PE62099A1 - Sulfonamidas n-enlazadas de tioesteres heterociclicos - Google Patents

Sulfonamidas n-enlazadas de tioesteres heterociclicos

Info

Publication number
PE62099A1
PE62099A1 PE1998000182A PE00018298A PE62099A1 PE 62099 A1 PE62099 A1 PE 62099A1 PE 1998000182 A PE1998000182 A PE 1998000182A PE 00018298 A PE00018298 A PE 00018298A PE 62099 A1 PE62099 A1 PE 62099A1
Authority
PE
Peru
Prior art keywords
optionally replaced
cicloalquil
refers
formula
compounds
Prior art date
Application number
PE1998000182A
Other languages
English (en)
Inventor
Gregory S Hamilton
Jia He-Li
Wei Huang
Original Assignee
Guilford Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/775,584 external-priority patent/US5874449A/en
Application filed by Guilford Pharm Inc filed Critical Guilford Pharm Inc
Publication of PE62099A1 publication Critical patent/PE62099A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/48—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/96—Sulfur atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Psychiatry (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA (I), DONDE A Y B FORMAN UN HETEROCICLO SATURADO O INSATURADO DE 5-7 MIEMBROS OPCIONALMENTE SUSTITUIDO CON CH2, O, ENTRE OTROS; X ES O o S; Y ES UN ENLACE, ALQUIL C1-C6, ENTRE OTROS; OPCIONALMENTE SUSTITUIDO CON AMINO, HALO, ENTRE OTROS; Z ES UN ENLACE, ALQUIL C1-C6 O ALQUENIL C2-C6 OPCIONALMENTE SUSTITUIDO CON AMINO, HALO, ENTRE OTROS; R2 ES H, ALQUIL C1-C6, ALQUENIL O ALQUINIL C3-C6, ENTRE OTROS; C Y D SON H, Ar, ALQUIL C1-C6 O ALQUENIL C2-C6 OPCIONALMENTE SUSTITUIDO CON CICLOALQUIL C3-C8, CICLOALQUIL C5-C7, ENTRE OTROS; Ar ES ARIL O HETEROARIL OPCIONALMENTE SUSTITUIDO; R1 ES Ar, CICLOALQUIL C3-C8, ALQUIL C1-C6, ALQUENIL C2-C6, ENTRE OTROS. TAMBIEN SE REFIERE A UN COMPUESTO DE FORMULA II, DONDE E, F, G Y H SON CH2, O, S, ENTRE OTROS; O COMPUESTOS DE FORMULA III o IV, n ES 1-3. UN COMPUESTO PREFERIDO ES 3-(4-METOXIFENIL)PROPIL (2S)-1-(FENILSULFONIL)-2-PIRROLIDINA CARBOTIOATO, ENTRE OTROS. TAMBIEN SE REFIERE AL PROCEDIMIENTO PARA PREPARAR COMPUESTOS DE FORMULAS I, II, III o IV; DICHOS COMPUESTOS TIENEN AFINIDAD POR LAS INMUNOFILINAS TIPO FKBP12, INHIBIENDO LA ACTIVIDAD DE LA ROTAMASA, PUEDIENDO SER UTILES PARA LA ESTIMULACION DE NEURONAS DANADAS, TRATAMIENTO DEL TRASTORNO NEUROLOGICO
PE1998000182A 1996-12-31 1998-03-16 Sulfonamidas n-enlazadas de tioesteres heterociclicos PE62099A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/775,584 US5874449A (en) 1996-12-31 1996-12-31 N-linked sulfonamides of heterocyclic thioesters
US08/996,342 US6121273A (en) 1996-12-31 1997-12-22 N-linked sulfonamides of heterocyclic thioesters
PCT/US1997/023526 WO1998029116A1 (en) 1996-12-31 1997-12-22 N-linked sulfonamides of heterocyclic thioesters

Publications (1)

