PE58099A1 - Ureas y carbamatos enlazados en n de esteres heterociclicos - Google Patents

Ureas y carbamatos enlazados en n de esteres heterociclicos

Info

Publication number
PE58099A1
PE58099A1 PE1998000075A PE00007598A PE58099A1 PE 58099 A1 PE58099 A1 PE 58099A1 PE 1998000075 A PE1998000075 A PE 1998000075A PE 00007598 A PE00007598 A PE 00007598A PE 58099 A1 PE58099 A1 PE 58099A1
Authority
PE
Peru
Prior art keywords
alkyl
neuron
compound
optionally substituted
ureas
Prior art date
Application number
PE1998000075A
Other languages
English (en)
Inventor
Gregory Scott Hamilton
Jia-He Li
Wei Huang
Original Assignee
Guilford Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/775,585 external-priority patent/US5935989A/en
Application filed by Guilford Pharm Inc filed Critical Guilford Pharm Inc
Publication of PE58099A1 publication Critical patent/PE58099A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA (I), SU SAL, ESTER O SOLVATO; DONDE: A Y B FORMAN UN HETEROCICLO DE 5-7 MIEMBROS SATURADO O NO SATURADO, SUSTITUIDO OPCIONALMENTE CON CH2, O, S, ENTRE OTROS; X ES O o S; Y ES UN ENLACE, ALQUILO C1-C6, ALQUENILO C2-C6, OPCIONALMENTE SUSTITUIDOS CON AMINO, HALO, ESTER, ENTRE OTROS; R2 ES H, ALQUILO C1-C6, ALQUENILO O ALQUINILO C3-C6 Y ALQUILO PUENTE C1-C4; Z ES UN ENLACE, ALQUILO C1-C6, ALQUENILO C2-C6 OPCIONALMENTE SUSTITUIDOS, ENTRE OTROS; "C" Y D SON INDEPENDIENTEMENTE H, Ar, ALQUILO C1-C6 O ALQUENILO C2-C6, OPCIONALMENTE SUSTITUIDOS; Ar ES ARILO O HETEROARILO OPCIONALMENTE SUSTITUIDO; W ES O o S; CUANDO U ES O, R1 ES UN PAR DE ELECTRONES Y R2 ES Ar, CICLOALQUILO C3-C4, ENTRE OTROS Y CUANDO U ES N, R1 Y R2 SON H, Ar, ENTRE OTROS; O R1 Y R2 FORMAN JUNTOS UN HETEROCICLO. TAMBIEN SE REFIERE A UN COMPUESTO DE FORMULA (II) DONDE E, F, G Y H SON CH2, O, S, ENTRE OTROS. UN COMPUESTO PREFERIDO ES 3-FENILPROPIL-(2S)-1-(1-CICLOHEXILCARBAMOIL)-2-PIRROLIDINACARBOTIOATO, ENTRE OTROS. EL COMPUESTO (I) TIENE AFINIDAD POR LAS INMUNOFILINAS TIPO FKPBP12 INHIBIENDO LA ACTIVIDAD DE LA ENZIMA ROTAMASA, PUDIENDO SER UTILES PARA EFECTUAR UNA ACTIVIDAD NEURONAL COMO ESTIMULACION DE NEURONAS LESIONADAS, PROMOCION DE REGENERACION NEURONAL, PREVENCION DE: LA NEURODEGENERACION Y TRATAMIENTO DE DESORDEN NEUROLOGICO
PE1998000075A 1996-12-31 1998-02-03 Ureas y carbamatos enlazados en n de esteres heterociclicos PE58099A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/775,585 US5935989A (en) 1996-12-31 1996-12-31 N-linked ureas and carbamates of heterocyclic thioesters
US08/997,451 US5958949A (en) 1996-12-31 1997-12-23 N-linked ureas and carbamates of piperidyl thioesters
PCT/US1997/024070 WO1998029117A1 (en) 1996-12-31 1997-12-23 N-linked ureas and carbamates of heterocyclic thioesters

Publications (1)

Publication Number Publication Date
PE58099A1 true PE58099A1 (es) 1999-06-16

Family

ID=27119070

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1998000075A PE58099A1 (es) 1996-12-31 1998-02-03 Ureas y carbamatos enlazados en n de esteres heterociclicos

Country Status (8)

Country Link
US (3) US5958949A (es)
EP (1) EP0959882A4 (es)
JP (1) JP2002515050A (es)
EA (1) EA002401B1 (es)
NO (1) NO992751L (es)
NZ (1) NZ336386A (es)
PE (1) PE58099A1 (es)
SK (1) SK57899A3 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6395758B1 (en) * 1998-08-14 2002-05-28 Gpi Nil Holdings, Inc. Small molecule carbamates or ureas for vision and memory disorders
US7253169B2 (en) 1999-11-12 2007-08-07 Gliamed, Inc. Aza compounds, pharmaceutical compositions and methods of use
US6417189B1 (en) 1999-11-12 2002-07-09 Gpi Nil Holdings, Inc. AZA compounds, pharmaceutical compositions and methods of use
JP2003518122A (ja) 1999-12-21 2003-06-03 ジーピーアイ エヌアイエル ホールディングズ インコーポレーテッド ヒダントイン誘導体化合物、医薬合成品およびこれらの使用方法
US20050002986A1 (en) * 2000-05-12 2005-01-06 Robert Falotico Drug/drug delivery systems for the prevention and treatment of vascular disease
US8236048B2 (en) 2000-05-12 2012-08-07 Cordis Corporation Drug/drug delivery systems for the prevention and treatment of vascular disease
US20040096089A1 (en) * 2002-08-16 2004-05-20 David Borsook Non-invasive functional imaging of peripheral nervous system activation in humans and animals
EP1402888A1 (en) * 2002-09-18 2004-03-31 Jerini AG The use of substituted carbocyclic compounds as rotamases inhibitors
US10058351B2 (en) 2015-03-19 2018-08-28 Michael Todd Beauty Lp Personal care appliance

