ATE238307T1 - Substituierte porphyrinen - Google Patents
Substituierte porphyrinenInfo
- Publication number
- ATE238307T1 ATE238307T1 AT98956457T AT98956457T ATE238307T1 AT E238307 T1 ATE238307 T1 AT E238307T1 AT 98956457 T AT98956457 T AT 98956457T AT 98956457 T AT98956457 T AT 98956457T AT E238307 T1 ATE238307 T1 AT E238307T1
- Authority
- AT
- Austria
- Prior art keywords
- substituted porphyrins
- oxidants
- relates
- processes
- modulating
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6411697P | 1997-11-03 | 1997-11-03 | |
PCT/US1998/023287 WO1999023097A1 (en) | 1997-11-03 | 1998-11-03 | Substituted porphyrins |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE238307T1 true ATE238307T1 (de) | 2003-05-15 |
Family
ID=22053669
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT98956457T ATE238307T1 (de) | 1997-11-03 | 1998-11-03 | Substituierte porphyrinen |
Country Status (10)
Country | Link |
---|---|
US (4) | US6916799B2 (de) |
EP (1) | EP1045851B1 (de) |
JP (2) | JP2001521939A (de) |
AT (1) | ATE238307T1 (de) |
AU (1) | AU737650B2 (de) |
CA (1) | CA2309154C (de) |
DE (1) | DE69813898T2 (de) |
ES (1) | ES2198767T3 (de) |
IL (1) | IL135949A0 (de) |
WO (1) | WO1999023097A1 (de) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6127356A (en) | 1993-10-15 | 2000-10-03 | Duke University | Oxidant scavengers |
CA2309154C (en) * | 1997-11-03 | 2010-02-16 | Duke University | Substituted porphyrins |
WO1999055388A1 (en) | 1998-04-24 | 1999-11-04 | Duke University | Substituted porphyrins |
WO2000023568A2 (en) * | 1998-10-06 | 2000-04-27 | Albert Einstein College Of Medicine Of Yeshiva University | Methods and compositions for decreasing mitochondrial overproduction of reactive oxygen species in cells |
ES2254142T3 (es) | 1999-01-25 | 2006-06-16 | National Jewish Medical And Research Center | Porfirinas sustituidas y su uso terapeutico. |
FR2806911B1 (fr) * | 2000-03-28 | 2003-01-10 | Univ Rene Descartes | Utilisation de mimetiques de la sod dans le traitement d'insuffisances hepatocellulaires |
ES2330728T3 (es) * | 2001-01-19 | 2009-12-15 | National Jewish Health | Medicamento para proteccion en radioterapia. |
US20040137638A1 (en) | 2002-03-04 | 2004-07-15 | Slomczynska Urszula J. | Chromatography of metal complexes |
EP1439842A4 (de) * | 2001-06-01 | 2009-09-02 | Nat Jewish Med & Res Center | Oxidantienfänger zur behandlung von diabetes oder zur verwendung bei der transplantation oder induktion von immuntoleranz |
MXPA04005601A (es) | 2001-12-14 | 2004-12-06 | Alcon Inc | Imitadores de superoxido dismutasa para el tratamiento de trastornos y enfermedades oculares. |
JP2006501163A (ja) * | 2002-06-07 | 2006-01-12 | デューク・ユニバーシティー | 置換ポルフィリン |
US20040116403A1 (en) * | 2002-12-06 | 2004-06-17 | Klimko Peter G. | Superoxide dismutase mimics for the treatment of ocular disorders and diseases |
MXPA05005937A (es) | 2002-12-06 | 2005-08-18 | Alcon Inc | Imitaciones de superoxido de dismutasa para el tratamiento de trastornos y enfermedades oculares. |
GB2397067B (en) * | 2002-12-23 | 2005-05-11 | Destiny Pharma Ltd | Porphin & azaporphin derivatives with at least one cationic-nitrogen-containing meso-substituent for use in photodynamic therapy & in vitro sterilisation |
NL1022597C2 (nl) * | 2003-02-05 | 2004-08-06 | Photobiochem N V | Toepassing van een fotosensitizerverbinding voor de bereiding van een farmaceutisch preparaat, werkwijze voor het bereiden van een farmaceutisch preparaat en een werkwijze voor het behandelen van een zoogdier. |
JP4741205B2 (ja) * | 2003-07-07 | 2011-08-03 | 真 湯浅 | 金属ポルフィリン錯体包埋リポソーム、その製造方法およびこれを利用する医薬 |
US7299082B2 (en) | 2003-10-31 | 2007-11-20 | Abbott Diabetes Care, Inc. | Method of calibrating an analyte-measurement device, and associated methods, devices and systems |
US7699964B2 (en) | 2004-02-09 | 2010-04-20 | Abbott Diabetes Care Inc. | Membrane suitable for use in an analyte sensor, analyte sensor, and associated method |
WO2005077269A1 (en) | 2004-02-09 | 2005-08-25 | Duke University | Substituted porphyrins |
US8165651B2 (en) * | 2004-02-09 | 2012-04-24 | Abbott Diabetes Care Inc. | Analyte sensor, and associated system and method employing a catalytic agent |
EP1740094A4 (de) * | 2004-03-29 | 2008-09-03 | Inotek Pharmaceuticals Corp | Pyridyl-substituierte porphyrin-verbindungen und anwendungsverfahren dafür |
GB2415372A (en) | 2004-06-23 | 2005-12-28 | Destiny Pharma Ltd | Non photodynamical or sonodynamical antimicrobial use of porphyrins and azaporphyrins containing at least one cationic-nitrogen-containing substituent |
US7642250B2 (en) * | 2005-09-28 | 2010-01-05 | Inotek Pharmaceuticals Corporation | N-benzyl substituted pyridyl porphyrin compounds and methods of use thereof |
US7885698B2 (en) | 2006-02-28 | 2011-02-08 | Abbott Diabetes Care Inc. | Method and system for providing continuous calibration of implantable analyte sensors |
ES2725023T3 (es) | 2006-10-12 | 2019-09-18 | Galera Labs Llc | Métodos para el tratamiento de la mucositis oral |
US20080289053A1 (en) * | 2007-05-15 | 2008-11-20 | The Regents Of The University Of California | Methods and systems for identifying modulators of longevity |
US8598150B1 (en) | 2008-04-02 | 2013-12-03 | Jonathan R. Brestoff | Composition and method for affecting obesity and related conditions |
US8987245B2 (en) | 2008-04-02 | 2015-03-24 | Jonathan R. Brestoff Parker | Composition and method for affecting obesity and related conditions |
RU2506083C2 (ru) | 2008-05-23 | 2014-02-10 | Нэшнл Джуиш Хелт | Способ лечения поражений, ассоциированных с воздействием алкилирующих веществ |
US8608950B2 (en) * | 2009-12-30 | 2013-12-17 | Uop Llc | Process for removing metals from resid |
EP2625180B1 (de) * | 2010-10-06 | 2016-03-02 | Aeolus Sciences, Inc. | Porphyrinbehandlung neurodegenerativer erkrankungen |
JP5823988B2 (ja) * | 2011-01-31 | 2015-11-25 | 国立大学法人宇都宮大学 | ポルフィリン型骨格を有する化合物の金属錯体の製造方法 |
CN103906756B (zh) | 2011-09-26 | 2020-03-03 | 加莱拉实验室有限责任公司 | 用于治疗疾病的方法 |
KR20140109386A (ko) | 2011-12-02 | 2014-09-15 | 더 리전츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코퍼레이트 | 금속포르피린 신경 치료 |
US20160113940A1 (en) | 2013-09-03 | 2016-04-28 | Biomimetix J.V., Llc | Methods of treating biofilms |
CN105899132B (zh) | 2013-12-31 | 2020-02-18 | 雅培糖尿病护理公司 | 自供电分析物传感器以及使用其的装置 |
WO2015112588A1 (en) | 2014-01-22 | 2015-07-30 | Biomimetix Jv, Llc | Methods of treating skin disorders |
US10080759B2 (en) | 2014-01-22 | 2018-09-25 | Duke University | Methods of treating pruritus |
EP3334744B1 (de) | 2015-08-11 | 2020-04-22 | Galera Labs, LLC | Makrocyclische pentaaza-ring-komplexe mit oraler bioverfügbarkeit |
IL269915B (en) | 2017-04-13 | 2022-09-01 | Galera Labs Llc | Cancer immunotherapy combined with a macrocyclic ring pentase complex |
WO2018237249A1 (en) * | 2017-06-22 | 2018-12-27 | Biomimetix Jv, Llc | METHODS, COMPOSITIONS AND KITS FOR TREATING AND PREVENTING INFLAMMATORY SKIN DISEASES |
US11918549B2 (en) | 2017-08-25 | 2024-03-05 | AZ Solutions LLC | System and method for wound treatment and irrigation |
KR20200079237A (ko) | 2017-09-29 | 2020-07-02 | 듀크 유니버시티 | 플루오로 치환 포르피린 화합물, 그를 포함하는 약제학적 조성물, 및 그를 제조하고 사용하는 방법 |
