JP5727292B2 - 複合フィルム - Google Patents
複合フィルム Download PDFInfo
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- JP5727292B2 JP5727292B2 JP2011105887A JP2011105887A JP5727292B2 JP 5727292 B2 JP5727292 B2 JP 5727292B2 JP 2011105887 A JP2011105887 A JP 2011105887A JP 2011105887 A JP2011105887 A JP 2011105887A JP 5727292 B2 JP5727292 B2 JP 5727292B2
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- drug
- biodegradable polymer
- film
- composite film
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- 239000002131 composite material Substances 0.000 title claims description 90
- 229940079593 drug Drugs 0.000 claims description 280
- 239000003814 drug Substances 0.000 claims description 280
- 229920002988 biodegradable polymer Polymers 0.000 claims description 103
- 239000004621 biodegradable polymer Substances 0.000 claims description 103
- 238000013268 sustained release Methods 0.000 claims description 85
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- 230000001070 adhesive effect Effects 0.000 claims description 79
- 239000000853 adhesive Substances 0.000 claims description 78
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 23
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- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 2
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- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- HCZQSLKOEQURLM-ZETCQYMHSA-N (4S)-4-amino-5-[2-[(2-methylpropan-2-yl)oxy]-2-oxoethoxy]-5-oxopentanoic acid Chemical compound CC(C)(C)OC(=O)COC(=O)[C@@H](N)CCC(O)=O HCZQSLKOEQURLM-ZETCQYMHSA-N 0.000 description 1
- UHKPXKGJFOKCGG-UHFFFAOYSA-N 2-methylprop-1-ene;styrene Chemical compound CC(C)=C.C=CC1=CC=CC=C1.C=CC1=CC=CC=C1 UHKPXKGJFOKCGG-UHFFFAOYSA-N 0.000 description 1
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- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
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- 229940088710 antibiotic agent Drugs 0.000 description 1
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- 239000003524 antilipemic agent Substances 0.000 description 1
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- 150000002215 flavonoids Chemical class 0.000 description 1
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- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 description 1
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- 108010044426 integrins Proteins 0.000 description 1
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- 150000002500 ions Chemical class 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N lactose group Chemical group OC1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@H](O2)CO)[C@H](O1)CO GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 238000002350 laparotomy Methods 0.000 description 1
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- 150000002632 lipids Chemical class 0.000 description 1
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- 229940096701 plain lipid modifying drug hmg coa reductase inhibitors Drugs 0.000 description 1
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- 229920006209 poly(L-lactide-co-D,L-lactide) Polymers 0.000 description 1
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- 229920002643 polyglutamic acid Polymers 0.000 description 1
- 239000004626 polylactic acid Substances 0.000 description 1
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- YFHICDDUDORKJB-UHFFFAOYSA-N trimethylene carbonate Chemical compound O=C1OCCCO1 YFHICDDUDORKJB-UHFFFAOYSA-N 0.000 description 1
- 229940121358 tyrosine kinase inhibitor Drugs 0.000 description 1
- 239000005483 tyrosine kinase inhibitor Substances 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7007—Drug-containing films, membranes or sheets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/06—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material
- B32B27/08—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B7/00—Layered products characterised by the relation between layers; Layered products characterised by the relative orientation of features between layers, or by the relative values of a measurable parameter between layers, i.e. products comprising layers having different physical, chemical or physicochemical properties; Layered products characterised by the interconnection of layers
