PE62099A1 - Sulfonamidas n-enlazadas de tioesteres heterociclicos - Google Patents
Sulfonamidas n-enlazadas de tioesteres heterociclicosInfo
- Publication number
- PE62099A1 PE62099A1 PE1998000182A PE00018298A PE62099A1 PE 62099 A1 PE62099 A1 PE 62099A1 PE 1998000182 A PE1998000182 A PE 1998000182A PE 00018298 A PE00018298 A PE 00018298A PE 62099 A1 PE62099 A1 PE 62099A1
- Authority
- PE
- Peru
- Prior art keywords
- optionally replaced
- cicloalquil
- refers
- formula
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
- C07D207/48—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Psychiatry (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA (I), DONDE A Y B FORMAN UN HETEROCICLO SATURADO O INSATURADO DE 5-7 MIEMBROS OPCIONALMENTE SUSTITUIDO CON CH2, O, ENTRE OTROS; X ES O o S; Y ES UN ENLACE, ALQUIL C1-C6, ENTRE OTROS; OPCIONALMENTE SUSTITUIDO CON AMINO, HALO, ENTRE OTROS; Z ES UN ENLACE, ALQUIL C1-C6 O ALQUENIL C2-C6 OPCIONALMENTE SUSTITUIDO CON AMINO, HALO, ENTRE OTROS; R2 ES H, ALQUIL C1-C6, ALQUENIL O ALQUINIL C3-C6, ENTRE OTROS; C Y D SON H, Ar, ALQUIL C1-C6 O ALQUENIL C2-C6 OPCIONALMENTE SUSTITUIDO CON CICLOALQUIL C3-C8, CICLOALQUIL C5-C7, ENTRE OTROS; Ar ES ARIL O HETEROARIL OPCIONALMENTE SUSTITUIDO; R1 ES Ar, CICLOALQUIL C3-C8, ALQUIL C1-C6, ALQUENIL C2-C6, ENTRE OTROS. TAMBIEN SE REFIERE A UN COMPUESTO DE FORMULA II, DONDE E, F, G Y H SON CH2, O, S, ENTRE OTROS; O COMPUESTOS DE FORMULA III o IV, n ES 1-3. UN COMPUESTO PREFERIDO ES 3-(4-METOXIFENIL)PROPIL (2S)-1-(FENILSULFONIL)-2-PIRROLIDINA CARBOTIOATO, ENTRE OTROS. TAMBIEN SE REFIERE AL PROCEDIMIENTO PARA PREPARAR COMPUESTOS DE FORMULAS I, II, III o IV; DICHOS COMPUESTOS TIENEN AFINIDAD POR LAS INMUNOFILINAS TIPO FKBP12, INHIBIENDO LA ACTIVIDAD DE LA ROTAMASA, PUEDIENDO SER UTILES PARA LA ESTIMULACION DE NEURONAS DANADAS, TRATAMIENTO DEL TRASTORNO NEUROLOGICO
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/775,584 US5874449A (en) | 1996-12-31 | 1996-12-31 | N-linked sulfonamides of heterocyclic thioesters |
US08/996,342 US6121273A (en) | 1996-12-31 | 1997-12-22 | N-linked sulfonamides of heterocyclic thioesters |
PCT/US1997/023526 WO1998029116A1 (en) | 1996-12-31 | 1997-12-22 | N-linked sulfonamides of heterocyclic thioesters |
Publications (1)
Publication Number | Publication Date |
---|---|
PE62099A1 true PE62099A1 (es) | 1999-06-17 |
Family
ID=27119069
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE1998000182A PE62099A1 (es) | 1996-12-31 | 1998-03-16 | Sulfonamidas n-enlazadas de tioesteres heterociclicos |
Country Status (7)
Country | Link |
---|---|
US (3) | US6121273A (es) |
JP (1) | JP2002515051A (es) |
EA (1) | EA002593B1 (es) |
NO (1) | NO992268L (es) |
NZ (1) | NZ335480A (es) |
PA (1) | PA8443901A1 (es) |
PE (1) | PE62099A1 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6274602B1 (en) * | 1998-06-03 | 2001-08-14 | Gpi Nil Holdings, Inc. | Heterocyclic thioester and ketone hair growth compositions and uses |
US20010049381A1 (en) * | 1997-06-04 | 2001-12-06 | Gpl Nil Holdings, Inc., | Pyrrolidine derivative hair growth compositions and uses |
US5945441A (en) * | 1997-06-04 | 1999-08-31 | Gpi Nil Holdings, Inc. | Pyrrolidine carboxylate hair revitalizing agents |
US6429215B1 (en) | 1998-06-03 | 2002-08-06 | Gpi Nil Holdings, Inc. | N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses |
US6274617B1 (en) * | 1998-06-03 | 2001-08-14 | Gpi Nil Holdings, Inc. | Heterocyclic ester and amide hair growth compositions and uses |
US7041283B1 (en) | 2001-02-16 | 2006-05-09 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Methods of using immunophilin binding drugs to improve integration and survival of neuronal cell transplants |
AU2003259846A1 (en) * | 2002-08-16 | 2004-03-03 | The General Hospital Corporation | Non-invasive functional imaging of peripheral nervous system activation in humans and animals |
EP1433778A1 (en) * | 2002-12-23 | 2004-06-30 | Jerini AG | Use of nitriles as rotamase inhibitors |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4070361A (en) * | 1977-04-21 | 1978-01-24 | E. R. Squibb & Sons, Inc. | Mercaptoalkylsulfonyl proline and pipecolic acid and esters thereof |
US5274097A (en) * | 1988-04-19 | 1993-12-28 | Bayer Aktiengesellschaft | 1,3-disubstituted pyrrolidines |
US5356890A (en) * | 1988-06-15 | 1994-10-18 | Brigham And Women's Hospital | S-nitroso derivatives of ace inhibitors and the use thereof |
US5192773A (en) * | 1990-07-02 | 1993-03-09 | Vertex Pharmaceuticals, Inc. | Immunosuppressive compounds |
US5723490A (en) * | 1992-09-08 | 1998-03-03 | Vertex Pharmaceuticals Incorporated | THF-containing sulfonamide inhibitors of aspartyl protease |
IS2334B (is) * | 1992-09-08 | 2008-02-15 | Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) | Aspartyl próteasi hemjari af nýjum flokki súlfonamíða |
JP3599287B2 (ja) * | 1993-04-28 | 2004-12-08 | 三菱化学株式会社 | スルホンアミド誘導体 |
JPH10500938A (ja) * | 1994-03-07 | 1998-01-27 | バーテックス ファーマシューティカルズ インコーポレイテッド | アスパラチルプロテアーゼインヒビターとしてのスルホンアミド誘導体 |
US5691372A (en) * | 1995-04-19 | 1997-11-25 | Vertex Pharmaceuticals Incorporated | Oxygenated-Heterocycle containing sulfonamide inhibitors of aspartyl protease |
US6037370A (en) * | 1995-06-08 | 2000-03-14 | Vertex Pharmaceuticals Incorporated | Methods and compositions for stimulating neurite growth |
US5717092A (en) * | 1996-03-29 | 1998-02-10 | Vertex Pharmaceuticals Inc. | Compounds with improved multi-drug resistance activity |
-
1997
- 1997-12-22 NZ NZ335480A patent/NZ335480A/en unknown
- 1997-12-22 JP JP52083498A patent/JP2002515051A/ja active Pending
- 1997-12-22 EA EA199900512A patent/EA002593B1/ru not_active IP Right Cessation
- 1997-12-22 US US08/996,342 patent/US6121273A/en not_active Expired - Fee Related
- 1997-12-31 PA PA19978443901A patent/PA8443901A1/es unknown
-
1998
- 1998-03-16 PE PE1998000182A patent/PE62099A1/es not_active Application Discontinuation
-
1999
- 1999-05-10 NO NO992268A patent/NO992268L/no not_active Application Discontinuation
-
2000
- 2000-03-01 US US09/516,239 patent/US6294551B1/en not_active Expired - Fee Related
-
2001
- 2001-08-10 US US09/925,630 patent/US20020049193A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20020049193A1 (en) | 2002-04-25 |
US6294551B1 (en) | 2001-09-25 |
NZ335480A (en) | 2001-04-27 |
EA002593B1 (ru) | 2002-06-27 |
NO992268D0 (no) | 1999-05-10 |
EA199900512A1 (ru) | 2000-02-28 |
PA8443901A1 (es) | 2000-05-24 |
NO992268L (no) | 1999-08-30 |
US6121273A (en) | 2000-09-19 |
JP2002515051A (ja) | 2002-05-21 |
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Legal Events
Date | Code | Title | Description |
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