CN111100133B (zh) * | 2019-12-30 | 2020-12-01 | 云南大学 | 一种金属卟啉化合物及其制法和应用 |
WO2022235781A1 (en) * | 2021-05-04 | 2022-11-10 | AZ solutions, LLC | Treatment of lung and airway diseases and disorders |
Family Cites Families (89)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2951799A (en) | 1957-11-13 | 1960-09-06 | Monsanto Chemicals | Photoxidation processes using heterocyclic photosensitizers |
EP0127797B1 (de) | 1983-06-03 | 1987-06-16 | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft | Markermoleküle für Fluoreszenz-Immuno-Assays sowie Verfahren und Zwischenprodukte zu deren Herstellung |
US4829984A (en) | 1983-12-15 | 1989-05-16 | Gordon Robert T | Method for the improvement of transplantation techniques and for the preservation of tissue |
US4963367A (en) | 1984-04-27 | 1990-10-16 | Medaphore, Inc. | Drug delivery compositions and methods |
US5087438A (en) | 1984-07-03 | 1992-02-11 | Gordon Robert T | Method for affecting intracellular and extracellular electric and magnetic dipoles |
GB8429845D0 (en) | 1984-11-26 | 1985-01-03 | Efamol Ltd | Porphyrins & cancer treatment |
US4758422A (en) | 1985-01-04 | 1988-07-19 | Salutar Inc. | Ferrioxamine paramagnetic contrast agents for MR imaging |
US4657902A (en) | 1985-03-25 | 1987-04-14 | The Rockefeller University | Therapeutic use of tin mesoporphyrin |
EP0223831B1 (de) | 1985-05-22 | 1992-07-15 | Liposome Technology, Inc. | Verfahren und system zum einatmen von liposomen |
DK402785D0 (da) | 1985-09-03 | 1985-09-03 | Syn Tek Ab | Fremgangsmaade til fremstilling af et enzym |
US5248603A (en) | 1985-09-03 | 1993-09-28 | Symbicom Aktiebolag | Superoxide dismutase |
US4866054A (en) | 1986-05-13 | 1989-09-12 | Chai-Tech Corporation | Antioxidant metallo-organic treatment of inflammation |
US4746735A (en) | 1986-11-21 | 1988-05-24 | The Dow Chemical Company | Regiospecific aryl nitration of meso-substituted tetraarylporphyrins |
US5162231A (en) | 1989-10-25 | 1992-11-10 | Cole Dean A | Method of using 5,10,15,20-tetrakis(carboxyphenyl)porphine for detecting cancers of the lung |
EP0282899B1 (de) | 1987-03-14 | 1996-01-10 | BOEHRINGER INGELHEIM INTERNATIONAL GmbH | Humane Mangan-Superoxiddismutase (hMn-SOD) |
US5227405A (en) | 1987-03-31 | 1993-07-13 | Duke University | Superoxide dismutase mimic |
US5223538A (en) | 1987-03-31 | 1993-06-29 | Duke University | Superoxide dismutase mimic |
US4892941A (en) | 1987-04-17 | 1990-01-09 | Dolphin David H | Porphyrins |
US4851403A (en) | 1987-04-21 | 1989-07-25 | Johnson Matthey, Inc. | Radiation sensitizers |
US4885114A (en) | 1987-04-22 | 1989-12-05 | Barnes Engineering Co. | Metallized tetra((meso)-5-methyl-2-thiophene)porphines, platinum (5-bromo octaethylporphine) and optical filters containing same |
US5051337A (en) | 1987-06-10 | 1991-09-24 | Director-General Of Agency Of Industrial Science And Technology | Optical recording material |
US5162519A (en) | 1988-03-11 | 1992-11-10 | Efamol Holdings Plc | Porphyrins and cancer treatment |
GB8805849D0 (en) | 1988-03-11 | 1988-04-13 | Efamol Holdings | Porphyrins & cancer treatment |
US5284647A (en) | 1988-03-18 | 1994-02-08 | Schering Aktiengesellschaft | Mesotetraphenylporphyrin complex compounds, process for their production and pharmaceutical agents containing them |
DE3809671A1 (de) | 1988-03-18 | 1989-09-28 | Schering Ag | Porphyrin-komplexverbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
