YU24399A - 1-fenilalkil-1,2,3,6-tetrahidropiridini za tretiranje alzheimer-ovog obolenja - Google Patents
1-fenilalkil-1,2,3,6-tetrahidropiridini za tretiranje alzheimer-ovog obolenjaInfo
- Publication number
- YU24399A YU24399A YU24399A YU24399A YU24399A YU 24399 A YU24399 A YU 24399A YU 24399 A YU24399 A YU 24399A YU 24399 A YU24399 A YU 24399A YU 24399 A YU24399 A YU 24399A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- alkyl
- alcoxycarbonyl
- mono
- group
- alcoxyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
Abstract
Pronalazak se odnosi na jedinjenje formule (I) u kojoj Y predstavlja -CH- ili -N-; R1 predstavlja vodonik, halogen, grupu CF3, (C1-C4) alkil ili (C1-C4) alkoksil; R2 predstavlja grupu metil ili etil; R3 i R4 svaki predstavlja vodonik ili (C1-C3) alkil; X predstavlja (a) (C1-C6) alkil, (C1-C6) alkoksil; (C3-C7) karboksialkil; (C1-C4) alkoksikarbonil (C1-C6) alkil; (C3-C7) karboksialkoksil ili (C1-C4) alkoksikarbonil (C1-C6) alkoksil; (b) radikal koji se bira izmedju (C3-C7) cikloalkil, (C3-C7) cikloalkiloksi; (C3-C7) cikloalkimetil, (C3-C7) cikloalkilamino i cikloheksil, pomenuti radikal moze da bude supstituisan sa jednim halogenom, hidroksi, (C1-C4) alkoksi, karboksi, (C1-C4) alkoksikarbonil, amino, mono- ili di-(C1-C4) alkilamino; (c) grupu koja se bira izmedju fenil, fenoksi, fenilamino, N-(C1-C3) alkilfenilamino, fenilmetil, feniletil, fenilkarbonil, feniltio, fenilsulfonil, fenilsulfinil ili stiril, pomenuta grupa moze da bude mono- ili polisupstituisana za fenil grupu sa halogenom, CF3, (C1-C4) alkil, (C1-C4) alkoksi, cijano, mono- ili di-(C1-C4)alkilamino, (C1-C4) alcilamino, karboksi, (C1-C4)alkoksikarbonil, aminokarbonil, mono- ili di-(C1-C4) alkilaminokarbonil, amino-(C1-C4) alkil, hidroksi (C1-C4) alkil ili halogeno (C1-C4) alkil. Pronalazak se takodje odnosi na postupak za njihovo dobijanje i na farmaceutski preparat koji ih sadrzi. Ova jedinjenja imaju neurotrofroticnu i neuroprotektorsku aktivnost.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9615335A FR2757160B1 (fr) | 1996-12-13 | 1996-12-13 | 1-phenylalkyl-1,2,3,6-tetrahydropyridines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU24399A true YU24399A (sh) | 2001-07-10 |
| RS49807B RS49807B (sr) | 2008-08-07 |
Family
ID=9498641
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US6034090A (sh) |
| EP (1) | EP0950048B1 (sh) |
| JP (1) | JP3881384B2 (sh) |
| KR (1) | KR100560358B1 (sh) |
| CN (1) | CN1129579C (sh) |
| AT (1) | ATE202561T1 (sh) |
| AU (1) | AU730143B2 (sh) |
| BR (1) | BR9713916A (sh) |
| CA (1) | CA2275353C (sh) |
| CY (1) | CY2274B1 (sh) |
| CZ (1) | CZ289789B6 (sh) |
| DE (1) | DE69705429T2 (sh) |
| DK (1) | DK0950048T3 (sh) |
| EE (1) | EE03763B1 (sh) |
| ES (1) | ES2160977T3 (sh) |
| FR (1) | FR2757160B1 (sh) |
| GR (1) | GR3036643T3 (sh) |
| HK (1) | HK1023997A1 (sh) |
| HU (1) | HU224347B1 (sh) |
| IL (1) | IL130003A (sh) |
| IS (1) | IS1969B (sh) |
| NO (1) | NO312720B1 (sh) |
| NZ (1) | NZ336033A (sh) |
| PL (1) | PL190789B1 (sh) |
| PT (1) | PT950048E (sh) |
| RS (1) | RS49807B (sh) |
| RU (1) | RU2189975C2 (sh) |
| SI (1) | SI0950048T1 (sh) |
| SK (1) | SK283331B6 (sh) |
| TR (1) | TR199901291T2 (sh) |
| UA (1) | UA52707C2 (sh) |
| WO (1) | WO1998025903A1 (sh) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2763847B1 (fr) * | 1997-05-28 | 2003-06-06 | Sanofi Sa | Utilisation de tetrahydropyridines 4-substituees pour fabriquer des medicaments agissant sur le tgf-beta-1 |
| UA81749C2 (uk) * | 2001-10-04 | 2008-02-11 | Х. Луннбек А/С | Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну |
| FR2832405B1 (fr) * | 2001-11-19 | 2004-12-10 | Sanofi Synthelabo | Tetrahydropyridyl-alkyl-heterocycles azotes, procede pour leur preparation et compositions pharmaceutiques les contenant |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1321701A (en) * | 1969-10-01 | 1973-06-27 | Continental Pharma | Amino-alcohols their salts and process for prepairing the same |
| IE34545B1 (en) * | 1969-10-01 | 1975-06-11 | Continental Pharma | Amino-alcohols,their salts and process for preparing the same |
| FR2650505B1 (fr) * | 1989-08-07 | 1994-06-03 | Midy Spa | Utilisation de trifluoromethylphenyltetrahydropyridines pour la preparation de medicaments destines a combattre les troubles de la motricite intestinale |
| FR2662355B1 (fr) * | 1990-05-22 | 1994-11-10 | Sanofi Sa | Utilisation de la 1-[2-(2-naphtyl)ethyl]-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine pour la preparation de medicaments destines au traitement de troubles cerebraux et neuronaux. |
| HU211019B (en) * | 1991-12-02 | 1995-09-28 | Richter Gedeon Vegyeszet | Process for producing new 1,2,3,6-tetrahydropyridine and piperidine derivatives substituted with n-(hydroxylalkyl) group and compositions comprising such compounds |
-
1996
- 1996-12-13 FR FR9615335A patent/FR2757160B1/fr not_active Expired - Fee Related
-
1997
- 1997-12-12 IL IL13000397A patent/IL130003A/en not_active IP Right Cessation
- 1997-12-12 BR BR9713916-5A patent/BR9713916A/pt not_active Application Discontinuation
- 1997-12-12 ES ES97951323T patent/ES2160977T3/es not_active Expired - Lifetime
- 1997-12-12 EP EP97951323A patent/EP0950048B1/fr not_active Expired - Lifetime
- 1997-12-12 NZ NZ336033A patent/NZ336033A/xx unknown
- 1997-12-12 SK SK786-99A patent/SK283331B6/sk unknown
- 1997-12-12 TR TR1999/01291T patent/TR199901291T2/xx unknown
- 1997-12-12 JP JP52632098A patent/JP3881384B2/ja not_active Expired - Fee Related
- 1997-12-12 UA UA99063286A patent/UA52707C2/uk unknown
- 1997-12-12 KR KR1019997005203A patent/KR100560358B1/ko not_active IP Right Cessation
- 1997-12-12 SI SI9730187T patent/SI0950048T1/xx unknown
- 1997-12-12 US US09/331,006 patent/US6034090A/en not_active Expired - Fee Related
- 1997-12-12 RU RU99115083/04A patent/RU2189975C2/ru not_active IP Right Cessation
- 1997-12-12 CZ CZ19992113A patent/CZ289789B6/cs not_active IP Right Cessation
- 1997-12-12 AU AU54893/98A patent/AU730143B2/en not_active Ceased
- 1997-12-12 CN CN97180581A patent/CN1129579C/zh not_active Expired - Fee Related
- 1997-12-12 DK DK97951323T patent/DK0950048T3/da active
- 1997-12-12 PL PL334071A patent/PL190789B1/pl unknown
- 1997-12-12 AT AT97951323T patent/ATE202561T1/de not_active IP Right Cessation
- 1997-12-12 PT PT97951323T patent/PT950048E/pt unknown
- 1997-12-12 CA CA002275353A patent/CA2275353C/en not_active Expired - Fee Related
- 1997-12-12 EE EEP199900237A patent/EE03763B1/xx not_active IP Right Cessation
- 1997-12-12 HU HU0001185A patent/HU224347B1/hu not_active IP Right Cessation
- 1997-12-12 DE DE69705429T patent/DE69705429T2/de not_active Expired - Fee Related
- 1997-12-12 RS YUP-243/99A patent/RS49807B/sr unknown
- 1997-12-12 WO PCT/FR1997/002286 patent/WO1998025903A1/fr not_active Application Discontinuation
-
1999
- 1999-06-10 IS IS5075A patent/IS1969B/is unknown
- 1999-06-11 NO NO19992869A patent/NO312720B1/no unknown
-
2000
- 2000-05-30 HK HK00103181A patent/HK1023997A1/xx not_active IP Right Cessation
-
2001
- 2001-09-18 GR GR20010401501T patent/GR3036643T3/el not_active IP Right Cessation
-
2002
- 2002-05-15 CY CY0200027A patent/CY2274B1/xx unknown
Also Published As
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