ES448386A1 - Procedimiento para la preparacion de anilidas de acido 5-me-til-isoxazol-4-carboxilico. - Google Patents

Procedimiento para la preparacion de anilidas de acido 5-me-til-isoxazol-4-carboxilico.

Info

Publication number
ES448386A1
ES448386A1 ES448386A ES448386A ES448386A1 ES 448386 A1 ES448386 A1 ES 448386A1 ES 448386 A ES448386 A ES 448386A ES 448386 A ES448386 A ES 448386A ES 448386 A1 ES448386 A1 ES 448386A1
Authority
ES
Spain
Prior art keywords
carboxylic acid
isoxazole
methyl
acid anilides
acid anilide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES448386A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2524959A external-priority patent/DE2524959C2/de
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES448386A1 publication Critical patent/ES448386A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/66—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen

Abstract

Procedimiento para la preparación de anilidas de ácido 5-metil-isoxazol-4-carboxílico de la fórmula I: **(Fórmula)** en donde R1, R2 y R3 pueden ser iguales o diferentes y significan alcohilo con 1, 2 o 3 átomos de carbono, alcoxi con 1, 2 o 3 átomos de carbono, alcohiltio con 1, 2 o 3 átomos de carbono, los cuales grupos pueden estar sustituidos en cada caso total o parcialmente con átomos de halógeno iguales o diferentes, o significan halógeno, nitro, ciano, carbalcoxi con 1, 2 o 3 átomos de carbono en el grupo alcohilo en donde R1 y R2 significan además hidrógeno, en cuyo caso, no obstante, R3 no puede ser metilo, pero en cuyo caso R3 significa adicionalmente fenilo, que eventualmente puede estar sustituido una o dos veces con fluor, cloro, bromo, yodo, alcohilo con 1, 2 o 3 átomos de carbono o alcoxi con 1, 2 o 3 átomos de carbono, o fenoxi, que eventualmente puede estar sustituido en cada caso una o dos veces con fluor, cloro, bromo, yodo, alcohilo con 1, 2 o 3 átomos de carbono o alcoxi con 1, 2 o 3 átomos de carbono, o en donde R1 significa hidrógeno y R2 y R3 significan en común un grupo metilendioxi o en común con el anillo fenilo que los lleva significan un anillo naftaleno.
ES448386A 1975-06-05 1976-05-31 Procedimiento para la preparacion de anilidas de acido 5-me-til-isoxazol-4-carboxilico. Expired ES448386A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2524959A DE2524959C2 (de) 1975-06-05 1975-06-05 5-Methyl-isoxazol-4-carbonsäureanilide, Verfahren zu ihrer Herstellung, diese Verbindungen enthaltende Mittel

Publications (1)

Publication Number Publication Date
ES448386A1 true ES448386A1 (es) 1978-04-16

Family

ID=5948292

Family Applications (1)

Application Number Title Priority Date Filing Date
ES448386A Expired ES448386A1 (es) 1975-06-05 1976-05-31 Procedimiento para la preparacion de anilidas de acido 5-me-til-isoxazol-4-carboxilico.

Country Status (15)