Family Cites Families (32)

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EP0017390A3 (en) * 1979-03-23 1981-06-24 American Home Products Corporation Bicyclic oxo-thiolactones, pharmaceutical compositions containing them, processes for their preparation and compounds useful as intermediates for their preparation
US4692458A (en) * 1980-03-05 1987-09-08 University Of Miami Anti-hypertensive agents
US4690936A (en) * 1980-03-05 1987-09-01 University Of Miami Anti-hypertensive agents
US4390695A (en) * 1980-06-23 1983-06-28 E. R. Squibb & Sons, Inc. Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids
US4578474A (en) * 1980-06-23 1986-03-25 E. R. Squibb & Sons, Inc. Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids
US4310461A (en) * 1980-06-23 1982-01-12 E. R. Squibb & Sons, Inc. Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids
US4596819A (en) * 1984-01-23 1986-06-24 Warner-Lambert Company Modified tripeptides
US4593102A (en) * 1984-04-10 1986-06-03 A. H. Robins Company, Inc. N-[(amino)alkyl]-1-pyrrolidine, 1-piperidine and 1-homopiperidinecarboxamides (and thiocarboxamides) with sulfur linked substitution in the 2, 3 or 4-position
US4886813A (en) * 1985-11-13 1989-12-12 Otsuka Pharmaceutical Factory, Inc. Proline derivatives
US5001142A (en) * 1989-07-19 1991-03-19 American Cyanamid Company 1-substituted-2-(3-amino-1-propynyl)pyrrolidine derivatives
US5192773A (en) * 1990-07-02 1993-03-09 Vertex Pharmaceuticals, Inc. Immunosuppressive compounds
CA2102180C (en) * 1991-05-09 2002-07-23 David M. Armistead Novel immunosuppressive pyrrolidine/piperidine/azepane-2-carboxylic acid derivatives
MX9202466A (es) * 1991-05-24 1994-06-30 Vertex Pharma Compuestos inmunosupresores novedosos.
HU211101B (en) * 1992-03-13 1995-10-30 Egyt Gyogyszervegyeszeti Gyar Process for preparing 1-[/2s/-methyl-3-mercapto-propionyl]-pyrrolidine-/2s/-carboxylic acid
IS2334B (is) * 1992-09-08 2008-02-15 Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
NZ314207A (en) * 1992-09-28 2000-12-22 Vertex Pharma 1-(2-Oxoacetyl)-piperidine-2-carboxylic acid derivatives as multi drug resistant cancer cell sensitizers
US5385918A (en) * 1993-02-09 1995-01-31 Miles Inc. Aminomethylene-peptides as immunosuppressants
US5798355A (en) * 1995-06-07 1998-08-25 Gpi Nil Holdings, Inc. Inhibitors of rotamase enzyme activity
US6127372A (en) * 1994-03-07 2000-10-03 Vertex Pharmaceuticals, Incorporated Sulfonamide inhibitors of aspartyl protease
US5744485A (en) * 1994-03-25 1998-04-28 Vertex Pharmaceuticals Incorporated Carbamates and ureas as modifiers of multi-drug resistance
US5463048A (en) * 1994-06-14 1995-10-31 American Home Products Corporation Rapamycin amidino carbamates
US5614657A (en) 1994-12-07 1997-03-25 Harada; Shintaro Three dimensionally measuring apparatus
US5726184A (en) * 1995-05-19 1998-03-10 Vertex Pharmaceuticals Incorporated Tetralin compounds with improved MDR activity
US5696135A (en) * 1995-06-07 1997-12-09 Gpi Nil Holdings, Inc. Inhibitors of rotamase enzyme activity effective at stimulating neuronal growth
US5614547A (en) * 1995-06-07 1997-03-25 Guilford Pharmaceuticals Inc. Small molecule inhibitors of rotamase enzyme
US5859031A (en) * 1995-06-07 1999-01-12 Gpi Nil Holdings, Inc. Small molecule inhibitors of rotamase enzyme activity
US6037370A (en) * 1995-06-08 2000-03-14 Vertex Pharmaceuticals Incorporated Methods and compositions for stimulating neurite growth
US5801197A (en) * 1995-10-31 1998-09-01 Gpi Nil Holdings, Inc. Rotamase enzyme activity inhibitors
US5717092A (en) * 1996-03-29 1998-02-10 Vertex Pharmaceuticals Inc. Compounds with improved multi-drug resistance activity
US5786378A (en) * 1996-09-25 1998-07-28 Gpi Nil Holdings, Inc. Heterocyclic thioesters
US5801187A (en) * 1996-09-25 1998-09-01 Gpi-Nil Holdings, Inc. Heterocyclic esters and amides
US5721256A (en) * 1997-02-12 1998-02-24 Gpi Nil Holdings, Inc. Method of using neurotrophic sulfonamide compounds

Also Published As

Publication number Publication date
SK57899A3 (en) 2000-05-16
US6274607B1 (en) 2001-08-14
EA199900511A1 (ru) 2000-02-28
JP2002515050A (ja) 2002-05-21
NO992751L (no) 1999-08-04
EP0959882A1 (en) 1999-12-01
NO992751D0 (no) 1999-06-07
US5958949A (en) 1999-09-28
NZ336386A (en) 2001-09-28
US20020049199A1 (en) 2002-04-25
EP0959882A4 (en) 2001-12-05
EA002401B1 (ru) 2002-04-25

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Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed