ES2152747T3 - Un procedimiento para preparar 5-(acetil(2,3-dihidroxipropil)amino)-n,n'-bis(2,3-dihidroxipropil)-2,4,6-triyodo-1,3-bencenodicarboxamida. - Google Patents
Un procedimiento para preparar 5-(acetil(2,3-dihidroxipropil)amino)-n,n'-bis(2,3-dihidroxipropil)-2,4,6-triyodo-1,3-bencenodicarboxamida.Info
- Publication number
- ES2152747T3 ES2152747T3 ES98928291T ES98928291T ES2152747T3 ES 2152747 T3 ES2152747 T3 ES 2152747T3 ES 98928291 T ES98928291 T ES 98928291T ES 98928291 T ES98928291 T ES 98928291T ES 2152747 T3 ES2152747 T3 ES 2152747T3
- Authority
- ES
- Spain
- Prior art keywords
- formula
- dihydroxipropil
- amino
- reaction
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 3
- -1 AMINO Chemical class 0.000 title 1
- 125000002777 acetyl group Chemical class [H]C([H])([H])C(*)=O 0.000 title 1
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- 239000002904 solvent Substances 0.000 abstract 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 239000002131 composite material Substances 0.000 abstract 2
- 150000002430 hydrocarbons Chemical class 0.000 abstract 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 abstract 1
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
- 229960000583 acetic acid Drugs 0.000 abstract 1
- 150000004945 aromatic hydrocarbons Chemical class 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 abstract 1
- 239000000920 calcium hydroxide Substances 0.000 abstract 1
- 229910001861 calcium hydroxide Inorganic materials 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000012362 glacial acetic acid Substances 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/08—Preparation of carboxylic acid amides from amides by reaction at nitrogen atoms of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/52—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the nitrogen atom of at least one of the carboxamide groups further acylated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Abstract
LA PRESENTE INVENCION SE REFIERE A UN PROCESO PARA LA PREPARACION DE 5 [ACETIL(2,3 -DIHIDROXIPROPIL)AMINO] -N, N'' -BIS(2, 3-DIHIDROXIPROPIL) 2,4,6-TRIIODO-1,3-BENCENODICARBOXAMIDA REPRESENTADO POR LA FORMULA (I) A PARTIR DEL ACIDO 5-AMINO-1,3-BENCENODICARBOXILICO DE FORMULA (II). DICHO PROCESO COMPRENDE LAS SIGUIENTES ETAPAS: (A) REACCION EN FASE HETEROGENEA ENTRE EL ACIDO 5-AMINO-2,4,6 -TRIIODO-1,3-BENCENODICARBOXILICO Y EL CLORURO DE TIONILO EN UN DISOLVENTE SELECCIONADO A PARTIR DEL GRUPO FORMADO POR: HIDROCARBUROS (C7-16) DE CADENA RAMIFICADA O LINEAL, HIDROCARBUROS AROMATICOS (C7-8), 1,1,1 TRICLOROETANO, ACETATO DE N -BUTILO, DIGLIME (DIETILENGLICOL DIMETIL ETER), EN PRESENCIA DE CANTIDADES CATALITICAS DE UNA AMINA TERCIARIA, PARA OBTENER UN COMPUESTO DE FORMULA (III); (B) REACCION DE ACETILACION DE DICHO COMPUESTO DE FORMULA (III) CON ACIDO ACETICO GLACIAL, QUE ACTUA A LA VEZ COMO DISOLVENTE Y COMO REACTIVO, Y CON CLORURO DE TIONILO; (C) LA FORMACION DE UN COMPUESTO DE FORMULA (V) MEDIANTE LA REACCION DEL COMPUESTO DE FORMULA (IV) CON 1 -AMINO -2,3 PROPANODIOL, MEDIANTE REACCION DEL COMPUESTO (IV) EN UN DISOLVENTE APROTICO DIPOLAR SELECCIONADO A PARTIR DEL GRUPO DE DIMETILFORMAMIDA (DMF), DIMETILACETAMIDA (DMA), DIMETILSULFOXIDO (DMSO) O N -METIL -PIRROLIDINA; (D) LA ALQUILACION DE DICHO COMPUESTO (V), EN SOLUCION ACUOSA A UN PH BASICO MEDIANTE LA ADICION DE UNA MEZCLA DE HIDROXIDO DE CALCIO E HIDROXIDO DE SODIO, CON EL 3 CLORO -1,2 -PROPANODIOL O EPICLORHIDRINA, Y A UNA TEMPERATURA ENTRE 40 Y 90º C.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT97MI001268A IT1292037B1 (it) | 1997-05-30 | 1997-05-30 | Processo per la preparazione di 5-(acetil 62,3-diidrossipropil)- ammino)-n,n'-bis(2,3-diidrossipropil)-2,4,6-triiodo-1,3-benzen- |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2152747T3 true ES2152747T3 (es) | 2001-02-01 |
