an individual's skin microbiome
US11998574B2 (en) 2013-12-20 2024-06-04 Seed Health, Inc. Method and system for modulating an individual's skin microbiome
EP2889030A1 (en) * 2013-12-30 2015-07-01 Uluru Inc. Controlling the erosion rates of mucoadhesive devices that deliver actives and other compounds and providing increased and variable therapeutic blood levels
KR102240525B1 (ko) * 2013-12-31 2021-04-16 존슨 앤드 존슨 컨수머 인코포레이티드 다층의 형상화된 필름을 형성하기 위한 방법
JP6636431B2 (ja) * 2013-12-31 2020-01-29 ジョンソン・アンド・ジョンソン・コンシューマー・インコーポレイテッド 賦形フィルム製品を形成するための方法
ES2703210T3 (es) * 2013-12-31 2019-03-07 Johnson & Johnson Consumer Inc Proceso en un solo paso para la formación de un producto en la forma de película de capas múltiples, producto y aparato
US20160144528A1 (en) 2014-11-25 2016-05-26 Biodelivery Sciences International, Inc. Patch devices, methods and apparatus for forming, and testing pharmaceutical agent delivery patch devices
US10213586B2 (en) 2015-01-28 2019-02-26 Chrono Therapeutics Inc. Drug delivery methods and systems
AU2016228779A1 (en) 2015-03-12 2017-09-07 Chrono Therapeutics Inc. Craving input and support system
CA3019769C (en) 2015-04-21 2021-10-12 Sunovion Pharmaceuticals Inc. Methods of treating parkinson's disease by administration of apomorphine to an oral mucosa
WO2016209882A2 (en) * 2015-06-22 2016-12-29 Johnson & Johnson Consumer Inc. Method for providing a benefit to skin
US20170079832A1 (en) * 2015-09-21 2017-03-23 Heng Henry Khun Female urinary barrier system
WO2017085262A1 (en) * 2015-11-19 2017-05-26 Dermtreat Aps A pharmaceutical film composition having improved residence time on the application site
US20170157283A1 (en) 2015-12-08 2017-06-08 Medtronic Xomed, Inc. Dissolvable nasal sinus sponge
JPWO2017135195A1 (ja) * 2016-02-03 2018-11-22 社会医療法人蘇西厚生会 まつなみリサーチパーク アレルギー症状の予防又は治療剤
US11166912B2 (en) 2016-03-03 2021-11-09 Ctt Pharma Inc. Orally administrable composition
BR112018071908A2 (pt) 2016-04-26 2019-02-05 Lts Lohmann Therapie Systeme Ag forma de administração tipo filme para a liberação transmucosa de peptídeos antidiabéticos e método para produção da mesma
CN109310646A (zh) 2016-05-05 2019-02-05 阿奎斯蒂弗医疗股份有限公司 增强递送的肾上腺素组合物
US11273131B2 (en) 2016-05-05 2022-03-15 Aquestive Therapeutics, Inc. Pharmaceutical compositions with enhanced permeation
WO2018092362A1 (ja) 2016-11-18 2018-05-24 パナソニックＩｐマネジメント株式会社 生体貼付用膜およびその製造方法
JP6868698B2 (ja) 2016-12-31 2021-05-12 バイオエクセル セラピューティクス，インコーポレイテッド 激越の治療のための舌下デクスメデトミジンの使用
WO2018129304A1 (en) 2017-01-06 2018-07-12 Chrono Therapeutics Inc. Transdermal drug delivery devices and methods
EP3634507A4 (en) 2017-06-07 2021-03-24 EGY-Nano Pharma, LP PROLONGED ORAL DRUG DELIVERY PLATFORMS
CA3066951A1 (en) * 2017-06-30 2019-01-03 Allergan, Inc. Dissolving film for delivery of a clostridial derivative
WO2019021476A1 (ja) * 2017-07-28 2019-01-31 社会医療法人蘇西厚生会 まつなみリサーチパーク アレルギー症状の予防又は治療剤
EP3691610A1 (en) * 2017-10-07 2020-08-12 Zim Laboratories Limited Process for the preparation of bi/multi-layer film, multi-layered film produced thereof and apparatus for producing such multi-layer films
EP3542788A1 (en) 2018-03-19 2019-09-25 MC2 Therapeutics Limited Topical composition comprising calcipotriol and betamethasone dipropionate
AU2019279884A1 (en) 2018-05-29 2020-12-10 Morningside Venture Investments Limited Drug delivery methods and systems
GB2575625A (en) 2018-06-22 2020-01-22 Church & Dwight Co Inc Oral care compositions comprising benzocaine and mucoadhesive thin films formed therefrom
MX2020014000A (es) 2018-06-27 2021-06-15 Bioxcel Therapeutics Inc Formulaciones en lámina que contienen dexmedetomidina y métodos para producirlas.
JP7277087B2 (ja) * 2018-08-17 2023-05-18 株式会社ダイセル 包装体、錠剤入り包装体、包装体の収容部材の製造方法、及び包装体の収容部材の製造装置
CN111848834B (zh) * 2019-04-30 2023-01-24 苏州大学 含氟化合物修饰的阳离子聚合物在制备药物的跨黏膜给药中的应用
US11298336B2 (en) 2019-05-30 2022-04-12 Soluble Technologies, Inc. Water soluble formulation
BR112022000992A2 (pt) 2019-07-19 2022-06-14 Arx Llc Regimes de tratamento de dexmedetomidina não sedantes
US20240099984A1 (en) * 2019-10-15 2024-03-28 The University Of North Carolina At Chapel Hill A biodissolvable film for localized and efficient treatment of vulvodynia
WO2021163529A2 (en) 2020-02-13 2021-08-19 Biodelivery Sciences International, Inc. Methods of treatment with buprenorphine
US11179331B1 (en) 2020-04-21 2021-11-23 Cure Pharmaceutcai Holding Corp Oral soluble film containing sildenafil citrate
US11786475B2 (en) 2020-07-22 2023-10-17 Soluble Technologies Inc. Film-based dosage form
US11806334B1 (en) 2023-01-12 2023-11-07 Bioxcel Therapeutics, Inc. Non-sedating dexmedetomidine treatment regimens

Family Cites Families (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB981372A (en) 1960-05-04 1965-01-27 Pfizer Ltd Pharmaceutical formulations for oral administration to animals
US3640741A (en) * 1970-02-24 1972-02-08 Hollister Inc Composition containing gel
US3996934A (en) * 1971-08-09 1976-12-14 Alza Corporation Medical bandage
JPS5562012A (en) * 1978-11-06 1980-05-10 Teijin Ltd Slow-releasing preparation
GB2042888B (en) * 1979-03-05 1983-09-28 Teijin Ltd Preparation for administration to the mucosa of the oral or nasal cavity
US4285934A (en) * 1979-07-13 1981-08-25 Tinnell James E Treatment for herpes virus
JPS56100714A (en) * 1980-01-16 1981-08-12 Teijin Ltd Pharmaceutical adhering to oral mucous membrane or nasal mucous membrane
US4286592A (en) * 1980-02-04 1981-09-01 Alza Corporation Therapeutic system for administering drugs to the skin
US4381296A (en) * 1980-06-23 1983-04-26 Tinnell James E Treatment for herpes virus
JPS5758615A (en) * 1980-09-26 1982-04-08 Nippon Soda Co Ltd Film agnent and its preparation
JPS5770816A (en) * 1980-10-17 1982-05-01 Ono Pharmaceut Co Ltd Multilayered film preparation of prostagladin of prolonged action
JPS57110254A (en) * 1980-12-29 1982-07-09 Teijin Ltd Coating agent of injured membrane part of oral cavity
CH653550A5 (de) 1981-10-20 1986-01-15 Sandoz Ag Pharmazeutische zusammensetzung zur verzoegerten freigabe eines medikamentes im mundbereich.