- B32B7/04—Interconnection of layers
- B32B7/12—Interconnection of layers using interposed adhesives or interposed materials with bonding properties
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2307/00—Properties of the layers or laminate
- B32B2307/70—Other properties
- B32B2307/716—Degradable
- B32B2307/7163—Biodegradable
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2535/00—Medical equipment, e.g. bandage, prostheses or catheter
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Laminated Bodies (AREA)
Description
11,21,61 薬物徐放部
12,32,42 接着部
13 薬物層
14 生分解性ポリマー層
23 薬物粒子
24 生分解性ポリマー
26 薬物体
27 外殻
33,43 空隙
Claims (3)
- 生分解性ポリマーと、薬物が一定の濃度以上で含まれる薬物体とを含み、前記生分解性ポリマーの分解と溶解との少なくともいずれか一方により前記薬物体から前記薬物を放出する薬物徐放部と、
前記薬物徐放部に層状に重なり、前記薬物徐放部を接着対象物に接着する接着部とを備え、
前記薬物徐放部は、
膜状に形成された前記薬物体と、
前記薬物体に重ねて膜状に形成された前記生分解性ポリマーとを有することを特徴とする複合フィルム。 - 前記接着部は、前記薬物徐放部に接する表面とは反対側の表面に複数の空隙が並んで形成され、前記接着対象物に含まれる水を毛管力によって前記空隙に保持することにより前記薬物徐放部を前記接着対象物に接着することを特徴とする請求項1に記載の複合フィルム。
- 前記接着部は、前記薬物徐放部の前記生分解性ポリマーよりも分解速度と溶解速度との少なくともいずれか一方が小さな生分解性ポリマーからなることを特徴とする請求項2に記載の複合フィルム。
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2011105887A JP5727292B2 (ja) | 2011-05-11 | 2011-05-11 | 複合フィルム |
PCT/JP2012/060319 WO2012153606A1 (ja) | 2011-05-11 | 2012-04-17 | 複合フィルム |
US14/075,614 US20140065202A1 (en) | 2011-05-11 | 2013-11-08 | Composite film |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2011105887A JP5727292B2 (ja) | 2011-05-11 | 2011-05-11 | 複合フィルム |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2012236787A JP2012236787A (ja) | 2012-12-06 |
JP5727292B2 true JP5727292B2 (ja) | 2015-06-03 |
Family
ID=47139092
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2011105887A Active JP5727292B2 (ja) | 2011-05-11 | 2011-05-11 | 複合フィルム |
Country Status (3)
Country | Link |
---|---|
US (1) | US20140065202A1 (ja) |
JP (1) | JP5727292B2 (ja) |
WO (1) | WO2012153606A1 (ja) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201505527D0 (en) | 2015-03-31 | 2015-05-13 | Jmedtech Pte Ltd | Composition |
EP3328355B1 (en) * | 2015-07-28 | 2021-09-01 | Board of Regents, The University of Texas System | Implant compositions for the unidirectional delivery of therapeutic compounds to the brain |
WO2019071246A2 (en) | 2017-10-06 | 2019-04-11 | Foundry Therapeutics, Inc. | IMPLANTABLE DEPOSITS FOR CONTROLLED RELEASE OF ANALGESICS TO TREAT POSTOPERATIVE PAIN, AND DEVICES, SYSTEMS, AND RELATED METHODS |
WO2020026061A1 (en) * | 2018-07-30 | 2020-02-06 | 3M Innovative Properties Company | Antimicrobial foam articles and method of making the same |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE227963T1 (de) * | 1992-04-24 | 2002-12-15 | Osteotech Inc | Vorrichtung zum vermeiden von gewebeadhäsionen |
US5800832A (en) * | 1996-10-18 | 1998-09-01 | Virotex Corporation | Bioerodable film for delivery of pharmaceutical compounds to mucosal surfaces |
US6495229B1 (en) * | 1999-09-17 | 2002-12-17 | Avery Dennison Corporation | Pattern coated adhesive article |
WO2005016321A1 (en) * | 2003-08-15 | 2005-02-24 | Qlt Usa, Inc. | Adhesive bioerodible transmucosal drug delivery system |
US20060269475A1 (en) * | 2005-04-11 | 2006-11-30 | Ryu Wonhyoung | Multi-layer structure having a predetermined layer pattern including an agent |
US20060266463A1 (en) * | 2005-05-27 | 2006-11-30 | Fuji Photo Film Co., Ltd. | Honeycomb composite film, and method for producing the same |
KR100785378B1 (ko) * | 2005-09-05 | 2007-12-14 | 주식회사 바이오레인 | 다층구조의 유착방지제 |
US10029034B2 (en) * | 2005-12-15 | 2018-07-24 | CARDINAL HEALTH SWITZERLAND 515 GmbH | Drug-eluting articles with improved drug release profiles |
EP2306981A1 (en) * | 2008-06-19 | 2011-04-13 | University Of The Witwatersrand, Johannesburg | A transmucosal delivery system |
-
2011
- 2011-05-11 JP JP2011105887A patent/JP5727292B2/ja active Active
-
2012
- 2012-04-17 WO PCT/JP2012/060319 patent/WO2012153606A1/ja active Application Filing
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2013
- 2013-11-08 US US14/075,614 patent/US20140065202A1/en not_active Abandoned
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JP2012236787A (ja) | 2012-12-06 |
US20140065202A1 (en) | 2014-03-06 |
WO2012153606A1 (ja) | 2012-11-15 |
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