US5109016A (en) | 1988-05-23 | 1992-04-28 | Georgia State University Foundation, Inc. | Method for inhibiting infection or replication of human immunodeficiency virus with porphyrin and phthalocyanine antiviral compositions |
US5192788A (en) | 1988-05-23 | 1993-03-09 | Georgia State University Foundation, Inc. | Porphyrin antiviral compositions |
FR2632187B1 (fr) | 1988-06-02 | 1990-09-14 | Centre Nat Rech Scient | Derives de metalloporphyrines, leur preparation, leur application en therapeutique et leur utilisation pour la preparation de molecules hybrides |
US5171680A (en) | 1988-06-14 | 1992-12-15 | Chiron Corporation | Superoxide dismutase analogs having novel binding properties |
WO1990010694A1 (en) | 1989-03-06 | 1990-09-20 | Suntory Limited | New superoxide dismutase |
JPH0341441A (ja) * | 1989-07-07 | 1991-02-21 | Konica Corp | スポット故障の改良されたハロゲン化銀写真感光材料 |
DK455789D0 (da) | 1989-09-15 | 1989-09-15 | Symbicom Ab | Polypeptid |
US5010073A (en) | 1989-10-05 | 1991-04-23 | The Rockefeller University | Use of liposomes as carriers for metalloporphyrins |
EP0424033A3 (en) | 1989-10-19 | 1991-07-31 | Pola Chemical Industries Inc | External skin preparation |
US5236915A (en) | 1990-05-31 | 1993-08-17 | Health Research, Inc. | Meso poly(4-sulfonatophenyl) porphines as MRI image enhancing agents |
EP0462836A3 (en) | 1990-06-20 | 1992-08-26 | Mitsui Toatsu Chemicals, Inc. | Recombinant vector plasmid capable of expressing human manganese superoxide dismutase, and process of producing this enzyme |
US5217966A (en) | 1990-09-13 | 1993-06-08 | The Regents Of The University Of California | Synthetic drug molecules that mimic metalloenzymes |
US5202317A (en) | 1990-09-13 | 1993-04-13 | The Regents Of The University Of California | Synthetic drug molecules that mimic metalloenzymes |
AU8947791A (en) | 1990-11-01 | 1992-05-26 | Scripps Research Institute, The | Glycosaminoglycan-targeted fusion proteins, their design, construction and compositions |
JPH06504041A (ja) | 1990-11-14 | 1994-05-12 | ユー・エー・ビー・リサーチ ファウンデーション | 虚血性傷害を減少させる方法と組成 |
US5192757A (en) | 1990-12-20 | 1993-03-09 | Glaxo Inc. | Cobalt porphyrins |
GB9103991D0 (en) | 1991-02-26 | 1991-04-10 | Nat Res Dev | Molecular electronic devices |
FR2676738B1 (fr) | 1991-05-22 | 1995-05-05 | Ir2M | Nouveau derive organique de metal de transition a structure porphyrinique, composition therapeutique le contenant, en particulier a activite hypoglycemiante. |
ATE164164T1 (de) | 1991-07-19 | 1998-04-15 | Monsanto Co | Mangan-komplexe mit stickstoff enthaltenden makrozyklischen liganden, wirksam als superoxiddismutasekatalysatoren. |
CA2072934C (en) | 1991-07-19 | 2007-08-28 | Karl William Aston | Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide |
US5262532A (en) | 1991-07-22 | 1993-11-16 | E.R. Squibb & Sons, Inc. | Paramagnetic metalloporphyrins as contrast agents for magnetic resonance imaging |
US5212300A (en) | 1991-09-12 | 1993-05-18 | Sun Company, Inc. (R&M) | Cyano- and polycyanometallo-porphyrins as catalysts for alkane oxidation |
US6011146A (en) | 1991-11-15 | 2000-01-04 | Institut Pasteur | Altered major histocompatibility complex (MHC) determinant and methods of using the determinant |
US5493017A (en) | 1992-08-14 | 1996-02-20 | The Trustees Of The University Of Pennsylvania | Ring-metalated porphyrins |
US5371199B1 (en) | 1992-08-14 | 1995-12-26 | Univ Pennsylvania | Substituted porphyrins porphyrin-containing polymers and synthetic methods therefor |
US5599924A (en) | 1992-08-14 | 1997-02-04 | Trustees Of The University Of Pennsylvania | Electron-deficient porphyrins and processes and intermediates for preparing same |