US4518721A (en) * 1982-03-26 1985-05-21 Richardson-Vicks Inc. Hydrophilic denture adhesive
JPS5948409A (ja) 1982-09-10 1984-03-19 Teikoku Seiyaku Kk 矯正的歯牙移動促進剤
CA1208558A (en) * 1982-10-07 1986-07-29 Kazuo Kigasawa Soft buccal
JPS604120A (ja) * 1983-06-22 1985-01-10 Shionogi & Co Ltd 作用持続型ピナシジル製剤
JPS60116630A (ja) 1983-11-29 1985-06-24 Nitto Electric Ind Co Ltd 口腔内製剤
JPS60159604A (ja) * 1984-01-31 1985-08-21 Niigata Eng Co Ltd 光電式操作ハンドル検出器
US4713246A (en) 1984-03-19 1987-12-15 Bristol-Myers Company Etoposide oral dosage form
EP0159604B1 (en) * 1984-04-09 1990-11-07 Toyo Boseki Kabushiki Kaisha Sustained-release preparation applicable to mucous membrane in oral cavity
EP0186019B1 (de) * 1984-12-22 1993-10-06 Schwarz Pharma Ag Wirkstoffpflaster
JPS61280423A (ja) 1985-06-05 1986-12-11 Kiyuukiyuu Yakuhin Kogyo Kk 口腔内粘膜貼付剤
JPH0653659B2 (ja) 1985-07-22 1994-07-20 ニチバン株式会社 粘膜付着製剤
GB8521494D0 (en) 1985-08-29 1985-10-02 Zyma Sa Controlled release tablet
JPS6256420A (ja) 1985-09-05 1987-03-12 Teijin Ltd フイルム状付着性製剤
JPH07553B2 (ja) 1985-12-09 1995-01-11 佐藤製薬株式会社 フイルム状製剤
US4755386A (en) 1986-01-22 1988-07-05 Schering Corporation Buccal formulation
JPH0729915B2 (ja) 1986-02-01 1995-04-05 帝國製薬株式会社 シ−ト状口腔内貼付剤
US4764378A (en) 1986-02-10 1988-08-16 Zetachron, Inc. Buccal drug dosage form
US4713243A (en) * 1986-06-16 1987-12-15 Johnson & Johnson Products, Inc. Bioadhesive extruded film for intra-oral drug delivery and process
CH668187A5 (de) 1986-08-07 1988-12-15 Ciba Geigy Ag Therapeutisches system mit systemischer wirkung.
US5196202A (en) * 1986-09-01 1993-03-23 Teikoku Seiyaku Kabushiki Kaisha Sustained release dosage form
JPH0794384B2 (ja) * 1986-09-01 1995-10-11 帝国製薬株式会社 徐放性口腔内用製剤
US4906463A (en) * 1986-12-22 1990-03-06 Cygnus Research Corporation Transdermal drug-delivery composition
JPH0744940B2 (ja) * 1986-12-24 1995-05-17 ライオン株式会社 口腔貼付用基材
JPS63262422A (ja) * 1987-04-20 1988-10-28 Mitsubishi Electric Corp 熱延ラインにおける分割型加熱炉
DE3714074A1 (de) * 1987-04-28 1988-11-10 Hoechst Ag Grundlage fuer schleimhaut- und prothesenhaft-pasten, verfahren zu ihrer herstellung sowie pasten auf basis dieser grundlage
US4867970A (en) * 1987-05-21 1989-09-19 E. R. Squibb & Sons, Inc. Moistureless oral drug delivery formulation and method for preparing same
JPS63310818A (ja) 1987-06-12 1988-12-19 Sato Seiyaku Kk シ−ト状口腔粘膜付着製剤
US4915948A (en) * 1987-08-31 1990-04-10 Warner-Lambert Company Tablets having improved bioadhesion to mucous membranes
US5059189A (en) * 1987-09-08 1991-10-22 E. R. Squibb & Sons, Inc. Method of preparing adhesive dressings containing a pharmaceutically active ingredient
