ES2113639T3 - Nuevos agentes antiparasitarios relacionados con las milbemicinas y las avermectinas. - Google Patents
Nuevos agentes antiparasitarios relacionados con las milbemicinas y las avermectinas.Info
- Publication number
- ES2113639T3 ES2113639T3 ES94905061T ES94905061T ES2113639T3 ES 2113639 T3 ES2113639 T3 ES 2113639T3 ES 94905061 T ES94905061 T ES 94905061T ES 94905061 T ES94905061 T ES 94905061T ES 2113639 T3 ES2113639 T3 ES 2113639T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- group
- link
- milbemicins
- avermectines
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Agronomy & Crop Science (AREA)
- Dentistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
COMPUESTOS ANTIPARASITARIOS DE FORMULA (I) EN DONDE LA LINEA INTERMITENTE EN LA POSICION 22-23 REPRESENTA UN ENLACE OPCIONAL, O BIEN ESTE ENLACE ESTA PRESENTE Y R1 ESTA AUSENTE O ESTE ENLACE ESTA AUSENTE Y R1 ES H, OH, OXO U OXIMINO OPCIONALMENTE SUSTITUIDOS POR UN GRUPO ALQUILO C1-C8, R2 ES ALQUILO C1 C8, ALQUENILO C2-C8 O UN GRUPO CICLOALQUILO C3-C8, O UN ANILLO DE 3-6 COMPONENTES HETEROCICLICOS QUE CONTENGAN UN ATOMO DE SULFURO U OXIGENO, DICHO ANILLO ESTARA SATURADO O TOTAL O PARCIALMENTE INSATURADO Y OPCIONALMENTE SUSTITUIDO POR UNO O MAS GRUPOS ALQUILO C1-C4 O ATOMOS HALOGENOS, R3 ES H O OH, Y R4 ES H O UN GRUPO CAPAZ DE SER HIDROLIZADO IN VIVO PARA PRODUCIR UN COMPUESTO EN EL QUE R4 ES H, R5 ES OH, OPCIONALMENTE SUSTITUIDO POR UN GRUPO CAPAZ DE SER HIDROLIZADO IN VIVO PARA PRODUCIR UN COMPUESTO EN EL QUE R5 ES OH, Y R6 ES H O ALQUILO C1-C4 O R6 ES H Y R5 ES AMINO, OPCIONALMENTE SUSTITUIDO POR AL MENOS UN GRUPO SELECCIONADO DE ALQUILO C1-C8 Y GRUPOS DE ACILO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB939300883A GB9300883D0 (en) | 1993-01-18 | 1993-01-18 | Antiparasitic agents |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2113639T3 true ES2113639T3 (es) | 1998-05-01 |
Family
ID=10728869
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94905061T Expired - Lifetime ES2113639T3 (es) | 1993-01-18 | 1994-01-12 | Nuevos agentes antiparasitarios relacionados con las milbemicinas y las avermectinas. |
Country Status (35)
Country | Link |
---|---|
EP (1) | EP0677054B1 (es) |
JP (1) | JP2732548B2 (es) |
KR (1) | KR0185480B1 (es) |
CN (1) | CN1043768C (es) |
AP (1) | AP522A (es) |
AT (1) | ATE164586T1 (es) |
AU (1) | AU679033B2 (es) |
BR (2) | BR9405811A (es) |
CA (1) | CA2152819C (es) |
CZ (1) | CZ284849B6 (es) |
DE (2) | DE10075003I1 (es) |
DK (1) | DK0677054T3 (es) |
EG (1) | EG20582A (es) |
ES (1) | ES2113639T3 (es) |
FI (1) | FI111727B (es) |
GB (1) | GB9300883D0 (es) |
GR (1) | GR3026710T3 (es) |
HR (1) | HRP940110B1 (es) |
HU (1) | HU221505B (es) |
IL (1) | IL108306A (es) |
LU (1) | LU90518I2 (es) |
MA (1) | MA23091A1 (es) |
MY (1) | MY141106A (es) |
NL (1) | NL300003I2 (es) |
NO (2) | NO304835B1 (es) |
NZ (1) | NZ259868A (es) |
OA (1) | OA10223A (es) |
PL (1) | PL176733B1 (es) |
RU (1) | RU2125059C1 (es) |
SG (1) | SG45131A1 (es) |
SK (1) | SK282031B6 (es) |
UA (1) | UA42707C2 (es) |
WO (1) | WO1994015944A1 (es) |
YU (1) | YU49169B (es) |
ZA (1) | ZA94310B (es) |
Families Citing this family (234)
Publication number | Priority date | Publication date | Assignee | Title |
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US6221894B1 (en) | 1995-03-20 | 2001-04-24 | Merck & Co., Inc. | Nodulisporic acid derivatives |
GB9716567D0 (en) * | 1997-08-05 | 1997-10-08 | Pfizer | Process |
US6136838A (en) * | 1998-03-19 | 2000-10-24 | Merck & Co., Inc. | Sulfurpentafluorophenylpyrazoles for controlling ectoparasitic infestations |
