MY106879A - C-linked pyrazole derivatives - Google Patents

Abstract

THE INVENTION PROVIDES COMPOUNDS OF THE GENERAL FORMULA (1):(FORMULA 1)OR A PHYSIOLOGICALLY ACCEPTABLE SALT, SOLVATE (E.G.HYDRATE) OR A METABOLICALLY LABILE ESTER THEREOF IN WHICH R1 REPRESENTS A HYDROGEN ATOM OR A GROUP SELECTED FROM C1-6ALKYL OR C2-6 ALKENYL;R2 REPRESENTS A HYDROGEN ATOM OR A GROUP SELECTED FROM C1-6 ALKYL, C3-7 CYCLOALKYL, C3-7CYCLOAKYLC1-ALKYL, C3-6ALKENYL, FLUOROC1-6 ALKYL, FLUOROC3-6ALKENYL, PHENYL, - (CH2)KCOR5 OR -(CH2) KSO2R5;R3 REPRESENTS A HYDROGEN ATOM OR A GROUP SELECTED FROM C1-6ALKYL OPTIONALLY SUBSTITUTED BY A HYDROXY OR C1-6ALKOXY GROUP,C2-6ALKENYL,FLUOROC1-6ALKYL,-(CH2)MR6,-(CH2)NCOR7 OR -(CH2)PNR8COR9;R4 REPRESENTS A GROUP SELECTED FROM -CO2H,-NHSO2CF3 OR A C-LINKED TETRAZOLYL GROUP;R5 REPRESENTS A GROUP SELECTED FROM C1-6ALKYL, C2-6ALKENYL,C1-6ALKOXY OR THE GROUP -NR 10R11;R6 REPRESENTS A PHENOXY OR BENZYLOXY GROUP;R7 REPRESENTS A HYDROGEN ATOM OR A GROUP SELECTED FROM HYDROXY, C1-6ALKYL, C1-6 ALKOXY, PHENYL,PHENOXY OR THE GROUP -NR10R11;R8 REPRESENTS A HYDROGEN ATOM OR A C1-6ALKYL GROUP;R9 REPRESENTS A HYDROGEN ATOM OR A GROUP SELECTED FROM C1-6ALKYL, C1-6ALKOXY, PHENYL, BENZYL, PHENOXY OR THE GROUP -NR10R11;R10 AND R11 WHICH MAYBE THE SAME OR DIFFERENT EACH INDEPENDENTLY REPRESENTS A HYDROGEN ATOM OR A C1-4ALKYL GROUP OR -NR10R11 FORMS A SATURATED HETEROCYCLIC RING WHICH HAS 5 OR 6 RING MEMBERS AND MAY OPTIONALLY CONTAIN INTHE RING ONE OXYGEN ATOM;