MXPA01007451A - Porfirinas sustituidas. - Google Patents

Porfirinas sustituidas.

Info

Publication number
MXPA01007451A
MXPA01007451A MXPA01007451A MXPA01007451A MXPA01007451A MX PA01007451 A MXPA01007451 A MX PA01007451A MX PA01007451 A MXPA01007451 A MX PA01007451A MX PA01007451 A MXPA01007451 A MX PA01007451A MX PA01007451 A MXPA01007451 A MX PA01007451A
Authority
MX
Mexico
Prior art keywords
substituted porphyrins
oxidants
relates
processes
modulating
Prior art date
Application number
MXPA01007451A
Other languages
English (en)
Inventor
James D Crapo
Original Assignee
Nat Jewish Med & Res Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nat Jewish Med & Res Center filed Critical Nat Jewish Med & Res Center
Publication of MXPA01007451A publication Critical patent/MXPA01007451A/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/555Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/409Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/06Free radical scavengers or antioxidants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B47/00Porphines; Azaporphines

Abstract

La presente invencion se refiere, en general, a un metodo para modular los procesos fisiologicos y patologicos, y en particular, a un metodo para modular los niveles celulares de oxidantes y por lo mismo los procesos en los que participan tales oxidantes. La invencion tambien se refiere a compuestos y composiciones adecuados para utilizarse en estos metodos.
MXPA01007451A 1999-01-25 2000-01-25 Porfirinas sustituidas. MXPA01007451A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11701099P 1999-01-25 1999-01-25
PCT/US2000/002062 WO2000043395A1 (en) 1999-01-25 2000-01-25 Substituted porphyrins

Publications (1)

Publication Number Publication Date
MXPA01007451A true MXPA01007451A (es) 2004-03-10

Family

ID=22370524

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA01007451A MXPA01007451A (es) 1999-01-25 2000-01-25 Porfirinas sustituidas.

Country Status (18)

