BE842689A - Nouveaux derives d'isoxazoles, leur procede de preparation et leurs applications - Google Patents
Nouveaux derives d'isoxazoles, leur procede de preparation et leurs applicationsInfo
- Publication number
- BE842689A BE842689A BE167707A BE167707A BE842689A BE 842689 A BE842689 A BE 842689A BE 167707 A BE167707 A BE 167707A BE 167707 A BE167707 A BE 167707A BE 842689 A BE842689 A BE 842689A
- Authority
- BE
- Belgium
- Prior art keywords
- applications
- preparation process
- new
- derivatives
- isoxazoles derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/66—Nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2524959A DE2524959C2 (de) | 1975-06-05 | 1975-06-05 | 5-Methyl-isoxazol-4-carbonsäureanilide, Verfahren zu ihrer Herstellung, diese Verbindungen enthaltende Mittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE842689A true BE842689A (fr) | 1976-12-08 |
Family
ID=5948292
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE167707A BE842689A (fr) | 1975-06-05 | 1976-06-08 | Nouveaux derives d'isoxazoles, leur procede de preparation et leurs applications |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US4087535A (xx) |
| JP (1) | JPS5938230B2 (xx) |
| AT (1) | AT349007B (xx) |
| BE (1) | BE842689A (xx) |
| CA (1) | CA1076584A (xx) |
| CH (1) | CH603608A5 (xx) |
| DK (1) | DK151013C (xx) |
| ES (1) | ES448386A1 (xx) |
| FR (1) | FR2313052A1 (xx) |
| GB (1) | GB1547452A (xx) |
| IE (1) | IE43136B1 (xx) |
| IT (1) | IT1063592B (xx) |
| LU (1) | LU75077A1 (xx) |
| MX (1) | MX3144E (xx) |
| NL (1) | NL178596C (xx) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0021207A1 (de) * | 1979-06-11 | 1981-01-07 | Ciba-Geigy Ag | Alphacarbamoyl-pyrrolpropionitrile, Verfahren zu ihrer Herstellung, sowie pharmazeutische Präparate die diese Verbindungen enthalten |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2654797A1 (de) * | 1976-12-03 | 1978-06-08 | Hoechst Ag | Verfahren zur herstellung von isoxazolderivaten |
| JPS54102196U (xx) * | 1977-12-28 | 1979-07-18 | ||
| DE2854439A1 (de) * | 1978-12-16 | 1980-07-03 | Hoechst Ag | Ein isoxazolderivat, verfahren zu seiner herstellung, diese verbindung enthaltende mittel und verwendung |
| DE2940189A1 (de) * | 1979-10-04 | 1981-04-16 | Basf Ag, 6700 Ludwigshafen | Isoxazolylcarbonsaeureanilide, verfahren zu ihrer herstellung und ihre verwendung als fungizide |
| FR2538806B1 (fr) * | 1982-12-30 | 1986-02-21 | Bago Sa Labor | Composes phenyl-3 methyl isoxazole-5 carboxy-4 anilides substitues, actifs therapeutiquement contre l'inflammation et la douleur |
| JPS6398092A (ja) * | 1986-10-14 | 1988-04-28 | 富士電機株式会社 | 金券用カ−ド残金精算装置 |
| US4935434A (en) * | 1988-01-26 | 1990-06-19 | Bristol-Myers Company | Antiarthritic isoxazole-4-carboxamides |
| DD297328A5 (de) | 1989-08-18 | 1992-01-09 | �������@���������k���Kk�� | 5-methyl-isoxalol-4-carbonsaeureanilide und 2 hydroxyethyliden-cyanoessigsaeureanilide zur behandlung von augenerkrankungen |
| US5583150A (en) * | 1989-08-18 | 1996-12-10 | Alcon Laboratories, Inc. | 5-methyl-isoxazole-4-carboxylic acid anilides and 2-hydroxyethylidene-cyano acetic anilides for the treatment of ocular diseases |
