ES2160977T3 - 1-fenilalquil-1,2,3,6-tetrahidropiridinas para el tratamiento de la enfermedad de alzheimer. - Google Patents
1-fenilalquil-1,2,3,6-tetrahidropiridinas para el tratamiento de la enfermedad de alzheimer.Info
- Publication number
- ES2160977T3 ES2160977T3 ES97951323T ES97951323T ES2160977T3 ES 2160977 T3 ES2160977 T3 ES 2160977T3 ES 97951323 T ES97951323 T ES 97951323T ES 97951323 T ES97951323 T ES 97951323T ES 2160977 T3 ES2160977 T3 ES 2160977T3
- Authority
- ES
- Spain
- Prior art keywords
- sub
- rent
- alcoxyl
- mono
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 208000024827 Alzheimer disease Diseases 0.000 title 1
- -1 CYCLOHEXENYL Chemical class 0.000 abstract 8
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical class [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 2
- SONNWYBIRXJNDC-VIFPVBQESA-N phenylephrine Chemical class CNC[C@H](O)C1=CC=CC(O)=C1 SONNWYBIRXJNDC-VIFPVBQESA-N 0.000 abstract 2
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 150000003973 alkyl amines Chemical class 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000001067 neuroprotector Effects 0.000 abstract 1
- 230000000508 neurotrophic effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 235000011962 puddings Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
Abstract
LA INVENCION SE REFIERE A COMPUESTOS DE FORMULA (I) EN LA QUE Y REPRESENTA -CH- O -N-; R 1 REPRESENTA HIDROGENO, UN HALOGENO, UN GRUPO CF 3 , (C 1 - C 4 )ALQUILO O (C 1 - C 4 )ALCOXILO; R 2 REPRESENTA UN GRUPO MET ILO O ETILO, R 3 Y R 4 REPRESENTAN CADA UNO HIDROGENO O UN (C 1 - C 3 )ALQUILO; X REPRESENTA (A) UN (C SUB,1 - C 6 )ALQUILO;, (C 1 - C 6 )ALCOXILO, UN (C SUB,3 - C 7 )CARBOXIALQUILO; O UN (C 1 C 4 )ALCOXICARBONIL(C 1 - C 6 )ALCOXILO; (B) UN RADICAL ELEGIDO ENTRE UN (C 3 - C 7 )CICLOALQUILO, (C 3 - C SUB,7 )CICLOALQUICOXI, (C 3 C 7 )CICLOALQUILMETILO, (C S UB,3 C 7 )CICLOALQUILAMINO Y CICLOHEXENILO, PUDIENDO DICHO RADICAL SUSTITUIRSE POR UN HALOGENO, HIDROXI, (C 1 C SUB,4)ALCOXI, CARBOXI, (C 1 - C 4 ALCOXICARBONILO, AMINO, MONO- O DI - (C 1 C 4 )ALQUILAMINO; O UN (C) UN GRUPO ELEGIDO ENTRE UN FENILO, FENOXI, FENILAMINO, N - (C 1 C 3 )ALQUILFENILAMINO, FENILMETILO, FENILETILO, FENILCARBO NILO, FENILTIO, FENILSULFONILO, FENILSULFINILO O ESTIRILO, PUDIENDO DICHO GRUPO SER MONO- O POLISUSTIRUIDO EN EL GRUPO FENILO POR UN HALOGENO, CF 3 , (C 1 C 4 ALQUILO, (C SUB,1 - C 4 )ALCOXI, CIANO, AMINO, MONO- O DI-(C 1 - C SUB,4 )ALQUILAMINO, (C 1 C 4 )ACILAMINO, CARBOXI, (C SUB,1 C 4 )ALCOXICARBONILO, AMINOCARBONILO, MONO- O DI (C 1 - C 4 )ALQUILAMINOCARBONILO, AMINO(C 1 C SUB,4 )ALQUILO, HIDROXI(C 1 - C 4 )ALQUILO O HALOGENO(C S 1 ) - C 4 ) ALQUILO ASI COMO A UN PROCEDIMIENTO PARA SU PREPARACION Y LAS COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN. ESTOS COMPUESTOS TIENEN UNA ACTIVIDAD NEUROTROFICA Y NEUROPROTECTORA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9615335A FR2757160B1 (fr) | 1996-12-13 | 1996-12-13 | 1-phenylalkyl-1,2,3,6-tetrahydropyridines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2160977T3 true ES2160977T3 (es) | 2001-11-16 |
Family
ID=9498641
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES97951323T Expired - Lifetime ES2160977T3 (es) | 1996-12-13 | 1997-12-12 | 1-fenilalquil-1,2,3,6-tetrahidropiridinas para el tratamiento de la enfermedad de alzheimer. |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US6034090A (es) |
| EP (1) | EP0950048B1 (es) |
| JP (1) | JP3881384B2 (es) |
| KR (1) | KR100560358B1 (es) |
| CN (1) | CN1129579C (es) |
| AT (1) | ATE202561T1 (es) |
| AU (1) | AU730143B2 (es) |
| BR (1) | BR9713916A (es) |
| CA (1) | CA2275353C (es) |
| CY (1) | CY2274B1 (es) |
| CZ (1) | CZ289789B6 (es) |
| DE (1) | DE69705429T2 (es) |
| DK (1) | DK0950048T3 (es) |
| EE (1) | EE03763B1 (es) |
| ES (1) | ES2160977T3 (es) |
| FR (1) | FR2757160B1 (es) |
| GR (1) | GR3036643T3 (es) |
| HK (1) | HK1023997A1 (es) |
| HU (1) | HU224347B1 (es) |
| IL (1) | IL130003A (es) |
| IS (1) | IS1969B (es) |
| NO (1) | NO312720B1 (es) |
| NZ (1) | NZ336033A (es) |
| PL (1) | PL190789B1 (es) |
| PT (1) | PT950048E (es) |
| RS (1) | RS49807B (es) |