JPS6471812A (en) 1987-09-11 1989-03-16 Sekisui Chemical Co Ltd Medical application agent
JP2635336B2 (ja) 1987-09-30 1997-07-30 帝國製薬株式会社 徐放性口腔内用製剤
US4990339A (en) * 1987-11-16 1991-02-05 H. B. Fuller Company Dermal treatment film
US5064654A (en) * 1989-01-11 1991-11-12 Ciba-Geigy Corporation Mixed solvent mutually enhanced transdermal therapeutic system
GB8804164D0 (en) 1988-02-23 1988-03-23 Tucker J M Bandage for administering physiologically active compound
JP2685055B2 (ja) 1988-03-08 1997-12-03 帝國製薬株式会社 シコン含有口腔粘膜貼付剤
US4900552A (en) 1988-03-30 1990-02-13 Watson Laboratories, Inc. Mucoadhesive buccal dosage forms
US5081157A (en) * 1988-05-02 1992-01-14 Zila Pharmaceuticals, Inc. Compositions and in situ methods for forming films on body tissue
US5081158A (en) * 1988-05-02 1992-01-14 Zila Pharmaceuticals, Inc. Compositions and in situ methods for forming films on body tissue
US5047244A (en) 1988-06-03 1991-09-10 Watson Laboratories, Inc. Mucoadhesive carrier for delivery of therapeutical agent
JP2656338B2 (ja) * 1989-01-31 1997-09-24 日東電工株式会社 口腔粘膜貼付製剤
JPH0645536B2 (ja) 1989-01-31 1994-06-15 日東電工株式会社 口腔粘膜貼付剤および口腔粘膜貼付製剤
US5750136A (en) 1989-11-03 1998-05-12 Riker Laboratories, Inc. Bioadhesive composition and patch
JP2839164B2 (ja) * 1989-12-25 1998-12-16 帝國製薬株式会社 消炎鎮痛貼付剤
US5298258A (en) * 1989-12-28 1994-03-29 Nitto Denko Corporation Acrylic oily gel bioadhesive material and acrylic oily gel preparation
JP2879695B2 (ja) 1990-02-22 1999-04-05 日本曹達株式会社 口腔内粘膜付着性フィルム製剤
JP2930374B2 (ja) 1990-06-28 1999-08-03 東亜医薬品工業株式会社 口腔内貼着型膜製剤
US5332576A (en) * 1991-02-27 1994-07-26 Noven Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
US5192802A (en) * 1991-09-25 1993-03-09 Mcneil-Ppc, Inc. Bioadhesive pharmaceutical carrier
US5254345A (en) 1991-10-11 1993-10-19 Merck & Co., Inc. Poly(orthocarbonate acetal) bioerodible polymers
GB2273044B (en) * 1992-12-02 1997-04-09 Pacific Chem Co Ltd Medicinal patches for percutaneous administration
US5346701A (en) 1993-02-22 1994-09-13 Theratech, Inc. Transmucosal delivery of macromolecular drugs
DE69422925T2 (de) * 1993-07-09 2000-08-17 Cygnus Therapeutic Systems Verfahren und vorrichtung für die transdermale oder transbuccale therapeutische verabreichung von nikotinsubstituten
JPH09504810A (ja) 1993-08-19 1997-05-13 シグナス，インコーポレイテッド 水溶性感圧粘膜接着剤
US5540930A (en) 1993-10-25 1996-07-30 Pharmos Corporation Suspension of loteprednol etabonate for ear, eye, or nose treatment
FR2712807B1 (fr) 1993-11-24 1996-02-23 Vetoquinol Sa Composition solide mucoadhésive, thérapeutique ou hygiénique, pour administration par application sur la muqueuse buccale ou nasale .