Country Link
US (1) US4087535A (es)
JP (1) JPS5938230B2 (es)
AT (1) AT349007B (es)
BE (1) BE842689A (es)
CA (1) CA1076584A (es)
CH (1) CH603608A5 (es)
DK (1) DK151013C (es)
ES (1) ES448386A1 (es)
FR (1) FR2313052A1 (es)
GB (1) GB1547452A (es)
IE (1) IE43136B1 (es)
IT (1) IT1063592B (es)
LU (1) LU75077A1 (es)
MX (1) MX3144E (es)
NL (1) NL178596C (es)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2654797A1 (de) * 1976-12-03 1978-06-08 Hoechst Ag Verfahren zur herstellung von isoxazolderivaten
JPS54102196U (es) * 1977-12-28 1979-07-18
DE2854439A1 (de) * 1978-12-16 1980-07-03 Hoechst Ag Ein isoxazolderivat, verfahren zu seiner herstellung, diese verbindung enthaltende mittel und verwendung
DE3070951D1 (en) * 1979-06-11 1985-09-12 Ciba Geigy Ag Alphacarbamoyl-pyrrolpropionitriles, process for their preparation and pharmaceutical preparations containing them
DE2940189A1 (de) * 1979-10-04 1981-04-16 Basf Ag, 6700 Ludwigshafen Isoxazolylcarbonsaeureanilide, verfahren zu ihrer herstellung und ihre verwendung als fungizide
FR2538806B1 (fr) * 1982-12-30 1986-02-21 Bago Sa Labor Composes phenyl-3 methyl isoxazole-5 carboxy-4 anilides substitues, actifs therapeutiquement contre l'inflammation et la douleur
JPS6398092A (ja) * 1986-10-14 1988-04-28 富士電機株式会社 金券用カ−ド残金精算装置
US4935434A (en) * 1988-01-26 1990-06-19 Bristol-Myers Company Antiarthritic isoxazole-4-carboxamides
US5583150A (en) * 1989-08-18 1996-12-10 Alcon Laboratories, Inc. 5-methyl-isoxazole-4-carboxylic acid anilides and 2-hydroxyethylidene-cyano acetic anilides for the treatment of ocular diseases
DD297328A5 (de) 1989-08-18 1992-01-09 �������@���������k���Kk�� 5-methyl-isoxalol-4-carbonsaeureanilide und 2 hydroxyethyliden-cyanoessigsaeureanilide zur behandlung von augenerkrankungen
US5108999A (en) * 1990-02-02 1992-04-28 Syntex (U.S.A.) Inc. 4-isoxazolecarboxamide derivatives
US5001124A (en) * 1990-02-02 1991-03-19 Syntex (U.S.A.) Inc. 4-isoxazolecarboxamide derivatives
DK0527736T3 (da) * 1990-05-18 1997-10-20 Hoechst Ag Isoxazol-4-carboxylsyreamider og hydroxyalkyliden-cyanoacetamider, lægemidler indeholdende disse forbindelser og anvendelsen af disse lægemidler.
US6133301A (en) * 1991-08-22 2000-10-17 Aventis Pharma Deutschland Gmbh Pharmaceuticals for the treatment of rejection reactions in organ transplantations
DE4127737A1 (de) * 1991-08-22 1993-02-25 Hoechst Ag Arzneimittel zur behandlung von abstossungsreaktionen bei organverpflanzungen
GB9320299D0 (en) * 1993-10-01 1993-11-17 Roussel Lab Ltd Isoxazole derivatives
US5700823A (en) * 1994-01-07 1997-12-23 Sugen, Inc. Treatment of platelet derived growth factor related disorders such as cancers
US6335356B1 (en) 1994-01-07 2002-01-01 Sugen, Inc. Method of treating a patient by parenteral administration of a lipophilic compound
US5610173A (en) * 1994-01-07 1997-03-11 Sugen, Inc. Formulations for lipophilic compounds
US5624946A (en) * 1994-07-05 1997-04-29 Williams; James Use of leflunomide to control and reverse chronic allograft rejection
US5721277A (en) * 1995-04-21 1998-02-24 Sugen, Inc. Compounds and methods for inhibiting hyper-proliferative cell growth
US6331555B1 (en) 1995-06-01 2001-12-18 University Of California Treatment of platelet derived growth factor related disorders such as cancers
US6316479B1 (en) 1997-05-19 2001-11-13 Sugen, Inc. Isoxazole-4-carboxamide compounds active against protein tryosine kinase related disorders
DK0903345T3 (da) * 1997-08-08 2000-10-23 Aventis Pharma Gmbh Krystalform af N-(4-trifluormethylphenyl)-5-methyl-isoxazol-4-carboxamid
US7691890B2 (en) 1998-03-11 2010-04-06 James W. Williams Anti-viral uses of leflunomide products
US20050255071A1 (en) * 1998-12-10 2005-11-17 Aventis Pharma Deutschland Gmbh Preparation having improved therapeutic breadth comprising nucleotide synthesis inhibitors
WO2002080897A1 (en) 2001-04-05 2002-10-17 Aventis Pharmaceuticals Inc. Use of (z)-2-cyano-3-hydroxy-but-2-enoic acid-(4'-trifluoromethylphenyl)-amide for treating multiple sclerosis
GB0123571D0 (en) * 2001-04-05 2001-11-21 Aventis Pharm Prod Inc Use of (Z)-2-cyano-3-hydroxy-but-2-enoic acid-(4'-trifluoromethylphenyl)-amide for treating multiple sclerosis
US20050158371A1 (en) * 2002-02-12 2005-07-21 Sumitomo Pharmaceuticals Co., Ltd. Novel external agent
WO2005033103A1 (en) * 2003-09-12 2005-04-14 Rigel Pharmaceuticals, Inc. Quinoline compounds and their uses
EP1781637A1 (en) * 2004-06-29 2007-05-09 Rigel Pharmaceuticals, Inc. 2-substituted quinoline compounds and their uses as inhibitors of the ige receptor signaling cascade
US20060024376A1 (en) * 2004-07-30 2006-02-02 The University Of Chicago Methods and compositions for reducing toxicity associated with leflunomide treatment
JOP20190207A1 (ar) 2017-03-14 2019-09-10 Actelion Pharmaceuticals Ltd تركيبة صيدلانية تشتمل على بونيسيمود