Country Link
US (7) US6544975B1 (es)
EP (3) EP2295435A1 (es)
JP (1) JP4501128B2 (es)
KR (1) KR100753184B1 (es)
CN (1) CN1156478C (es)
AT (2) ATE312103T1 (es)
AU (1) AU779283B2 (es)
BR (1) BR0007720B1 (es)
CA (1) CA2359116C (es)
DE (1) DE60024588T2 (es)
DK (2) DK1155019T3 (es)
ES (2) ES2385486T3 (es)
HK (2) HK1047744A1 (es)
IL (3) IL144503A0 (es)
MX (1) MXPA01007451A (es)
NZ (1) NZ513164A (es)
WO (1) WO2000043395A1 (es)
ZA (1) ZA200106107B (es)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6127356A (en) 1993-10-15 2000-10-03 Duke University Oxidant scavengers
US5747026A (en) * 1993-10-15 1998-05-05 University Of Alabama At Birmingham Research Foundation Antioxidants
IL135949A0 (en) * 1997-11-03 2001-05-20 Univ Duke Substituted porphyrins
CA2329751C (en) 1998-04-24 2010-10-12 Duke University Substituted porphyrins
ATE312103T1 (de) 1999-01-25 2005-12-15 Nat Jewish Med & Res Center Substituierte porphyrine und deren therapeutische verwendungen
FR2806911B1 (fr) * 2000-03-28 2003-01-10 Univ Rene Descartes Utilisation de mimetiques de la sod dans le traitement d'insuffisances hepatocellulaires
US20030069281A1 (en) * 2000-06-14 2003-04-10 Irwin Fridovich Tetrapyrroles
WO2002060383A2 (en) 2001-01-19 2002-08-08 National Jewish Medical And Research Center Cancer therapy
KR100833371B1 (ko) * 2001-04-27 2008-05-28 젠야쿠코교가부시키가이샤 헤테로시클릭 화합물 및 이를 유효 성분으로 하는 항종양제
JP2005508864A (ja) * 2001-06-01 2005-04-07 ナショナル・ジュウィッシュ・メディカル・アンド・リサーチ・センター 糖尿病の治療、または移植術における使用、または免疫寛容の誘導のためのオキシダントスカベンジャー
US20030086916A1 (en) * 2001-10-12 2003-05-08 Goligorsky Michael S. Use of peroxynitrite scavengers or peroxynitrite formation inhibitors that do not diminish nitric oxide synthesis or activity to reverse or prevent premature vascular senescence
US7485721B2 (en) * 2002-06-07 2009-02-03 Duke University Substituted porphyrins
US20040127479A1 (en) * 2002-08-27 2004-07-01 Merck Patent Gmbh Peroxynitrite rearrangement catalysts
CA2505608A1 (en) * 2002-12-06 2004-06-24 Alcon, Inc. Superoxide dismutase mimics for the treatment of ocular disorders and diseases
GB2397067B (en) * 2002-12-23 2005-05-11 Destiny Pharma Ltd Porphin & azaporphin derivatives with at least one cationic-nitrogen-containing meso-substituent for use in photodynamic therapy & in vitro sterilisation
EP1452175A1 (en) * 2003-02-28 2004-09-01 Medesis Pharma S.A. Manganese based organometallic complexes, pharmaceutical compositions and dietetic products
WO2005037990A2 (en) * 2003-05-29 2005-04-28 Albert Einstein College Of Medecine Of Yeshiva University Use of parp inhibitors for prevention and treatment of diabetic and insulin resistance complications
US7299082B2 (en) 2003-10-31 2007-11-20 Abbott Diabetes Care, Inc. Method of calibrating an analyte-measurement device, and associated methods, devices and systems
EP1718201B1 (en) 2004-02-09 2016-09-14 Duke University Substituted porphyrins
US7699964B2 (en) 2004-02-09 2010-04-20 Abbott Diabetes Care Inc. Membrane suitable for use in an analyte sensor, analyte sensor, and associated method
US8165651B2 (en) 2004-02-09 2012-04-24 Abbott Diabetes Care Inc. Analyte sensor, and associated system and method employing a catalytic agent
EA010834B1 (ru) 2004-03-29 2008-12-30 Инотек Фармасьютикалз Корпорейшн Пиридилзамещённые порфириновые соединения и способы их применения
GB2415372A (en) 2004-06-23 2005-12-28 Destiny Pharma Ltd Non photodynamical or sonodynamical antimicrobial use of porphyrins and azaporphyrins containing at least one cationic-nitrogen-containing substituent
WO2006037050A2 (en) * 2004-09-24 2006-04-06 Metaphore Pharmaceuticals, Inc. Methods for treating congestive heart failure
GB0424294D0 (en) * 2004-11-03 2004-12-01 Elam T Ltd Buffer layer
