PE59599A1 - N-oxidos de esteres, amidas, tioesteres y cetonas heterociclicos - Google Patents

N-oxidos de esteres, amidas, tioesteres y cetonas heterociclicos

Info

Publication number
PE59599A1
PE59599A1 PE1998000141A PE00014198A PE59599A1 PE 59599 A1 PE59599 A1 PE 59599A1 PE 1998000141 A PE1998000141 A PE 1998000141A PE 00014198 A PE00014198 A PE 00014198A PE 59599 A1 PE59599 A1 PE 59599A1
Authority
PE
Peru
Prior art keywords
alkyl
formula
compound
prevene
alkyll
Prior art date
Application number
PE1998000141A
Other languages
English (en)
Inventor
Gregory S Hamilton
Eric S Burak
Joseph P Steiner
Original Assignee
Guilford Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guilford Pharm Inc filed Critical Guilford Pharm Inc
Publication of PE59599A1 publication Critical patent/PE59599A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyrrole Compounds (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA (I) DONDE "A Y B" FORMAN UN HETEROCICLO SATURADO O NO SATURADO DE 5 A 7 MIEMBROS, QUE CONTIENEN CH2, O, S, SO, SO2, NH, NR1; W ES O, S, CH2 o H2; R ES ALQUILO O ALQUENILO C1-C6 SUSTITUIDO POR CICLOALQUILO C3-C8, CICLOALQUILO C3 o C5, ENTRE OTROS; X ES O, NH, NR1, S, CH, CR1 o C(R1)2; Y ES UN ENLACE, ALQUILO O ALQUENILO C1-C6 OPCIONALMENTE SUSTITUIDOS POR ALQUILO O ALQUENILO C1-C6, CICLOALQUILO C3-C8, HIDROXIDO, Ar, ENTRE OTROS; Z ES ALQUIL AMINA AROMATICA O TERCIARIA OXIDADA A SU CORRESPONDIENTE N-OXIDO; Ar ES UN ANILLO MONO, BI O TRICICLICO, CARBO O HETEROCICLICO OPCIONALMENTE SUSTITUIDO EN 1-3 POSICIONES CON HALO, OH, TRIFLUOROMETILO, ENTRE OTROS; R1 ES H, ALQUILO C1-C4, ALQUENILO O ALQUINILO C3-C4, Y-Z. TAMBIEN SE REFIERE A UN COMPUESTO DE FORMULA (II); DONDE: E, F, G Y H SON CH2, O, S, SO, SO2, NH, NR1; Y A COMPUESTOS DE FORMULA (III) o (IV), n ES 1-3. UN COMPUESTO PREFERIDO ES 3-(2-PIRIDIL)-1-PROPIL(2S)-1-(1,1-DIMETIL-1,2-DIOXO-PENTIL)-2-PIRROLIDIN CARBOXILATO, N-OXIDO O SUS SALES, ENTRE OTROS. EL COMPUESTO DE FORMULA (I) TIENE AFINIDAD POR LAS INMUNOFILINAS DE TIPO FKBP12, INHIBIENDO LA ACTIVIDAD ENZIMATICA DE LA ROTAMASA POR LO QUE PUEDE SER UTIL PARA ESTIMULAR LAS NEURONAS DANADAS, PROMOVER LA REGENERACION NEURONAL, PREVENIR LA NEURODEGENERACION, TRATAR DESORDENES NEUROLOGICOS
PE1998000141A 1997-02-28 1998-02-27 N-oxidos de esteres, amidas, tioesteres y cetonas heterociclicos PE59599A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/807,406 US5846979A (en) 1997-02-28 1997-02-28 N-oxides of heterocyclic esters, amides, thioesters, and ketones

Publications (1)

Publication Number Publication Date
PE59599A1 true PE59599A1 (es) 1999-06-17

Family

ID=25196300

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1998000141A PE59599A1 (es) 1997-02-28 1998-02-27 N-oxidos de esteres, amidas, tioesteres y cetonas heterociclicos

Country Status (16)

Country Link
US (4) US5846979A (es)
EP (1) EP0993299A4 (es)
JP (1) JPH10310581A (es)
KR (1) KR20000075502A (es)
CN (1) CN1249681A (es)
AR (1) AR011882A1 (es)
AU (1) AU723374B2 (es)
CA (1) CA2229707A1 (es)
GT (1) GT199800041A (es)
HU (1) HUP0001461A3 (es)
IL (1) IL131251A0 (es)
PA (1) PA8448001A1 (es)
PE (1) PE59599A1 (es)
TW (1) TW458976B (es)
WO (1) WO1998037885A1 (es)
ZA (1) ZA981474B (es)

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US7338976B1 (en) * 1998-08-14 2008-03-04 Gpi Nil Holdings, Inc. Heterocyclic esters or amides for vision and memory disorders
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Also Published As

Publication number Publication date
AR011882A1 (es) 2000-09-13
US6251892B1 (en) 2001-06-26
PA8448001A1 (es) 2000-05-24
AU723374B2 (en) 2000-08-24
HUP0001461A3 (en) 2002-04-29
IL131251A0 (en) 2001-01-28
TW458976B (en) 2001-10-11
US20010036942A1 (en) 2001-11-01
US6486151B2 (en) 2002-11-26
EP0993299A4 (en) 2001-03-07
JPH10310581A (ja) 1998-11-24
KR20000075502A (ko) 2000-12-15
AU6181598A (en) 1998-09-18
US5846979A (en) 1998-12-08
US6054452A (en) 2000-04-25
ZA981474B (en) 1998-06-08
WO1998037885A1 (en) 1998-09-03
HUP0001461A2 (hu) 2001-04-28
EP0993299A1 (en) 2000-04-19
CA2229707A1 (en) 1998-08-28
CN1249681A (zh) 2000-04-05
GT199800041A (es) 1999-08-14

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