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK54063C (da) * 1935-02-22 1937-12-27 Hoffmann La Roche Fremgangsmaade til Fremstilling af dialkylsubstituerede Amider af Isoksazolkarbonsyrer.
DE634286C (de) * 1935-02-23 1936-08-26 Hoffmann La Roche & Co Akt Ges Verfahren zur Herstellung dialkylsubstituierter Amide von Isoxazolcarbonsaeuren
US2126329A (en) * 1936-03-20 1938-08-09 Hoffmann La Roche Amide derivatives of isoxazole carboxylic acids
DE673111C (de) * 1938-01-18 1939-03-16 Hoffmann La Roche & Co Akt Ges Verfahren zur Darstellung amidartiger Abkoemmlinge von Homologen der Isoxazolcarbonsaeuren
DK58903C (da) * 1940-02-27 1941-08-04 Hoffmann La Roche Fremgangsmaade til Fremstilling af substituerede Amider af 3,5-Dimetyl-isoksazol-karbonsyre-(4).
US2288863A (en) * 1940-02-27 1942-07-07 Hoffmann La Roche Process for the manufacture of substituted amides of 3,5-dimethylisoxazole-4-carboxylic acid

Also Published As

Publication number Publication date
DK151013B (da) 1987-10-12
GB1547452A (en) 1979-06-20
NL7605841A (nl) 1976-12-07
ATA413776A (de) 1978-08-15
CH603608A5 (es) 1978-08-31
BE842689A (fr) 1976-12-08
FR2313052A1 (fr) 1976-12-31
IE43136B1 (en) 1980-12-31
AT349007B (de) 1979-03-12
JPS5938230B2 (ja) 1984-09-14
LU75077A1 (es) 1977-03-09
DK151013C (da) 1988-03-07
IT1063592B (it) 1985-02-11
NL178596C (nl) 1986-04-16
US4087535A (en) 1978-05-02
JPS527960A (en) 1977-01-21
DK248376A (da) 1976-12-06
CA1076584A (en) 1980-04-29
MX3144E (es) 1980-05-09
FR2313052B1 (es) 1979-09-28
IE43136L (en) 1976-12-05

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20100616