US7501508B2 (en) * 2005-07-29 2009-03-10 North Caroline State University Methods and intermediates for the synthesis of porphyrins
US7582751B2 (en) * 2005-07-29 2009-09-01 North Carolina State University Methods and intermediates for the synthesis of porphyrins
US7885698B2 (en) 2006-02-28 2011-02-08 Abbott Diabetes Care Inc. Method and system for providing continuous calibration of implantable analyte sensors
AU2007329539A1 (en) * 2006-12-01 2008-06-12 George Mason University Inhibition of brain enzymes involved in cerebral amyloid angiopathy and macular degeneration
US20080289053A1 (en) * 2007-05-15 2008-11-20 The Regents Of The University Of California Methods and systems for identifying modulators of longevity
WO2009004339A2 (en) * 2007-07-03 2009-01-08 Imperial Innovations Limited Compositions and methods relating to manipulation of the myeloid immune compartment during respiratory infection
AU2008293376B2 (en) * 2007-08-28 2013-07-11 Technion Research & Development Foundation Ltd. Transition metal complexes of corroles for preventing cardiovascular diseases or disorders
US8987245B2 (en) 2008-04-02 2015-03-24 Jonathan R. Brestoff Parker Composition and method for affecting obesity and related conditions
US8598150B1 (en) 2008-04-02 2013-12-03 Jonathan R. Brestoff Composition and method for affecting obesity and related conditions
JP5608644B2 (ja) * 2008-05-23 2014-10-15 ナショナル ジューイッシュ ヘルス アルキル化種の被爆に関連する損傷の処置方法
US20120065181A1 (en) * 2009-05-26 2012-03-15 Warner David S Method of providing neuroprotection using substituted porphyrins
AU2010289385A1 (en) * 2009-09-02 2012-03-15 The Regents Of The University Of Colorado, A Body Corporate Methods of treating mitochondrial disorders using metalloporhyrins
PL2625180T3 (pl) * 2010-10-06 2016-10-31 Leczenie chorób neurodegeneracyjnych związkami porfirynowymi
JP5823988B2 (ja) * 2011-01-31 2015-11-25 国立大学法人宇都宮大学 ポルフィリン型骨格を有する化合物の金属錯体の製造方法
CA2856552A1 (en) 2011-12-02 2013-09-06 The Regents Of The University Of Colorado, A Body Corporate Metalloporphyrin neurological treatments
CN102775415B (zh) * 2012-07-10 2014-10-22 西北大学 一种卟啉的合成方法
WO2014028823A1 (en) * 2012-08-16 2014-02-20 Leading Energy Designs, Ltd. Led bracket apparatus for high-output led lighting systems
WO2015034778A1 (en) * 2013-09-03 2015-03-12 Biomimetix J.V., Llc Methods of treating erectile dysfunction
AU2014352752A1 (en) * 2013-11-22 2016-06-16 Aeolus Sciences, Inc. Synthesis and formulations of porphyrin compounds
CA2933166C (en) 2013-12-31 2020-10-27 Abbott Diabetes Care Inc. Self-powered analyte sensor and devices using the same
WO2015112586A1 (en) 2014-01-22 2015-07-30 Duke University Methods of treating pruritus
WO2015112588A1 (en) * 2014-01-22 2015-07-30 Biomimetix Jv, Llc Methods of treating skin disorders
AT516549B1 (de) * 2014-11-20 2017-05-15 Wenatex Forschung - Entw - Produktion Gmbh Antimikrobielles Mittel zum biociden Ausrüsten von Polymeren
US10385082B2 (en) 2015-08-18 2019-08-20 University of Pittsburgh—of the Commonwealth System of Higher Education Antioxidant compounds and their use
US20190330220A1 (en) * 2016-12-20 2019-10-31 Duke University Methods of making substituted porphyrin pharmaceutical compounds and compositions
CN110352036B (zh) * 2016-12-21 2022-11-15 普罗菲尤萨股份有限公司 可聚合的近红外染料
CN110028514B (zh) * 2019-05-30 2021-07-02 湖南科技大学 5,10,15,20-四芳基-2,3-咪唑稠合-21-碳叶绿素化合物及制备方法
US20220372043A1 (en) * 2019-06-14 2022-11-24 Universidade De Coimbra Small cationic ortho-5,15-di-heteroaryl-porphyrins derivatives and their applications in photoinactivation of microorganisms
CN116284017B (zh) * 2023-03-27 2024-03-22 中国科学院青岛生物能源与过程研究所 一种利用仿酶高效催化氧化制备酰胺化合物的方法

Family Cites Families (123)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US437221A (en) * 1890-09-30 Circular-saw-smithing machine
US2951799A (en) 1957-11-13 1960-09-06 Monsanto Chemicals Photoxidation processes using heterocyclic photosensitizers
JPS5641611B2 (es) * 1973-04-19 1981-09-29
EP0127797B1 (de) 1983-06-03 1987-06-16 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Markermoleküle für Fluoreszenz-Immuno-Assays sowie Verfahren und Zwischenprodukte zu deren Herstellung
US4829984A (en) * 1983-12-15 1989-05-16 Gordon Robert T Method for the improvement of transplantation techniques and for the preservation of tissue
US4963367A (en) 1984-04-27 1990-10-16 Medaphore, Inc. Drug delivery compositions and methods
US5087438A (en) * 1984-07-03 1992-02-11 Gordon Robert T Method for affecting intracellular and extracellular electric and magnetic dipoles
US4911920A (en) * 1986-07-30 1990-03-27 Alcon Laboratories, Inc. Sustained release, comfort formulation for glaucoma therapy
GB8429845D0 (en) 1984-11-26 1985-01-03 Efamol Ltd Porphyrins & cancer treatment
US4758422A (en) 1985-01-04 1988-07-19 Salutar Inc. Ferrioxamine paramagnetic contrast agents for MR imaging
US4657902A (en) 1985-03-25 1987-04-14 The Rockefeller University Therapeutic use of tin mesoporphyrin
ATE78158T1 (de) 1985-05-22 1992-08-15 Liposome Technology Inc Verfahren und system zum einatmen von liposomen.
US5248603A (en) 1985-09-03 1993-09-28 Symbicom Aktiebolag Superoxide dismutase
DK402785D0 (da) 1985-09-03 1985-09-03 Syn Tek Ab Fremgangsmaade til fremstilling af et enzym
FR2588189B1 (fr) * 1985-10-03 1988-12-02 Merck Sharp & Dohme Composition pharmaceutique de type a transition de phase liquide-gel
US4866054A (en) * 1986-05-13 1989-09-12 Chai-Tech Corporation Antioxidant metallo-organic treatment of inflammation
US4746735A (en) 1986-11-21 1988-05-24 The Dow Chemical Company Regiospecific aryl nitration of meso-substituted tetraarylporphyrins
US5162231A (en) 1989-10-25 1992-11-10 Cole Dean A Method of using 5,10,15,20-tetrakis(carboxyphenyl)porphine for detecting cancers of the lung
DE3854872D1 (de) 1987-03-14 1996-02-22 Boehringer Ingelheim Int Humane Mangan-Superoxiddismutase (hMn-SOD)
DE3800973C2 (de) * 1987-03-25 1992-03-19 Degussa Ag, 6000 Frankfurt, De Oxowolfram(v)-porphyrin-komplexe wo(p)x
US5227405A (en) 1987-03-31 1993-07-13 Duke University Superoxide dismutase mimic
US5223538A (en) 1987-03-31 1993-06-29 Duke University Superoxide dismutase mimic
US4892941A (en) 1987-04-17 1990-01-09 Dolphin David H Porphyrins
US4851403A (en) 1987-04-21 1989-07-25 Johnson Matthey, Inc. Radiation sensitizers
US4885114A (en) * 1987-04-22 1989-12-05 Barnes Engineering Co. Metallized tetra((meso)-5-methyl-2-thiophene)porphines, platinum (5-bromo octaethylporphine) and optical filters containing same
US5051337A (en) 1987-06-10 1991-09-24 Director-General Of Agency Of Industrial Science And Technology Optical recording material
DE3805697A1 (de) * 1988-02-24 1989-09-07 Bayer Ag Verfahren zur herstellung von p-hydroxy-benzaldehyden
US5162519A (en) 1988-03-11 1992-11-10 Efamol Holdings Plc Porphyrins and cancer treatment
GB8805849D0 (en) 1988-03-11 1988-04-13 Efamol Holdings Porphyrins & cancer treatment
US5284647A (en) 1988-03-18 1994-02-08 Schering Aktiengesellschaft Mesotetraphenylporphyrin complex compounds, process for their production and pharmaceutical agents containing them
DE3809671A1 (de) * 1988-03-18 1989-09-28 Schering Ag Porphyrin-komplexverbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
US5192788A (en) * 1988-05-23 1993-03-09 Georgia State University Foundation, Inc. Porphyrin antiviral compositions
US5109016A (en) 1988-05-23 1992-04-28 Georgia State University Foundation, Inc. Method for inhibiting infection or replication of human immunodeficiency virus with porphyrin and phthalocyanine antiviral compositions
FR2632187B1 (fr) 1988-06-02 1990-09-14 Centre Nat Rech Scient Derives de metalloporphyrines, leur preparation, leur application en therapeutique et leur utilisation pour la preparation de molecules hybrides
US5171680A (en) 1988-06-14 1992-12-15 Chiron Corporation Superoxide dismutase analogs having novel binding properties
JPH0746212B2 (ja) 1988-12-03 1995-05-17 工業技術院長 異方性lb膜の製造法
JPH02213088A (ja) * 1989-02-13 1990-08-24 Nec Corp 有機薄膜el素子及びその製造方法
EP0414915B1 (en) 1989-03-06 1996-06-12 Suntory Limited New superoxide dismutase
DK455789D0 (da) 1989-09-15 1989-09-15 Symbicom Ab Polypeptid
US5010073A (en) * 1989-10-05 1991-04-23 The Rockefeller University Use of liposomes as carriers for metalloporphyrins
EP0424033A3 (en) 1989-10-19 1991-07-31 Pola Chemical Industries Inc External skin preparation
US5236915A (en) 1990-05-31 1993-08-17 Health Research, Inc. Meso poly(4-sulfonatophenyl) porphines as MRI image enhancing agents
EP0462836A3 (en) 1990-06-20 1992-08-26 Mitsui Toatsu Chemicals, Inc. Recombinant vector plasmid capable of expressing human manganese superoxide dismutase, and process of producing this enzyme
US5417111A (en) * 1990-08-17 1995-05-23 Analog Devices, Inc. Monolithic chip containing integrated circuitry and suspended microstructure
US5217966A (en) 1990-09-13 1993-06-08 The Regents Of The University Of California Synthetic drug molecules that mimic metalloenzymes
US5202317A (en) 1990-09-13 1993-04-13 The Regents Of The University Of California Synthetic drug molecules that mimic metalloenzymes
WO1992007935A1 (en) 1990-11-01 1992-05-14 The Scripps Research Institute Glycosaminoglycan-targeted fusion proteins, their design, construction and compositions
EP0557417A4 (en) 1990-11-14 1994-06-08 Uab Research Foundation Compositions for reducing oxidative injury
US5192757A (en) * 1990-12-20 1993-03-09 Glaxo Inc. Cobalt porphyrins
EP0495421B1 (en) * 1991-01-15 1996-08-21 Alcon Laboratories, Inc. Use of carrageenans in topical ophthalmic compositions
GB9103991D0 (en) 1991-02-26 1991-04-10 Nat Res Dev Molecular electronic devices
US5212162A (en) * 1991-03-27 1993-05-18 Alcon Laboratories, Inc. Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions
FR2676738B1 (fr) 1991-05-22 1995-05-05 Ir2M Nouveau derive organique de metal de transition a structure porphyrinique, composition therapeutique le contenant, en particulier a activite hypoglycemiante.
DE69224839T2 (de) 1991-07-19 1998-10-08 Monsanto Co Mangan-Komplexe mit Stickstoff enthaltenden makrozyklischen Liganden, wirksam als Superoxiddismutasekatalysatoren.
CA2072934C (en) * 1991-07-19 2007-08-28 Karl William Aston Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
US5262532A (en) 1991-07-22 1993-11-16 E.R. Squibb & Sons, Inc. Paramagnetic metalloporphyrins as contrast agents for magnetic resonance imaging
US5212300A (en) 1991-09-12 1993-05-18 Sun Company, Inc. (R&M) Cyano- and polycyanometallo-porphyrins as catalysts for alkane oxidation
US5976551A (en) * 1991-11-15 1999-11-02 Institut Pasteur And Institut Nationale De La Sante Et De La Recherche Medicale Altered major histocompatibility complex (MHC) determinant and method of using the determinant
US5371199B1 (en) 1992-08-14 1995-12-26 Univ Pennsylvania Substituted porphyrins porphyrin-containing polymers and synthetic methods therefor
US5599924A (en) 1992-08-14 1997-02-04 Trustees Of The University Of Pennsylvania Electron-deficient porphyrins and processes and intermediates for preparing same
US5493017A (en) 1992-08-14 1996-02-20 The Trustees Of The University Of Pennsylvania Ring-metalated porphyrins