DE4341442C2 (de) 1993-12-04 1998-11-05 Lohmann Therapie Syst Lts Vorrichtung zur kontrollierten Freisetzung von Wirkstoffen sowie ihre Verwendung
US5466465A (en) * 1993-12-30 1995-11-14 Harrogate Holdings, Limited Transdermal drug delivery system
US5679714A (en) * 1995-06-07 1997-10-21 Weg; Stuart L. Administration of ketamine for detoxification and treatment of tobacco addiction
AU2703795A (en) * 1994-06-23 1996-01-19 Procter & Gamble Company, The Treatment of nicotine craving and/or smoking withdrawal symptoms with a transdermal or transmucosal composition containing nicotine and caffeine or xanthine
DE69625549T2 (de) * 1995-06-27 2003-05-15 Kao Corp Pflaster mit wasserlöslicher Klebeschicht
US5849322A (en) 1995-10-23 1998-12-15 Theratech, Inc. Compositions and methods for buccal delivery of pharmaceutical agents
JP2791317B2 (ja) * 1995-12-26 1998-08-27 株式会社三和化学研究所 多層フィルム製剤
FR2742989B1 (fr) 1995-12-29 1998-01-23 Adir Composition pharmaceutique bioadhesive pour la liberation controlee de principes actifs
US5985317A (en) 1996-09-06 1999-11-16 Theratech, Inc. Pressure sensitive adhesive matrix patches for transdermal delivery of salts of pharmaceutical agents
US5800832A (en) 1996-10-18 1998-09-01 Virotex Corporation Bioerodable film for delivery of pharmaceutical compounds to mucosal surfaces
DE19646392A1 (de) 1996-11-11 1998-05-14 Lohmann Therapie Syst Lts Zubereitung zur Anwendung in der Mundhöhle mit einer an der Schleimhaut haftklebenden, Pharmazeutika oder Kosmetika zur dosierten Abgabe enthaltenden Schicht
US20050048102A1 (en) 1997-10-16 2005-03-03 Virotex Corporation Pharmaceutical carrier device suitable for delivery of pharmaceutical compounds to mucosal surfaces
US6284262B1 (en) 1999-01-26 2001-09-04 Virgil A. Place Compact dosage unit for buccal administration of a pharmacologically active agent

Also Published As

Publication number Publication date
PT973497E (pt) 2003-04-30
US20160101061A1 (en) 2016-04-14
ATE229322T1 (de) 2002-12-15
US6159498A (en) 2000-12-12
US20120027839A1 (en) 2012-02-02
EP0973497A1 (en) 2000-01-26
CA2268187A1 (en) 1998-04-30
US20120231064A1 (en) 2012-09-13
US20050147658A1 (en) 2005-07-07
US20100003308A1 (en) 2010-01-07
US5800832A (en) 1998-09-01
CA2268187C (en) 2007-06-05
DK0973497T3 (da) 2002-12-30
EP0973497B1 (en) 2002-12-11
AU4757497A (en) 1998-05-15
JP2005281322A (ja) 2005-10-13
JP2001508037A (ja) 2001-06-19
US20150118285A1 (en) 2015-04-30
WO1998017251A1 (en) 1998-04-30
AU729516B2 (en) 2001-02-01
JP2010270153A (ja) 2010-12-02
DE69717862D1 (de) 2003-01-23
JP3964465B2 (ja) 2007-08-22
US20130344127A1 (en) 2013-12-26
US7579019B2 (en) 2009-08-25
DE69717862T2 (de) 2003-05-08

Similar Documents

Publication Publication Date Title
ES2188907T3 (es) Dispositivo de soporte farmaceutico adecuado ppara la administracion de compuestos farmaceuticos a las superficies de las mucosas.
PT1079813E (pt) Dispositivo transportador farmaceutico adequado para entrega de compostos farmaceuticos as superficies mucosas
MXPA04001491A (es) Dispositivo de liberacion de farmaco erosionable mucoadhesivo para la administracion controlada de compuestos activos farmaceuticos y otros compuestos activos.
KR950703383A (ko) 초음파 경피약제전달 시스템(ultrasonic transdermal drug delivery system)
PT93191A (pt) Sistema terapeutico para a administracao retardada e controlada transdermica ou transmucosica de substancias activas
DE69531488D1 (de) Medikament enthaltende, adhesive, zusammenbaubare, transdermale abgabevorrichtung
ATE216220T1 (de) Osmotische darreichungsform mit zwei mantelschichten
DE69829961D1 (de) Transdermale vorrichtung zur verabreichungvon von testosteron
NO950725D0 (no) Trykket transdermal medikamentavleveringsinnretning
NO950931L (no) Dexpanthenol-holdig plaster for transdermal applikasjon av steroidhormoner
NO992674L (no) Konturen til et transdermalt terapeutisk system
CA2403949A1 (en) Transdermal therapeutic system for the delivery of lerisetron
DK0705085T3 (da) Molykylært transdermalt transportsystem
LV10749A (lv) Transdermala terapeitiska sistema fizostigmina uzliksanai uz adas un tas izgatavosanas panemiens
FI970053A (fi) Transdermaalinen lääkeaineen antosysteemi
FI960435A (fi) Lääkkeiden transdermaalisen antotapaan tarkoitettu koostumus