HRP20050739A2 - Cycloalkyl-substituted alkanoic acid derivatives, methods for the production thereof, and use thereof as a medicament - Google Patents

Cycloalkyl-substituted alkanoic acid derivatives, methods for the production thereof, and use thereof as a medicament

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Publication number
HRP20050739A2
HRP20050739A2 HR20050739A HRP20050739A HRP20050739A2 HR P20050739 A2 HRP20050739 A2 HR P20050739A2 HR 20050739 A HR20050739 A HR 20050739A HR P20050739 A HRP20050739 A HR P20050739A HR P20050739 A2 HRP20050739 A2 HR P20050739A2
Authority
HR
Croatia
Prior art keywords
production
acid derivatives
alkanoic acid
substituted alkanoic
medicament
Prior art date
Application number
HR20050739A
Other languages
Croatian (hr)
Inventor
Stapper Christian
Glombik Heiner
Falk Eugen
Gretzke Dirk
Goerlitzer Jochen
Keil Stefanie
Schaefer Hans-Ludwig
Wendler Wolfgang
Original Assignee
Sanofi-Aventis Deutschland Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Aventis Deutschland Gmbh filed Critical Sanofi-Aventis Deutschland Gmbh
Publication of HRP20050739A2 publication Critical patent/HRP20050739A2/en

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    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/06—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
    • C07C275/10—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/20—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C275/24—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/26—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of rings other than six-membered aromatic rings
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Abstract

Izum se odnosi na derivate alkanske kiseline supstituirane s arilcikloalkilom, kao i na njihove fiziološki podnošljive soli i fiziološki funkcionalnederivate. Opisani su spojevi formule (I),u kojoj radikali imaju navedena značenja, kao i njihove fiziološki podnošljive soli i postupci za njihovu proizvodnju. Ovi spojevi su prikladni za liječenje .i/ili prevenciju poremećaja metabolizma masne kiselina i poremećaja trošenja glukoze, kao i poremećaja u kojima ima ulogu inzulinska rezistencija.The invention relates to arylcycloalkyl substituted alkanoic acid derivatives, as well as to their physiologically tolerable salts and physiologically functional derivatives. Described are compounds of formula (I), wherein the radicals have the meanings given, as well as their physiologically tolerable salts and processes for their production. These compounds are suitable for the treatment and / or prevention of disorders of fatty acid metabolism and glucose depletion disorders, as well as disorders in which insulin resistance plays a role.

HR20050739A 2003-02-27 2005-08-26 Cycloalkyl-substituted alkanoic acid derivatives, methods for the production thereof, and use thereof as a medicament HRP20050739A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10308356A DE10308356A1 (en) 2003-02-27 2003-02-27 Cycloalkyl substituted alkanoic acid derivatives, process for their preparation and their use as medicaments
PCT/EP2004/001587 WO2004076401A1 (en) 2003-02-27 2004-02-19 Cycloalkyl-substituted alkanoic acid derivatives, methods for the production thereof, and use thereof as a medicament

Publications (1)

Publication Number Publication Date
HRP20050739A2 true HRP20050739A2 (en) 2006-08-31

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Family Applications (1)

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HR20050739A HRP20050739A2 (en) 2003-02-27 2005-08-26 Cycloalkyl-substituted alkanoic acid derivatives, methods for the production thereof, and use thereof as a medicament

Country Status (22)

Country Link
EP (1) EP1599443B1 (en)
JP (1) JP2006519200A (en)
KR (1) KR20050115255A (en)
CN (1) CN100469761C (en)
AR (1) AR043431A1 (en)
AT (1) ATE538086T1 (en)
BR (1) BRPI0407871A (en)
CA (1) CA2516633A1 (en)
CO (1) CO5690544A2 (en)
DE (1) DE10308356A1 (en)
HR (1) HRP20050739A2 (en)
IL (1) IL170315A (en)
MA (1) MA27743A1 (en)
MX (1) MXPA05008990A (en)
NO (1) NO20054389L (en)
PA (1) PA8596701A1 (en)
PE (1) PE20040958A1 (en)
PL (1) PL377755A1 (en)
RU (1) RU2005129998A (en)
TW (1) TW200505830A (en)
WO (1) WO2004076401A1 (en)
ZA (1) ZA200505766B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA015169B1 (en) 2005-09-14 2011-06-30 Такеда Фармасьютикал Компани Лимитед Use of dipeptidyl peptidase inhibitors
CN102675221A (en) 2005-09-16 2012-09-19 武田药品工业株式会社 Intermediate in method for preparing pyrimidinedione derivative
WO2007039177A2 (en) 2005-09-29 2007-04-12 Sanofi-Aventis Phenyl- and pyridinyl- 1, 2 , 4 - oxadiazolone derivatives, processes for their preparation and their use as pharmaceuticals
WO2007112347A1 (en) 2006-03-28 2007-10-04 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
TW200838536A (en) 2006-11-29 2008-10-01 Takeda Pharmaceutical Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor

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IE61716B1 (en) * 1987-06-02 1994-11-30 Warner Lambert Co Antihyperlipidemic and antiatherosclerotic urea compounds
US5420164A (en) * 1991-04-04 1995-05-30 Yoshitomi Pharmaceutical Industries, Ltd. Cycloalkylurea compounds
GB9606805D0 (en) * 1996-03-30 1996-06-05 Glaxo Wellcome Inc Medicaments
US6057338A (en) * 1997-04-04 2000-05-02 Merck & Co., Inc. Somatostatin agonists
BR9811988A (en) * 1997-08-22 2000-09-05 Hoffmann La Roche N-alkanoylphenylalanine derivatives
WO1999022735A1 (en) * 1997-10-30 1999-05-14 Merck & Co., Inc. Somatostatin agonists
JP2002201171A (en) * 2000-10-27 2002-07-16 Toa Eiyo Ltd Ureacarboxylic acid derivative
JP2002201127A (en) * 2000-12-28 2002-07-16 Pola Chem Ind Inc Urea derivative
MXPA03007372A (en) * 2001-02-15 2003-12-04 Pfizer Prod Inc Proliferative activator receptor (ppar) compounds.

Also Published As

Publication number Publication date
IL170315A (en) 2010-11-30
AU2004215678A1 (en) 2004-09-10
CA2516633A1 (en) 2004-09-10
ZA200505766B (en) 2006-05-31
NO20054389L (en) 2005-11-03
CN100469761C (en) 2009-03-18
KR20050115255A (en) 2005-12-07
ATE538086T1 (en) 2012-01-15
AR043431A1 (en) 2005-07-27
RU2005129998A (en) 2006-03-20
PL377755A1 (en) 2006-02-20
DE10308356A1 (en) 2004-09-09
NO20054389D0 (en) 2005-09-22
WO2004076401A1 (en) 2004-09-10
JP2006519200A (en) 2006-08-24
EP1599443B1 (en) 2011-12-21
MXPA05008990A (en) 2005-10-18
MA27743A1 (en) 2006-02-01
CO5690544A2 (en) 2006-10-31
PE20040958A1 (en) 2005-02-01
BRPI0407871A (en) 2006-03-01
EP1599443A1 (en) 2005-11-30
CN1753865A (en) 2006-03-29
TW200505830A (en) 2005-02-16
PA8596701A1 (en) 2004-09-16

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