| RU (1) | RU2189975C2 (es) |
| SI (1) | SI0950048T1 (es) |
| SK (1) | SK283331B6 (es) |
| TR (1) | TR199901291T2 (es) |
| UA (1) | UA52707C2 (es) |
| WO (1) | WO1998025903A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2763847B1 (fr) * | 1997-05-28 | 2003-06-06 | Sanofi Sa | Utilisation de tetrahydropyridines 4-substituees pour fabriquer des medicaments agissant sur le tgf-beta-1 |
| UA81749C2 (uk) * | 2001-10-04 | 2008-02-11 | Х. Луннбек А/С | Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну |
| FR2832405B1 (fr) * | 2001-11-19 | 2004-12-10 | Sanofi Synthelabo | Tetrahydropyridyl-alkyl-heterocycles azotes, procede pour leur preparation et compositions pharmaceutiques les contenant |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1321701A (en) * | 1969-10-01 | 1973-06-27 | Continental Pharma | Amino-alcohols their salts and process for prepairing the same |
| IE34545B1 (en) * | 1969-10-01 | 1975-06-11 | Continental Pharma | Amino-alcohols,their salts and process for preparing the same |
| FR2650505B1 (fr) * | 1989-08-07 | 1994-06-03 | Midy Spa | Utilisation de trifluoromethylphenyltetrahydropyridines pour la preparation de medicaments destines a combattre les troubles de la motricite intestinale |
| FR2662355B1 (fr) * | 1990-05-22 | 1994-11-10 | Sanofi Sa | Utilisation de la 1-[2-(2-naphtyl)ethyl]-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine pour la preparation de medicaments destines au traitement de troubles cerebraux et neuronaux. |
| HU211019B (en) * | 1991-12-02 | 1995-09-28 | Richter Gedeon Vegyeszet | Process for producing new 1,2,3,6-tetrahydropyridine and piperidine derivatives substituted with n-(hydroxylalkyl) group and compositions comprising such compounds |
-
1996
- 1996-12-13 FR FR9615335A patent/FR2757160B1/fr not_active Expired - Fee Related
-
1997
- 1997-12-12 IL IL13000397A patent/IL130003A/en not_active IP Right Cessation
- 1997-12-12 BR BR9713916-5A patent/BR9713916A/pt not_active Application Discontinuation
- 1997-12-12 ES ES97951323T patent/ES2160977T3/es not_active Expired - Lifetime
- 1997-12-12 EP EP97951323A patent/EP0950048B1/fr not_active Expired - Lifetime
- 1997-12-12 NZ NZ336033A patent/NZ336033A/xx unknown
- 1997-12-12 SK SK786-99A patent/SK283331B6/sk unknown
- 1997-12-12 TR TR1999/01291T patent/TR199901291T2/xx unknown
- 1997-12-12 JP JP52632098A patent/JP3881384B2/ja not_active Expired - Fee Related
- 1997-12-12 UA UA99063286A patent/UA52707C2/uk unknown
- 1997-12-12 KR KR1019997005203A patent/KR100560358B1/ko not_active IP Right Cessation
- 1997-12-12 SI SI9730187T patent/SI0950048T1/xx unknown
- 1997-12-12 US US09/331,006 patent/US6034090A/en not_active Expired - Fee Related
- 1997-12-12 RU RU99115083/04A patent/RU2189975C2/ru not_active IP Right Cessation
- 1997-12-12 CZ CZ19992113A patent/CZ289789B6/cs not_active IP Right Cessation
- 1997-12-12 AU AU54893/98A patent/AU730143B2/en not_active Ceased
- 1997-12-12 CN CN97180581A patent/CN1129579C/zh not_active Expired - Fee Related
- 1997-12-12 DK DK97951323T patent/DK0950048T3/da active
- 1997-12-12 PL PL334071A patent/PL190789B1/pl unknown
- 1997-12-12 AT AT97951323T patent/ATE202561T1/de not_active IP Right Cessation
- 1997-12-12 PT PT97951323T patent/PT950048E/pt unknown
- 1997-12-12 CA CA002275353A patent/CA2275353C/en not_active Expired - Fee Related
- 1997-12-12 EE EEP199900237A patent/EE03763B1/xx not_active IP Right Cessation
- 1997-12-12 HU HU0001185A patent/HU224347B1/hu not_active IP Right Cessation
- 1997-12-12 DE DE69705429T patent/DE69705429T2/de not_active Expired - Fee Related
- 1997-12-12 RS YUP-243/99A patent/RS49807B/sr unknown
- 1997-12-12 WO PCT/FR1997/002286 patent/WO1998025903A1/fr not_active Application Discontinuation
-
1999
- 1999-06-10 IS IS5075A patent/IS1969B/is unknown
- 1999-06-11 NO NO19992869A patent/NO312720B1/no unknown
-
2000
- 2000-05-30 HK HK00103181A patent/HK1023997A1/xx not_active IP Right Cessation
-
2001
- 2001-09-18 GR GR20010401501T patent/GR3036643T3/el not_active IP Right Cessation
-
2002
- 2002-05-15 CY CY0200027A patent/CY2274B1/xx unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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