DK0646578T3 - Phenylcarboxamidisoxazoler og deres salte, fremgangsmåde til deres fremstilling, deres anvendelse som lægemidler og farmace - Google Patents

Phenylcarboxamidisoxazoler og deres salte, fremgangsmåde til deres fremstilling, deres anvendelse som lægemidler og farmace

Info

Publication number
DK0646578T3
DK0646578T3 DK94402183T DK94402183T DK0646578T3 DK 0646578 T3 DK0646578 T3 DK 0646578T3 DK 94402183 T DK94402183 T DK 94402183T DK 94402183 T DK94402183 T DK 94402183T DK 0646578 T3 DK0646578 T3 DK 0646578T3
Authority
DK
Denmark
Prior art keywords
group
carbon atoms
salts
preparation
ncx3
Prior art date
Application number
DK94402183T
Other languages
English (en)
Inventor
Elizabeth Anne Kuo
Robert Westwood
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Application granted granted Critical
Publication of DK0646578T3 publication Critical patent/DK0646578T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
DK94402183T 1993-10-01 1994-09-29 Phenylcarboxamidisoxazoler og deres salte, fremgangsmåde til deres fremstilling, deres anvendelse som lægemidler og farmace DK0646578T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939320299A GB9320299D0 (en) 1993-10-01 1993-10-01 Isoxazole derivatives

Publications (1)

Publication Number Publication Date
DK0646578T3 true DK0646578T3 (da) 2000-10-30

Family

ID=10742865

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94402183T DK0646578T3 (da) 1993-10-01 1994-09-29 Phenylcarboxamidisoxazoler og deres salte, fremgangsmåde til deres fremstilling, deres anvendelse som lægemidler og farmace

Country Status (11)

Country Link
US (2) US5476866A (da)
EP (1) EP0646578B1 (da)
JP (1) JP3723589B2 (da)
AT (1) ATE193531T1 (da)
CA (1) CA2133140C (da)
DE (1) DE69424734T2 (da)
DK (1) DK0646578T3 (da)
ES (1) ES2146643T3 (da)
GB (1) GB9320299D0 (da)
GR (1) GR3034023T3 (da)
PT (1) PT646578E (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5721277A (en) * 1995-04-21 1998-02-24 Sugen, Inc. Compounds and methods for inhibiting hyper-proliferative cell growth
DE19539638A1 (de) * 1995-10-25 1997-04-30 Hoechst Ag Die Verwendung von Isoxazol- und Crotonsäureamidderivaten zur Behandlung von Krebserkrankungen
US6316479B1 (en) 1997-05-19 2001-11-13 Sugen, Inc. Isoxazole-4-carboxamide compounds active against protein tryosine kinase related disorders
EP1012150A4 (en) * 1997-05-19 2002-05-29 Sugen Inc HETEROARYLCARBOXAMIDE COMPOUNDS THAT ARE EFFECTIVE OF DISEASES CAUSED BY PROTEIN-TYROSIN-KINASE
DE59801792D1 (de) * 1997-08-08 2001-11-22 Aventis Pharma Gmbh Kristallform von N-(4-Trifluormethylphenyl)-5-methylisoxazol-4-carbonsäureamid
US6579880B2 (en) 2000-06-06 2003-06-17 Ortho-Mcneil Pharmaceutical, Inc. Isoxazoles and oxadiazoles as anti-inflammatory inhibitors of IL-8
WO2002007783A2 (en) * 2000-07-20 2002-01-31 Regents Of The University Of Minnesota Radiolabeled immunotoxins
WO2003006424A1 (en) 2001-07-10 2003-01-23 4Sc Ag Novel compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents
KR20030063046A (ko) * 2002-01-22 2003-07-28 주식회사 엘지생명과학 엘비84068을 함유하는 염증으로 인한 질환의 예방 및치료용 조성물 및 이를 포함하는 제제
EP1581477B1 (en) 2002-12-23 2009-12-02 4Sc Ag Cycloalkene dicarboxylic acid compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents
UA108760C2 (uk) 2010-07-01 2015-06-10 Кальцієві солі сполуки як протизапальні, імуномодулюючі та антипроліферативні засоби
AU2014352920A1 (en) 2013-11-22 2016-06-23 Genzyme Corporation Novel methods for treating neurodegenerative diseases
CA3093984A1 (en) 2018-03-16 2019-09-19 Immunic Ag Calcium salt polymorphs as anti-inflammatory, immunomodulatory and anti-proliferatory agents

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES448386A1 (es) * 1975-06-05 1978-04-16 Hoechst Ag Procedimiento para la preparacion de anilidas de acido 5-me-til-isoxazol-4-carboxilico.
GB8619432D0 (en) * 1986-08-08 1986-09-17 Lilly Industries Ltd Pharmaceutical compounds
US4935434A (en) * 1988-01-26 1990-06-19 Bristol-Myers Company Antiarthritic isoxazole-4-carboxamides
GB9209330D0 (en) * 1992-04-30 1992-06-17 Roussel Lab Ltd Chemical compounds

Also Published As

Publication number Publication date
JPH07149743A (ja) 1995-06-13
DE69424734T2 (de) 2000-11-16
PT646578E (pt) 2000-09-29
EP0646578A1 (fr) 1995-04-05
DE69424734D1 (de) 2000-07-06
GR3034023T3 (en) 2000-11-30
US5506249A (en) 1996-04-09
ES2146643T3 (es) 2000-08-16
EP0646578B1 (fr) 2000-05-31
US5476866A (en) 1995-12-19
CA2133140A1 (en) 1995-04-02
CA2133140C (en) 2006-07-25
GB9320299D0 (en) 1993-11-17
JP3723589B2 (ja) 2005-12-07
ATE193531T1 (de) 2000-06-15

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