Family
ID=11377250
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES98928291T Expired - Lifetime ES2152747T3 (es) | 1997-05-30 | 1998-05-19 | Un procedimiento para preparar 5-(acetil(2,3-dihidroxipropil)amino)-n,n'-bis(2,3-dihidroxipropil)-2,4,6-triyodo-1,3-bencenodicarboxamida. |
Country Status (18)
Country | Link |
---|---|
US (1) | US5965772A (es) |
EP (1) | EP0915835B1 (es) |
JP (1) | JP3437584B2 (es) |
KR (1) | KR20000029649A (es) |
CN (1) | CN1228079A (es) |
AT (1) | ATE198191T1 (es) |
AU (1) | AU729759B2 (es) |
CA (1) | CA2261656A1 (es) |
CZ (1) | CZ25399A3 (es) |
DE (1) | DE69800434T2 (es) |
DK (1) | DK0915835T3 (es) |
ES (1) | ES2152747T3 (es) |
GR (1) | GR3035123T3 (es) |
IT (1) | IT1292037B1 (es) |
NO (1) | NO323475B1 (es) |
PL (1) | PL331208A1 (es) |
PT (1) | PT915835E (es) |
WO (1) | WO1998054124A1 (es) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE520688C2 (sv) * | 2000-04-11 | 2003-08-12 | Bone Support Ab | Ett injicerbart ersättningsmaterial för benmineral |
SE517168C2 (sv) * | 2000-07-17 | 2002-04-23 | Bone Support Ab | En komposition för ett injicerbart ersättningsmaterial för benmineral |
SE522098C2 (sv) | 2001-12-20 | 2004-01-13 | Bone Support Ab | Ett nytt benmineralsubstitut |
SE0300620D0 (sv) | 2003-03-05 | 2003-03-05 | Bone Support Ab | A new bone substitute composition |
WO2004087637A1 (en) * | 2003-03-31 | 2004-10-14 | Takasago International Corporation | Production of n-alkylamide compounds |
SE0302983D0 (sv) * | 2003-11-11 | 2003-11-11 | Bone Support Ab | Anordning för att förse spongiöst ben med benersättnings- och/eller benförstärkningsmaterial och förfarande i samband därmed |
SE527528C2 (sv) * | 2004-06-22 | 2006-04-04 | Bone Support Ab | Anordning för framställning av härdbar massa samt användning av anordningen |
PT103391B (pt) * | 2005-11-24 | 2008-10-30 | Hovione Farmaciencia S A | Processo para fabrico de lohexol |
CN100344606C (zh) * | 2005-12-28 | 2007-10-24 | 江苏省原子医学研究所 | 一种碘昔兰的制备方法 |
CA2684067A1 (en) * | 2007-04-25 | 2008-11-06 | F. Hoffmann-La Roche Ag | Novel process for the preparation of acid chlorides |
BRPI0911170B1 (pt) | 2008-04-04 | 2018-05-29 | F. Hoffmann-La Roche Ag | Processo para a preparação de derivados do ácido ciclo-hexanocarboxílico via o correpondente derivado de ciclo-hexanocarboxamida |
CN101981001B (zh) | 2008-04-04 | 2016-06-08 | 弗·哈夫曼-拉罗切有限公司 | 制备环己烷甲酸衍生物的新方法 |
KR101098553B1 (ko) * | 2008-04-30 | 2011-12-26 | 주식회사 엘지생명과학 | 이오프로마이드의 신규한 제조방법 |
EP2297081B1 (en) | 2008-06-17 | 2017-03-08 | F. Hoffmann-La Roche AG | 1-(2-ethyl-butyl)-cyclohexanecarboxylic acid ester as an intermediate in the preparation of pharmaceutically active amides |
MX2011005236A (es) | 2008-11-18 | 2011-06-16 | Bracco Imaging Spa | Proceso para la preparacion de agente de contraste yodado. |
AU2009355814B2 (en) | 2009-11-26 | 2016-06-30 | Imax Diagnostic Imaging Holding Ltd | Preparation and purification of iodixanol |
US9180137B2 (en) | 2010-02-09 | 2015-11-10 | Bone Support Ab | Preparation of bone cement compositions |