ES2157221T3 (es) | 1992-09-03 | 2001-08-16 | Univ California | Composiciones metaloporfirinicas. |
US5403834A (en) | 1992-12-07 | 1995-04-04 | Eukarion, Inc. | Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease |
US5834509A (en) | 1992-12-07 | 1998-11-10 | Eukarion, Inc. | Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease |
US5696109A (en) | 1992-12-07 | 1997-12-09 | Eukarion, Inc. | Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease |
US6204259B1 (en) | 1993-01-14 | 2001-03-20 | Monsanto Company | Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide |
DE4305523A1 (de) | 1993-02-17 | 1994-08-18 | Diagnostikforschung Inst | Meso-Tetraphenylporphyrin-Komplexverbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel |
US6417182B1 (en) | 1993-08-25 | 2002-07-09 | Anormed Inc. | Pharmaceutical compositions comprising metal complexes |
US5994339A (en) | 1993-10-15 | 1999-11-30 | University Of Alabama At Birmingham Research Foundation | Oxidant scavengers |
US6127356A (en) | 1993-10-15 | 2000-10-03 | Duke University | Oxidant scavengers |
US5747026A (en) | 1993-10-15 | 1998-05-05 | University Of Alabama At Birmingham Research Foundation | Antioxidants |
US5608054A (en) | 1993-12-29 | 1997-03-04 | Sun Company, Inc. (R&M) | Porphyrins and metal complexes thereof having haloalkyl side chains |
US5405369A (en) | 1994-01-25 | 1995-04-11 | Medical College Of Ohio | Photochemical ablation of gastro-intestinal tissue for augmentation of an organ |
US5604199A (en) | 1994-03-29 | 1997-02-18 | The Nemours Foundation | Method of treating fibrosis in skeletal muscle tissue |
US6245758B1 (en) | 1994-05-13 | 2001-06-12 | Michael K. Stern | Methods of use for peroxynitrite decomposition catalysts, pharmaceutical compositions therefor |
BR9507643A (pt) | 1994-05-13 | 1997-09-23 | Monsanto Co | Métodos de uso para catalisadores de decomposição de peroxinitrito composições farmacéuticas para os mesmos |
US5563132A (en) | 1994-06-21 | 1996-10-08 | Bodaness; Richard S. | Two-step cancer treatment method |
FR2723694B1 (fr) * | 1994-08-19 | 1996-09-27 | Oreal | Utilisation de sels de derives cationiques de porphine comme agents photosensibilisants de bacteries de type gram-negatif |
WO1996009053A1 (en) | 1994-09-20 | 1996-03-28 | Duke University | Oxidoreductase activity of manganic porphyrins |
CA2132690A1 (en) | 1994-09-22 | 1996-03-23 | Dean Willis | Control and modulation of inflammatory response in humans in need of such control and modulation |
US6013241A (en) | 1995-01-23 | 2000-01-11 | Schering Aktiengesellschaft | Use of porphyrin-complex or expanded porphyrin-complex compounds as an infarction localization diagnosticum |
ES2249784T3 (es) * | 1995-06-07 | 2006-04-01 | Duke University | Antioxidantges de oxidantes. |
AU6722496A (en) | 1995-08-17 | 1997-03-12 | Monsanto Company | Methods of diagnostic image analysis using metal complexes of nitrogen-containing macrocyclic ligands |
US5648523A (en) | 1995-10-26 | 1997-07-15 | Chiang Long Y | Fullerene derivatives as free-radical scavengers |
US5948771A (en) | 1996-01-31 | 1999-09-07 | The Trustees Of Columbia University In The City Of New York | Method for treating heart failure using tetrapyrroles and metallotetrapyrroles |
US5756492A (en) | 1996-09-09 | 1998-05-26 | Sangstat Medical Corporation | Graft survival prolongation with porphyrins |
US6087493A (en) | 1997-02-05 | 2000-07-11 | Regents Of The University Of Texas System | Porphyrin compounds as telomerase inhibitors |