| US5108999A (en) * | 1990-02-02 | 1992-04-28 | Syntex (U.S.A.) Inc. | 4-isoxazolecarboxamide derivatives |
| US5001124A (en) * | 1990-02-02 | 1991-03-19 | Syntex (U.S.A.) Inc. | 4-isoxazolecarboxamide derivatives |
| EP0527736B1 (de) * | 1990-05-18 | 1997-04-16 | Hoechst Aktiengesellschaft | Isoxazol-4-carbonsäureamide und hydroxyalkyliden-cyanessigsäureamide, diese verbindungen enthaltende arzneimittel und deren verwendung |
| US6133301A (en) * | 1991-08-22 | 2000-10-17 | Aventis Pharma Deutschland Gmbh | Pharmaceuticals for the treatment of rejection reactions in organ transplantations |
| DE4127737A1 (de) | 1991-08-22 | 1993-02-25 | Hoechst Ag | Arzneimittel zur behandlung von abstossungsreaktionen bei organverpflanzungen |
| GB9320299D0 (en) * | 1993-10-01 | 1993-11-17 | Roussel Lab Ltd | Isoxazole derivatives |
| US5610173A (en) * | 1994-01-07 | 1997-03-11 | Sugen, Inc. | Formulations for lipophilic compounds |
| US5700823A (en) * | 1994-01-07 | 1997-12-23 | Sugen, Inc. | Treatment of platelet derived growth factor related disorders such as cancers |
| US6335356B1 (en) | 1994-01-07 | 2002-01-01 | Sugen, Inc. | Method of treating a patient by parenteral administration of a lipophilic compound |
| US5624946A (en) * | 1994-07-05 | 1997-04-29 | Williams; James | Use of leflunomide to control and reverse chronic allograft rejection |
| US5721277A (en) * | 1995-04-21 | 1998-02-24 | Sugen, Inc. | Compounds and methods for inhibiting hyper-proliferative cell growth |
| US6331555B1 (en) | 1995-06-01 | 2001-12-18 | University Of California | Treatment of platelet derived growth factor related disorders such as cancers |
| US6316479B1 (en) | 1997-05-19 | 2001-11-13 | Sugen, Inc. | Isoxazole-4-carboxamide compounds active against protein tryosine kinase related disorders |
| EP0987256B1 (de) * | 1997-08-08 | 2001-10-17 | Aventis Pharma Deutschland GmbH | Kristallform von N-(4-Trifluormethylphenyl)-5-methylisoxazol-4-carbonsäureamid |
| US7691890B2 (en) | 1998-03-11 | 2010-04-06 | James W. Williams | Anti-viral uses of leflunomide products |
| US20050255071A1 (en) * | 1998-12-10 | 2005-11-17 | Aventis Pharma Deutschland Gmbh | Preparation having improved therapeutic breadth comprising nucleotide synthesis inhibitors |
| GB0123571D0 (en) * | 2001-04-05 | 2001-11-21 | Aventis Pharm Prod Inc | Use of (Z)-2-cyano-3-hydroxy-but-2-enoic acid-(4'-trifluoromethylphenyl)-amide for treating multiple sclerosis |
| SI1381356T1 (sl) | 2001-04-05 | 2008-12-31 | Aventis Pharma Inc | Uporaba (Z)-2-ciano-3-hidroksi-but-2-enojska kislina-(4'-trifluorometilfenil)-amida za zdravljenje multiple skleroze |
| US20050158371A1 (en) * | 2002-02-12 | 2005-07-21 | Sumitomo Pharmaceuticals Co., Ltd. | Novel external agent |
| WO2005033103A1 (en) * | 2003-09-12 | 2005-04-14 | Rigel Pharmaceuticals, Inc. | Quinoline compounds and their uses |
| WO2006004865A1 (en) * | 2004-06-29 | 2006-01-12 | Rigel Pharmaceuticals, Inc. | 2-substituted quinoline compounds and their uses as inhibitors of the ige receptor signaling cascade |
| US20060024376A1 (en) * | 2004-07-30 | 2006-02-02 | The University Of Chicago | Methods and compositions for reducing toxicity associated with leflunomide treatment |