GB9825402D0 (en) * | 1998-11-19 | 1999-01-13 | Pfizer Ltd | Antiparasitic formulations |
GB9916052D0 (en) * | 1999-07-08 | 1999-09-08 | Pfizer Ltd | Anthelmintic compositions |
US6787342B2 (en) | 2000-02-16 | 2004-09-07 | Merial Limited | Paste formulations |
GB0008353D0 (en) * | 2000-04-03 | 2000-05-24 | Pfizer Ltd | Method of treating a parasitic infection |
GB0108485D0 (en) * | 2001-04-04 | 2001-05-23 | Pfizer Ltd | Combination therapy |
US20040077703A1 (en) | 2002-10-02 | 2004-04-22 | Soll Mark D. | Nodulisporic acid derivative spot-on formulations for combating parasites |
US7195751B2 (en) | 2003-01-30 | 2007-03-27 | Applera Corporation | Compositions and kits pertaining to analyte determination |
US7355045B2 (en) | 2004-01-05 | 2008-04-08 | Applera Corporation | Isotopically enriched N-substituted piperazine acetic acids and methods for the preparation thereof |
US20050148771A1 (en) | 2004-01-05 | 2005-07-07 | Applera Corporation. | Active esters of N-substituted piperazine acetic acids, including isotopically enriched versions thereof |
AU2005223483B2 (en) | 2004-03-18 | 2009-04-23 | Zoetis Llc | N-(1-arylpyrazol-4l)sulfonamides and their use as parasiticides |
PL2035390T3 (pl) | 2006-07-05 | 2016-06-30 | Merial Inc | Związki będące pochodnymi 1-arylo-5-alkilopirazolu, sposoby ich wytwarzania i zastosowania |
DE102007007750A1 (de) | 2006-08-17 | 2008-02-21 | Bayer Cropscience Ag | Avermectinderivate |
SI3428148T1 (sl) | 2007-05-15 | 2021-04-30 | Boehringer Ingelheim Animal Health USA Inc. | Ariloazol-2-il cianoetilamino spojine, postopek njihove izdelave in postopek njihove uporabe |
EA019606B1 (ru) | 2008-11-14 | 2014-04-30 | Мериал Лимитед | Арилоазол-2-илцианоэтиламино соединения противопаразитарного действия, обогащенные одним из энантиомеров |
CN102271672B (zh) | 2008-11-19 | 2015-02-04 | 梅里亚有限公司 | 用于治疗寄生物感染的包含单独的或与甲脒组合的1-芳基吡唑的组合物 |
US8426460B2 (en) | 2008-12-04 | 2013-04-23 | Merial Limited | Dimeric avermectin and milbemycin derivatives |
TWI487486B (zh) | 2009-12-01 | 2015-06-11 | Syngenta Participations Ag | 以異唑啉衍生物為主之殺蟲化合物 |
BR112012013482B1 (pt) | 2009-12-04 | 2018-11-06 | Basf Se | compostos de bis-organossulfurados pesticidas |
SG181679A1 (en) | 2009-12-17 | 2012-07-30 | Merial Ltd | Anti parasitic dihydroazole compounds and compositions comprising same |
US8980896B2 (en) | 2009-12-17 | 2015-03-17 | Merial, Inc. | Compositions comprising macrocyclic lactone compounds and spirodioxepinoindoles |
US8754053B2 (en) | 2010-02-17 | 2014-06-17 | Syngenta Crop Protection Llc | Isoxazoline derivatives as insecticides |
EP2539330B1 (en) | 2010-02-22 | 2016-11-09 | Syngenta Participations AG | Dihydrofuran derivatives as insecticidal compounds |
EA201201179A1 (ru) | 2010-02-25 | 2013-04-30 | Зингента Партисипейшнс Аг | Способ получения изоксазолиновых производных |
UA108641C2 (uk) | 2010-04-02 | 2015-05-25 | Паразитицидна композиція, яка містить чотири активних агенти, та спосіб її застосування | |
CN103153949A (zh) | 2010-10-05 | 2013-06-12 | 先正达参股股份有限公司 | 杀虫的吡咯烷-基-芳基-甲酰胺 |
WO2012049327A2 (en) | 2010-10-15 | 2012-04-19 | Syngenta Participations Ag | Pesticidal mixtures |
CA2811926A1 (en) | 2010-10-20 | 2012-04-26 | Galderma S.A. | Method of treating otitis externa using macrocyclic lactone compound |
WO2012054328A1 (en) | 2010-10-20 | 2012-04-26 | Galderma S.A. | Method of treating hemorrhoids using macrocyclic lactone compound |
WO2012068202A1 (en) | 2010-11-16 | 2012-05-24 | Merial Limited | Novel monensin derivatives for the treatment and prevention of protozoal infections |
EP2643302A1 (en) | 2010-11-23 | 2013-10-02 | Syngenta Participations AG | Insecticidal compounds |
WO2012080376A1 (en) | 2010-12-17 | 2012-06-21 | Syngenta Participations Ag | Insecticidal compounds |
BR112013020213A2 (pt) | 2011-02-09 | 2016-08-02 | Syngenta Participations Ag | compostos inseticidas |
EP2688864A1 (en) | 2011-03-22 | 2014-01-29 | Syngenta Participations AG | Insecticidal compounds |
US8895587B2 (en) | 2011-05-18 | 2014-11-25 | Syngenta Participations Ag | Insecticidal compounds based on arylthioacetamide derivatives |
US9339505B2 (en) | 2011-05-31 | 2016-05-17 | Syngenta Participations Ag | Pesticidal mixtures including isoxazoline derivatives |
AR086587A1 (es) | 2011-05-31 | 2014-01-08 | Syngenta Participations Ag | Compuestos insecticidas |
WO2012175474A1 (en) | 2011-06-20 | 2012-12-27 | Syngenta Participations Ag | 1,2,3 triazole pesticides |
US20120329832A1 (en) | 2011-06-27 | 2012-12-27 | Jean Delaveau | Novel Insect-Repellent Coumarin Derivatives, Syntheses, and Methods of Use |
AU2012275435B2 (en) | 2011-06-27 | 2016-07-21 | Boehringer Ingelheim Animal Health USA Inc. | Amido-pyridyl ether compounds and compositions and their use against parasites |
WO2013026726A1 (en) | 2011-08-22 | 2013-02-28 | Syngenta Participations Ag | Dihydrofuran derivatives as insecticidal compounds |
US20140343049A1 (en) | 2011-08-22 | 2014-11-20 | Syngenta Participations Ag | Dihydrofuran derivatives as insecticidal compounds |
WO2013026695A1 (en) | 2011-08-25 | 2013-02-28 | Syngenta Participations Ag | Isoxazoline derivatives as insecticidal compounds |
EP2748154B1 (en) | 2011-08-25 | 2018-07-04 | Syngenta Participations AG | Process for the preparation of thietane derivatives |
WO2013026929A1 (en) | 2011-08-25 | 2013-02-28 | Syngenta Participations Ag | Dihydropyrrole derivatives as insecticidal compounds |
CN106045962A (zh) | 2011-08-25 | 2016-10-26 | 先正达参股股份有限公司 | 作为杀虫化合物的异噁唑啉衍生物 |
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WO2013044118A2 (en) | 2011-09-23 | 2013-03-28 | Merial Limited | Indirect modeling of new repellent molecules active against insects, acarids, and other arthropods |
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JP2014534182A (ja) | 2011-10-03 | 2014-12-18 | シンジェンタ パーティシペーションズ アクチェンゲゼルシャフト | 殺虫化合物としてのイソオキサゾリン誘導体 |
JP6249568B2 (ja) | 2011-11-17 | 2017-12-20 | メリアル インコーポレイテッド | アリールピラゾールと置換イミダゾールを含む組成物、その使用方法 |
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CN103360444B (zh) * | 2012-04-03 | 2016-05-11 | 浙江海正药业股份有限公司 | 抗寄生虫药赛拉菌素的合成新工艺 |
KR102160836B1 (ko) | 2012-04-20 | 2020-09-28 | 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 | 벤즈이미다졸 유도체를 포함하는 구충 조성물, 방법 및 그의 용도 |
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BR112015009475A2 (pt) | 2012-10-31 | 2017-07-04 | Syngenta Participations Ag | compostos inseticidas |
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UY36570A (es) | 2015-02-26 | 2016-10-31 | Merial Inc | Formulaciones inyectables de acción prolongada que comprenden un agente activo isoxazolina, métodos y usos de las mismas |
MA40816A1 (fr) | 2015-03-27 | 2017-10-31 | Syngenta Participations Ag | Dérivés hétérobicycliques microbiocides |
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CN108347936B (zh) | 2015-10-28 | 2021-04-20 | 先正达参股股份有限公司 | 杀微生物的噁二唑衍生物 |
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2001
- 2001-06-11 NO NO2001010C patent/NO2001010I1/no unknown
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