US6180620B1 (en) | 1997-06-20 | 2001-01-30 | G.D. Searle & Co. | Analgesic methods using synthetic catalysts for the dismutation of superoxide radicals |
US6214817B1 (en) | 1997-06-20 | 2001-04-10 | Monsanto Company | Substituted pyridino pentaazamacrocyle complexes having superoxide dismutase activity |
CA2309154C (en) * | 1997-11-03 | 2010-02-16 | Duke University | Substituted porphyrins |
ES2254142T3 (es) | 1999-01-25 | 2006-06-16 | National Jewish Medical And Research Center | Porfirinas sustituidas y su uso terapeutico. |
US6608050B2 (en) | 1999-07-20 | 2003-08-19 | Pharmacia & Upjohn Company | Lyophilizate of lipid complex of water insoluble porphyrins |
AU1087401A (en) | 1999-10-13 | 2001-04-23 | Uab Research Foundation | Metalloporphyrin treatment of neurologic disease |
KR100667644B1 (ko) | 1999-11-30 | 2007-01-12 | 가부시키가이샤 히까리케미카루겡뀨쇼 | 니트로이미다졸 담지 포르피린 착체 |
JP3383839B2 (ja) | 2000-03-13 | 2003-03-10 | 奈良先端科学技術大学院大学長 | 新規なメルカプト置換イミダゾリルポルフィリン金属錯体単量体及びこれを繰り返し単位として有する重合体並びにこれらの製造方法 |
US6624187B1 (en) | 2000-06-12 | 2003-09-23 | Health Research, Inc. | Long wave length absorbing bacteriochlorin alkyl ether analogs |
US6403788B1 (en) | 2000-07-11 | 2002-06-11 | Eukarion, Inc. | Non-genotoxic metalloporphyrins as synthetic catalytic scavengers of reactive oxygen species |
US6573258B2 (en) * | 2000-09-27 | 2003-06-03 | Frontier Scientific, Inc. | Photodynamic porphyrin antimicrobial agents |
US6566517B2 (en) | 2001-06-06 | 2003-05-20 | Brookhaven Science Associates, Llc | Metalloporphyrins and their uses as imageable tumor-targeting agents for radiation therapy |
-
1998
- 1998-11-03 CA CA2309154A patent/CA2309154C/en not_active Expired - Lifetime
- 1998-11-03 EP EP98956457A patent/EP1045851B1/de not_active Expired - Lifetime
- 1998-11-03 AT AT98956457T patent/ATE238307T1/de active
- 1998-11-03 JP JP2000518967A patent/JP2001521939A/ja active Pending
- 1998-11-03 WO PCT/US1998/023287 patent/WO1999023097A1/en active IP Right Grant
- 1998-11-03 IL IL13594998A patent/IL135949A0/xx not_active IP Right Cessation
- 1998-11-03 DE DE69813898T patent/DE69813898T2/de not_active Expired - Lifetime
- 1998-11-03 ES ES98956457T patent/ES2198767T3/es not_active Expired - Lifetime
- 1998-11-03 AU AU12979/99A patent/AU737650B2/en not_active Expired
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2001
- 2001-06-14 US US09/880,125 patent/US6916799B2/en not_active Expired - Lifetime
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2005
- 2005-05-12 US US11/127,302 patent/US20060074062A1/en not_active Abandoned
-
2006
- 2006-09-15 US US11/532,408 patent/US20070179124A1/en not_active Abandoned
-
2008
- 2008-01-17 US US12/016,157 patent/US20080113956A1/en not_active Abandoned
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2010
- 2010-06-09 JP JP2010131845A patent/JP5312404B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US20060074062A1 (en) | 2006-04-06 |
US20080113956A1 (en) | 2008-05-15 |
CA2309154A1 (en) | 1999-05-14 |
US20020042407A1 (en) | 2002-04-11 |
AU1297999A (en) | 1999-05-24 |
IL135949A0 (en) | 2001-05-20 |
JP2010229145A (ja) | 2010-10-14 |
DE69813898D1 (de) | 2003-05-28 |
EP1045851A1 (de) | 2000-10-25 |
US20070179124A1 (en) | 2007-08-02 |
AU737650B2 (en) | 2001-08-23 |
WO1999023097A1 (en) | 1999-05-14 |
EP1045851A4 (de) | 2001-05-09 |
EP1045851B1 (de) | 2003-04-23 |
ES2198767T3 (es) | 2004-02-01 |
JP2001521939A (ja) | 2001-11-13 |
DE69813898T2 (de) | 2004-03-11 |
US6916799B2 (en) | 2005-07-12 |
CA2309154C (en) | 2010-02-16 |
JP5312404B2 (ja) | 2013-10-09 |
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