IT1403988B1 (it) * | 2010-07-15 | 2013-11-08 | Bracco Imaging Spa | Processo per la preparazione di agenti di contrasto. |
TR201807495T4 (tr) | 2013-02-20 | 2018-06-21 | Bone Support Ab | Sertleştirilebilir kemik ikamesine yönelik geliştirilmiş katılaştırma. |
KR101520187B1 (ko) * | 2013-10-25 | 2015-05-13 | 주식회사 대웅제약 | 이오프로마이드의 중간체의 제조방법 |
CN106316878B (zh) * | 2015-06-15 | 2018-01-19 | 重庆常捷医药有限公司 | 一种碘美普尔杂质的制备方法 |
CN110023279B (zh) * | 2016-12-05 | 2022-03-11 | 伯拉考成像股份公司 | 放射照相剂中间体的机械化学合成 |
KR102128423B1 (ko) * | 2018-09-17 | 2020-07-01 | (주)유케이케미팜 | 조영제 이오메프롤의 제조방법 |
CN114478298B (zh) * | 2020-11-12 | 2024-09-27 | 成都西岭源药业有限公司 | 一种造影剂碘佛醇的纯化方法 |
CN113387833A (zh) * | 2021-05-25 | 2021-09-14 | 成都丽璟科技有限公司 | 一种低渗透性泛影酸衍生物造影剂及其制备方法 |
CN115872894A (zh) * | 2022-11-15 | 2023-03-31 | 上海慧聚药业有限公司 | 非离子型造影剂的合成 |
CN116332787B (zh) * | 2023-03-03 | 2023-10-27 | 安庆朗坤药业有限公司 | 一种造影剂中间体乙酰碘化物的制备方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH608189A5 (es) * | 1974-12-13 | 1978-12-29 | Savac Ag | |
GB1548594A (en) * | 1976-06-11 | 1979-07-18 | Nyegaard & Co As | Triiodoisophthalic acid amides |
JP4012566B2 (ja) * | 1995-05-23 | 2007-11-21 | ブラッコ イメージング エッセ ピ ア | ジカルボン酸二塩化物の製造方法 |
-
1997
- 1997-05-30 IT IT97MI001268A patent/IT1292037B1/it active IP Right Grant
-
1998
- 1998-05-19 KR KR1019997000722A patent/KR20000029649A/ko not_active Application Discontinuation
- 1998-05-19 AT AT98928291T patent/ATE198191T1/de not_active IP Right Cessation
- 1998-05-19 ES ES98928291T patent/ES2152747T3/es not_active Expired - Lifetime
- 1998-05-19 JP JP50018399A patent/JP3437584B2/ja not_active Expired - Lifetime
- 1998-05-19 PT PT98928291T patent/PT915835E/pt unknown
- 1998-05-19 PL PL98331208A patent/PL331208A1/xx unknown
- 1998-05-19 DK DK98928291T patent/DK0915835T3/da active
- 1998-05-19 EP EP98928291A patent/EP0915835B1/en not_active Expired - Lifetime
- 1998-05-19 AU AU80185/98A patent/AU729759B2/en not_active Ceased
- 1998-05-19 WO PCT/EP1998/002927 patent/WO1998054124A1/en not_active Application Discontinuation
- 1998-05-19 CN CN98800714A patent/CN1228079A/zh active Pending
- 1998-05-19 CA CA002261656A patent/CA2261656A1/en not_active Abandoned
- 1998-05-19 DE DE69800434T patent/DE69800434T2/de not_active Expired - Lifetime
- 1998-05-19 CZ CZ99253A patent/CZ25399A3/cs unknown
- 1998-05-28 US US09/084,922 patent/US5965772A/en not_active Expired - Lifetime
-
1999
- 1999-01-25 NO NO19990334A patent/NO323475B1/no not_active IP Right Cessation
-
2000
- 2000-12-21 GR GR20000402639T patent/GR3035123T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
US5965772A (en) | 1999-10-12 |
ITMI971268A1 (it) | 1998-11-30 |
PL331208A1 (en) | 1999-07-05 |
PT915835E (pt) | 2001-03-30 |
NO323475B1 (no) | 2007-05-21 |
ATE198191T1 (de) | 2001-01-15 |
JP3437584B2 (ja) | 2003-08-18 |
DE69800434D1 (de) | 2001-01-25 |
IT1292037B1 (it) | 1999-01-25 |
NO990334L (no) | 1999-03-26 |
CA2261656A1 (en) | 1998-12-03 |
CZ25399A3 (cs) | 1999-07-14 |
CN1228079A (zh) | 1999-09-08 |
JP2000505820A (ja) | 2000-05-16 |
KR20000029649A (ko) | 2000-05-25 |
AU729759B2 (en) | 2001-02-08 |
EP0915835A1 (en) | 1999-05-19 |
NO990334D0 (no) | 1999-01-25 |
GR3035123T3 (en) | 2001-03-30 |
DK0915835T3 (da) | 2001-02-05 |
AU8018598A (en) | 1998-12-30 |
WO1998054124A1 (en) | 1998-12-03 |
ITMI971268A0 (es) | 1997-05-30 |
DE69800434T2 (de) | 2001-04-19 |
EP0915835B1 (en) | 2000-12-20 |
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