| JOP20190207A1 (ar) | 2017-03-14 | 2019-09-10 | Actelion Pharmaceuticals Ltd | تركيبة صيدلانية تشتمل على بونيسيمود |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK54063C (da) * | 1935-02-22 | 1937-12-27 | Hoffmann La Roche | Fremgangsmaade til Fremstilling af dialkylsubstituerede Amider af Isoksazolkarbonsyrer. |
| DE634286C (de) * | 1935-02-23 | 1936-08-26 | Hoffmann La Roche & Co Akt Ges | Verfahren zur Herstellung dialkylsubstituierter Amide von Isoxazolcarbonsaeuren |
| US2126329A (en) * | 1936-03-20 | 1938-08-09 | Hoffmann La Roche | Amide derivatives of isoxazole carboxylic acids |
| DE673111C (de) * | 1938-01-18 | 1939-03-16 | Hoffmann La Roche & Co Akt Ges | Verfahren zur Darstellung amidartiger Abkoemmlinge von Homologen der Isoxazolcarbonsaeuren |
| US2288863A (en) * | 1940-02-27 | 1942-07-07 | Hoffmann La Roche | Process for the manufacture of substituted amides of 3,5-dimethylisoxazole-4-carboxylic acid |
| DK58903C (da) * | 1940-02-27 | 1941-08-04 | Hoffmann La Roche | Fremgangsmaade til Fremstilling af substituerede Amider af 3,5-Dimetyl-isoksazol-karbonsyre-(4). |
-
1976
- 1976-05-31 NL NLAANVRAGE7605841,A patent/NL178596C/xx not_active IP Right Cessation
- 1976-05-31 ES ES448386A patent/ES448386A1/es not_active Expired
- 1976-06-02 CH CH696276A patent/CH603608A5/xx not_active IP Right Cessation
- 1976-06-03 US US05/692,306 patent/US4087535A/en not_active Expired - Lifetime
- 1976-06-03 IT IT23923/76A patent/IT1063592B/it active
- 1976-06-03 LU LU75077A patent/LU75077A1/xx unknown
- 1976-06-04 DK DK248376A patent/DK151013C/da not_active IP Right Cessation
- 1976-06-04 IE IE1202/76A patent/IE43136B1/en unknown
- 1976-06-04 JP JP51065476A patent/JPS5938230B2/ja not_active Expired
- 1976-06-04 MX MX000270U patent/MX3144E/es unknown
- 1976-06-04 CA CA254,134A patent/CA1076584A/en not_active Expired
- 1976-06-04 FR FR7617038A patent/FR2313052A1/fr active Granted
- 1976-06-04 GB GB23185/76A patent/GB1547452A/en not_active Expired
- 1976-06-04 AT AT413776A patent/AT349007B/de not_active IP Right Cessation
- 1976-06-08 BE BE167707A patent/BE842689A/xx not_active IP Right Cessation
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0021207A1 (de) * | 1979-06-11 | 1981-01-07 | Ciba-Geigy Ag | Alphacarbamoyl-pyrrolpropionitrile, Verfahren zu ihrer Herstellung, sowie pharmazeutische Präparate die diese Verbindungen enthalten |
| EP0143142A3 (de) * | 1979-06-11 | 1985-07-17 | Ciba-Geigy Ag | Alphacarbamoyl-pyrrolpropionitrile, Verfahren zu ihrer Herstellung, pharmazeutische Präparate enthaltend diese Verbindungen, sowie ihre therapeutische Verwendung |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS527960A (en) | 1977-01-21 |
| CH603608A5 (xx) | 1978-08-31 |
| GB1547452A (en) | 1979-06-20 |
| NL178596C (nl) | 1986-04-16 |
| IT1063592B (it) | 1985-02-11 |
| MX3144E (es) | 1980-05-09 |
| DK151013C (da) | 1988-03-07 |
| NL7605841A (nl) | 1976-12-07 |
| ES448386A1 (es) | 1978-04-16 |
| FR2313052B1 (xx) | 1979-09-28 |
| US4087535A (en) | 1978-05-02 |
| IE43136B1 (en) | 1980-12-31 |
| DK151013B (da) | 1987-10-12 |
| CA1076584A (en) | 1980-04-29 |
