EE03763B1 - 1-fenüülalküül-1,2,3,6-tetrahüdropüridiinid Alzheimeri tõve raviks - Google Patents

1-fenüülalküül-1,2,3,6-tetrahüdropüridiinid Alzheimeri tõve raviks

Info

Publication number
EE03763B1
EE03763B1 EEP199900237A EE9900237A EE03763B1 EE 03763 B1 EE03763 B1 EE 03763B1 EE P199900237 A EEP199900237 A EE P199900237A EE 9900237 A EE9900237 A EE 9900237A EE 03763 B1 EE03763 B1 EE 03763B1
Authority
EE
Estonia
Prior art keywords
alkyl
alkoxy
amino
pct
group
Prior art date
Application number
EEP199900237A
Other languages
English (en)
Other versions
EE9900237A (et
Inventor
Baroni Marco
Cardamone Rosanna
Fournier Jacqueline
Guzzi Umberto
Original Assignee
Sanofi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi filed Critical Sanofi
Publication of EE9900237A publication Critical patent/EE9900237A/et
Publication of EE03763B1 publication Critical patent/EE03763B1/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
EEP199900237A 1996-12-13 1997-12-12 1-fenüülalküül-1,2,3,6-tetrahüdropüridiinid Alzheimeri tõve raviks EE03763B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9615335A FR2757160B1 (fr) 1996-12-13 1996-12-13 1-phenylalkyl-1,2,3,6-tetrahydropyridines
PCT/FR1997/002286 WO1998025903A1 (fr) 1996-12-13 1997-12-12 1-phenylalkyl-1,2,3,6-tetrahydropyridines pour le traitement de la maladie d'alzheimer

Publications (2)

Publication Number Publication Date
EE9900237A EE9900237A (et) 1999-12-15
EE03763B1 true EE03763B1 (et) 2002-06-17

Family

ID=9498641

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP199900237A EE03763B1 (et) 1996-12-13 1997-12-12 1-fenüülalküül-1,2,3,6-tetrahüdropüridiinid Alzheimeri tõve raviks

Country Status (32)

Country Link
US (1) US6034090A (et)
EP (1) EP0950048B1 (et)
JP (1) JP3881384B2 (et)
KR (1) KR100560358B1 (et)
CN (1) CN1129579C (et)
AT (1) ATE202561T1 (et)
AU (1) AU730143B2 (et)
BR (1) BR9713916A (et)
CA (1) CA2275353C (et)
CY (1) CY2274B1 (et)
CZ (1) CZ289789B6 (et)
DE (1) DE69705429T2 (et)
DK (1) DK0950048T3 (et)
EE (1) EE03763B1 (et)
ES (1) ES2160977T3 (et)
FR (1) FR2757160B1 (et)
GR (1) GR3036643T3 (et)
HK (1) HK1023997A1 (et)
HU (1) HU224347B1 (et)
IL (1) IL130003A (et)
IS (1) IS1969B (et)
NO (1) NO312720B1 (et)
NZ (1) NZ336033A (et)
PL (1) PL190789B1 (et)
PT (1) PT950048E (et)
RS (1) RS49807B (et)
RU (1) RU2189975C2 (et)
SI (1) SI0950048T1 (et)
SK (1) SK283331B6 (et)
TR (1) TR199901291T2 (et)
UA (1) UA52707C2 (et)
WO (1) WO1998025903A1 (et)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2763847B1 (fr) * 1997-05-28 2003-06-06 Sanofi Sa Utilisation de tetrahydropyridines 4-substituees pour fabriquer des medicaments agissant sur le tgf-beta-1
UA81749C2 (uk) * 2001-10-04 2008-02-11 Х. Луннбек А/С Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну
FR2832405B1 (fr) * 2001-11-19 2004-12-10 Sanofi Synthelabo Tetrahydropyridyl-alkyl-heterocycles azotes, procede pour leur preparation et compositions pharmaceutiques les contenant