DE69330275T2 (de) 1992-09-03 2001-10-31 Univ California Metallporphyrinzusammensetzungen
US5403834A (en) * 1992-12-07 1995-04-04 Eukarion, Inc. Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease
US5696109A (en) 1992-12-07 1997-12-09 Eukarion, Inc. Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease
US5834509A (en) * 1992-12-07 1998-11-10 Eukarion, Inc. Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease
US6204259B1 (en) * 1993-01-14 2001-03-20 Monsanto Company Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
DE4305523A1 (de) 1993-02-17 1994-08-18 Diagnostikforschung Inst Meso-Tetraphenylporphyrin-Komplexverbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel
US5428037A (en) 1993-04-09 1995-06-27 Syntex Pharmaceuticals, Ltd. Heterocyclic derivatives in the treatment of Ischaemia and related diseases
JP3273082B2 (ja) 1993-06-18 2002-04-08 三和電気工業株式会社 光コネクタ用スリ−ブホルダ
JPH0743337A (ja) * 1993-07-30 1995-02-14 Toppan Printing Co Ltd マンガンポルフィリン錯体を感応物質とする陰イオン選択性電極
US6417182B1 (en) * 1993-08-25 2002-07-09 Anormed Inc. Pharmaceutical compositions comprising metal complexes
US5994339A (en) 1993-10-15 1999-11-30 University Of Alabama At Birmingham Research Foundation Oxidant scavengers
US5747026A (en) 1993-10-15 1998-05-05 University Of Alabama At Birmingham Research Foundation Antioxidants
US6127356A (en) * 1993-10-15 2000-10-03 Duke University Oxidant scavengers
US5488145A (en) 1993-12-23 1996-01-30 Oklahoma Medical Research Foundation 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceutical free radical traps
US5608054A (en) 1993-12-29 1997-03-04 Sun Company, Inc. (R&M) Porphyrins and metal complexes thereof having haloalkyl side chains
US5405369A (en) * 1994-01-25 1995-04-11 Medical College Of Ohio Photochemical ablation of gastro-intestinal tissue for augmentation of an organ
US5604199A (en) * 1994-03-29 1997-02-18 The Nemours Foundation Method of treating fibrosis in skeletal muscle tissue
US6245758B1 (en) * 1994-05-13 2001-06-12 Michael K. Stern Methods of use for peroxynitrite decomposition catalysts, pharmaceutical compositions therefor
JPH10500671A (ja) * 1994-05-13 1998-01-20 モンサント カンパニー ペルオキシ亜硝酸塩分解触媒の使用方法、そのための薬剤組成物
US5563132A (en) * 1994-06-21 1996-10-08 Bodaness; Richard S. Two-step cancer treatment method
WO1996009053A1 (en) 1994-09-20 1996-03-28 Duke University Oxidoreductase activity of manganic porphyrins
CA2132690A1 (en) 1994-09-22 1996-03-23 Dean Willis Control and modulation of inflammatory response in humans in need of such control and modulation
US6013241A (en) * 1995-01-23 2000-01-11 Schering Aktiengesellschaft Use of porphyrin-complex or expanded porphyrin-complex compounds as an infarction localization diagnosticum
IL122451A0 (en) * 1995-06-07 1998-06-15 Univ Duke Oxidant scavengers
AU700958B2 (en) 1995-08-17 1999-01-14 Monsanto Company Bioconjugates of manganese complexes and their application as catalysts
NZ315505A (en) * 1995-08-17 2000-01-28 Monsanto Co Methods of diagnostic image analysis using metal complexes of nitrogen-containing macrocyclic ligands
EP0846003A1 (en) 1995-08-17 1998-06-10 Monsanto Company Methods of diagnostic image analysis using bioconjugates of metal complexes of nitrogen-containing macrocyclic ligands
US5648523A (en) * 1995-10-26 1997-07-15 Chiang Long Y Fullerene derivatives as free-radical scavengers
US5948771A (en) * 1996-01-31 1999-09-07 The Trustees Of Columbia University In The City Of New York Method for treating heart failure using tetrapyrroles and metallotetrapyrroles
CN1225631A (zh) 1996-03-13 1999-08-11 孟山都公司 有歧化过氧化物催化剂效果的含氮大环配位体锰或铁配合物的生物缀合物
CA2248964A1 (en) 1996-03-13 1997-09-18 Monsanto Company Iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