Publication Number Publication Date
PE62099A1 true PE62099A1 (es) 1999-06-17

Family

ID=27119069

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1998000182A PE62099A1 (es) 1996-12-31 1998-03-16 Sulfonamidas n-enlazadas de tioesteres heterociclicos

Country Status (7)

Country Link
US (3) US6121273A (es)
JP (1) JP2002515051A (es)
EA (1) EA002593B1 (es)
NO (1) NO992268L (es)
NZ (1) NZ335480A (es)
PA (1) PA8443901A1 (es)
PE (1) PE62099A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6274602B1 (en) * 1998-06-03 2001-08-14 Gpi Nil Holdings, Inc. Heterocyclic thioester and ketone hair growth compositions and uses
US20010049381A1 (en) * 1997-06-04 2001-12-06 Gpl Nil Holdings, Inc., Pyrrolidine derivative hair growth compositions and uses
US5945441A (en) * 1997-06-04 1999-08-31 Gpi Nil Holdings, Inc. Pyrrolidine carboxylate hair revitalizing agents
US6429215B1 (en) 1998-06-03 2002-08-06 Gpi Nil Holdings, Inc. N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses
US6274617B1 (en) * 1998-06-03 2001-08-14 Gpi Nil Holdings, Inc. Heterocyclic ester and amide hair growth compositions and uses
US7041283B1 (en) 2001-02-16 2006-05-09 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Methods of using immunophilin binding drugs to improve integration and survival of neuronal cell transplants
AU2003259846A1 (en) * 2002-08-16 2004-03-03 The General Hospital Corporation Non-invasive functional imaging of peripheral nervous system activation in humans and animals
EP1433778A1 (en) * 2002-12-23 2004-06-30 Jerini AG Use of nitriles as rotamase inhibitors

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4070361A (en) * 1977-04-21 1978-01-24 E. R. Squibb & Sons, Inc. Mercaptoalkylsulfonyl proline and pipecolic acid and esters thereof
US5274097A (en) * 1988-04-19 1993-12-28 Bayer Aktiengesellschaft 1,3-disubstituted pyrrolidines
US5356890A (en) * 1988-06-15 1994-10-18 Brigham And Women's Hospital S-nitroso derivatives of ace inhibitors and the use thereof
US5192773A (en) * 1990-07-02 1993-03-09 Vertex Pharmaceuticals, Inc. Immunosuppressive compounds
US5723490A (en) * 1992-09-08 1998-03-03 Vertex Pharmaceuticals Incorporated THF-containing sulfonamide inhibitors of aspartyl protease
IS2334B (is) * 1992-09-08 2008-02-15 Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
JP3599287B2 (ja) * 1993-04-28 2004-12-08 三菱化学株式会社 スルホンアミド誘導体
JPH10500938A (ja) * 1994-03-07 1998-01-27 バーテックス ファーマシューティカルズ インコーポレイテッド アスパラチルプロテアーゼインヒビターとしてのスルホンアミド誘導体
US5691372A (en) * 1995-04-19 1997-11-25 Vertex Pharmaceuticals Incorporated Oxygenated-Heterocycle containing sulfonamide inhibitors of aspartyl protease
US6037370A (en) * 1995-06-08 2000-03-14 Vertex Pharmaceuticals Incorporated Methods and compositions for stimulating neurite growth
US5717092A (en) * 1996-03-29 1998-02-10 Vertex Pharmaceuticals Inc. Compounds with improved multi-drug resistance activity

Also Published As

Publication number Publication date
US20020049193A1 (en) 2002-04-25
US6294551B1 (en) 2001-09-25
NZ335480A (en) 2001-04-27
EA002593B1 (ru) 2002-06-27
NO992268D0 (no) 1999-05-10
EA199900512A1 (ru) 2000-02-28
PA8443901A1 (es) 2000-05-24
NO992268L (no) 1999-08-30
US6121273A (en) 2000-09-19
JP2002515051A (ja) 2002-05-21

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