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1321701A (en) * 1969-10-01 1973-06-27 Continental Pharma Amino-alcohols their salts and process for prepairing the same
IE34545B1 (en) * 1969-10-01 1975-06-11 Continental Pharma Amino-alcohols,their salts and process for preparing the same
FR2650505B1 (fr) * 1989-08-07 1994-06-03 Midy Spa Utilisation de trifluoromethylphenyltetrahydropyridines pour la preparation de medicaments destines a combattre les troubles de la motricite intestinale
FR2662355B1 (fr) * 1990-05-22 1994-11-10 Sanofi Sa Utilisation de la 1-[2-(2-naphtyl)ethyl]-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine pour la preparation de medicaments destines au traitement de troubles cerebraux et neuronaux.
HU211019B (en) * 1991-12-02 1995-09-28 Richter Gedeon Vegyeszet Process for producing new 1,2,3,6-tetrahydropyridine and piperidine derivatives substituted with n-(hydroxylalkyl) group and compositions comprising such compounds

Also Published As

Publication number Publication date
JP3881384B2 (ja) 2007-02-14
BR9713916A (pt) 2000-02-29
DE69705429D1 (de) 2001-08-02
PT950048E (pt) 2001-12-28
NO992869L (no) 1999-06-11
AU730143B2 (en) 2001-03-01
DK0950048T3 (da) 2001-09-24
NO992869D0 (no) 1999-06-11
HU224347B1 (hu) 2005-08-29
TR199901291T2 (xx) 1999-10-21
IL130003A (en) 2004-09-27
HUP0001185A3 (en) 2002-10-28
CZ211399A3 (cs) 2000-09-13
KR100560358B1 (ko) 2006-03-14
IL130003A0 (en) 2000-02-29
SK283331B6 (sk) 2003-06-03
CA2275353C (en) 2007-05-22
CY2274B1 (en) 2003-07-04
CN1129579C (zh) 2003-12-03
EE9900237A (et) 1999-12-15
HUP0001185A2 (hu) 2000-10-28
CZ289789B6 (cs) 2002-04-17
ES2160977T3 (es) 2001-11-16
WO1998025903A1 (fr) 1998-06-18
RU2189975C2 (ru) 2002-09-27
JP2001505902A (ja) 2001-05-08
US6034090A (en) 2000-03-07
YU24399A (sh) 2001-07-10
FR2757160A1 (fr) 1998-06-19
CA2275353A1 (en) 1998-06-18
IS1969B (is) 2004-12-15
NZ336033A (en) 2000-12-22
EP0950048A1 (fr) 1999-10-20
CN1240427A (zh) 2000-01-05
KR20000069422A (ko) 2000-11-25
UA52707C2 (uk) 2003-01-15
RS49807B (sr) 2008-08-07
GR3036643T3 (en) 2001-12-31
NO312720B1 (no) 2002-06-24
PL190789B1 (pl) 2006-01-31
AU5489398A (en) 1998-07-03
SK78699A3 (en) 2000-01-18
IS5075A (is) 1999-06-10
FR2757160B1 (fr) 1999-03-12
DE69705429T2 (de) 2002-05-16
PL334071A1 (en) 2000-01-31
ATE202561T1 (de) 2001-07-15
SI0950048T1 (en) 2001-10-31
EP0950048B1 (fr) 2001-06-27
HK1023997A1 (en) 2000-09-29

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Legal Events

Date Code Title Description
KB4A Valid patent at the end of a year

Effective date: 20021231

KB4A Valid patent at the end of a year

Effective date: 20031231

HC1A Change of owner name
KB4A Valid patent at the end of a year

Effective date: 20041231

KB4A Valid patent at the end of a year

Effective date: 20051231

KB4A Valid patent at the end of a year

Effective date: 20061231

KB4A Valid patent at the end of a year

Effective date: 20071231

KB4A Valid patent at the end of a year

Effective date: 20081231

MM4A Lapsed by not paying the annual fees

Effective date: 20081212