JPH1062350A (ja) * 1996-08-14 1998-03-06 Ebara Corp ガス反応性色素を用いたガス検知方法及びガス検知装置
US5756492A (en) * 1996-09-09 1998-05-26 Sangstat Medical Corporation Graft survival prolongation with porphyrins
EP0988037A1 (en) 1997-02-05 2000-03-29 Board Of Regents, The University Of Texas System Porphyrin compounds as telomerase inhibitors
US6180620B1 (en) 1997-06-20 2001-01-30 G.D. Searle & Co. Analgesic methods using synthetic catalysts for the dismutation of superoxide radicals
US6214817B1 (en) * 1997-06-20 2001-04-10 Monsanto Company Substituted pyridino pentaazamacrocyle complexes having superoxide dismutase activity
GB9716446D0 (en) 1997-08-05 1997-10-08 Agrevo Uk Ltd Fungicides
JP3564962B2 (ja) * 1997-08-26 2004-09-15 松下電器産業株式会社 光記録媒体及びその光記録再生方法
US6620961B1 (en) 1997-08-26 2003-09-16 Kumiai Chemical Industry Co., Ltd. Biarylalkylenecarbamic acid derivatives and bacteriocides for agricultural and horticultural use
IL135949A0 (en) * 1997-11-03 2001-05-20 Univ Duke Substituted porphyrins
CA2329751C (en) * 1998-04-24 2010-10-12 Duke University Substituted porphyrins
WO2000004868A2 (en) 1998-07-23 2000-02-03 Metaphore, Inc. Libraries of polyhydroxamates and their analogs
WO2000023568A2 (en) 1998-10-06 2000-04-27 Albert Einstein College Of Medicine Of Yeshiva University Methods and compositions for decreasing mitochondrial overproduction of reactive oxygen species in cells
ATE312103T1 (de) 1999-01-25 2005-12-15 Nat Jewish Med & Res Center Substituierte porphyrine und deren therapeutische verwendungen
ES2240101T3 (es) 1999-05-27 2005-10-16 Monsanto Company Biomateriales modificados con mimeticos de superoxido dismutasa.
US6448239B1 (en) 1999-06-03 2002-09-10 Trustees Of Princeton University Peroxynitrite decomposition catalysts and methods of use thereof
US6608050B2 (en) * 1999-07-20 2003-08-19 Pharmacia & Upjohn Company Lyophilizate of lipid complex of water insoluble porphyrins
AU1087401A (en) 1999-10-13 2001-04-23 Uab Research Foundation Metalloporphyrin treatment of neurologic disease
WO2001040233A1 (fr) * 1999-11-30 2001-06-07 Photochemical Co., Ltd. Complexe porphyrine servant de support a un nitroimidazole
JP3383839B2 (ja) * 2000-03-13 2003-03-10 奈良先端科学技術大学院大学長 新規なメルカプト置換イミダゾリルポルフィリン金属錯体単量体及びこれを繰り返し単位として有する重合体並びにこれらの製造方法
US6624187B1 (en) * 2000-06-12 2003-09-23 Health Research, Inc. Long wave length absorbing bacteriochlorin alkyl ether analogs
EP1320532A1 (en) 2000-06-14 2003-06-25 Duke University Tetrapyrroles
US6403788B1 (en) * 2000-07-11 2002-06-11 Eukarion, Inc. Non-genotoxic metalloporphyrins as synthetic catalytic scavengers of reactive oxygen species
US6573258B2 (en) * 2000-09-27 2003-06-03 Frontier Scientific, Inc. Photodynamic porphyrin antimicrobial agents
WO2002060383A2 (en) * 2001-01-19 2002-08-08 National Jewish Medical And Research Center Cancer therapy
WO2002078670A1 (en) 2001-03-02 2002-10-10 Neuron Therapeutics, Inc. Neuroprotectants formulations and methods
JP2004532251A (ja) 2001-05-31 2004-10-21 ミラヴァント ファーマシューティカルズ インコーポレイテッド 光線力学療法で使用のメタロテトラピロール系光増感剤
US6566517B2 (en) * 2001-06-06 2003-05-20 Brookhaven Science Associates, Llc Metalloporphyrins and their uses as imageable tumor-targeting agents for radiation therapy
DE10240343A1 (de) 2002-08-27 2004-03-11 Schering Ag Peroxynitrit-Umlagerungskatalysatoren
EP1718201B1 (en) 2004-02-09 2016-09-14 Duke University Substituted porphyrins
RU2007143040A (ru) 2005-04-21 2009-05-27 Гленн А. ГОЛДШТЕЙН (US) Амид n-ацетилцистеина (амид nac) в лечении заболеваний и состояний, связанных с окислительным стрессом
AU2010289385A1 (en) 2009-09-02 2012-03-15 The Regents Of The University Of Colorado, A Body Corporate Methods of treating mitochondrial disorders using metalloporhyrins