| JPS5938230B2 (ja) | 1984-09-14 |
| LU75077A1 (xx) | 1977-03-09 |
| IE43136L (en) | 1976-12-05 |
| ATA413776A (de) | 1978-08-15 |
| FR2313052A1 (fr) | 1976-12-31 |
| DK248376A (da) | 1976-12-06 |
| AT349007B (de) | 1979-03-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BE842689A (fr) | Nouveaux derives d'isoxazoles, leur procede de preparation et leurs applications | |
| BE875174A (fr) | Nouveaux derives de carbostyrile, leur procede de preparation et leurs applications en therapeutique | |
| FR2332009A1 (fr) | Nouveaux derives polyprenyliques, leur procede de preparation et leurs applications | |
| FR2315930A1 (fr) | Derives de 1,4-dihydropyridine et leur procede de preparation | |
| FR2312247A1 (fr) | Derives de la thieno-pyridine, leur procede de preparation et leurs applications | |
| FR2320295A1 (fr) | Nouveaux derives de la 2,3-dioxopiperazine et leur procede de preparation | |
| FR2335216A1 (fr) | Nouveaux derives d'indol substitues par des bases, leur procede de preparation et leurs applications | |
| BE861503R (fr) | Nouveaux derives d'isoxazoles, leur procede de preparation et leurs applications | |
| FR2321297A1 (fr) | Nouveaux derives de dopamine, leur procede de preparation et leurs applications | |
| FR2313930A1 (fr) | Derives d'eburnamenine, leur procede de preparation et leurs applications | |
| BE845497A (fr) | 3-phenylspiro-(isobenzofuranne-1,4'-pipieridine)-sulfenamides, leur procede de preparation et leurs applications | |
| BE794589A (fr) | Nouveaux derives du 1,1-diphenyl-ethylene, leur procede de preparation et leurs applications | |
| FR2315925A1 (fr) | Nouveaux derives de 5-benzyle-2-oxazolidone, leur procede de preparation et leur application en therapeutique | |
| FR2313063A1 (fr) | Derives de pyrrolotriazolopyrimidine leur procede de preparation et leurs applications en therapeutique | |
| BE844229A (fr) | Nouveaux derives d'apovincaminol leur procede de preparation et leur application | |
| FR2310752A1 (fr) | Anthraquinone-bis-amidines, leur procede de preparation et leurs applications | |
| FR2290207A1 (fr) | Nouveaux derives de 3,4-dihydrocarbostyril et leur procede de preparation | |
| BE861500R (fr) | Nouveaux derives d'isoxazoles, leur procde de preparation et leur applications | |
| BE847352A (fr) | Nouveaux derives de thiazolidine, leur procede de preparation et leurs applications | |
| FR2310763A1 (fr) | Derives 1,4-disubstitues de la piperazine, leur procede de preparation et leurs applications | |
| FR2321894A1 (fr) | Nouveaux derives de phenothiazine, leur procede de preparation et leurs applications | |
| FR2337550A1 (fr) | Nouveaux derives de l'hydrazine, leur procede de preparation et leurs applications | |
| BE861502R (fr) | Nouveaux derives d'isoxazoles, leur procde de preparation et leurs applications | |
| BE848627A (fr) | Derives substitues d'aminobenzaldehydes et leur procede de preparation, | |
| BE837605A (fr) | Derives de 2-aminoacetamindo- -phenyllenzylidene aminoalcanols, leur procede de preparation et leurs applications en therapeutique |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RE20 | Patent expired |
Owner name: HOECHST A.G. Effective date: 19960608 |