CO5690544A2 - Derivados de acido alcanoico sustituido con cicloalquilo metodos para su produccion y su uso como medicamentos - Google Patents

Derivados de acido alcanoico sustituido con cicloalquilo metodos para su produccion y su uso como medicamentos

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Publication number
CO5690544A2
CO5690544A2 CO05085507A CO05085507A CO5690544A2 CO 5690544 A2 CO5690544 A2 CO 5690544A2 CO 05085507 A CO05085507 A CO 05085507A CO 05085507 A CO05085507 A CO 05085507A CO 5690544 A2 CO5690544 A2 CO 5690544A2
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Colombia
Prior art keywords
alkyl
cycloalkyl
medications
derivatives
production
Prior art date
Application number
CO05085507A
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English (en)
Inventor
Christian Stapper
Original Assignee
Sanofi Aventis Deutschland
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Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of CO5690544A2 publication Critical patent/CO5690544A2/es

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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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    • A61P11/06—Antiasthmatics
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    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/06—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
    • C07C275/10—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/20—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C275/24—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/26—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of rings other than six-membered aromatic rings
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    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
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  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
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  • Ophthalmology & Optometry (AREA)
  • Child & Adolescent Psychology (AREA)
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Abstract

1.- Un compuesto de la fórmula Ien la que el anillo A es cicloalcanodiilo (C3-C8) o cicloalquenodiilo(C3-C8), donde en los anillos cicloalcano- o cicloalquenodiilo uno o más átomos de carbono pueden estar reemplazados por átomos de oxígeno;R1 y R2, independientemente entre sí, son H, alquilo (C1-C6), cicloalquilo (C3-C8) o arilo (C6-C10);R3 es cicloalquilo (C3-C6) o alquilo (C1-C12), que están opcionalmente sustituidos con arilo (C6-C10), heteroarilo (C5-C6) o cicloalquilo (C3-C6), donde arilo, heteroarilo o cicloalquilo por su parte, pueden estar sustituidos con alquilo (C1-C6), alcoxi (C1-C6), CI, Br, I, CO-alquilo (C1-C6), CO-O-alquilo (C1-C6), CO-NH-alquilo (C1-C6) o CO-N(alquilo (C1-C6))2;X es alcanodiilo (C1-C6), donde en el grupo alcanodiilo uno o más átomos de carbono pueden reemplazarse por átomos de oxígeno;Y1 es CO o un enlace;Y2 es NH, alcanodiilo (C1-C12), donde en el grupo alcanodiilo uno o más átomos de carbono pueden reemplazarse por átomos de oxígeno;R4 es alquilo (C1-C8);R5 es H, alquilo (C1-C6);R6 es H;y sus sales fisiológicamente aceptables.
CO05085507A 2003-02-27 2005-08-26 Derivados de acido alcanoico sustituido con cicloalquilo metodos para su produccion y su uso como medicamentos CO5690544A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10308356A DE10308356A1 (de) 2003-02-27 2003-02-27 Cycloalkyl substituierte Alkansäurederivate, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel

Publications (1)

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CO5690544A2 true CO5690544A2 (es) 2006-10-31

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CO05085507A CO5690544A2 (es) 2003-02-27 2005-08-26 Derivados de acido alcanoico sustituido con cicloalquilo metodos para su produccion y su uso como medicamentos

Country Status (22)

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EP (1) EP1599443B1 (es)
JP (1) JP2006519200A (es)
KR (1) KR20050115255A (es)
CN (1) CN100469761C (es)
AR (1) AR043431A1 (es)
AT (1) ATE538086T1 (es)
BR (1) BRPI0407871A (es)
CA (1) CA2516633A1 (es)
CO (1) CO5690544A2 (es)
DE (1) DE10308356A1 (es)
HR (1) HRP20050739A2 (es)
IL (1) IL170315A (es)
MA (1) MA27743A1 (es)
MX (1) MXPA05008990A (es)
NO (1) NO20054389L (es)
PA (1) PA8596701A1 (es)
PE (1) PE20040958A1 (es)
PL (1) PL377755A1 (es)
RU (1) RU2005129998A (es)
TW (1) TW200505830A (es)
WO (1) WO2004076401A1 (es)
ZA (1) ZA200505766B (es)

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PL1942898T5 (pl) 2005-09-14 2014-10-31 Takeda Pharmaceuticals Co Inhibitory peptydazy dipeptydylowej do leczenia cukrzycy
CN102675221A (zh) 2005-09-16 2012-09-19 武田药品工业株式会社 用于制备嘧啶二酮衍生物的方法中的中间体
CA2624102A1 (en) 2005-09-29 2007-04-12 Sanofi-Aventis Phenyl- and pyridinyl- 1, 2 , 4 - oxadiazolone derivatives, processes for their preparation and their use as pharmaceuticals
WO2007112347A1 (en) 2006-03-28 2007-10-04 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
TW200838536A (en) 2006-11-29 2008-10-01 Takeda Pharmaceutical Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE61716B1 (en) * 1987-06-02 1994-11-30 Warner Lambert Co Antihyperlipidemic and antiatherosclerotic urea compounds
US5420164A (en) * 1991-04-04 1995-05-30 Yoshitomi Pharmaceutical Industries, Ltd. Cycloalkylurea compounds
GB9606805D0 (en) * 1996-03-30 1996-06-05 Glaxo Wellcome Inc Medicaments
US6057338A (en) * 1997-04-04 2000-05-02 Merck & Co., Inc. Somatostatin agonists
BR9811988A (pt) * 1997-08-22 2000-09-05 Hoffmann La Roche Derivados de n-alcanoilfenilalanina
WO1999022735A1 (en) * 1997-10-30 1999-05-14 Merck & Co., Inc. Somatostatin agonists
JP2002201171A (ja) * 2000-10-27 2002-07-16 Toa Eiyo Ltd ウレアカルボン酸誘導体
JP2002201127A (ja) * 2000-12-28 2002-07-16 Pola Chem Ind Inc ウレア誘導体
BR0207227A (pt) * 2001-02-15 2004-02-10 Pfizer Prod Inc Compostos receptores ativados proliferadores ppar

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MXPA05008990A (es) 2005-10-18
RU2005129998A (ru) 2006-03-20
ATE538086T1 (de) 2012-01-15
NO20054389D0 (no) 2005-09-22
WO2004076401A1 (de) 2004-09-10
CN100469761C (zh) 2009-03-18
PE20040958A1 (es) 2005-02-01
PA8596701A1 (es) 2004-09-16
HRP20050739A2 (en) 2006-08-31
CN1753865A (zh) 2006-03-29
BRPI0407871A (pt) 2006-03-01
CA2516633A1 (en) 2004-09-10
MA27743A1 (fr) 2006-02-01
EP1599443B1 (de) 2011-12-21
EP1599443A1 (de) 2005-11-30
NO20054389L (no) 2005-11-03
AR043431A1 (es) 2005-07-27
AU2004215678A1 (en) 2004-09-10
TW200505830A (en) 2005-02-16
ZA200505766B (en) 2006-05-31
PL377755A1 (pl) 2006-02-20
DE10308356A1 (de) 2004-09-09
KR20050115255A (ko) 2005-12-07
IL170315A (en) 2010-11-30
JP2006519200A (ja) 2006-08-24

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