Also Published As

Publication number Publication date
KR100753184B1 (ko) 2007-08-30
CN1156478C (zh) 2004-07-07
EP1155019B1 (en) 2005-12-07
EP1155019A1 (en) 2001-11-21
CA2359116A1 (en) 2000-07-27
CA2359116C (en) 2009-03-17
ATE552260T1 (de) 2012-04-15
US9289434B2 (en) 2016-03-22
US20110065679A1 (en) 2011-03-17
WO2000043395A1 (en) 2000-07-27
JP2002535332A (ja) 2002-10-22
US20150231150A1 (en) 2015-08-20
JP4501128B2 (ja) 2010-07-14
CN1355802A (zh) 2002-06-26
EP1616869A1 (en) 2006-01-18
BR0007720B1 (pt) 2014-04-08
HK1047744A1 (en) 2003-03-07
US20070197496A1 (en) 2007-08-23
DK1155019T3 (da) 2006-04-18
IL144503A (en) 2007-10-31
ES2385486T3 (es) 2012-07-25
US8546562B2 (en) 2013-10-01
US7820644B2 (en) 2010-10-26
EP1616869B1 (en) 2012-04-04
DK1616869T3 (da) 2012-05-07
US6544975B1 (en) 2003-04-08
NZ513164A (en) 2006-03-31
IL183953A0 (en) 2007-10-31
DE60024588T2 (de) 2006-08-17
US7189707B2 (en) 2007-03-13
AU779283C (en) 2000-08-07
ES2254142T3 (es) 2006-06-16
US20120214780A1 (en) 2012-08-23
HK1083626A1 (en) 2006-07-07
WO2000043395A8 (en) 2000-08-31
BR0007720A (pt) 2001-10-30
IL183953A (en) 2010-12-30
AU2740700A (en) 2000-08-07
DE60024588D1 (de) 2006-01-12
AU779283B2 (en) 2005-01-13
ATE312103T1 (de) 2005-12-15
KR20010108130A (ko) 2001-12-07
EP1155019A4 (en) 2002-07-03
US8217026B2 (en) 2012-07-10
US20140011794A1 (en) 2014-01-09
US8946202B2 (en) 2015-02-03
IL144503A0 (en) 2002-05-23
EP2295435A1 (en) 2011-03-16
ZA200106107B (en) 2002-12-24
US20040023941A1 (en) 2004-02-05

Similar Documents

Publication Publication Date Title
MXPA01007451A (es) Porfirinas sustituidas.
IL135949A0 (en) Substituted porphyrins
EP1071474A4 (en) SUBSTITUTED PORPHYRINE
EP1432714A4 (en) CHEMICAL COMPOUNDS
AU5624699A (en) Use of 5ht-6 antagonists
AP2001002225A0 (en) 1-heterocycle substituted diarylamines.
CY2538B1 (en) Tetrahydropyrido compounds
ZA200108446B (en) Novel method of treatment.
UA66865C2 (uk) Інденопіролокарбазоли, фармацевтична композиція, спосіб інгібування кіназної активності та спосіб лікування (варіанти)
IL122451A0 (en) Oxidant scavengers
DE69938192D1 (en) Imidazonaphthyridine
MXPA03001536A (es) (aminoalcoxibenzoil) benzofuranos o benzotiofenos, metodo para preparar los mismo y composiciones que los contienen.
UA83203C2 (uk) Тіазол-(бі)циклоалкілкарбоксаніліди, засіб на їх основі та застосування для боротьби з небажаними мікроорганізмами
IL144199A0 (en) Novel bretylium compositions and kits, and their use in preventing and treating cardiovascular conditions
WO2003039484A3 (en) Novel compositions and methods for cancer
EP1436279A4 (en) CHEMICAL COMPOUNDS
UA35854A (uk) Спосіб лікування приховано протікаючого силікотуберкульозу
YU47301A (sh) Diarilamini sa supstituisanim 1-heterociklom

Legal Events

Date Code Title Description
FG Grant or registration
HC Change of company name or juridical status